期刊
OPEN BIOLOGY
卷 6, 期 10, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsob.160119
关键词
Hippo pathway; arrhythmogenic cardiomyopathy; Sveinsson's chorioretinal atrophy; Alzheimer's disease; amyotrophic lateral sclerosis; diabetes
资金
- Ministry of Science and Technology of Taiwan [MOST 105-2311-B-016-001-MY2]
- Human Frontier Science Program Organization (HFSPO)
The Hippo signalling pathway regulates cellular proliferation, apoptosis and differentiation, thus exerting profound effects on cellular homeostasis. Inhibition of Hippo signalling has been frequently implicated in human cancers, indicating a well-known tumour suppressor function of the Hippo pathway. However, it is less certain whether and how hyperactivation of the Hippo pathway affects biological outcome in living cells. This review describes current knowledge of the regulatory mechanisms of the Hippo pathway, mainly focusing on hyperactivation of the Hippo signalling nexus. The disease implications of hyperactivated Hippo signalling have also been discussed, including arrhythmogenic cardiomyopathy, Sveinsson's chorioretinal atrophy, Alzheimer's disease, amyotrophic lateral sclerosis and diabetes. By highlighting the significance of disease-relevant Hippo signalling activation, this review can offer exciting prospects to address the onset and potential reversal of Hippo-related disorders.
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