Acute Malaria Induces PD1+CTLA4+ Effector T Cells with Cell-Extrinsic Suppressor Function

Unique human immune signature of Ebola virus disease in Guinea

(2016) Paula Ruibal et al.   NATURE

Immuno-regulatory antibodies for the treatment of cancer

(2015) Jamie Honeychurch et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Confusing signals: Recent progress in CTLA-4 biology

(2015) Lucy S.K. Walker et al.   TRENDS IN IMMUNOLOGY

Heightened inflammation in severe malaria is associated with decreased IL-10 expression levels and neutrophils

(2014) Anusree Mahanta et al.   Innate Immunity

Detrimental Contribution of the Immuno-Inhibitor B7-H1 to Rabies Virus Encephalitis

(2014) M. Lafon et al.   JOURNAL OF IMMUNOLOGY

The Common  -Chain Cytokines IL-2, IL-7, IL-15, and IL-21 Induce the Expression of Programmed Death-1 and Its Ligands

(2014) A. L. Kinter et al.   JOURNAL OF IMMUNOLOGY

PlasmodiumSuppresses Expansion of T Cell Responses to Heterologous Infections

(2014) Chelsi E. White et al.   JOURNAL OF IMMUNOLOGY

CD4+ T Cell Responses to the Plasmodium falciparum Erythrocyte Membrane Protein 1 in Children with Mild Malaria

(2014) E. N. Gitau et al.   JOURNAL OF IMMUNOLOGY

CTLA-4 Is Expressed by Activated Mouse NK Cells and Inhibits NK Cell IFN-  Production in Response to Mature Dendritic Cells

(2014) A. Stojanovic et al.   JOURNAL OF IMMUNOLOGY

Exposure-Dependent Control of Malaria-Induced Inflammation in Children

(2014) Silvia Portugal et al.   PLoS Pathogens

IFNγ/IL-10 Co-producing Cells Dominate the CD4 Response to Malaria in Highly Exposed Children

(2014) Prasanna Jagannathan et al.   PLoS Pathogens

The Transcription Factor T-bet Regulates Parasitemia and Promotes Pathogenesis during Plasmodium berghei ANKA Murine Malaria

(2013) M. S. Oakley et al.   JOURNAL OF IMMUNOLOGY

A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application

(2013) Taku Okazaki et al.   NATURE IMMUNOLOGY

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

(2013) Nicola Gagliani et al.   NATURE MEDICINE

PD-1 Dependent Exhaustion of CD8+ T Cells Drives Chronic Malaria

(2013) Joshua M. Horne-Debets et al.   Cell Reports

Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models

(2013) Marta Caridade et al.   Frontiers in Immunology

T cell control of malaria pathogenesis

(2012) Philip J Spence et al.   CURRENT OPINION IN IMMUNOLOGY

T cell-derived IL-10 and its impact on the regulation of host responses during malaria

(2012) Ana Paula Freitas do Rosario et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Cutting Edge: CTLA-4 on Effector T Cells Inhibits In Trans

(2012) E. Corse et al.   JOURNAL OF IMMUNOLOGY

Chronic Exposure to Plasmodium falciparum Is Associated with Phenotypic Evidence of B and T Cell Exhaustion

(2012) J. Illingworth et al.   JOURNAL OF IMMUNOLOGY

The CTLA-4 and PD-1/PD-L1 Inhibitory Pathways Independently Regulate Host Resistance to Plasmodium-induced Acute Immune Pathology

(2012) Julius Clemence R. Hafalla et al.   PLoS Pathogens

Responsiveness of HIV-specific CD4 T cells to PD-1 blockade

(2011) F. Porichis et al.   BLOOD

SPICE: Exploration and analysis of post-cytometric complex multivariate datasets

(2011) Mario Roederer et al.   CYTOMETRY PART A

Inhibitory Molecules That Regulate Expansion and Restoration of HCV-Specific CD4+ T Cells in Patients With Chronic Infection

(2011) Bijan Raziorrouh et al.   GASTROENTEROLOGY

IL-27 Promotes IL-10 Production by Effector Th1 CD4+ T Cells: A Critical Mechanism for Protection from Severe Immunopathology during Malaria Infection

(2011) A. P. Freitas do Rosario et al.   JOURNAL OF IMMUNOLOGY

Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection

(2011) Noah S Butler et al.   NATURE IMMUNOLOGY

The Th1 life cycle: molecular control of IFN-γ to IL-10 switching

(2011) Andrew Cope et al.   TRENDS IN IMMUNOLOGY

siRNA silencing of PD-L1 and PD-L2 on dendritic cells augments expansion and function of minor histocompatibility antigen-specific CD8+ T cells

(2010) W. Hobo et al.   BLOOD

Vascular endothelial cells cultured from patients with cerebral or uncomplicated malaria exhibit differential reactivity to TNF

(2010) Samuel Crocodile Wassmer et al.   CELLULAR MICROBIOLOGY

HIV-1 impairs in vitro priming of naïve T cells and gives rise to contact-dependent suppressor T cells

(2010) Karlhans F. Che et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance

(2010) Bruno B Andrade et al.   MALARIA JOURNAL

PD-1 expression on peripheral CD8+ TEM/TEMRA subsets closely correlated with HCV viral load in chronic hepatitis C patients

(2010) Tao Shen et al.   Virology Journal

Identification and characterization of IL-10/IFN-γ–producing effector-like T cells with regulatory function in human blood

(2009) Barbara Häringer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10

(2009) Jie Sun et al.   NATURE MEDICINE

Distinct Roles for FOXP3+ and FOXP3− CD4+ T Cells in Regulating Cellular Immunity to Uncomplicated and Severe Plasmodium falciparum Malaria

(2009) Michael Walther et al.   PLoS Pathogens

Dynamic Programmed Death 1 Expression by Virus-Specific CD8 T Cells Correlates With the Outcome of Acute Hepatitis B

(2008) Zheng Zhang et al.   GASTROENTEROLOGY

In vivo switch to IL-10–secreting T regulatory cells in high dose allergen exposure

(2008) Flurina Meiler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-10 from CD4+CD25−Foxp3−CD127− Adaptive Regulatory T Cells Modulates Parasite Clearance and Pathology during Malaria Infection

(2008) Kevin N. Couper et al.   PLoS Pathogens