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Endocrinology & Metabolism
Shigenobu Matsumura, Motoki Miyakita, Haruka Miyamori, Satomi Kyo, Daisuke Shima, Takumi Yokokawa, Fuka Ishikawa, Tsutomu Sasaki, Tomoki Jinno, Jin Tanaka, Tsuyoshi Goto, Keiko Momma, Kengo Ishihara, Rebecca Berdeaux, Kazuo Inoue
Summary: This study demonstrates that G(s) signaling in MC4R-expressing cells regulates energy expenditure, appetite, and locomotor activity.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Multidisciplinary Sciences
Zheng-Dong Zhao, Xiao Han, Renchao Chen, Yiqiong Liu, Aritra Bhattacherjee, Wenqiang Chen, Yi Zhang
Summary: The striatum plays a critical role in regulating addiction-related behaviors. A subtype of D1 MSNs, Tac2+, demonstrates an unconventional and subtype/projection-specific negative regulatory function in drug addiction.
Article
Neurosciences
Emma E. Boxer, JungMin Kim, Brett Dunn, Jason Aoto
Summary: Ventral subiculum (vSUB) is the major output region of ventral hippocampus (vHIPP) and its hyperactivity is associated with substance use disorders. Modulation of vSUB activity alters drug seeking and drug reinstatement behavior in rodents.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Elizabeth A. Sneddon, Kristen M. Schuh, John W. Frankel, Anna K. Radke
Summary: The study found that inhibiting the NAc core can reduce compulsive ethanol intake in mice, but exciting the NAc core has no effect. Inhibiting neurons expressing D-1 or D-2 receptors does not alter compulsive ethanol intake.
Article
Neurosciences
Jenya Kolpakova, Vincent van der Vinne, Pablo Gimenez-Gomez, Timmy Le, Gilles E. Martin
Summary: Animal studies support the important role of striatal cholinergic interneurons in basal ganglia function, particularly in associative learning, reward processing, and motor control. ChIs regulate synaptic excitability of medium spiny neurons by modulating dopamine, glutamate, and GABA neurotransmission. The effect of ChIs on dopamine D1- and D2 receptor-expressing neurons differs, and is altered after binge alcohol drinking.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
You-Hsin Lin, Yukie Yamahashi, Keisuke Kuroda, Omar Faruk, Xinjian Zhang, Kiyofumi Yamada, Akihiro Yamanaka, Taku Nagai, Kozo Kaibuchi
Summary: The study revealed that accumbal D2R-MSNs regulate negative reinforcement through the A2aR-PKA-Rap1-MEK pathway. Inhibition of this pathway has been shown to attenuate aversive responses.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Neurosciences
Robert A. Phillips, Jennifer J. Tuscher, N. Dalton Fitzgerald, Ethan Wan, Morgan E. Zipperly, Corey G. Duke, Lara Ianov, Jeremy J. Day
Summary: Drugs of abuse increase dopamine levels in the brain and lead to long-lasting changes in cellular and behavioral responses. This study used snRNA-seq to analyze the transcriptional profiles of NAc cells in rats after cocaine exposure, revealing distinct cell populations and their specific responses to cocaine. The findings also showed similarities in cell types across species and highlighted the importance of understanding cell composition in the NAc.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jing He, Michael Kleyman, Jianjiao Chen, Aydin Alikaya, Kathryn M. Rothenhoefer, Bilge Esin Ozturk, Morgan Wirthlin, Andreea C. Bostan, Kenneth Fish, Leah C. Byrne, Andreas R. Pfenning, William R. Stauffer
Summary: This study identified at least nine subtypes of medium spiny neurons (MSNs) in the striatum of Rhesus monkeys, showing greater heterogeneity than previously thought at the transcriptional level. Each MSN subtype was characterized by discontinuities in gene expression, but continuous variation within subtypes corresponded to anatomical locations and potential functional specializations.
Review
Behavioral Sciences
Anil Joshi, Marion Schott, Susanne Eva la Fleur, Michel Barrot
Summary: Food intake is a necessary behavior for all animals, but excessive consumption of fat and sugar can lead to obesity. This review provides insights into the impact of food intake on the striatal complex and the modulation of palatable food intake by different neurochemical systems.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Cell Biology
Ryota Imai, Keita Mizuno, Yuji Omiya, Kazushige Mizoguchi, Yuko Maejima, Kenju Shimomura
Summary: The study suggests that ninjin'yoeito (NYT) may modulate appetite and motivational behaviors by influencing the activity of dopaminergic neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNpc), as well as medium spiny neurons in the nucleus accumbens (NAc).
Article
Medicine, General & Internal
Cajsa Aranaes, Christian E. Edvardsson, Olesya T. Shevchouk, Qian Zhang, Sarah Witley, Sebastian Blid Skoeldheden, Lindsay Zentveld, Daniel Valloef, Maximilian Tufvesson-Alm, Elisabet Jerlhag
Summary: This study found that glucagon-like peptide1 receptor (GLP-1R) agonists can reduce alcohol intake and prevent relapse in rodents. The results also showed that semaglutide has a suppressive effect on alcohol-induced behavior and its impact on the brain. These findings suggest that semaglutide may be effective in reducing alcohol consumption and body weight by reducing the rewarding effects of alcohol and its impact on neurons.
Article
Biochemistry & Molecular Biology
Katalin Eszter Ibos, Eva Bodnar, Zsolt Bagosi, Zsolt Bozso, Gabor Toth, Gyula Szabo, Krisztina Csabafi
Summary: Kp-8 treatment in rats resulted in decreased exploratory and spontaneous locomotion, increased anxiety-related behaviors, and activation of the reproductive axis through Kiss1r. The neurochemical changes in GABA and dopamine release further support the findings.
Review
Behavioral Sciences
Benjamin L. Thompson, Marlene Oscar-Berman, Gary B. Kaplan
Summary: Opioid Use Disorder (OUD) is a chronic condition with significant morbidity and mortality even with treatment. Neuroplasticity plays a key role in OUD development, with alterations in dopaminergic and glutamatergic pathways potentially leading to behavioral symptoms.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Michael Okas, Abigail Kastner, Dominic Gioia, John J. J. Woodward
Summary: Research has shown that inhaling volatile organic solvents like toluene can affect brain function, specifically by acting on ion channels involved in regulating neuronal excitability. In this study, the firing activity of medium spiny neurons (MSNs) in the nucleus accumbens (NAc) core and shell was examined after exposure to intoxicating concentrations of toluene vapor. The results indicate that while the firing of NAc core MSNs remained unchanged, the activity of NAc shell MSNs was enhanced at low current steps but reduced at higher current steps. Additionally, the firing of D2-positive MSNs in the NAc shell was affected by toluene exposure, while D2-negative MSNs showed no changes in firing.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Giuseppe Aceto, Luca Nardella, Giacomo Lazzarino, Barbara Tavazzi, Alessia Bertozzi, Simona Nanni, Claudia Colussi, Marcello D'Ascenzo, Claudio Grassi
Summary: This study found that acute restrain stress (ARS) may activate endogenous histamine type 2 receptor (H2R) signaling in medium spiny neurons (MSNs), suggesting the involvement of H2R signaling in stress-related motivational states.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
L. E. Jin, M. Wang, S-T Yang, Y. Yang, V. C. Galvin, T. C. Lightbourne, D. Ottenheimer, Q. Zhong, J. Stein, A. Raja, C. D. Paspalas, A. F. T. Arnsten
MOLECULAR PSYCHIATRY
(2017)
Article
Biology
Giuseppe D'Agostino, David J. Lyons, Claudia Cristiano, Luke K. Burke, Joseph C. Madara, John N. Campbell, Ana Paula Garcia, Benjamin B. Land, Bradford B. Lowell, Ralph J. Dileone, Lora K. Heisler
Article
Immunology
Katherine Conant, Stefano Daniele, P. Lorenzo Bozzelli, Tsion Abdi, Amanda Edwards, Arek Szklarczyk, India Olchefske, David Ottenheimer, Kathleen Maguire-Zeiss
JOURNAL OF NEUROINFLAMMATION
(2017)
Article
Neurosciences
Colby R. Keistler, Emma Hammarlund, Jacqueline M. Barker, Colin W. Bond, Ralph J. DiLeone, Christopher Pittenger, Jane R. Taylor
JOURNAL OF NEUROSCIENCE
(2017)
Article
Developmental Biology
Jaime G. Maldonado-Aviles, Douglas J. Guarnieri, Xianglong Zhu, Ralph J. DiLeone
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2018)
Article
Multidisciplinary Sciences
David Ottenheimer, Jocelyn M. Richard, Patricia H. Janak
NATURE COMMUNICATIONS
(2018)
Article
Neurosciences
David J. Ottenheimer, Karen Wang, Alexandria Haimbaugh, Patricia H. Janak, Jocelyn M. Richard
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Article
Biology
Youna Vandaele, Nagaraj R. Mahajan, David J. Ottenheimer, Jocelyn M. Richard, Shreesh P. Mysore, Patricia H. Janak
Article
Neurosciences
David J. Ottenheimer, Bilal A. Bari, Elissa Sutlief, Kurt M. Fraser, Tabitha H. Kim, Jocelyn M. Richard, Jeremiah Y. Cohen, Patricia H. Janak
NATURE NEUROSCIENCE
(2020)
Article
Neurosciences
Youna Vandaele, David J. Ottenheimer, Patricia H. Janak
Summary: The activity pattern of the dorsomedial striatum gradually changes during the execution of goal-directed action sequences, allowing for accurate decoding of sequence progress from neural activity. The link between dorsomedial striatum activity and the execution of behavioral sequences that require monitoring of ongoing behavior is suggested by the data.
Article
Biochemistry & Molecular Biology
Boyoung Lee, Santosh Pothula, Min Wu, Hyeyeon Kang, Matthew J. Girgenti, Marina R. Picciotto, Ralph J. DiLeone, Jane R. Taylor, Ronald S. Duman
Summary: Researchers tested a novel NMDAR-positive modulator, NYX-783, in rodent models of PTSD and found that it significantly reduced spontaneous recovery and enhanced fear extinction. The study elucidated the cellular targets and molecular mechanisms underlying NYX-783's effects on PTSD symptoms.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Ruth H. Asch, Santosh Pothula, Takuya Toyonaga, Krista Fowles, Stephanie M. Groman, Rolando Garcia-Milian, Ralph J. DiLeone, Jane R. Taylor, Irina Esterlis
Summary: Clinical investigations have shown that metabotropic glutamate receptor 5 (mGluR5) is involved in the pathophysiology of fear learning in trauma-related disorders. This study used a 4-day fear learning paradigm combined with positron emission tomography (PET) to examine the relationship between mGluR5 availability and the response of rats to repeated footshock exposure. The results suggest that increased mGluR5 availability following footshock exposure may be related to greater contextual fear memory, and there are sex differences in the molecular response to footshock, including differential involvement of mGluR5-related molecular networks.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biology
David J. Ottenheimer, Madelyn M. Hjort, Anna J. Bowen, Nicholas A. Steinmetz, Garret D. Stuber
Summary: This study demonstrates the stable encoding of cue-reward learning by individual prefrontal neurons and reveals a certain advantage of the prefrontal cortex in value coding.
Article
Endocrinology & Metabolism
Katy A. van Galen, Anouk Schrantee, Kasper W. ter Horst, Susanne E. la Fleur, Jan Booij, R. Todd Constable, Gary J. Schwartz, Ralph J. DiLeone, Mireille J. Serlie
Summary: This study found that intragastric glucose and lipid infusions can induce cerebral neuronal activity and striatal dopamine release in individuals with a healthy body weight, but these responses are severely impaired in individuals with obesity. Furthermore, the impaired neuronal responses are not restored after diet-induced weight loss.
Article
Multidisciplinary Sciences
David J. Ottenheimer, Karen Wang, Xiao Tong, Kurt M. Fraser, Jocelyn M. Richard, Patricia H. Janak