The Occurrence of the Holometabolous Pupal Stage Requires the Interaction between E93, Krüppel-Homolog 1 and Broad-Complex

20-Hydroxyecdysone (20E) Primary Response GeneE93Modulates 20E Signaling to PromoteBombyxLarval-Pupal Metamorphosis

(2015) Xi Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Krüppel Homolog 1 Inhibits Insect Metamorphosis via Direct Transcriptional Repression ofBroad-Complex, a Pupal Specifier Gene

(2015) Takumi Kayukawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expressional and functional analysis of CYP15A1, a juvenile hormone epoxidase, in the red flour beetle Tribolium castaneum

(2015) Chieka Minakuchi et al.   JOURNAL OF INSECT PHYSIOLOGY

Knockout silkworms reveal a dispensable role for juvenile hormones in holometabolous life cycle

(2015) Takaaki Daimon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Importance of juvenile hormone signaling arises with competence of insect larvae to metamorphose

(2014) Vlastimil Smykal et al.   DEVELOPMENTAL BIOLOGY

Hormonal regulation and developmental role of Krüppel homolog 1, a repressor of metamorphosis, in the silkworm Bombyx mori

(2014) Takumi Kayukawa et al.   DEVELOPMENTAL BIOLOGY

The MEKRE93 (Methoprene tolerant-Krüppel homolog 1-E93) pathway in the regulation of insect metamorphosis, and the homology of the pupal stage

(2014) Xavier Belles et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Juvenile hormone regulates Aedes aegypti Krüppel homolog 1 through a conserved E box motif

(2014) Yingjun Cui et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Phylogenetic Distribution of Extant Richness Suggests Metamorphosis Is a Key Innovation Driving Diversification in Insects

(2014) James L. Rainford et al.   PLoS One

Transcription factor E93 specifies adult metamorphosis in hemimetabolous and holometabolous insects

(2014) E. Urena et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the molecular mechanisms underlying diversified wing venation among insects

(2014) O. Shimmi et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Fossil evidence for key innovations in the evolution of insect diversity

(2014) D. B. Nicholson et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Phylogenomics resolves the timing and pattern of insect evolution

(2014) B. Misof et al.   SCIENCE

Insights into insect wing origin provided by functional analysis of vestigial in the red flour beetle, Tribolium castaneum

(2013) C. M. Clark-Hachtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Establishment of a versatile cell line for juvenile hormone signaling analysis in Tribolium castaneum

(2013) Takumi Kayukawa et al.   Scientific Reports

Broad-complex functions in postembryonic development of the cockroach Blattella germanica shed new light on the evolution of insect metamorphosis

(2012) Jia-Hsin Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Control of target gene specificity during metamorphosis by the steroid response gene E93

(2012) X. Mou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional regulation of juvenile hormone-mediated induction of Kruppel homolog 1, a repressor of insect metamorphosis

(2012) T. Kayukawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation of Rigid, Non-Flight Forewings (Elytra) of a Beetle Requires Two Major Cuticular Proteins

(2012) Yasuyuki Arakane et al.   PLoS Genetics

DPP-mediated TGF  signaling regulates juvenile hormone biosynthesis by activating the expression of juvenile hormone acid methyltransferase

(2011) J. Huang et al.   DEVELOPMENT

Common and Distinct Roles of Juvenile Hormone Signaling Genes in Metamorphosis of Holometabolous and Hemimetabolous Insects

(2011) Barbora Konopova et al.   PLoS One

Wnt Signaling Cross-Talks with JH Signaling by Suppressing Met and gce Expression

(2011) Mohamed Abdou et al.   PLoS One

Conserved repressive function of Krüppel homolog 1 on insect metamorphosis in hemimetabolous and holometabolous species

(2011) Jesus Lozano et al.   Scientific Reports

The hormonal pathway controlling cell death during metamorphosis in a hemimetabolous insect

(2010) Daniel Mané-Padrós et al.   DEVELOPMENTAL BIOLOGY

Developmental profile and hormonal regulation of the transcription factors broad and Krüppel homolog 1 in hemimetabolous thrips

(2010) Chieka Minakuchi et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Broad-Complex acts downstream of Met in juvenile hormone signaling to coordinate primitive holometabolan metamorphosis

(2008) B. Konopova et al.   DEVELOPMENT

The role of Broad in the development of Tribolium castaneum: implications for the evolution of the holometabolous insect pupa

(2008) Y. Suzuki et al.   DEVELOPMENT

Krüppel homolog 1, an early juvenile hormone-response gene downstream of Methoprene-tolerant, mediates its anti-metamorphic action in the red flour beetle Tribolium castaneum

(2008) Chieka Minakuchi et al.   DEVELOPMENTAL BIOLOGY

RNAi-mediated knockdown of juvenile hormone acid O-methyltransferase gene causes precocious metamorphosis in the red flour beetle Tribolium castaneum

(2008) Chieka Minakuchi et al.   FEBS Journal

The role of 20-hydroxyecdysone and juvenile hormone in pupal commitment of the epidermis of the silkworm, Bombyx mori

(2008) Daisuke Muramatsu et al.   MECHANISMS OF DEVELOPMENT

Transcription factor broad suppresses precocious development of adult structures during larval–pupal metamorphosis in the red flour beetle, Tribolium castaneum

(2007) R. Parthasarathy et al.   MECHANISMS OF DEVELOPMENT