期刊
JOURNAL OF SAUDI CHEMICAL SOCIETY
卷 20, 期 1, 页码 7-12出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jscs.2012.05.004
关键词
Cholest-5-en-7-one; 2,4-Dinitrophenylhydrazine; Pyrazoline; Antimicrobial; Anticancer
资金
- University Grants Commission
A convenient synthesis of 2 '-(2 '',4 ''-dinitropheny1)-5 alpha-cholestano [5,7-c d] pyrazolines 4-6 from cholest-5-en-7-one 1-3 was performed and structural assignment of the products was confirmed on the basis of IR, H-1 NMR, C-13 NMR, MS and analytical data. The synthesized compounds were screened for in vitro antimicrobial activity against different strains during which compound 6 showed potent antimicrobial behaviour against Corynebacterium xerosis and Staphylococcus epidermidis. The synthesized compounds were also screened for in vitro anticancer activity against human cancer cell lines during which compound 5 exhibited significant anticancer activity. (C) 2012 King Saud University. Production and hosting by Elsevier B.V. All rights reserved.
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