Article
Materials Science, Multidisciplinary
Louise Breloy, Vlasta Brezova, Zuzana Barbierikova, Yoshihiro Ito, Jun Akimoto, Annalisa Chiappone, Samir Abbad-Andaloussi, Jean-Pierre Malval, Davy-Louis Versace
Summary: This study reported the high initiating properties of quinizarin derivatives under visible-light irradiation, achieving high conversions when combined with various co-initiators. The use of soybean oil acrylate led to highly cross-linked materials with comparable mechanical properties under visible-light. Moreover, the copolymerization of the photosensitizer with the polymer matrix not only prevented leakage, but also ensured antiadhesion properties against Staphylococcus aureus under visible-light activation.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Microbiology
Viswanath Ragupathy, Mohan Haleyurgirisetty, Neetu Dahiya, Caitlin Stewart, John Anderson, Scott MacGregor, Michelle Maclean, Indira Hewlett, Chintamani Atreya
Summary: Despite advances in ensuring blood supply safety, there is still a risk of transfusion transmitted infections (TTIs) from emerging infections. New pathogen reduction technologies (PRTs) using violet-blue light at 405 nm have shown promise in effectively inactivating pathogens in blood, including bacteria, parasites, and viruses.
Article
Multidisciplinary Sciences
Raveen Rathnasinghe, Sonia Jangra, Lisa Miorin, Michael Schotsasert, Clifford Yahnke, Adolfo Garcia-Sastre
Summary: Research shows that visible light (405 nm) has potential in germicidal applications, utilizing reactive oxygen species to deactivate pathogens, especially effective against respiratory pathogens such as SARS-CoV-2 and influenza virus. This method, which is porphyrin-independent, is safe and commercially viable.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Environmental
Gokulakrishnan Subramanian, Halan Prakash
Summary: The visible light/Cu(II)/H2O2 system showed enhanced disinfection compared to the Cu(II)/H2O2 system without the need for reducing agents or organic ligands. Experimental results demonstrated that the visible light/Cu(II)/H2O2 system caused significant damage to bacterial cell membranes and proposed a ligand to metal charge transfer mechanism for enhanced disinfection. Energy efficiency and cost-effectiveness of the visible light/Cu(II)/H2O2 system were determined to be favorable for practical applications.
Article
Biotechnology & Applied Microbiology
Young-gyun Park, Young Su Lee, Souvic Sarker, Eun Hye Ham, Un Taek Lim
Summary: Recently, the potential of using positive phototaxis exhibited by natural enemies to enhance pest control efficiency in agriculture has been explored in Korea and Japan. This study evaluated the responses of seven natural enemies to different wavelengths of LED light and assessed how mating status and gender affected their responses using a video tracking system. The results showed that wavelengths of 385 nm and 405 nm were highly attractive to most natural enemies, except for two species. Unmated females of one species moved greater distances than mated ones, while both males and females of another species remained longer under UV light. Therefore, the use of UV or near-UV lighting could help retain natural enemies in specific agricultural contexts for better pest control.
BIOLOGICAL CONTROL
(2023)
Article
Oncology
Leonardo Moreira Teodosio, Leticia Gambarini, Andre Luis Faria-e-Silva, Fernanda de Carvalho Panzeri Pires-de-Souza, Aline Evangelista de Souza-Gabriel, Jardel Francisco Mazzi-Chaves, Manoel D. Sousa-Neto, Fabiane Carneiro Lopes-Olhe
Summary: This study evaluated the whiteness index and color stability of stained endodontically treated teeth after bleaching with violet LED and hydrogen peroxide. The results showed that violet LED alone had a lower bleaching effect compared to bleaching treatment with hydrogen peroxide. However, the color stability was observed for all groups, regardless of whether violet LED was used alone or in combination with hydrogen peroxide.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Microbiology
Davide Amodeo, Pietro Manzi, Isa De Palma, Alessandro Puccio, Nicola Nante, Mariella Barcaccia, Daniele Marini, Donatella Pietrella
Summary: Violet-blue light at 405 nm has demonstrated effective antimicrobial properties in healthcare facilities. It significantly reduces bacterial levels on high-contact surfaces and shows promise for MRSA disinfection. While it has the potential to reduce microbial contamination in hospital environments, it should be used in combination with standard cleaning practices and infection control protocols.
Article
Multidisciplinary Sciences
Hanyu Chen, Yifan Cheng, Carmen I. Moraru
Summary: This study investigates the antimicrobial effectiveness of 405 nm LEDs against various pathogens and evaluates the impact of different surfaces and packaging materials. The results demonstrate the significant potential of 405 nm LEDs for antimicrobial applications in food processing and healthcare industry.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Physical
Fumiaki Amano, Akira Yamamoto, Jun Kumagai
Summary: Hydrogen-treated rutile TiO2 showed higher photocatalytic activity than traditional titanium oxide catalysts under UV irradiation, indicating the potential for enhanced performance.
Article
Oncology
Ana Eliza Castanho Garrini Santos, Sandra Kalil Bussadori, Marcelo Mendes Pinto, Aldo Brugnera, Fatima Antonia Aparecida Zanin, Tamiris Silva, Ana Luiza Cabrera Martinbianco, Dacio Antonio Pantano Junior, Maria Fernanda Setubal Dextro Rodrigues, Hilana Paula Carrillo Artese, Alessandro Melo Deana, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana
Summary: The results of this study showed that violet LED alone was not as effective in whitening teeth as when combined with 35% CP. However, the LED + 35% CP treatment did not result in as much pain as 35% HP, suggesting a similar whitening effect with better pain outcomes. All treatments showed an improvement in quality of life.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Chemistry, Physical
Yunkai Liao, Junxiang Wang, Xiao Song, Guan Zhang, Baiyang Chen
Summary: This study discovered the photocatalytic water disinfection and antibacterial ability of phenolic-formaldehyde resins under LED lamp or natural sunlight irradiation for the first time. The resin photocatalysts exhibited superior E. coli inactivation performance and practical application feasibility for water purification. This work provides a new approach for developing resin-based products with antibacterial function or solar water purification products.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2021)
Article
Infectious Diseases
Dan Wang, Takayuki Nambu, Hiroaki Tanimoto, Naohiro Iwata, Kazushi Yoshikawa, Toshinori Okinaga, Kazuyo Yamamoto
Summary: The study reveals that violet LED irradiation significantly reduces the relative abundance of Fusobacterium species in the oral microbiome, while leading to a significant increase in species such as Veillonella and Campylobacter. This method shows potential for adjusting the balance of the oral microbiome without inducing antibiotic resistance.
Article
Multidisciplinary Sciences
Nofar Atari, Hadas Mamane, Alon Silberbush, Neta Zuckerman, Michal Mandelboim, Yoram Gerchman
Summary: This study explores the disinfection kinetics of SARS-CoV-2 variants by 267 nm UV-LED. The results show that all variants have an average reduction in copy number of more than 5 logs at 5 mJ/cm(2) dose, but there is inconsistency, especially for the Alpha variant. Increasing the dose to 7 mJ/cm(2) does not increase average inactivation, but significantly reduces the inactivation inconsistency, making it the recommended minimum dose. Sequence analysis suggests that the difference between the variants may be due to small differences in the frequency of specific UV extra-sensitive nucleotide sequence motifs. The use of UV-LED for the prevention of SARS-CoV-2 spread offers many advantages but careful consideration of UV dose is necessary.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Akihiro Shirai, Kaito Kawasaka, Koichiro Tsuchiya
Summary: The aim of this study was to investigate the fungicidal spectrum of six phenolic-cinnamic and-benzoic acid derivatives using four fungi, and to assess the mechanism of action involving oxidative damage. The results showed that ferulic acid and vanillic acid exhibited synergistic activity with 405-nm light irradiation, leading to decreased viability of the fungi. The study also revealed the generation of reactive oxygen species and a decrease in intracellular ATP levels, which resulted in growth delay.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Engineering, Environmental
Hongchen Shen, Zhe Zhou, Haihuan Wang, Jiahao Chen, Mengyang Zhang, Minghao Han, Yun Shen, Danmeng Shuai
Summary: Photosensitized electrospun nanofibrous membranes were developed to capture and inactivate airborne coronavirus aerosols. The membranes with ultrafine fiber diameter and small pore size effectively filtered and killed the viruses. Singlet oxygen generated by the photosensitizer damaged the virus genome and prevented virus binding to host cells. This study holds promise for applications in personal protective equipment and indoor air filters.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Cell & Tissue Engineering
Eva Goldberg-Bockhorn, Ulla Wenzel, Marie-Nicole Theodoraki, Johannes Doescher, Ricarda Riepl, Marlene C. Wigand, Cornelia Brunner, Martin Hessling, Thomas K. Hoffmann, Johann Kern, Nicole Rotter
Summary: Cartilage tissue engineering is a promising alternative, but challenges exist due to complex interactions between cells and extracellular matrix. This study used a custom-made glass bioreactor to enhance cell migration into decellularized porcine cartilage scaffolds in order to mimic physiological conditions.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Optics
Martin Hessling, Bernhard Lau, Petra Vatter
Summary: The COVID-19 pandemic has driven the search for new antiviral techniques. Studies have shown that bacteria and fungi can be inactivated by both ultraviolet radiation and visible light. However, it is still uncertain to what extent the riboflavin concentration in the applied media can influence the results. More research is needed in this field.
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicole Fehler, Christian Lingenfelder, Sebastian Kupferschmid, Martin Hessling
Summary: This study investigates the effect of wavelength-dependent multiple reflections inside the eye on the increase in retinal irradiance during ophthalmic surgery. It examines the role of eye pigmentation in this effect and its potential influence on photochemical and thermal hazard to the retina.
ZEITSCHRIFT FUR MEDIZINISCHE PHYSIK
(2022)
Article
Microbiology
Anna-Maria Gierke, Martin Hessling
Summary: Due to the increase in multidrug-resistant pathogens, it is important to investigate further antimicrobial options. In this study, the suitability of possible surrogate candidates for ESKAPE pathogens for UVC applications was examined and compared inactivation sensitivities to 222 and 254 nm radiation. The results showed that more than half of the studied ESKAPE relatives can be applied as surrogates for ESKAPE pathogens, but further research is needed for certain strains due to lack of data.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Martin Hessling, Ben Sicks, Bernhard Lau
Summary: This study investigated the efficacy of far-UVC radiation at 222 nm for hand disinfection. The results showed that radiation at a dose of 23 mJ/cm² reduced bacterial colonies on hands by one log level, while a dose of 100 mJ/cm² reduced bacterial colonies on gloves by 1.3 log levels. Compared to a commercial disinfectant, the reduction in bacterial colonies by radiation was lower. In conclusion, far-UVC radiation can effectively reduce microorganisms, but its disinfection efficacy on hands and gloves is relatively poor compared to results in suspensions.
Article
Ophthalmology
N. Fehler, C. Lingenfelder, M. Hessling, S. Kupferschmid
Summary: This study aimed to investigate the potential retinal risk of different light sources and light guides under bright illumination in vitreoretinal surgery. The results showed that the retinal hazard increased with decreasing distance of the light source's tip. The maximum exposition time was longest for the halogen lamp, followed by the xenon lamp and LED, when normalized to the same brightness. The choice of the most suitable lamp and illumination fiber depends on the intensity and spectral distribution of the system.
JOURNAL FRANCAIS D OPHTALMOLOGIE
(2023)
Article
Medicine, General & Internal
Nicole Fehler, Martin Hessling
Summary: This study measured the correlated color temperature (CCT) during ophthalmic surgery and found that diaphanoscopic illumination causes a strong red shift, making it difficult for surgeons to identify eye structures. It is important to compensate for this red shift in the development of new illumination systems.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Optics
Nicole Fehler, Martin Hessling
Summary: It is crucial to have sufficient lighting during eye surgery for small structures to be clearly visible. The luminous flux during surgery plays a significant role in intraocular brightness. This study investigates the luminous flux in lightly and strongly pigmented eyes using endoillumination and diaphanoscopic illumination.
Article
Optics
Ben Sicks, Anna-Maria Gierke, Florian Sommerfeld, Martin Klein, Martin Hessling
Summary: Side-coupled UVA radiation can safely disinfect touch screens automatically, but the required irradiation times are still relatively long. Increasing the UVA intensity may reduce the disinfection durations.
Review
Microbiology
Martin Hessling, Nicole Fehler, Anna-Maria Gierke, Ben Sicks, Petra Vatter
Summary: The study found significant differences in the heat sensitivity of previous influenza viruses in different media, but relatively small differences between viruses within the same medium. At a temperature of 60 degrees C, previous influenza viruses can be reduced by 4 or more orders of magnitude within approximately 30 min in almost all media.
MICROBIOLOGY RESEARCH
(2022)
Review
Public, Environmental & Occupational Health
Martin Hessling, Anna -Maria Gierke, Ben Sicks, Nicole Fehler, Petra Vatter
Summary: This study investigated the efficacy of ultraviolet radiation in inactivating influenza viruses and found that both UVC and far-UVC wavelengths are effective. There was no significant difference in the UV sensitivity of different influenza virus types.
GMS HYGIENE AND INFECTION CONTROL
(2022)
Article
Microbiology
Laura Weyersberg, Eva Klemens, Jule Buehler, Petra Vatter, Martin Hessling
Summary: This study determines the irradiation doses of Phi6, a potential surrogate for SARS-CoV-2, under different UV wavelengths, and compares them with the log-reduction doses of SARS-CoV-2. The results show that Phi6 requires much higher irradiation doses compared to SARS-CoV-2, indicating that Phi6 is not a convincing surrogate for SARS-CoV-2 in UV applications.
Article
Medicine, General & Internal
Katja Zeller, Stephan Muhleisen, Pranavi Shanmugarajah, Nicole Fehler, Robin Haag, Martin Hessling
Summary: This study investigates whether violet or red light can cause cataract formation in porcine lenses and compares the impact of different wavelengths. The results show that short wavelengths of visible light can cause cataract formation in porcine eyes, which may also pose a risk to human eyes.
MEDICINA-LITHUANIA
(2022)
Article
Engineering, Biomedical
Martin Hessling, Tobias Meurle, Katharina Hoenes
Summary: The article introduces a lighting device that uses visible light to reduce pathogens. It is found in the experiment that it takes 34 hours to reduce the Staphylococcus concentration by 90% with white light illumination, while the additional violet light illumination can shorten it to about 3.5 hours. Increasing the violet component can enhance the disinfection effect.
AIMS BIOENGINEERING
(2022)
Review
Public, Environmental & Occupational Health
Martin Hessling, Robin Haag, Ben Sicks
Summary: This study highlights the microbial contamination on touchscreens and the desire for safe and automatic disinfection methods. It suggests that UV irradiation, especially UVC, can effectively eliminate common microorganisms with minimal harm to humans. The doses required for disinfection vary across different UV spectral ranges, with UVC showing the most efficient results in a short duration.
GMS HYGIENE AND INFECTION CONTROL
(2021)
