Expected and unexpected features of protein-binding RNA aptamers

Tissue-type plasminogen activator-binding RNA aptamers inhibiting low-density lipoprotein receptor family-mediated internalisation

(2015) Kenneth A. Bøtkjær et al.   THROMBOSIS AND HAEMOSTASIS

Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer

(2015) Laure Yatime et al.   Nature Communications

Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2

(2015) Dominik Oberthür et al.   Nature Communications

Protein-Binding RNA Aptamers Affect Molecular Interactions Distantly from Their Binding Sites

(2015) Daniel M. Dupont et al.   PLoS One

Aptamers as Drug Delivery Vehicles

(2014) Sven Kruspe et al.   ChemMedChem

Structure analysis of free and bound states of an RNA aptamer against ribosomal protein S8 from Bacillus anthracis

(2014) Milya Davlieva et al.   NUCLEIC ACIDS RESEARCH

An RNA aptamer possessing a novel monovalent cation-mediated fold inhibits lysozyme catalysis by inhibiting the binding of long natural substrates

(2014) C. S. Padlan et al.   RNA

Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents

(2014) John C Rohloff et al.   Molecular Therapy-Nucleic Acids

Dissecting the Effect of RNA Aptamer Binding on the Dynamics of Plasminogen Activator Inhibitor 1 Using Hydrogen/Deuterium Exchange Mass Spectrometry

(2013) Morten B. Trelle et al.   ACS Chemical Biology

Solution structure of a DNA mimicking motif of an RNA aptamer against transcription factor AML1 Runt domain

(2013) Yusuke Nomura et al.   JOURNAL OF BIOCHEMISTRY

A Novel C5a-neutralizing Mirror-image (l-)Aptamer Prevents Organ Failure and Improves Survival in Experimental Sepsis

(2013) Kai Hoehlig et al.   MOLECULAR THERAPY

The Runt domain of AML1 (RUNX1) binds a sequence-conserved RNA motif that mimics a DNA element

(2013) J. Fukunaga et al.   RNA

Potent Inhibition of HIV-1 Reverse Transcriptase and Replication by Nonpseudoknot, “UCAA-motif” RNA Aptamers

(2013) Angela S Whatley et al.   Molecular Therapy-Nucleic Acids

Targeting Tumor Cell Invasion and Dissemination In Vivo by an Aptamer That Inhibits Urokinase-type Plasminogen Activator through a Novel Multifunctional Mechanism

(2012) K. A. Botkjaer et al.   MOLECULAR CANCER RESEARCH

High-throughput sequence analysis reveals structural diversity and improved potency among RNA inhibitors of HIV reverse transcriptase

(2012) Mark A. Ditzler et al.   NUCLEIC ACIDS RESEARCH

Molecular Mechanism for Inhibition of G Protein-Coupled Receptor Kinase 2 by a Selective RNA Aptamer

(2012) Valerie M. Tesmer et al.   STRUCTURE

Nucleic Acid Aptamers Against Proteases

(2011) D. M. Dupont et al.   CURRENT MEDICINAL CHEMISTRY

Nucleic Acid Aptamers: Clinical Applications and Promising New Horizons

(2011) X. Ni et al.   CURRENT MEDICINAL CHEMISTRY

Crystal structure of Hfq from Bacillus subtilis in complex with SELEX-derived RNA aptamer: insight into RNA-binding properties of bacterial Hfq

(2011) Tatsuhiko Someya et al.   NUCLEIC ACIDS RESEARCH

Discovery and Development of Therapeutic Aptamers

(2010) P.R. Bouchard et al.   Annual Review of Pharmacology and Toxicology

RNA Aptamers as Conformational Probes and Regulatory Agents for Plasminogen Activator Inhibitor-1

(2010) Jeppe B. Madsen et al.   BIOCHEMISTRY

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Conformational plasticity of RNA for target recognition as revealed by the 2.15 Å crystal structure of a human IgG–aptamer complex

(2010) Yusuke Nomura et al.   NUCLEIC ACIDS RESEARCH

Serum-stable RNA aptamers to urokinase-type plasminogen activator blocking receptor binding

(2010) D. M. Dupont et al.   RNA

Aptamers that recognize drug-resistant HIV-1 reverse transcriptase

(2008) N. Li et al.   NUCLEIC ACIDS RESEARCH

An RNA molecule that specifically inhibits G-protein-coupled receptor kinase 2 in vitro

(2008) G. Mayer et al.   RNA

Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G

(2008) S. Miyakawa et al.   RNA

Crystal structure of an RNA aptamer bound to thrombin

(2008) S. B. Long et al.   RNA

Computational characterization of B-cell epitopes

(2007) Nimrod D. Rubinstein et al.   MOLECULAR IMMUNOLOGY