期刊
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
卷 14, 期 3, 页码 304-308出版社
BENTHAM SCIENCE PUBL
DOI: 10.2174/1871527314666150123122851
关键词
Antidepressant; glucocorticoid; microglia; norepinephrine; stress
Psychological stress leads to activation and proliferation of microglial cells in different brain regions. These effects are mediated by inflammatory cytokines, as well as stress hormones including glucocorticoids and norepinephrine. Eliminating microglia from the nervous system or blocking their activation prevented the stress-induced impairments on brain cognitive functions. We conclude that microglial cells are important meditators underlying anti-depression therapies.
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