Article
Endocrinology & Metabolism
Jiang Deng, Yonghong Zhang, Limei Bu, Haitao Shi, Hailing Tang, Shenhao Wang, Qian Wang, Shuangsuo Dang, Ming Li, Zhiyi Han, Xiaolan Lu
Summary: The study found that the prevalence of non-obese fatty liver disease is high and rapidly increasing in Karamay. Triglycerides are the best predictor of non-obese fatty liver in non-obese individuals undergoing physical examinations. An increase in body mass index is associated with an increased risk of non-obese fatty liver disease.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Ning Gao, Jiang Deng, Jinhai Wang, Zhihua Zhou, Cong Yao, Mimi Zhou, Xin Xing, Qian Wang, Xiaolan Lu, Haitao Shi
Summary: The study aimed to analyze the prevalence, associated comorbidities, influencing factors, and identifying factors of non-obese fatty liver disease. The findings revealed that elevated triglycerides levels were common among individuals with non-obese fatty liver disease and proposed triglycerides as a potentially useful indicator for extensive screening of the condition.
FRONTIERS IN MEDICINE
(2022)
Article
Geriatrics & Gerontology
Pinar Soysal, Saadet Koc Okudur, Nazli Kilic, Ozlem Ipar, Lee Smith
Summary: This study investigated the prevalence of undernutrition and related factors in older obese patients. The results showed that half of the older patients were obese and undernutrition was observed in one out of every three older obese patients. Undernutrition was associated with decreased functional capacity, impairment in balance and gait functions, falls, and depressed mood.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Marie Auzanneau, Alexander J. Eckert, Sebastian M. Meyhoefer, Martin Heni, Anton Gillessen, Lars Schwettmann, Peter M. Jehle, Michael Hummel, Reinhard W. Holl, DPV Initiative
Summary: In Germany, there are inequalities in the use of diabetes technology among adults with type 1 diabetes, with older age, male gender, and migration background associated with lower technology use. The relationship between technology use and area deprivation is more complex and not linear.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Ahmed Abdallah Salman, Mohamed Abdalla Salman, Mohamed A. Marie, Ahmed Rabiee, Mona Youssry Helmy, Mohamed Sabry Tourky, Mohamed Gamal Qassem, Hossam El-Din Shaaban, Mohamed D. Sarhan
Summary: Independent predictors of complete remission of T2DM after LSG were younger age, shorter duration, single oral antidiabetic, lower HOMA-IR, and higher C-peptide. The combined marker of young age, short duration of DM, and low HOMA-IR had a sensitivity of 93% and specificity of 82% in predicting complete remission.
SCIENTIFIC REPORTS
(2021)
Review
Nutrition & Dietetics
Anna Izzo, Elena Massimino, Gabriele Riccardi, Giuseppe Della Pepa
Summary: Type 2 diabetes mellitus is a major health burden for the elderly, affecting approximately 25% of those over 65 years old. Sarcopenia, characterized by loss of skeletal muscle mass and function, has been identified as a new complication in elderly individuals with T2DM. It is important for researchers and clinicians to understand the risk factors and associations of sarcopenia in T2DM patients in order to provide appropriate therapeutic interventions.
Article
Public, Environmental & Occupational Health
Dana Hyassat, Saba Al-Saeksaek, Duha Naji, Awn Mahasneh, Yousef Khader, Mousa Abujbara, Mohammad El-Khateeb, Kamel Ajlouni
Summary: This study investigated the prevalence and patterns of dyslipidemia among patients with type 2 diabetes and its associated risk factors. The results showed that combined dyslipidemia, characterized by high triglycerides and low HDL-cholesterol, was the most common type. Factors such as diabetes duration, statin non-compliance, HbA1c level, and smoking were associated with different types of dyslipidemia.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Miguel A. Simon, Ana M. Bueno, Vanessa Blanco, Patricia Otero, Fernando L. Vazquez
Summary: This study aimed to determine the prevalence and associated factors of poor sleep quality in non-professional caregivers. The results showed that poor sleep quality was more common among caregivers of individuals with mental disorders, and they experienced higher levels of perceived burden, psychological distress, and overall poor sleep quality. The study also found that caregiver burden and psychological distress were significantly associated with sleep quality in family caregivers.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Obiageli Uzoamaka Agbogu-Ike, Dimie Ogoina, Geoffrey Chukwubuike Onyemelukwe
Summary: The study revealed higher plasma leptin concentrations in obese and pre-obese Nigerian-Africans, with females showing higher levels compared to males. Leptin was independently associated with BMI, body fat percentage, waist circumference, female sex, and generalized/central obesity, particularly in males. The results also showed sex-specific correlations of leptin with age, fasting insulin, and HOMA-IR.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Medicine, General & Internal
Geraldo Jose De Amorim, Cinthia Katiane Martins Calado, Bruno Carlos Souza de Oliveira, Renata Patricia Oliveira Araujo, Tayrine Ordonio Filgueira, Matheus Santos De Sousa Fernandes, Angela Castoldi, Gisele Vajgel, Lucila Maria Valente, Jose Luiz De Lima-Filho, Paulo Roberto Cavalcanti Carvalho, Fabricio Oliveira Souto
Summary: This study investigated the prevalence and factors associated with sarcopenia in ND-CKD individuals. The results showed that sarcopenia was common in this population and was associated with age, body mass index, phase angle, gait speed, and serum markers.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Jinghua Wang, Yishu Chen, Shenghui Chen, Xinyu Wang, Haoliang Zhai, Chengfu Xu
Summary: The prevalence and factors associated with hyperuricaemia in non-obese Chinese population were investigated in this study. The results showed that the prevalence of hyperuricaemia in non-obese subjects was 9.4%, with 16.3% in men and 4.6% in women. Additionally, hyperuricaemia was significantly associated with metabolic syndrome and fatty liver disease.
Article
Multidisciplinary Sciences
Takayuki Teruya, Sumito Sunagawa, Ayaka Mori, Hiroaki Masuzaki, Mitsuhiro Yanagida
Summary: Definitive differences in blood metabolite profiles between obese and non-obese Type 2 diabetes (T2D) have been identified through LC-MS-based non-targeted metabolomic analysis. The T2D group showed significant increases or decreases in 20 compounds, mainly nucleobases and glucose metabolites. Among these compounds, 11 enriched in red blood cells (RBCs) have rarely been studied in the context of diabetes, indicating extensive disruption of RBC metabolism.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Sara J. J. Cromer, Chirag M. M. Lakhani, Josep M. M. Mercader, Timothy D. D. Majarian, Philip Schroeder, Joanne B. B. Cole, Jose C. C. Florez, Chirag J. J. Patel, Alisa K. K. Manning, Sherri-Ann M. Burnett-Bowie, Jordi Merino, Miriam S. S. Udler
Summary: This study quantified the impact of genetic and socioeconomic factors on the risk of type 2 diabetes and obesity. The results showed that area-level socioeconomic factors were strongly associated with both diseases, independent of genetic risk. Higher genetic and socioeconomic burden was associated with higher prevalence of type 2 diabetes and obesity. Favorable socioeconomic status was associated with lower disease prevalence, even in individuals with high genetic risk. Genetic and socioeconomic factors together accounted for 13.2% and 16.7% of the prevalence of type 2 diabetes and obesity, respectively.
Review
Biochemistry & Molecular Biology
Harshita Shailesh, Ajaz A. Bhat, Ibrahim A. Janahi
Summary: Obesity and asthma are common health issues with increased prevalence worldwide. Obesity exacerbates asthma symptoms and reduces therapeutic response. Recent studies have found that obesity-associated non-T2 factors, including mechanical stress, hyperinsulinemia, systemic inflammation, play a role in worsening asthma symptoms in obese asthmatic individuals. This review also discusses potential future therapies to reduce asthma symptoms in obese individuals by addressing these obesity-associated factors.
Article
Surgery
Daiji Kano, Chengcheng Hu, Caitlin J. Thornley, Cecilia Y. Cruz, Nathaniel J. Soper, Jennifer F. Preston
Summary: The positioning during surgery can affect the risk of venous thromboembolism (VTE), with the reverse-Trendelenburg position potentially increasing the risk of postoperative VTE. Therefore, appropriate positioning choice in laparoscopic surgery can help decrease the risk of VTE.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Clinical Neurology
Steve Simpson-Yap, Roberts Atvars, Leigh Blizzard, Ingrid van der Mei, Bruce Taylor
Summary: The Greater Hobart region of Tasmania has the highest prevalence and incidence rates of multiple sclerosis (MS) in Australia, and these rates have been increasing over the past 68 years. The recent data shows a 36% increase in prevalence and a 65% increase in incidence from 2009 to 2019. The prevalence and incidence rates are higher in females compared to males, and the incidence rate is also increasing. Comparisons with Newcastle show that the latitudinal gradients for prevalence and incidence have almost disappeared in Hobart, likely due to changes in the population demographics.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Amin Zarghami, Ingrid van der Mei, Mohammad Akhtar Hussain, Suzi B. Claflin, Barnabas Bessing, Steve Simpson-Yap, Anne-Louise Ponsonby, Jeanette Lechner-Scott, Simon Broadley, Leigh Blizzard, Bruce Taylor
Summary: This study analyzed the prospective trajectories of employment-related outcomes in multiple sclerosis patients following a first episode of CNS demyelination. Different trajectories were identified for employment status, workhours, and disability support pension. Female patients were more likely to have stable part-time jobs, while those with higher disability levels and more comorbidities were more likely to experience early and late deteriorated employment trajectories. The number of relapses and the rate of disability accrual were also associated with employment trajectories.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Endocrinology & Metabolism
Xueran Huang, Yang Qiu, Yongfen Gao, Rong Zhou, Qiantu Hu, Zouyan He, Yingnan Lv, Xi Wang, Wanrong Chen, Yuqing Deng, Zhuangzhuang An, Haiying Zhang, Zengnan Mo, Rui Lin
Summary: This study investigated the association between serum melatonin and type 2 diabetes risk in a southern Chinese population. The results showed that higher levels of serum melatonin were associated with a lower risk of type 2 diabetes, and gut microbiota played a role in this association.
Article
Nutrition & Dietetics
Xueran Huang, Yongfen Gao, Wanrong Chen, Qiantu Hu, Zouyan He, Xi Wang, Dan Li, Rui Lin
Summary: The study found that dietary variety was related to gut microbiota. Individuals with higher dietary variety had higher microbial diversity and higher abundance of some potentially beneficial bacteria, while the abundance of some potentially pathogenic bacteria was lower. Therefore, a diverse diet should be recommended in daily life.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Health Care Sciences & Services
Julie A. Campbell, Hasnat Ahmad, Gang Chen, Ingrid van der Mei, Bruce Taylor, Suzi Claflin, Glen J. Henson, Steve Simpson-Yap, Laura L. Laslett, Kirsty Hawkes, Carol Hurst, Hilary Waugh, Andrew J. Palmer
Summary: This study aimed to externally validate the EQ-5D-5L-Psychosocial in a large cohort of people with multiple sclerosis (pwMS) and explore the discriminatory power of the new instrument with EQ-5D-5L/AQoL-8D. The results showed that the EQ-5D-5L-Psychosocial is more sensitive than the EQ-5D-5L in pwMS whose health state utilities approach those reflecting full health.
QUALITY OF LIFE RESEARCH
(2023)
Article
Clinical Neurology
Xin Lin, Yuanhao Yang, Valery Fuh-Ngwa, Xianyong Yin, Steve Simpson-Yap, Ingrid van der Mei, Simon A. Broadley, Anne-Louise Ponsonby, Kathryn P. Burdon, Bruce Taylor, Yuan Zhou
Summary: This study identifies serine as a potential biomarker for the onset and disability progression of multiple sclerosis (MS) through Mendelian randomisation methods.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Alexander Fidao, George Jelinek, Steve Simpson-Yap, Sandra Neate, Nupur Nag
Summary: People with multiple sclerosis (pwMS) have reduced quality of life, and engaging in healthy lifestyle behaviors such as a healthy diet and regular physical activity can improve their quality of life. This study aims to assess the benefits of individual lifestyle behaviors on quality of life, and whether engaging in multiple healthy behaviors concurrently has additive benefits.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Alice M. Saul, Bruce Taylor, Leigh Blizzard, Steve Simpson-Yap, Wendy H. Oddy, Nittin Shivappa, James R. Hebert, Lucinda J. Black, Anne-Louise Ponsonby, Simon A. Broadley, Jeanette Lechner-Scott, Ingrid van der Mei
Summary: This study found that a pro-inflammatory diet is associated with chronic inflammation in the central nervous system, and multiple sclerosis is an inflammatory disease of the CNS. Dietary Inflammatory Index (DII) scores are associated with measures of MS progression and inflammatory activity.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Health Care Sciences & Services
Harry Kirkland, Julie Campbell, Jeanette Reece, Nupur Nag, Yasmine Probst, Sandra Neate, Alysha De Livera, George Jelinek, Steve Simpson-Yap
Summary: This study assessed the association between diet quality and health state utilities (HSU) and found that higher quality-of-the-diet was associated with higher HSUs in people living with multiple sclerosis (MS) 2.5- and 5-years later. Specifically, higher intake of fat, fiber, and fruits/vegetables was strongly and consistently associated with better HSU outcomes, while meat and dairy consumption were associated with lower HSUs.
QUALITY OF LIFE RESEARCH
(2023)
Article
Clinical Neurology
Steve Simpson-Yap, Federico Frascoli, Lucinda Harrison, Charles Malpas, James Burrell, Nicholas Child, Lauren P. Giles, Christian Lueck, Merrilee Needham, Benjamin Tsang, Tomas Kalincik
Summary: This study provides a comprehensive analysis of the Australian neurological workforce and supply/demand dynamics. It highlights a significant shortfall of supply relative to current and projected demand for neurologist services. Interventions to increase the workforce may alleviate the shortage but won't eliminate it completely. Additional measures such as improving efficiency and utilizing support staff are necessary.
BMJ NEUROLOGY OPEN
(2023)
Article
Clinical Neurology
Jeanette C. Reece, Sandra L. Neate, Rebekah A. Davenport, Elasma Milanzi, Nupur Nag, William Bevens, Maggie Yu, George A. Jelinek, Steve Simpson-Yap
Summary: This study aims to investigate the relationship between stressful life events and fatigue and depressive symptoms in people living with multiple sclerosis (plwMS). The findings suggest that the number and load of stressful life events are not associated with higher prevalence of fatigue or depressive symptoms, except for those events with a perceived negative emotional impact.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Clinical Neurology
Steve Simpson-Yap, Sandra L. Neate, Nupur Nag, Yasmine C. Probst, Maggie Yu, George A. Jelinek, Jeanette C. Reece
Summary: This study aimed to examine the relationship between diet quality and subsequent disability in people with MS. The results showed that higher diet quality was associated with lower disability risk, while meat and dairy consumption was associated with increased disability risk.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Amin Zarghami, Valery B. Fuh-Ngwa, Suzi Claflin, Ingrid van Der Mei, Anne-Louise Ponsonby, Simon Broadley, Steve V. Simpson-Yap, Ausimmune AusLong Investigator Grou, Bruce Taylor
Summary: This study aimed to understand predictors of employment status changes among people with multiple sclerosis (MS). The results showed that there was a significant rate of employment transition during the early years after a diagnosis of central nervous system demyelination (FCD). Females, individuals with higher disability levels, and those with a higher relapse count were more likely to lose employment.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Julie A. Campbell, Ingrid van der Mei, Bruce Taylor, Andrew J. Palmer, Glen J. Henson, Laura Louise Laslett, Steve Simpson-Yap, Suzi B. Claflin
Summary: This study investigated the lived experience of a large cohort of Australians living with different levels of multiple sclerosis (MS)-related disability during the COVID-19 pandemic. The study found negative impacts of multitasking and social isolation for PwMS, while working from home was identified as beneficial for some.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Steve Simpson-Yap, Duncan Maddox, Jeannette Lechner-Scott, Cameron Shaw, Bruce Taylor, Tomas Kalincik, Anneke van der Walt, Mike Boggild
Summary: This study aims to assess the epidemiology of multiple sclerosis (MS) in Townsville from 2012 to 2022. The results show that Townsville is a high-frequency region for MS, with prevalence and incidence on par with that seen at higher latitudes in Australia.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
