Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2
出版年份 2016 全文链接
标题
Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2
作者
关键词
Trypanosoma, Glycerol, Permeability, Cations, Point mutation, Arginine, Trypanosoma brucei gambiense, Trypanosoma brucei
出版物
PLoS Pathogens
Volume 12, Issue 2, Pages e1005436
出版商
Public Library of Science (PLoS)
发表日期
2016-02-02
DOI
10.1371/journal.ppat.1005436
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Challenges and achievements in the therapeutic modulation of aquaporin functionality
- (2015) Eric Beitz et al. PHARMACOLOGY & THERAPEUTICS
- Identity of a Plasmodium lactate/H+ symporter structurally unrelated to human transporters
- (2015) Binghua Wu et al. Nature Communications
- Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis
- (2015) Juan D. Unciti-Broceta et al. PLoS Pathogens
- Understanding transporter specificity and the discrete appearance of channel-like gating domains in transporters
- (2014) George Diallinas Frontiers in Pharmacology
- Aquaporins with anion/monocarboxylate permeability: mechanisms, relevance for pathogen–host interactions
- (2014) Janis Rambow et al. Frontiers in Pharmacology
- Parasite aquaporins: Current developments in drug facilitation and resistance
- (2013) Jie Song et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Trypanosoma Brucei Aquaglyceroporins Facilitate the Uptake of Arsenite and Antimonite in a pH Dependent Way
- (2013) Néstor L. Uzcátegui et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs
- (2013) J. C. Munday et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Mechanism of Trypanosoma brucei gambiense resistance to human serum
- (2013) Pierrick Uzureau et al. NATURE
- Subangstrom Resolution X-Ray Structure Details Aquaporin-Water Interactions
- (2013) U. Kosinska Eriksson et al. SCIENCE
- Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich's vision of chemotherapy
- (2013) Sam Alsford et al. TRENDS IN PARASITOLOGY
- Molar concentrations of sorbitol and polyethylene glycol inhibit the Plasmodium aquaglyceroporin but not that of E. coli: Involvement of the channel vestibules
- (2012) Jie Song et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Structure, function and translational relevance of aquaporin dual water and ion channels
- (2012) Andrea J. Yool et al. MOLECULAR ASPECTS OF MEDICINE
- Targeting Aquaporin Function: Potent Inhibition of Aquaglyceroporin-3 by a Gold-Based Compound
- (2012) Ana Paula Martins et al. PLoS One
- The formate channel FocA exports the products of mixed-acid fermentation
- (2012) W. Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes
- (2012) N. Baker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MIPModDB: a central resource for the superfamily of major intrinsic proteins
- (2011) A. B. Gupta et al. NUCLEIC ACIDS RESEARCH
- Requirement for asparagine in the aquaporin NPA sequence signature motifs for cation exclusion
- (2010) Dorothea Wree et al. FEBS Journal
- Novel Channel Enzyme Fusion Proteins Confer Arsenate Resistance
- (2010) Binghua Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6
- (2010) Nicola Baker et al. MOLECULAR AND BIOCHEMICAL PARASITOLOGY
- Concerted action of two cation filters in the aquaporin water channel
- (2009) Binghua Wu et al. EMBO JOURNAL
- The trypanosome flagellar pocket
- (2009) Mark C. Field et al. NATURE REVIEWS MICROBIOLOGY
- Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei
- (2008) Sam Alsford et al. MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started