期刊
CLINICS IN GERIATRIC MEDICINE
卷 31, 期 1, 页码 101-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cger.2014.08.021
关键词
Type 2 diabetes; Cognition; Cognitive decline; Dementia; Aging; Epidemiology
资金
- National Institute on Aging grant [K24 AG031155]
- National Institute of Diabetes and Digestive and Kidney Diseases grant [R01DK081796]
- BrightFocus Foundation
Dementia is a major cause of disability and death among older adults. Those with type 2 diabetes (T2D) are 50-100% more likely to develop dementia than those without T2D, but it is unknown whether this association reflects a causal relationship. Proposed mechanisms through which T2D could cause dementia include the effects of insulin dysregulation and chronic hyperglycemia on features of Alzheimer's disease and macrovascular and microvascular disorders in the brain. More research is needed to elucidate the link between T2D and dementia and identify strategies to maintain cognitive function among people with T2D.
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