期刊
APPLIED CLINICAL INFORMATICS
卷 7, 期 2, 页码 260-274出版社
GEORG THIEME VERLAG KG
DOI: 10.4338/ACI-2015-09-RA-0125
关键词
Data integration; medical information systems; translational medicine; translational research platform
资金
- French SIRIC program Cancer Research and Personalized Medicine - CARPEM program
- Cancer Research and Personalized Medicine - CARPEM program (Cancer Research Site - SIRIC)
Cancer research involves numerous disciplines. The multiplicity of data sources and their heterogeneous nature render the integration and the exploration of the data more and more complex. Translational research platforms are a promising way to assist scientists in these tasks. In this article, we identify a set of scientific and technical principles needed to build a translational research platform compatible with ethical requirements, data protection and data-integration problems. We describe the solution adopted by the CARPEM cancer research program to design and deploy a platform able to integrate retrospective, prospective, and day-to-day care data. We designed a three-layer architecture composed of a data collection layer, a data integration layer and a data access layer. We leverage a set of open-source resources including i2b2 and tranSMART.
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