Article
Biochemistry & Molecular Biology
Nayely Leyva-Lopez, Melissa Peraza-Arias, Anaguiven Avalos-Soriano, Crisantema Hernandez, Cynthia E. Lizarraga-Velazquez, J. Basilio Heredia
Summary: Polyphenolic extracts from spent coffee grounds exhibit antioxidative protective effects against oxidative stress in C. viridis brain cells by enhancing antioxidant enzyme activity and reducing lipid peroxidation.
Article
Chemistry, Applied
Everton Ribeiro, Thais de Souza Rocha, Sandra Helena Prudencio
Summary: Protein extracts from green and roasted coffee beans, as well as spent coffee grounds, were evaluated for bioactive peptides. In silico analysis showed high occurrence of dipeptidyl peptidase-IV (DPP-IV) and angiotensin I-converting enzyme (ACE) inhibitor peptides in the 11S coffee globulin, which could be released after digestion. In vitro digestion revealed that green bean and spent coffee ground proteins were more susceptible to proteolysis, releasing small peptides with high anti-hypertensive potentials.
Article
Agricultural Engineering
Ales Hanc, Tereza Hrebeckova, Alena Grasserova, Tomas Cajthaml
Summary: The study focused on vermicomposting of spent coffee grounds (SCG) and its mixtures with straw pellets, evaluating the biological and physico-chemical properties of the process. The treatment with 25% vol. SCG + 75% vol. straw pellets showed the highest number and biomass of earthworms. Earthworm weight decreased as layer age increased, with the oldest treatment layer having suitable agrochemical properties. Earthworms were effective in reducing caffeine stimulant content during the vermicomposting process.
BIORESOURCE TECHNOLOGY
(2021)
Article
Energy & Fuels
Jiawei Fu, Xijian Wu, Jingyong Liu, Fatih Evrendilek, Tao Chen, Wuming Xie, Weijie Xu, Yao He
Summary: Co-pyrolysis of spent coffee grounds and polyethylene can reduce waste streams and pollution, while valorizing energy and by-products. The co-pyrolysis performance is influenced by temperature and blend ratio. The study revealed that co-pyrolysis consists of two stages, the degradation of spent coffee grounds followed by the depolymerization of polyethylene and lignin. The products of co-pyrolysis include a variety of oxygen-containing compounds, and CP73 showed the highest yields of hydrocarbons and alcohols, beneficial for further utilization.
Article
Chemistry, Multidisciplinary
Hyeok-Jin Kim, Sea-Cheon Oh
Summary: The study showed that hydrothermal carbonization with subcritical water can improve the fuel characteristics of spent coffee grounds, increasing fixed carbon content and heating value, making the fuel characteristics similar to coal as the reaction temperature increases.
APPLIED SCIENCES-BASEL
(2021)
Article
Green & Sustainable Science & Technology
Nurulfarah Adilah Rosmahadi, Hemamalini Rawindran, Jun Wei Lim, Worapon Kiatkittipong, Suttichai Assabumrungrat, Vesna Najdanovic-Visak, Jiawei Wang, Boredi Silas Chidi, Chii-Dong Ho, Eman Alaaeldin Abdelfattah, Sze Mun Lam, Jin Chung Sin
Summary: One economical approach to harvesting mature microalgal biomass is through the attached growth system. This study found that spent coffee grounds can serve as a support material for Chlorella vulgaris sp. microalgae, enhancing the attached microalgal growth. Additionally, a specific photoperiod regime with a dark period cycle of 4 hours per day resulted in the maximum microalgal density, allowing the attached microalgae to strengthen their mixotrophic growth and accumulate a significant amount of lipid.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2022)
Article
Agricultural Engineering
Gwi-Taek Jeong
Summary: Due to increased coffee consumption, spent coffee grounds (SCG) have become a growing waste management concern. However, this study shows that by using acid catalysts and thermochemical conversion, valuable platform chemicals can be produced from lipid-extracted SCG. This finding has important implications for the recycling and reuse of coffee grounds.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Engineering, Chemical
Xi-Er Chen, Dave Mangindaan, Hsiu-Wen Chien
Summary: This study discovered that spent coffee grounds (SCG) possess photothermal properties under near-infrared laser irradiation, making them suitable for applications as photothermal materials. Additionally, when incorporated into polyNIPAM hydrogels, SCGs can induce thermal shrinkage and bending, indicating their potential as photothermal actuators. These findings provide new insights for the recycling and reuse of SCGs.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2022)
Article
Food Science & Technology
Luigi Castaldo, Sonia Lombardi, Anna Gaspari, Mario Rubino, Luana Izzo, Alfonso Narvaez, Alberto Ritieni, Michela Grosso
Summary: The study demonstrated that spent coffee ground with high content in bioactive molecules could be used to enhance the bioactive potential of baked foods, with SCGc showing higher antioxidant activity during simulated gastrointestinal digestion.
Article
Energy & Fuels
Jackie Massaya, Ka Ho Chan, Ben Mills-Lamptey, Christopher J. Chuck
Summary: The study explores the utilization of spent coffee grounds (SCGs) through integrated subcritical water extraction (SWE) and hydrothermal carbonisation (HTC) to derive three products: a bioactive extract, a protein isolate (SCG PI), and solid fuel. The optimized processes result in high-quality products, surpassing previous single-product systems. This work highlights the potential of subcritical water processing to produce commercially viable products across the value chain.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Materials Science, Multidisciplinary
Victoria Bejenari, Alexandra Marcu, Alina-Mirela Ipate, Daniela Rusu, Nita Tudorachi, Ion Anghel, Ioana-Emilia Sofran, Gabriela Lisa
Summary: The study demonstrates that firelighters containing coffee grounds have superior combustion performance and can serve as an alternative utilization method. Additionally, these firelighters produce less residue and have a longer burning time.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Green & Sustainable Science & Technology
J. Rajesh Banu, R. Yukesh Kannah, M. Dinesh Kumar, Preethi, S. Kavitha, M. Gunasekaran, Guangyin Zhen, Mukesh Kumar Awasthi, Gopalakrishnan Kumar
Summary: Coffee consumption leads to the generation of large amounts of spent coffee grounds (SCG), which contains various valuable components. Valorisation of SCG through integrated biorefinery approach not only brings more valuable products, but also enhances environmental sustainability and economic benefits. The future perspective of SCG biorefinery shows the potential for higher production of bioactive compounds and bioenergy, contributing to the development of a circular bioeconomy.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2021)
Review
Green & Sustainable Science & Technology
Mohammad Saberian, Jie Li, Anita Donnoli, Ethan Bonderenko, Paolo Oliva, Bailey Gill, Simon Lockrey, Rafat Siddique
Summary: Through literature review, it can be concluded that SCGs have the potential to be used as aggregates in construction materials across a wide range of civil engineering applications. However, further comprehensive studies are needed in this specific area due to limited research and lack of evidence of successful practical applications.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Food Science & Technology
Raffaele Romano, Lucia De Luca, Giulia Basile, Chiara Nitride, Fabiana Pizzolongo, Paolo Masi
Summary: This study utilized green technologies to extract bioactive compounds from spent coffee grounds (SCG) using supercritical and liquid CO2. The extracts obtained showed high yields and antioxidant activity, with high contents of polyphenols and known antioxidant and antimicrobial compounds. These extracts have potential applications in the cosmetic, pharmaceutical, and food sectors.
Review
Food Science & Technology
Adriana S. Franca, Leandro S. Oliveira
Summary: Spent coffee grounds are generated worldwide in large quantities, mainly disposed of in landfills or for energy recovery, which may result in greenhouse gas and toxic emissions. However, the grounds contain various compounds that can be recovered and used in applications such as biofuels, cosmetics, and food ingredients.
Article
Food Science & Technology
Esther Garcia-Diez, Helena Senchez-Ayora, Maria Blanch, Sonia Ramos, Maria Angeles Martin, Jara Perez-Jimenez
Summary: Evidence suggests that combining carob with cocoa can result in a blend with high dietary fiber, methylxanthines, and polyphenols, and less bitterness compared to pure cocoa. This blend may serve as a suitable alternative to commercial sugar-rich soluble cocoa powders.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Physical
Marco Campanile, Rosario Oliva, Gerardino D'Errico, Pompea Del Vecchio, Luigi Petraccone
Summary: LL-III is an anticancer peptide that can translocate across tumor cell membranes. However, the mechanism through which it enters the cell cytoplasm is still unknown. In this study, we used physico-chemical techniques to characterize the interaction of LL-III with liposomes resembling the lipid matrix of the tumor cell membrane. Our results show that the peptide selectively interacts with the model tumor cell membrane without disrupting the lipid bilayer, but alters its properties by promoting lipid reorganization and increasing membrane permeability.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Engineering, Biomedical
Raffaele Conte, Ilenia De Luca, Anna Valentino, Pierfrancesco Cerruti, Parisa Pedram, Gustavo Cabrera-Barjas, Arash Moeini, Anna Calarco
Summary: In this study, we prepared hyaluronic acid hydrogels containing resveratrol-loaded chitosan nanoparticles and evaluated their potential therapeutic effects in treating atopic dermatitis. The prepared chitosan nanoparticles showed sizes ranging from 120 to 500 nm and high encapsulation efficiency of resveratrol. Embedding the nanoparticles in hyaluronic acid hydrogels slowed down their degradation and resveratrol release. Resveratrol released from the nanoparticle-loaded hydrogel demonstrated anti-oxidative effects in an in vitro model of atopic dermatitis and reduced proinflammatory cytokine secretion and gene expression in HaCaT cells. The physicochemical analysis and in vitro assay confirmed that the formulated hydrogel could serve as an efficient and sustained resveratrol delivery system in the treatment of atopic dermatitis.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Sara Viggiano, Lucia Panzella, Maria Reichenbach, Joachim Hans, Alessandra Napolitano
Summary: Immediate pigment darkening, the rapid onset of melanin pigmentation resulting from oxidation, can lead to irregular pigmentation and dark spots. Phenolic cosmetic ingredients (CIs) such as paradol-6 and phenylethyl resorcinol can decrease the oxidation and melanin formation of 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole-2-carboxylic acid (DHICA). CIs also show photoprotective effects in model systems, reducing peroxidation and generation of reactive oxygen species. These findings have potential implications for the development of skincare formulations to improve skin spots and counteract aging processes associated with sun exposure.
Review
Biochemistry & Molecular Biology
Rodolfo Esposito, Immacolata Speciale, Cristina De Castro, Gerardino D'Errico, Irene Russo Krauss
Summary: To protect human and environmental health, researchers are focusing on discovering and developing new molecules with high biocompatibility and biodegradability. Surfactants are particularly urgent in this matter, and biosurfactants derived from microorganisms are a promising alternative. Rhamnolipids, a well-known family of biosurfactants, have been extensively studied for their production and physicochemical characterization, although a clear structure-function relationship is still lacking. This review aims to provide a comprehensive discussion of the physicochemical properties of rhamnolipids under different solution conditions and their structure, while also addressing unresolved issues for their potential replacement of conventional surfactants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rita Argenziano, Maria Laura Alfieri, Noemi Gallucci, Gerardino D'Errico, Lucia Panzella, Alessandra Napolitano
Summary: The search for new synthetic melanin-related pigments with antioxidant and photoprotective properties is important for dermo-cosmetic purposes. In this study, a melanin derived from 5,6-dihydroxyindole-2-carboxylic acid (DHICA) was synthesized and found to have similar structural properties to DHICA melanin. The synthesized pigment demonstrated stronger UV-visible absorption and improved solubility compared to DHICA melanin. Furthermore, the pigment exhibited marked antioxidant properties and enhanced inhibitory action against lipid peroxidation. These findings suggest that the melanin derived from DHICA has potential as a functional ingredient in dermo-cosmetic formulations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Noemi Faggio, Angela Marotta, Veronica Ambrogi, Pierfrancesco Cerruti, Gennaro Gentile
Summary: Epoxy resins are widely used in various applications due to their mechanical strength, chemical resistance, and adhesion properties. However, the use of bisphenol A (BPA) derivatives in epoxy resins raises health concerns. This study explores furan-based epoxies as promising bio-based alternatives. By replacing methyl nadic anhydride (MNA) with maleic anhydride (MA) derived from vegetable feedstocks, a fully bio-based epoxy resin was developed. The resin showed higher reactivity towards MA and exhibited superior adhesive strength on carbon fiber-reinforced thermosetting plastics (CFRP) joints compared to traditional epoxy resins. This research demonstrates the potential of BOMF-based epoxy resins as sustainable alternatives to DGEBA-containing systems.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Carmela Spagnuolo, Federica Moccia, Idolo Tedesco, Eva Adabbo, Lucia Panzella, Gian Luigi Russo, Alessandra Napolitano
Summary: The extract obtained from the waste of fermented strawberry distillate production exhibited high antioxidant and antiproliferative properties, mainly attributed to the presence of ellagic acid and p-coumaric acid. It showed strong antiproliferative effects on human cancer cell lines, especially on HL-60 cells, through rapid apoptosis induction. The extract also exhibited antioxidant activity and modulation of cellular oxidative stress and signaling pathways.
Article
Biochemistry & Molecular Biology
Ilenia De Luca, Francesca Di Cristo, Raffaele Conte, Gianfranco Peluso, Pierfrancesco Cerruti, Anna Calarco
Summary: Dry eye disease is a dynamic and complex disease that can cause damage and discomfort to the ocular surface, affecting the patient's quality of life. Phytochemicals like resveratrol have attracted attention for their potential in treating this disease. However, the low bioavailability and poor therapeutic response of resveratrol limit its clinical application. Combining cationic polymeric nanoparticles with in situ gelling polymers could be a promising strategy to improve drug delivery and effectiveness for treating dry eye disease.
Article
Chemistry, Multidisciplinary
Flaviana Di Lorenzo, Simone Nicolardi, Roberta Marchetti, Adele Vanacore, Noemi Gallucci, Katarzyna Duda, Ferran Nieto Fabregat, Ha Ngoc Anh Nguyen, Djamel Gully, James Saenz, Eric Giraud, Luigi Paduano, Antonio Molinaro, Gerardino D'Errico, Alba Silipo
Summary: The ability of Methylobacterium extorquens to grow on methanol as the sole carbon and energy source is influenced by the composition and function of the lipopolysaccharide (LPS) in the outer membrane. The LPS of M. extorquens is unique, with non-phosphorylated and heavily O-methylated core oligosaccharides, and a distinctive lipid A structure. These chemical features impact the resistance of the membrane to methanol, regulating membrane ordering and dynamics.
Review
Materials Science, Multidisciplinary
Valentina Marturano, Angela Marotta, Sarai Agustin Salazar, Veronica Ambrogi, Pierfrancesco Cerruti
Summary: In recent years, there has been increasing global concern about the depletion of fossil fuels and the environmental impact of oil-based compounds, which has led to the development of more sustainable approaches in the development of polymer-based materials. The replacement of synthetic additives with natural compounds in polymer commodities is gradually taking place, and the production of bio-plastics is predicted to grow exponentially. However, these materials may have limitations in terms of processability and end-use, prompting academic and industrial communities to focus on fully bio-based formulations with improved performance and tailored for specific applications.
PROGRESS IN MATERIALS SCIENCE
(2023)
Article
Nutrition & Dietetics
Paula Martinez-Oca, Claudio Alba, Alicia Sanchez-Roncero, Tamara Fernandez-Marcelo, Maria Angeles Martin, Fernando Escriva, Juan Miguel Rodriguez, Carmen Alvarez, Elisa Fernandez-Millan
Summary: This study suggests that maternal malnutrition during lactation can impact the microbial composition of mother's milk and offspring gut colonization. These microbial changes compromise the correlations between milk and fecal samples and lead to increased offspring gut permeability and altered expression of goblet cell markers.
Article
Biochemistry & Molecular Biology
Esther Garcia-Diez, Maria Elvira Lopez-Oliva, Francisco Perez-Vizcaino, Jara Perez-Jimenez, Sonia Ramos, Maria Angeles Martin
Summary: In this study, it was shown that a cocoa-carob blend rich in polyphenols improved gut health and gut microbiota composition in diabetic rats. The blend regulated the levels of mucin and tight-junction proteins, reduced oxidative stress and inflammation, and modulated the composition of gut bacteria. Several phenolic metabolites in the blend were found to be associated with specific changes in gut bacteria composition.
Article
Engineering, Environmental
Virginia Venezia, Mariavittoria Verrillo, Noemi Gallucci, Rocco Di Girolamo, Giuseppina Luciani, Gerardino D'Errico, Luigi Paduano, Alessandro Piccolo, Giuseppe Vitiello
Summary: The waste-to-wealth strategy promotes the design of new value-added materials using biowastes. Humic Acids (HA) are intriguing due to their supramolecular associations, which enable adsorption, chelation, redox behavior, and antibacterial activity. Combining HA with semiconductor nanoparticles allows for the creation of nanostructured hybrids with advanced properties. The study provides insights into producing low-cost organo-inorganic nanomaterials with redox and biocide properties to address environmental and health issues.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
