Article
Medicine, General & Internal
Can Ihsan Oztorun, Hayal Doruk, Dogus Guney, Ulfet Nihal Irdem Kose, Tugba Ornek Demir, Vildan Selin Cayhan, Sabri Demir, Ahmet Erturk, Ali Gungor, Aysun Kara Uzun, Cemil Nural, Salim Neselioglu, Mujdem Nur Azili, Emrah Senel
Summary: This study demonstrated changes in thiol-disulphide balance and ischaemia-modified albumin levels in favor of oxidative stress in children with trauma, indicating that they cannot be used as a laboratory marker to determine the need for surgical intervention.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Ayse Kaya Kalem, Bircan Kayaaslan, Salim Neselioglu, Fatma Eser, Imran Hasanoglu, Adalet Aypak, Esragul Akinci, H. Nisa Akca, Ozcan Erel, Rahmet Guner
Summary: Severe COVID-19 patients exhibited lower NT and TT levels compared to healthy controls and mild to moderate patients (P < 0.001). ROC analysis results indicated that IL-6 and NT had the highest AUC values between the control and COVID-19 patients (AUC = 0.97, AUC = 0.96), while CRP and NT had the highest AUC values between mild to moderate and severe patients (AUC = 0.85, AUC = 0.83).
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Medical Laboratory Technology
Ertan Kucuksayan, Serkan Ozben, Selma Topaloglu Tuac, Mesrure Koseoglu, Ozcan Erel, Salim Neselioglu, Tomris Ozben
Summary: The study revealed increased oxidative stress levels in restless legs syndrome (RLS) patients, as indicated by decreased levels of native and total thiol, and increased levels of disulphide, with positive correlations between disulphide levels and different rating scores. The dynamic thiol-disulphide homeostasis (TDH) status is suggested to be used as a novel biomarker for the diagnosis and follow-up of RLS patients.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Dermatology
Yavuz Otal, Neslihan Ozkok Koz, Fatih Ahmet Kahraman, F. Gullu Haydar Ercan, Ozcan Erel, Gamze Avcioglu
Summary: Acute urticaria patients showed lower levels of total thiol and native thiol, but higher levels of disulfide and ischemia-modified albumin, indicating oxidative stress.
INDIAN JOURNAL OF DERMATOLOGY
(2021)
Article
Medicine, General & Internal
Simona Roxana Georgescu, Cristina Iulia Mitran, Madalina Irina Mitran, Clara Matei, Gabriela Loredana Popa, Ozcan Erel, Mircea Tampa
Summary: This article reviews the role of thiol-disulfide homeostasis (TDH) in various skin diseases. The results indicate that the changes in TDH may shift towards disulfides or thiols, depending on the extent of oxidative damage.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Munevver Sari, Unal Erkorkmaz, Hayrullah Yazar, Ibrahim Kocayigit, Bahadir Omar, Elnur Alizade, M. N. Murat Aksoy, Abdulkadir Uslu, Gozde Cakirsoy Cakar, Selcuk Pala
Summary: The study found that levels of thiol/disulphide in the serum of HCM patients were significantly lower compared to the control group, indicating impaired antioxidant capacity. However, the ratios of thiol/disulphide remained low, maintaining a reducing state in the extracellular environment.
Article
Peripheral Vascular Disease
Ufuk Turan Kursat Korkmaz, Ahmet Yuksel, Ayhan Cetinkaya, Yusuf Velioglu, Erhan Renan Ucaroglu, Mustafa Cagdas Cayir, Gencehan Kumtepe, Ferhat Borulu, Ceylan Bal, Kemalettin Erdem, Gamze Gok, Seda Duygulu Devay
Summary: This study examined dynamic thiol/disulphide homeostasis metrics as a novel risk factor of oxidative stress in patients with peripheral arterial disease. Results showed significant abnormalities in thiol/disulphide homeostasis parameters in these patients. Logistic regression analysis identified systolic blood pressure, ferroxidase and myeloperoxidase levels as independent predictors of peripheral arterial disease.
Article
Biology
Alessandra Preziuso, Silvia Piccirillo, Giorgia Cerqueni, Tiziano Serfilippi, Valentina Terenzi, Antonio Vinciguerra, Monia Orciani, Salvatore Amoroso, Simona Magi, Vincenzo Lariccia
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects elderly people and is characterized by brain cell deterioration. The study found that silencing the NCX3 protein can improve cell viability, increase energy production, reduce oxidative stress damage, and decrease abnormal protein levels associated with AD. This discovery provides a potential strategy for preventing the development of AD.
Article
Biochemistry & Molecular Biology
Yildirim Kayacan, Ayhan Cetinkaya, Hayrullah Yazar, Yucel Makaraci
Summary: The study showed that moderate-intensity treadmill exercises are more effective in reducing oxidative stress compared to low and high-intensity exercises.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Nuray Yilmaz Cakmak, Emin Gemcioglu, Salih Baser, Sukran Erten, Ozcan Erel
Summary: The study showed that thiol/disulphide balance shifted towards disulphide in patients with pSS, with lower total thiol and native thiol levels compared to the control group.
JOURNAL OF MEDICAL BIOCHEMISTRY
(2021)
Article
Clinical Neurology
Yuting Nie, Changbiao Chu, Qi Qin, Huixin Shen, Lulu Wen, Yi Tang, Miao Qu
Summary: This study identified significant differences in lipid metabolism between Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) patients compared to normal controls (NC). Three sphingomyelin (SPH) biomarkers were found to effectively distinguish AD and aMCI patients from NC. Additionally, AD patients exhibited elevated oxidative stress, and there were complex interactions between lipid metabolites and oxidative stress.
Review
Clinical Neurology
Merve Ergin Tuncay, Murat Ilhan Atagun, Ozcan Erel
Summary: The thiol-disulfide couple is important for maintaining intracellular redox status and plays crucial roles in metabolic processes, signal mechanisms, inflammation, and antioxidant defense. Imbalances in thiol-disulfide homeostasis have been implicated in numerous diseases. This comprehensive review identifies studies on thiol-disulfide homeostasis in psychiatric disorders, which reveal alterations in the thiol-disulfide balance, usually shifting towards the oxidative side. The use of N-acetylcysteine, a thiol-containing compound, as a potential treatment and the role of glutathione, the most abundant thiol in the brain, highlight the importance of evaluating thiol-disulfide balance in psychiatric disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Obstetrics & Gynecology
T. Kiremitli, S. Kiremitli, O. Erel, E. Oguz, K. Dinc, U. Nayki, C. Nayki, C. Turkler, A. Kirkinci
Summary: The study found that maternal serum -SH and -SH + -SS values were significantly lower in isolated oligohydramnios (IO) patients compared to the control group, and the -SS/-SH and -SS/-SH + -SS ratios were significantly higher, while the -SH/-SH + -SS ratio was significantly lower. IMA value was significantly higher in the IO group, and all these parameters have diagnostic value for IO.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Leyla Kazancioglu, Sule Batcik, Medeni Arpa, Basar Erdivanli, Zerrin Ozergin Coskun, Ozlem Celebi Erdivanli, Ilkay Bahceci, Hizir Kazdal, Ozcan Erel, Salim Neselioglu
Summary: This study investigated the effects of hypotensive anaesthesia on oxidative stress with serum thiol/disulphide balance in patients undergoing elective septoplasty procedures. The results showed that hypotensive anaesthesia did not have an adverse effect on dynamic thiol/disulphide balance in elective surgeries, while age over 40 and female gender were found to have a significant effect on oxidative stress.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Talia Ho, Soha Ahmadi, Kagan Kerman
Summary: Alzheimer's disease, a progressive neurodegenerative disorder, affects approximately 40 million people worldwide. Despite extensive research on its pathogenesis and risk factors, treatment options remain limited. The role of copper and glutathione in Alzheimer's disease, as well as their interactions, have been relatively understudied. This review aims to provide a more accessible understanding of their individual roles and interactions in Alzheimer's disease by collecting and assessing relevant research.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Pathology
Seyit Ahmet Erol, Atakan Tanacan, Orhan Altinboga, Filiz Halici Ozturk, Burcin Salman Ozgu, Yasemin Tasci, Salim Neselioglu, Ozcan Erel, Dilek Sahin
Summary: This study found that fetal distress is associated with a shift in thiol-disulfide homeostasis towards oxidation and an increase in ischemia-modified albumin (IMA) levels, which could be a reliable indicator of non-acute ischemic conditions.
FETAL AND PEDIATRIC PATHOLOGY
(2022)
Article
Environmental Sciences
Osman Gokhan Ozakinci, Meside Gunduzoz, Murat Buyuksekerci, Mevlut Karatas, Ahmet Rifat Balik, Salim Neselioglu, Ozcan Erel
Summary: This study used a novel and automated colorimetric measurement method to determine thiol-disulfide homeostasis as indices of oxidative stress in painters. The results showed that the levels of disulfide/native thiol and disulfide/total thiol were significantly higher in painters with longer duration of work. There was a positive correlation between urinary phenol and thiol-disulfide homeostasis, ischemia-modified albumin levels, disulfide levels, and duration of work. The newly developed automated colorimetric method proposed in this study can be a promising and practical test for evaluating the oxidative status of painters.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Obstetrics & Gynecology
Ozgur Aglamis, Seval Yilmaz Ergani, Ozcan Erel, Sevki Celen, Ali Turhan Caglar
Summary: This study evaluated antioxidant balance in pregnant women with meconium-stained amniotic fluid by examining IMA levels and thiol/disulfide homeostasis. Results showed a decrease in SH and total thiol levels and an increase in IMA levels in the meconium group, indicating a shift towards oxidant in antioxidant balance.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Veterinary Sciences
Osman Safa Terzi, Erdal Kara, Yasin Senel, Ebubekir Ceylan, Salim Neselioglu, Ozcan Erel
Summary: The study investigates the TDH parameters and IMA levels in calves with neonatal diarrhea compared to healthy controls. The results show that calves with neonatal diarrhea have significantly decreased levels of native thiol and total thiol compared to healthy controls. The study also finds that IMA levels are increased in calves with neonatal diarrhea due to oxidative stress.
ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI
(2023)
Article
Medicine, General & Internal
Simona Roxana Georgescu, Cristina Iulia Mitran, Madalina Irina Mitran, Clara Matei, Gabriela Loredana Popa, Ozcan Erel, Mircea Tampa
Summary: This article reviews the role of thiol-disulfide homeostasis (TDH) in various skin diseases. The results indicate that the changes in TDH may shift towards disulfides or thiols, depending on the extent of oxidative damage.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medical Laboratory Technology
Elif Guler Kazanci, Muhammet Furkan Korkmaz, Funda Eren, Ozcan Erel
Summary: This study aimed to evaluate the oxidant/antioxidant balance in individuals with beta-thalassemia major (beta-TM) and healthy children, and found that thiol/disulfide homeostasis was weakened in beta-TM patients. The study also revealed that the oxidant imbalance worsened when beta-TM patients did not receive regular chelation therapy.
LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Yunus H. Polat, Sukran Erten, Ahmet Kor, Ismail Dogan, Yuksel Maras, Orhan Kucuksahin, Guniz Y. Ustuner, Ozcan Erel
Summary: This study aimed to evaluate the thiol/disulfide balance in patients with rheumatoid arthritis (RA) compared to healthy controls, and to examine its relationship with Disease Activity Score-28 (DAS28). The results showed that RA patients had lower thiol levels and higher disulfide levels compared to controls. Additionally, the group in remission had higher thiol levels and lower disulfide levels compared to other DAS28 groups. These findings suggest that the antioxidant defense system is impaired in RA patients, leading to oxidative stress and imbalance.
CLINICAL BIOCHEMISTRY
(2023)
Article
Neurosciences
Birsen Can Demirdogen, Osman Oguzhan Kilic, Ata Ayhan Yilmaz, Semra Mungan, Salim Neselioglu, Ozcan Erel
Summary: This study aimed to investigate the association between cognitive impairment and oxidative stress biomarkers TDH and IMA in multiple sclerosis patients. The results showed that plasma native thiol and total thiol levels were significantly decreased in patients with SPMS. The study also found significant correlations between TDH, BICAMS scores, clinical indices of disease severity, and MRI parameters.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Pathology
Ilknur Surucu Kara, Cuma Mertoglu, Guelsah Siranli, Yusuf Kemal Arslan, Gamze Gok, Ozcan Erel
Summary: The aim of the study is to examine the relationship between obesity, Vitamin-D deficiency, and protein oxidation. The results showed that obese children had lower vitamin-D levels than pre-obese and normal-weight children. Thiol-disulfide homeostasis was negatively affected by low vitamin D levels, pubertal period, and high triglyceride levels.
FETAL AND PEDIATRIC PATHOLOGY
(2023)
Article
Medicine, General & Internal
Kadriye Erdogan, Nazli Tunca Sanlier, Emine Utlu Ozen, Sueleyman Erol, Inci Kahyaoglu, Salim Neselioglu, Ozcan Erel, Serra Akar, Yaprak Engin Ustun
Summary: This study evaluates the role of oxidative stress in unexplained infertility (UEI) by assessing dysfunctional high-density lipoprotein (HDL) through the myeloperoxidase (MPO) and paraoxonase (PON) ratio. The results show that patients with UEI have higher total dosages of gonadotropin, lower number of Grade 1 embryos and quality of blastocysts, and higher serum MPO/PON ratio. Serum MPO/PON ratio can significantly predict the duration of infertility.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Sukru Alperen Korkmaz, Sadice Kizgin, Esra Firat Oguz, Salim Neselioglu, Ozcan Erel
Summary: This study found significant differences in levels of thiol-disulphide parameters, ischemia-modified albumin (IMA), and C-reactive protein (CRP) between bipolar disorder (BD) patients in acute mania and early remission compared to healthy controls. Additionally, during the manic phase, markers such as neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammatory index (SII), platelet-to-albumin ratio (PAR), and CRP levels were significantly higher. These findings highlight the importance of inflammation in bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Cetin Turan, Guliz Senormanci, Salim Neselioglu, Yasemin Budak, Ozcan Erel, Omer Senormanci
Summary: This study aimed to investigate the differences in oxidative stress and systemic inflammation biomarkers between methamphetamine users and the control group. Serum thiol/disulfide balance and ischemia-modified albumin levels were used to assess oxidative stress, while serum interleukin-6 (IL-6) levels and complete blood count (CBC) were used to evaluate inflammation.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Neurosciences
Almila Senat, Esra Kabadayi-Sahin, Ibrahim Sogut, Tomris Duymaz, Ozcan Erel
Summary: This study aimed to evaluate oxidative contributors of atherosclerotic risk factors in patients with Alcohol Use Disorder (AUD). The results showed significantly elevated oxidative markers in AUD patients and decreased antioxidant capacity. Atherosclerotic markers were also higher and correlated with alcohol intake. Thus, oxidative markers may serve as indicators for atherosclerotic risk and therapeutic interventions targeting oxidative load may help prevent clinical manifestation of atherosclerotic diseases.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Yasemin Dogan, Yucel Yilmaz, Saban Kelesoglu, Bekir Calapkorur, Salim Neselioglu, Ozcan Erel, Nihat Kalay
Summary: The aim of this study was to investigate the relationship between thiol, the main component of the antioxidant system, and coronary collateral circulation (CCC). The results showed that patients with stable coronary artery disease (sCAD) who developed poor CCC had lower levels of native thiol, total thiol, and disulfide compared to those with good CCC. Additionally, DM, total thiol, and disulfide were identified as independent predictors of poor CCC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Gamze Yilmaz, Salim Neselioglu, Fatma Nur Ceylan, Burak Elmas, Fatmanur Ece Aydogdu, Ozcan Erel, Ozlem Uzunlar, Esma Sarikaya, Ozlem Moraloglu Tekin
Summary: This study reveals that the highest level of antioxidant status can be observed in full-term pregnancies, and it is correlated with better APGAR scores in newborns. However, no significant difference in maternal oxidant balance was found between different gestational stages.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2023)
