Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection

Germinal Center T Follicular Helper Cells Are Highly Permissive to HIV-1 and Alter Their Phenotype during Virus Replication

(2016) Stephanie L. Kohler et al.   JOURNAL OF IMMUNOLOGY

Distinct Patterns of Bcl-2 Expression Occur in R5- and X4-Tropic HIV-1-Producing Lymphoid Tissue Cells Infected Ex Vivo

(2015) Michelle K. Haas et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques

(2015) Luca Micci et al.   JOURNAL OF CLINICAL INVESTIGATION

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

(2015) Yoshinori Fukazawa et al.   NATURE MEDICINE

Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection

(2015) Brodie Miles et al.   Nature Communications

Human and Mouse CD8+CD25+FOXP3+ Regulatory T Cells at Steady State and during Interleukin-2 Therapy

(2015) Guillaume Churlaud et al.   Frontiers in Immunology

Compartmentalization of Simian Immunodeficiency Virus Replication within Secondary Lymphoid Tissues of Rhesus Macaques Is Linked to Disease Stage and Inversely Related to Localization of Virus-Specific CTL

(2014) Elizabeth Connick et al.   JOURNAL OF IMMUNOLOGY

CD8 down-regulation and functional impairment of SIV-specific cytotoxic T lymphocytes in lymphoid and mucosal tissues during SIV infection

(2013) Huanbin Xu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Expansion of HIV-specific T follicular helper cells in chronic HIV infection

(2012) Madelene Lindqvist et al.   JOURNAL OF CLINICAL INVESTIGATION

CD4 T follicular helper cell dynamics during SIV infection

(2012) Constantinos Petrovas et al.   JOURNAL OF CLINICAL INVESTIGATION

Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production

(2012) Matthieu Perreau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of CD8+ Regulatory T Cells Protects Macaques against SIV Challenge

(2012) Wei Lu et al.   Cell Reports

Regulatory T cells control HIV replication in activated T cells through a cAMP-dependent mechanism

(2011) M. E. Moreno-Fernandez et al.   BLOOD

CD8+Foxp3+ T cells share developmental and phenotypic features with classical CD4+Foxp3+ regulatory T cells but lack potent suppressive activity

(2011) Christian T. Mayer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

HLA-DR+ CD38+ CD4+ T Lymphocytes Have Elevated CCR5 Expression and Produce the Majority of R5-Tropic HIV-1 RNA In Vivo

(2011) A. L. Meditz et al.   JOURNAL OF VIROLOGY

CD8+T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice

(2011) Hye-Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

(2010) Rachel H. McMahan et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

(2010) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+T cell dysfunction in melanoma patients

(2010) Julien Fourcade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of follicular T-helper cells by CD8+ regulatory T cells is essential for self tolerance

(2010) Hye-Jung Kim et al.   NATURE

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

(2010) H.-T. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Galectin-9/TIM-3 Interaction Regulates Virus-Specific Primary and Memory CD8+ T Cell Response

(2010) Sharvan Sehrawat et al.   PLoS Pathogens

IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells

(2009) M. A. Brockman et al.   BLOOD

Interleukin-15 expression affects homeostasis and function of B cells through NK cell-derived interferon-γ

(2009) Navkiran Gill et al.   CELLULAR IMMUNOLOGY

Glycerol monolaurate prevents mucosal SIV transmission

(2009) Qingsheng Li et al.   NATURE

Localized Populations of CD8low/− MHC Class I Tetramer+ SIV-Specific T Cells in Lymphoid Follicles and Genital Epithelium

(2009) Jung Joo Hong et al.   PLoS One

Tim-3-Galectin-9 pathway involves the suppression induced by CD4+CD25+ regulatory T cells

(2008) Feng Wang et al.   IMMUNOBIOLOGY

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

(2008) R. Brad Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8+ T Cells

(2008) Hendrik Streeck et al.   PLOS MEDICINE