Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia

There and back again: coordinated transcription, translation and transport in axonal survival and regeneration

(2016) Ozge E Tasdemir-Yilmaz et al.   CURRENT OPINION IN NEUROBIOLOGY

Sensory and autonomic deficits in a new humanized mouse model of familial dysautonomia

(2016) Elisabetta Morini et al.   HUMAN MOLECULAR GENETICS

The effects of acute and chronic administration of phosphatidylserine on cell proliferation and survival in the dentate gyrus of adult and middle-aged rats

(2015) Heloisa Maragno et al.   BRAIN RESEARCH

Effect of phosphatidylserine on memory in patients and rats with Alzheimer’s disease

(2015) Y.Y. Zhang et al.   GENETICS AND MOLECULAR RESEARCH

Pannexin-1 Up-regulation in the Dorsal Root Ganglion Contributes to Neuropathic Pain Development

(2015) Yuhao Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia

(2015) Mayumi Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone deacetylase 6 in health and disease

(2015) Carole Seidel et al.   Epigenomics

SF3B1 Association with Chromatin Determines Splicing Outcomes

(2015) Nir Kfir et al.   Cell Reports

Familial Dysautonomia (FD) Human Embryonic Stem Cell Derived PNS Neurons Reveal that Synaptic Vesicular and Neuronal Transport Genes Are Directly or Indirectly Affected by IKBKAP Downregulation

(2015) Sharon Lefler et al.   PLoS One

A neuron autonomous role for the familial dysautonomia gene ELP1 in sympathetic and sensory target tissue innervation

(2014) M. Z. Jackson et al.   DEVELOPMENT

Current treatments in familial dysautonomia

(2014) Jose-Alberto Palma et al.   EXPERT OPINION ON PHARMACOTHERAPY

IKAP Deficiency in an FD Mouse Model and in Oligodendrocyte Precursor Cells Results in Downregulation of Genes Involved in Oligodendrocyte Differentiation and Myelin Formation

(2014) David Cheishvili et al.   PLoS One

Involvement of IKAP in Peripheral Target Innervation and in Specific JNK and NGF Signaling in Developing PNS Neurons

(2014) Anastasia Abashidze et al.   PLoS One

PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system

(2014) Radhika Puttagunta et al.   Nature Communications

Heterozygous Ambra1 Deficiency in Mice: A Genetic Trait with Autism-Like Behavior Restricted to the Female Gender

(2014) Ekrem Dere et al.   Frontiers in Behavioral Neuroscience

Rabies Virus Hijacks and Accelerates the p75NTR Retrograde Axonal Transport Machinery

(2014) Shani Gluska et al.   PLoS Pathogens

Dynamic changes in IKBKAP mRNA levels during crisis of familial dysautonomia patients

(2013) David Cheishvili et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model

(2013) Ron Bochner et al.   HUMAN MOLECULAR GENETICS

Axon–soma communication in neuronal injury

(2013) Ida Rishal et al.   NATURE REVIEWS NEUROSCIENCE

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons

(2013) L. George et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell length sensing for neuronal growth control

(2013) Christin A. Albus et al.   TRENDS IN CELL BIOLOGY

WIS-neuromath enables versatile high throughput analyses of neuronal processes

(2012) Ida Rishal et al.   Developmental Neurobiology

Epigenetic mechanisms in neurological disease

(2012) Mira Jakovcevski et al.   NATURE MEDICINE

Enhanced learning and memory of normal young rats by repeated oral administration of Krill Phosphatidylserine

(2012) Hyun-Jung Park et al.   NUTRITIONAL NEUROSCIENCE

IKAP/Elp1 Is Required In Vivo for Neurogenesis and Neuronal Survival, but Not for Neural Crest Migration

(2012) Barbara J. Hunnicutt et al.   PLoS One

Translational Control of Cell Division by Elongator

(2012) Fanelie Bauer et al.   Cell Reports

Depletion of gut commensal bacteria attenuates intestinal ischemia/reperfusion injury

(2011) Kazuhisa Yoshiya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

IKAP/Elp1 involvement in cytoskeleton regulation and implication for familial dysautonomia

(2011) D. Cheishvili et al.   HUMAN MOLECULAR GENETICS

Genome-wide analysis of familial dysautonomia and kinetin target genes with patient olfactory ecto-mesenchymal stem cells

(2011) Nathalie Boone et al.   HUMAN MUTATION

HDAC6 α-tubulin deacetylase: A potential therapeutic target in neurodegenerative diseases

(2011) Guoyi Li et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6

(2011) Fabienne C Fiesel et al.   Molecular Neurodegeneration

Kinetin Improves IKBKAP mRNA Splicing in Patients With Familial Dysautonomia

(2011) Felicia B Axelrod et al.   PEDIATRIC RESEARCH

Deletion of Exon 20 of the Familial Dysautonomia Gene Ikbkap in Mice Causes Developmental Delay, Cardiovascular Defects, and Early Embryonic Lethality

(2011) Paula Dietrich et al.   PLoS One

Complicated Peptic Ulcer Disease in Three Patients With Familial Dysautonomia

(2010) David W. Wan et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

HDAC inhibitors and neurodegeneration: At the edge between protection and damage

(2010) Karen C. Dietz et al.   PHARMACOLOGICAL RESEARCH

Phosphatidylserine Increases IKBKAP Levels in Familial Dysautonomia Cells

(2010) Hadas Keren et al.   PLoS One

Retrograde axonal transport: pathways to cell death?

(2010) Eran Perlson et al.   TRENDS IN NEUROSCIENCES

The Caenorhabditis elegans Elongator Complex Regulates Neuronal α-tubulin Acetylation

(2010) Jachen A. Solinger et al.   PLoS Genetics

Elongator Controls the Migration and Differentiation of Cortical Neurons through Acetylation of α-Tubulin

(2009) Catherine Creppe et al.   CELL

Pax6 dosage requirements in iris and ciliary body differentiation

(2009) Noa Davis et al.   DEVELOPMENTAL BIOLOGY

A conditioning lesion induces changes in gene expression and axonal transport that enhance regeneration by increasing the intrinsic growth state of axons

(2009) Paul N. Hoffman   EXPERIMENTAL NEUROLOGY

Neuroimaging supports central pathology in familial dysautonomia

(2009) Felicia B. Axelrod et al.   JOURNAL OF NEUROLOGY

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs

(2009) Gabsang Lee et al.   NATURE

Kinetin in Familial Dysautonomia Carriers: Implications for a New Therapeutic Strategy Targeting mRNA Splicing

(2009) Gabrielle Gold-von Simson et al.   PEDIATRIC RESEARCH

HDAC6 is a target for protection and regeneration following injury in the nervous system

(2009) M. A. Rivieccio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elongator – an emerging role in neurological disorders

(2009) Laurent Nguyen et al.   TRENDS IN MOLECULAR MEDICINE

Deregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elongator deficiency in colon cancer cells

(2008) Isabelle Cornez et al.   BIOCHEMICAL PHARMACOLOGY

IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration

(2008) L. D. Johansen et al.   JOURNAL OF CELL SCIENCE

Loss of Mouse Ikbkap, a Subunit of Elongator, Leads to Transcriptional Deficits and Embryonic Lethality That Can Be Rescued by Human IKBKAP

(2008) Y.-T. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY