期刊
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnbeh.2016.00208
关键词
maternal undernutrition; endocannabinoids; hypothalamus; hippocampus; rat; development; metabolism; behavior
资金
- Institute de Salud Carlos III
- Ministerio de Economia y Competitividad [PI13/0226, CP12/03109, PSI-2012-35388]
- Red de Trastornos Adictivos [RD12/0028/0001]
- CABERobn
- Consejeria de Economia, Innovation y Ciencia
- Junta de Andalucia
- UE/ERDF [P145403, CTS-8221, CTS-433]
- Consejeria de Salud, Junta de Andalucia [SAS111224]
- German Research Foundation DFG [FOR926]
- FPU predoctoral fellowship of the Spanish Ministerio de Educacion, Cultura y Deporte [AP-2009-0225]
- National System of Health, ISCIII [CP12/03109]
Exposure to inadequate nutritional conditions in critical windows of development has been associated to disturbances on metabolism and behavior in the offspring later in life. The role of the endocannabinoid system, a known regulator of energy expenditure and adaptive behaviors, in the modulation of these processes is unknown. In the present study, we investigated the impact of exposing rat dams to diet restriction (20% less calories than standard diet) during pre-gestational and gestational periods on: (a) neonatal outcomes; (b) endocannabinoid content in hypothalamus, hippocampus and olfactory bulb at birth; (c) metabolism-related parameters; and (d) behavior in adult male offspring. We found that calorie restricted dams tended to have a reduced litter size, although the offspring showed normal weight at birth. Pups from calorie-restricted dams also exhibited a strong decrease in the levels of anandamide (AEA), 2-arachidonoylglycerol (2-AG), arachidonic acid (AA) and palm itoylethanolamide (PEA) in the hypothalamus at birth. Additionally, pups from diet restricted dams displayed reduced levels of AEA in the hippocampus without significant differences in the olfactory bulb. Moreover, offspring exhibited increased weight gain, body weight and adiposity in adulthood as well as increased anxiety-related responses. We propose that endocannabinoid signaling is altered by a maternal caloric restriction implemented during the preconceptional and pregnancy periods, which might lead to modifications of the hypothalamic and hippocampal circuits, potentially contributing to the long-term effects found in the adult offspring.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据