Article
Biochemistry & Molecular Biology
Hayden Waller, Thomas Blankers, Mingzi Xu, Kerry L. Shaw
Summary: Sexual signalling traits and their associated genetic components are crucial for the speciation process. However, our understanding of the genetic basis of variable sexual signalling traits linked to speciation is limited. This study provides new genetic evidence of Quantitative Trait Loci (QTL) underlying divergent sexual signalling behaviour in Hawaiian crickets. By sequencing RNA in the brain and central nervous system, candidate genes associated with pulse rate are identified, shedding light on the genetic processes driving reproductive isolation and species diversity.
INSECT MOLECULAR BIOLOGY
(2023)
Article
Cell Biology
Zhenying Dong, Yanbo Wang, Jianxi Bao, Ya'nan Li, Zechao Yin, Yan Long, Xiangyuan Wan
Summary: Maize is a crucial food crop and increasing its yield is a priority for breeding programs. Ear traits, which are quantitatively inherited, play a significant role in maize yield. This study identified and analyzed genetic loci associated with ear traits, refining multiple QTL and QTN clusters. Common intervals detectable by both QTL mapping and GWAS, as well as pleiotropic intervals affecting ear traits, were identified. Additionally, potential candidate genes for improving maize yield were predicted.
Article
Biochemistry & Molecular Biology
Shuai Wang, Huangai Li, Zhenying Dong, Cheng Wang, Xun Wei, Yan Long, Xiangyuan Wan
Summary: Stalk lodging seriously affects crop yield and quality due to various factors, and breeding of resistant varieties is important for maize breeders. This study used QTL mapping and GWAS to identify genetic loci associated with stalk lodging resistance in maize. By integrating and mapping these loci, candidate genes and molecular regulatory networks related to stalk lodging resistance were predicted and constructed. This study provides valuable insights into the molecular mechanisms and strategies for improving crop yields by enhancing stalk lodging resistance.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Plant Sciences
Hao Ai, Daxia Wu, Chunli Li, Mengmeng Hou
Summary: This article summarizes the molecular mechanisms of cadmium absorption and transport in rice, as well as the variation in cadmium accumulation among rice varieties and the associated QTLs. It also discusses the direction of future research.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Muqing He, Deqing Zou, Weizhong Qiang, Shouhuai Xu, Wenbo Wu, Hai Jin
Summary: In this study, we propose a scheme for systematically breaching genomic privacy and quantify the probability of privacy risk for continuous trait data. Our experiments reveal the significant impact of factors such as the size of genetic signatures, sensitivity, minor allele frequency, and the size of the matching quantitative trait locus dataset on the assessment of privacy risk.
APPLIED SCIENCES-BASEL
(2022)
Article
Agronomy
Jun Zhang, Samuel Clay McDonald, Chengjun Wu, Miles W. Ingwers, Hussein Abdel-Haleem, Pengyin Chen, Zenglu Li
Summary: Flooding tolerance in soybean is a complex trait controlled by multiple QTLs and significantly affected by QTL x environment interactions. The results of this study provide valuable information for soybean breeders to develop flooding tolerant cultivars.
Article
Plant Sciences
Wenfei Li, Shilai Zhang, Guangfu Huang, Liyu Huang, Jing Zhang, Zheng Li, Fengyi Hu
Summary: The rhizome is an important organ for vegetative propagation in perennial plants. Through studying a wild rice species, researchers have identified multiple loci that affect rhizome-related traits and constructed a comprehensive genetic network to understand the genetic regulation of rhizome development.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agronomy
Prabin Bajgain, James A. Anderson
Summary: The study genetically mapped six domestication traits of intermediate wheatgrass and identified markers and haplotype blocks significantly associated with these traits. Results suggest that increasing the frequency of favorable alleles in IWG populations via marker-assisted selection and genomic selection is an effective approach to improve IWG's domestication traits.
Article
Agronomy
Xiaozhou Hu, Guoliang Chen, Rui Zhang, Mengxuan Xu, Ling Zhao, Hailong Tang, Jinlong Ni, Ming Zhou
Summary: In this study, we identified a major quantitative trait locus (QTL), qFOT6, on chromosome 6, and 13 potential candidate genes associated with Floret-opening time (FOT) in rice. Our findings provide valuable insights for rice breeding.
Article
Biotechnology & Applied Microbiology
Grazyella M. Yoshida, Jose M. Yanez
Summary: The study utilized a multi-trait genome-wide association approach to identify quantitative trait loci (QTL) and genes associated with body traits in Nile tilapia. By combining summary statistics from single-trait genome-wide association studies, the study increased the statistical power for detecting genetic associations with body traits. The high-resolution mtGWAS allowed the detection of significant SNPs linked to functional candidate genes, providing further insights into genetic variants underlying body trait variation in cichlid fish.
Article
Multidisciplinary Sciences
Nicolas Merieux, Pierre Cordier, Marie-Helene Wagner, Sylvie Ducournau, Sophie Aligon, Dominique Job, Philippe Grappin, Edwin Grappin
Summary: The ScreenSeed technology is a high throughput phenotyping tool developed for seed germination, allowing characterization of seed samples' germination behavior with Arabidopsis thaliana seeds in 96-well microplates. This technology provides a fast and accurate procedure for handling thousands of seeds without compromising repeatability. Comparison with commonly used germination tests based on visual scoring shows very similar germination kinetics.
SCIENTIFIC REPORTS
(2021)
Article
Behavioral Sciences
Jun Seob Song, Yujiro Yamada, Ryo Kataoka, Vickie Wong, Robert W. Spitz, Zachary W. Bell, Jeremy P. Loenneke
Summary: A single bout of exercise can reduce pain sensitivity in healthy individuals, but exercise-induced hypoalgesia is often impaired in individuals with chronic pain. Existing literature suggests that training interventions may induce hypoalgesic adaptations, potentially driven by central nervous system and immune system factors, but further research is needed to understand the underlying mechanisms.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Agriculture, Multidisciplinary
Chun-hua Zhao, Na Zhang, Xiao-li Fan, Jun Ji, Xiao-li Shi, Fa Cui, Hong-qing Ling, Jun-ming Li
Summary: The roles of foundation parents in wheat genetic improvement were investigated, particularly regarding yield potential. The genetic basis of a candidate parent, KN9204, with high yield potential and nitrogen fertilizer utilization, was characterized using high-throughput whole-genome re-sequencing. The study provided theoretical reference for molecular breeding of high-yield wheat varieties.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Meghan May, Deborah Barlow, Radwa Ibrahim, Karen L. Houseknecht
Summary: Atypical antipsychotic (AA) medications are associated with an increased incidence of non-alcoholic fatty liver disease (NAFLD), but the underlying mechanisms are not fully understood. This study used multi-omic datasets from preclinical murine models and clinical patients to identify differentially expressed traits related to iron homeostasis and NAFLD pathways, providing mechanisms for the development of AA-associated NAFLD and dysregulated iron homeostasis.
Article
Biotechnology & Applied Microbiology
Xiaohong Fei, Yifei Wang, Yunxiao Zheng, Xiaomeng Shen, E. Lizhu, Junqiang Ding, Jinsheng Lai, Weibin Song, Haiming Zhao
Summary: This study conducted a comprehensive analysis of the genetic architecture of maize kernel row number (KRN) using a new NAM population. Multiple QTLs related to KRN were identified, and candidate genes contributing to KRN were found. These findings provide valuable information for improving maize yield.
Article
Multidisciplinary Sciences
Matthew B. Taylor, Joann Phan, Jonathan T. Lee, Madelyn McCadden, Ian M. Ehrenreich
NATURE COMMUNICATIONS
(2016)
Article
Genetics & Heredity
Jonathan T. Lee, Alessandro L. Coradini, Amy Shen, Ian M. Ehrenreich
Article
Microbiology
Jonathan T. Lee, Qingyi Yang, Alexey Gribenko, B. Scott Perrin, Yuao Zhu, Rhonda Cardin, Paul A. Liberator, Annaliesa S. Anderson, Li Hao
Summary: This study analyzed the mutational landscape of SARS-CoV-2 M-pro and found that mutations related to nirmatrelvir binding and protease functionality were rare. The M-pro enzyme remained highly conserved relative to the spike protein. This research provides a robust analysis framework for monitoring potential antiviral resistance.
Article
Biochemistry & Molecular Biology
Takeshi Matsui, Jonathan T. Lee, Ian M. Ehrenreich