Review
Oncology
Jiasheng Wang, Leland Metheny
Summary: Cord blood is an important source for allogeneic hematopoietic cell transplantation and is also being developed for cell therapy products. The unique cellular composition of cord blood, including higher percentages of hematopoietic stem cells and progenitor cells, offers advantages in immune tolerance and off-the-shelf cell therapy development. In addition, cord blood-derived mesenchymal stem cells have potential in regenerative medicine and inflammatory/autoimmune conditions. This review focuses on recent clinical development of cord blood-derived therapies in oncology.
FRONTIERS IN ONCOLOGY
(2023)
Article
Reproductive Biology
Ali Sarhadi Roodbari, Somayeh Solhjoo, Maria Grazia Palmerini, Mahna Mansouri, Massood Ezzatabadipour
Summary: This study aimed to investigate the effects of human menstrual blood-derived stem cells (MenSCs) on the ovarian histology of a polycystic ovary syndrome (PCOS) model of Wistar rats. The results showed that MenSCs treatment improved folliculogenesis in PCOS rats and ameliorated PCOS symptoms by improving fibrosis, angiogenesis, and weight gain.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Naeun Park, Kyoung Sub Kim, Kun Na
Summary: This study presents an approach for manipulating paracrine factors and signaling pathways in adipose-derived stem cells to achieve effective tumor immunotherapy. The method involves precise control of reactive oxygen species concentration and regulation of specific signaling pathways to induce the secretion of inflammatory cytokines and inhibit the secretion of cell growth factors. When injected into a tumor animal model, the modified stem cells autonomously target and accumulate at the tumor site, generating anti-inflammatory factors and reducing angiogenesis growth factors upon laser irradiation, leading to effective melanoma and pancreatic tumor treatment in mice. This technology holds significant promise for the treatment of various diseases.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Biochemistry & Molecular Biology
Mariana Robalo Cordeiro, Carlota Anjinho Carvalhos, Margarida Figueiredo-Dias
Summary: The human endometrium contains stem cells called menstrual blood-derived stem cells (MenSC) that have the potential to play a critical role in the development and maintenance of endometriosis. These cells have been studied as biomarkers for the early diagnosis of endometriosis and for the development of targeted therapies. However, further research is needed to ensure their long-term safety and effectiveness before they can be widely implemented in the management of this complex disease.
Article
Gastroenterology & Hepatology
Dazhi Chen, Ruichao Zeng, Guigen Teng, Chao Cai, Tongtong Pan, Hanxiao Tu, Hongwei Lin, Qingjing Du, Huahong Wang, Yongping Chen
Summary: Menstrual blood-derived mesenchymal stem cells (MenSCs) can alleviate acute liver failure (ALF) induced liver injury by inhibiting TLR4-mediated signaling pathway and reducing the release of inflammatory cytokines. A2AR agonist can synergistically enhance the therapeutic effects of MenSCs.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Giedre Skliute, Raminta Bausyte, Veronika Borutinskaite, Giedre Valiuliene, Algirdas Kaupinis, Mindaugas Valius, Diana Ramasauskaite, Ruta Navakauskiene
Summary: The study found that menstrual blood stem cells have good proliferation and regenerative abilities, can perform decidualization through differentiation into epithelial cells, and express genes related to decidualization and angiogenesis, demonstrating the potential for treating reproductive disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Surgery
Yantao He, Yanhua Han, Yun Ye
Summary: Menstrual blood-derived stem cell transplantation shows great potential in treating intrauterine adhesion, with its properties such as antifibrosis, angiogenesis, anti-inflammation, and immunoregulation bringing hope for clinical therapy.
FRONTIERS IN SURGERY
(2022)
Article
Immunology
Soon Kyu Lee, Min-Jung Park, Jeong Won Choi, Jin-Ah Baek, Se-Young Kim, Ho Joong Choi, Young Kyoung You, Jeong Won Jang, Pil Soo Sung, Si Hyun Bae, Seung Kew Yoon, Jong Young Choi, Mi-La Cho
Summary: In this study, a patient-derived avatar model was developed to predict immune homeostasis in liver transplantation patients. The model showed promise in evaluating treatment responses and reducing risks to patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell & Tissue Engineering
Elisha Purcell, Timothy Nguyen, Madeleine Smith, Tayla Penny, Madison C. B. Paton, Lindsay Zhou, Graham Jenkin, Suzanne L. Miller, Courtney A. McDonald, Atul Malhotra
Summary: This study systematically reviewed the effects of UCBCs on brain outcomes in animal models of perinatal brain injury. It found differential benefits of UCBCs across different subgroups, such as greater efficacy in IVH model compared to HI model, UCB-MSCs compared to UCB-MNCs, and local administrative routes compared to systemic routes. However, the study identified a serious risk of bias and overall low certainty of evidence.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Fen Zhang, Linxiao Fan, Qiuhong Liu, Shima Tang, Sainan Zhang, Lanlan Xiao, Lingjian Zhang, Qian Li, Nueraili Maihemuti, Lanjuan Li
Summary: MenSCs treatment can alleviate autoimmune hepatitis by inhibiting macrophages and M1 polarization in the liver tissue.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ilona Uzieliene, Paulina Bialaglovyte, Rokas Miksiunas, Ignas Lebedis, Jolita Pachaleva, Raminta Vaiciuleviciute, Almira Ramanaviciene, Giedrius Kvederas, Eiva Bernotiene
Summary: This study investigated the potential of paracrine factors secreted by menstrual blood-derived mesenchymal stem cells (MenSCs) in stimulating chondrogenic differentiation of bone marrow mesenchymal stem cells (BMMSCs) and protecting cartilage tissue from degradation. The results suggest that MenSCs can stimulate the chondrogenic response in BMMSCs by secreting activin A and TGF-beta 3, and may have a protective effect on cartilage tissue ECM by decreasing the release of GAGs.
BIOENGINEERING-BASEL
(2023)
Article
Cell & Tissue Engineering
Jiang Du, Yan Jiang, Xinlei Liu, Xiang Ji, Bo Xu, Yan Zhang, Yanli Liu, Tao Zhang, Juntang Lin
Summary: MenSCs secrete hepatocyte growth factor (HGF) to downregulate hepatic Rnf186 expression, thereby attenuating glucose and lipid accumulation in nonalcoholic fatty liver disease (NAFLD) mice by regulating the AMPK-mTOR pathway, suggesting MenSCs or Rnf186 as potential therapeutic targets for NAFLD.
Review
Oncology
Wencheng Zhang, Yangyang Cui, Yuan Du, Yong Yang, Ting Fang, Fengfeng Lu, Weixia Kong, Canjun Xiao, Jun Shi, Lola M. Reid, Zhiying He
Summary: The liver is composed of various types of cells and has a high regenerative capacity. The main cell types, hepatocytes and cholangiocytes, work together with non-parenchymal cells to perform liver functions. The regulation of liver cells involves complex interactions between the extracellular matrix and soluble signals. Recent advancements in genetic sequencing have allowed for a better understanding of liver cell composition and regulation. Furthermore, breakthroughs in cell transplantation strategies offer potential solutions for treating end-stage liver diseases.
FRONTIERS OF MEDICINE
(2023)
Article
Medicine, General & Internal
Antonio Lo Nigro, Alessia Gallo, Matteo Bulati, Giampiero Vitale, Diego Sebastian Paini, Mariangela Pampalone, Daniele Galvagno, Pier Giulio Conaldi, Vitale Miceli
Summary: The global prevalence of end-stage liver diseases is high, with liver transplantation being the main treatment option. Research on alternative therapies, such as cell therapy, is ongoing.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Maria Florencia Tellechea, Flavia S. Donaires, Vinicius S. de Carvalho, Barbara A. Santana, Fernanda B. da Silva, Raissa S. Tristao, Lilian F. Moreira, Aline F. de Souza, Yordanka M. Armenteros, Lygia Pereira, Rodrigo T. Calado
Summary: This study used iPSCs to model immune aplastic anemia and found that the differentiation potential of hematopoietic cells in this disease is significantly reduced, suggesting that specific epigenetic changes in HSPCs caused by immune attack may limit cell proliferation and differentiation.
CELL DEATH & DISEASE
(2022)
Review
Oncology
Jingjing Qu, Quanhui Mei, Lijun Chen, Jianying Zhou
Summary: The development of genetically engineered T cells, especially CAR-T cells, has shown great promise in basic and clinical cancer studies, particularly in the treatment of NSCLC. However, challenges such as lack of tumor-specific antigens, immunosuppressive tumor microenvironment, low infiltration levels of CAR-T cells into tumor tissue, and tumor antigen escape still need to be addressed. Optimizing CAR-T-cell design for NSCLC is urgently needed to overcome on-target/off-tumor toxicities and increase efficacy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Xiaowei Xu, Wanli Jiang, Lijun Chen, Zhenyu Xu, Qiang Zhang, Mengfei Zhu, Peng Ye, Hang Li, Liang Yu, Xiaoyang Zhou, Chenliang Zhou, Xiaobei Chen, Xiaoqin Zheng, Kaijin Xu, Hongliu Cai, Shufa Zheng, Wubian Jiang, Xiaojun Wu, Dong Li, Lu Chen, Qingqing Luo, Yingyan Wang, Jingjing Qu, Yifei Li, Wendi Zheng, Yingan Jiang, Lingling Tang, Charlie Xiang, Lanjuan Li
Summary: A study showed that using menstrual blood-derived MSCs to treat severe COVID-19 patients can reduce mortality, improve dyspnea, and increase oxygen saturation levels. This MSC-based therapy may be a promising alternative for treating severe COVID-19.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Cell & Tissue Engineering
Lijun Chen, Jingjing Qu, Quanhui Mei, Xin Chen, Yangxin Fang, Lu Chen, Yifei Li, Charlie Xiang
Summary: Menstrual blood-derived mesenchymal stem cells (MenSCs) show promising therapeutic effects in regenerative medicine. The study of MenSC-derived small extracellular vesicles (EVs) is still in early stages but has potential in treating various diseases. Continued research is needed to further understand and harness the therapeutic potential of MenSC EVs.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Soil Science
Qiong Hou, Ting Zuo, Jian Wang, Shan Huang, Xiaojun Wang, Longren Yao, Wuzhong Ni
Summary: The addition of biochar can enhance the nitrification process in soil by increasing the diversity and activity of nitrifying bacteria, especially in fertile soils or small macroaggregates. Biochar addition alters the structure of soil microbial communities, thereby regulating the nitrification process.
APPLIED SOIL ECOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lijun Chen, Jingjing Qu, Farhin Shaheed Kalyani, Qi Zhang, Lingzhi Fan, Yangxin Fang, Yifei Li, Charlie Xiang
Summary: This review discusses the origins, pathogenesis, and clinical features of COVID-19, as well as the potential uses of mesenchymal stem cells (MSCs) in treating patients infected with SARS-CoV-2. Preliminary data from ongoing clinical trials are promising, but long-term safety evaluations and larger trials are needed for more conclusive judgments regarding MSC-based therapies.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemical Research Methods
Xiu-Qin Wang, Princess Jane Albitos, Yong-Fu Hao, Hang Zhang, Li-Xia Yuan, Yu-Feng Zang
Summary: Hyperactivity is one of the core symptoms of ADHD, but objective assessments for hyperactivity are seldom used compared to measures of inattention and impulsivity. Actigraph and QbTest are two devices that can be used to objectively measure hyperactivity, but they have limitations in distinguishing ADHD from other disorders or different types of ADHD.
JOURNAL OF NEUROSCIENCE METHODS
(2022)
Article
Engineering, Multidisciplinary
Xiaojun Wang, Zhipeng Mao, Wendi Wang
Summary: This study analyzes the stress mode of the jet grouting pile-mini steel pipe pile composite foundation and proposes corresponding calculation equations and processes. The accuracy of the method is verified through field tests. Results show that this method meets the requirements of engineering design and application.
MATHEMATICAL PROBLEMS IN ENGINEERING
(2022)
Article
Computer Science, Interdisciplinary Applications
Na Zhao, Juan Yue, Zi-Jian Feng, Yang Qiao, Qiu Ge, Li-Xia Yuan, Jue Wang, Yu-Tao Xiang, Yu-Feng Zang
Summary: This study aimed to investigate the reliability of RS-fMRI FC location and the impact of various factors on FC strength. The results showed low to moderate reliability of FC strength, while the center of gravity (COG) of seed-based FC had smaller distances, suggesting it as a potential stimulation target.
Article
Psychiatry
Xing-Ke Wang, Xiu-Qin Wang, Xue Yang, Li-Xia Yuan
Summary: This study used a multivariate method, SSM-PCA, to analyze sMRI and identified a GM network associated with attention in children with ADHD. The study found that this network is different from that in adolescents and adults with ADHD. The expression of the ADHD-related pattern was also found to be correlated with inattention symptoms. The study also explored the influence of sample size on the analysis.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biotechnology & Applied Microbiology
Runan Zhang, Genhua Zhang, Baohua Li, Juan Wang, Jvfang Wang, Jia Che, Xiaojun Wang, Zhen Zhang
Summary: This study evaluated the expression levels of LINC01314 and miR-96 in CRC patients and found that both were associated with vascular metastasis and survival rates. These findings contribute to a better understanding of the molecular mechanism of lncRNAs in CRC.
Article
Clinical Neurology
Bo Yang, Min Wang, Weiran Zhou, Xiuqin Wang, Shuaiyu Chen, Marc N. Potenza, Li-Xia Yuan, Guang-Heng Dong
Summary: Changes in the brain's default mode network (DMN) are closely related to autism spectrum disorder (ASD), with ASD subjects showing higher participation coefficient (PC) of the DMN than healthy controls (HCs). This difference is due to lower intra-module connections within the DMN and higher inter-network connections between the DMN and other networks. The findings were consistent across different age groups and subtypes of ASD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Bo Yang, Min Wang, Weiran Zhou, Xiuqin Wang, Shuaiyu Chen, Li-Xia Yuan, Guang-Heng Dong
Summary: Neuroscientific evidence suggests that the pathological symptoms associated with autism spectrum disorders (ASD) involve networks of the brain on a larger spatial scale. Analyzing edge-edge interactions can provide important insights on the organization and function of complex systems. Using resting-state fMRI data, this study compares brain connectivity in 238 ASD patients and 311 healthy controls, finding abnormalities in key brain regions and functional connections that may be related to disturbances in the reward system and functional network features in ASD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Min Wang, Lingxiao Wang, Bo Yang, Lixia Yuan, Xiuqin Wang, Marc N. Potenza, Guang-Heng Dong
Summary: Using community structure analyses, this study explored the functional network features of individuals with autism spectrum disorder and found aberrant recruitment and integration in different networks. These findings explain the impaired brain networks in autism spectrum disorder and have important therapeutic implications.
BRAIN COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Shan Huang, Ting Zuo, Xin Zheng, Chao Zhuo, Qiong Hou, Longren Yao, Xiaojun Wang, Jian Wang, Wuzhong Ni
Summary: Research shows that foliar application of Zn2 + GB2 significantly increases the weight, total N, Zn, theaflavin, and total amino acid content in young leaves of WL-1, while decreasing chlorophyll a content. Total catechins and caffeine are lower in Zn2 + GB2 treatment compared to other treatments. Comprehensive analysis indicates that Zn2 + GB2 treatment is beneficial for the overall quality of WL-1.
Review
Oncology
Jingjing Qu, Quanhui Mei, Li Liu, Tianli Cheng, Peng Wang, Lijun Chen, Jianying Zhou
Summary: The use of PD-1/PD-L1 inhibitors is the standard therapy for NSCLC patients, prolonging survival without significant side effects. However, the lack of optimal prognostic markers remains a challenge for further clinical applications.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2021)