Article
Cardiac & Cardiovascular Systems
Jose R. Gonzalez-Juanatey, Alberto Cordero, Jose Ma Castellano, Luis Masana, Regina Dalmau, Emilio Ruiz, Antonio Sicras-Mainar, Valentin Fuster
Summary: This study suggests that treatment with the CNIC-Polypill in secondary prevention patients is associated with a significant reduction in the incidence of recurrent MACE, improved control rates for blood pressure and LDL cholesterol, and increased medication persistence compared to control groups.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Clinical Neurology
Michael Brainin, Yvonne Teuschl, Sheila Martins
Summary: A polypill-type strategy has been proposed as a potential method for preventing cardiovascular and stroke events, especially when combined with community health workers interventions for modifying risk behavior. Despite some issues with nonadherence or potential side effects, this strategy seems to have a significant overall effect in underserved regions of high-income countries as well as in low- and middle-income countries.
Article
Cardiac & Cardiovascular Systems
Nathan K. Itoga, Daniel S. Taw, Maria E. Montez-Rath, Tara I. Chang
Summary: The study found that there are differences in the risk pattern of systolic blood pressure (SBP) and diastolic blood pressure (DBP) depending on clinical outcomes, with different SBP and DBP ranges associated with the lowest risk for different cardiovascular events. This suggests that individualization of blood pressure targets may be necessary based on the specific cardiovascular event for which a patient is most at risk.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
J. Mesquita Bastos, Lisa Ferraz, Flavio G. Pereira, Susana Lopes
Summary: This study found that ambulatory blood pressure monitoring (ABPM) can predict cardiovascular events in patients with resistant hypertension. The study revealed that 24 h systolic blood pressure, night systolic blood pressure, and 24 h pulse pressure were independent predictors of cardiovascular events. Particularly, patients with a 24 h daytime and nighttime pulse pressure > 60 mm Hg had a higher risk of future cardiovascular events.
Article
Peripheral Vascular Disease
Florence Lamarche, Mohsen Agharazii, Francois Madore, Remi Goupil
Summary: This study found that central blood pressure measured with a type I device was statistically but likely not clinically superior to brachial blood pressure in a general population without prior cardiovascular disease. The optimal central systolic blood pressure threshold associated with increased risk of major adverse cardiovascular events was identified as 112 mm Hg.
Article
Cardiac & Cardiovascular Systems
Prakriti Gaba, Michelle L. O'Donoghue, Jeong-Gun Park, Stephen D. Wiviott, Dan Atar, Julia F. Kuder, KyungAh Im, Sabina A. Murphy, Gaetano M. De Ferrari, Zbigniew A. Gaciong, Kalman Toth, Ioanna Gouni-Berthold, Jose Lopez-Miranda, Francois Schiele, Francois Mach, Jose H. Flores-Arredondo, J. Antonio G. Lopez, Mary Elliott-Davey, Bei Wang, Maria Laura Monsalvo, Siddique Abbasi, Robert P. Giugliano, Marc S. Sabatine
Summary: This study found that long-term achievement of lower LDL-C levels (below 20 mg/dL) in patients with atherosclerotic cardiovascular disease was associated with a lower risk of cardiovascular events without significant safety concerns.
Article
Peripheral Vascular Disease
Leo F. Buckley, William L. Baker, Benjamin W. Van Tassell, Jordana B. Cohen, Omar Alkhezi, Adam P. Bress, Dave L. Dixon
Summary: The study found that the amount of time spent within the target range for blood pressure is associated with adverse kidney and cardiovascular events. Better blood pressure control in hypertensive patients is linked to a lower risk of kidney and cardiovascular problems.
Article
Cardiac & Cardiovascular Systems
Michael Boehm, Stefan D. Anker, Javed Butler, Gerasimos Filippatos, Joao Pedro Ferreira, Stuart J. Pocock, Felix Mahfoud, Martina Brueckmann, Waheed Jamal, Anne Pernille Ofstad, Elke Schueler, Piotr Ponikowski, Christoph Wanner, Faiez Zannad, Milton Packer
Summary: Empagliflozin was found to be effective and safe in patients with reduced ejection fraction heart failure, with no significant interaction between systolic blood pressure and the drug's effects. Patients with baseline systolic blood pressure <110 mm Hg did not experience an increased rate of symptomatic hypotension when treated with empagliflozin.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Khalid Al Faraidy, Mousa Akbar, Mohamed Shehri, Mohammad Aljarallah, Gamal Abdin Hussein, Raja Dashti, Ahmad Al Qudaimi, Fahad Al Nouri, Zuhier Awan, Ahmed Essam, Alaa Emara
Summary: This study aimed to describe the characteristics of patients receiving evolocumab in clinical practice. The results showed that evolocumab is an effective lipid-lowering treatment that improves the achievement of LDL-C goals, with high tolerability and persistence.
Article
Peripheral Vascular Disease
Hokyou Lee, Yuichiro Yano, So Mi Jemma Cho, Ji Eun Heo, Dong-Wook Kim, Sungha Park, Donald M. Lloyd-Jones, Hyeon Chang Kim
Summary: Treatment and control rates for high blood pressure are unsatisfactory among young adults, with poor adherence to pharmacological treatment associated with higher risk for future cardiovascular events.
Article
Peripheral Vascular Disease
Christopher E. Clark, Fiona C. Warren, Kate Boddy, Sinead T. J. McDonagh, Sarah F. Moore, Maria Teresa Alzamora, Rafel Ramos Blanes, Shao-Yuan Chuang, Michael H. Criqui, Marie Dahl, Gunnar Engstrom, Raimund Erbel, Mark Espeland, Luigi Ferrucci, Maelenn Guerchet, Andrew Hattersley, Carlos Lahoz, Robyn L. McClelland, Mary M. McDermott, Jackie Price, Henri E. Stoffers, Ji-Guang Wang, Jan Westerink, James White, Lyne Cloutier, Rod S. Taylor, Angela C. Shore, Richard J. McManus, Victor Aboyans, John L. Campbell
Summary: The study found that using blood pressure readings from the higher arm instead of the lower arm can more accurately diagnose and manage hypertension. Models based on higher arm BP performed better in predicting cardiovascular events and resulted in a higher reclassification rate of participants.
Article
Cardiac & Cardiovascular Systems
Jin-Kai Wang, Yang Li, Xiao-Lu Zhao, Yuan-Bin Liu, Jing Tan, Yu-Ying Xing, Dilare Adi, Yong-Tao Wang, Zhen-Yan Fu, Yi-Tong Ma, Song-Mei Liu, Yong Liu, Yan Wang, Xiong-Jie Shi, Xiao-Yi Lu, Bao-Liang Song, Jie Luo
Summary: This study demonstrates that prekallikrein (PK) regulates circulating cholesterol levels by binding to LDL receptor (LDLR) and inducing its lysosomal degradation. Genetic depletion of Klkb1 increases hepatic LDLR and decreases circulating cholesterol, thus slowing the progression of atherosclerosis.
Article
Peripheral Vascular Disease
Atefeh Talebi, Rikke Normark Mortensen, Thomas Alexander Gerds, Jorgen Lykke Jeppesen, Christian Torp-Pedersen
Summary: The study found that adding systolic blood pressure, whether from office or 24-hour ambulatory monitoring, did not significantly improve the predictive ability for cardiovascular mortality and events. Additionally, office blood pressure did not provide additional prognostic information compared to diastolic pressure within a 10-year timeframe.
JOURNAL OF CLINICAL HYPERTENSION
(2022)
Review
Medicine, General & Internal
Keisuke Narita, Satoshi Hoshide, Kazuomi Kario
Summary: Although various guidelines for cardiovascular disease prevention have been established, the optimal drug therapy is often not implemented due to poor medication adherence and clinical inertia. Polypill strategies, which include combination tablets of three or more medications, have been proven to be useful in preventing cardiovascular disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Peripheral Vascular Disease
Yi-Bang Cheng, Lutgarde Thijs, Lucas S. Aparicio, Qi-Fang Huang, Fang-Fei Wei, Yu-Ling Yu, Jessica Barochiner, Chang-Sheng Sheng, Wen-Yi Yang, Teemu J. Niiranen, Jose Boggia, Zhen-Yu Zhang, Katarzyna Stolarz-Skrzypek, Natasza Gilis-Malinowska, Valerie Tikhonoff, Wiktoria Wojciechowska, Edoardo Casiglia, Krzysztof Narkiewicz, Jan Filipovsky, Kalina Kawecka-Jaszcz, Ji-Guang Wang, Yan Li, Jan A. Staessen
Summary: This study investigated the relationship between cardiovascular risk and central and brachial systolic pressure and proposed thresholds to differentiate hypertension from normal blood pressure. Regardless of brachial blood pressure status, central hypertension was associated with increased cardiovascular and cerebrovascular risk, highlighting the importance of controlling central hypertension.
Article
Pharmacology & Pharmacy
Joan Minguet, Helen M. Sims, Katherine H. Smith, Peter Bramlage
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Nikolaos Bonaros, Rainer Petzina, Riccardo Cocchieri, Dariusz Jagielak, Marco Aiello, Joel Lapeze, Mika Laine, Sidney Chocron, Douglas Muir, Walter Eichinger, Matthias Thielmann, Louis Labrousse, Vinayak Bapat, Kjell Arne Rein, Jean-Philippe Verhoye, Gino Gerosa, Hardy Baumbach, Markus Kofler, Peter Bramlage, Cornelia Deutsch, Martin Thoenes, Derk Frank, Mauro Romano
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2017)
Correction
Cardiac & Cardiovascular Systems
Peter Bramlage, Stephanie L. Swift, Martin Thoenes, Joan Minguet, Carmen Ferrero, Roland E. Schmieder
EUROPEAN JOURNAL OF HEART FAILURE
(2017)
Correction
Pediatrics
Beate Beime, Cornelia Deutsch, Ralf Kruger, Andreas Wolf, Peter Mueller, Gertrud Hammel, Peter Bramlage
EUROPEAN JOURNAL OF PEDIATRICS
(2017)
Article
Pediatrics
Beate Beime, Cornelia Deutsch, Ralf Krueger, Andreas Wolf, Peter Mueller, Gertrud Hammel, Peter Bramlage
EUROPEAN JOURNAL OF PEDIATRICS
(2017)
Article
Cardiac & Cardiovascular Systems
P. Bramlage, W. Maerz, D. Westermann, B. Weisser, J. H. Wirtz, U. Zeymer, P. Baumgart, G. van Mark, U. Laufs, B. K. Kraemer, T. Unger
Article
Medicine, General & Internal
Christian Butter, Jessica Gross, Anja Haase-Fielitz, Helen Sims, Cornelia Deutsch, Peter Bramlage, Michael Neuss
JOURNAL OF CLINICAL MEDICINE
(2018)
Review
Respiratory System
Maria Giulia Caponcello, Lucia M. Banderas, Carmen Ferrero, Carsten Bramlage, Martin Thoenes, Peter Bramlage
JOURNAL OF THORACIC DISEASE
(2020)
Article
Biochemistry & Molecular Biology
Thomas Kubin, Ayse Cetinkaya, Natalia Kubin, Peter Bramlage, Bedriye Sen-Hild, Praveen Gajawada, Hakan Akintuerk, Markus Schoenburg, Wolfgang Schaper, Yeong-Hoon Choi, Miroslav Barancik, Manfred Richter
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Medicine, General & Internal
Katja Bohmann, Christof Burgdorf, Tobias Zeus, Michael Joner, Hector Alvarez, Kira Lisanne Berning, Maren Schikowski, Albert Markus Kasel, Gesine van Mark, Cornelia Deutsch, Jana Kurucova, Martin Thoenes, Derk Frank, Steffen Wundram, Peter Bramlage, Barbara Miller, Verena Veulemans
Summary: Implementation of a dedicated TAVI coordinator program can improve pathway efficiency, enhance patient satisfaction, and optimize post-TAVI care.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Carmen Ferrero, Marta Casas, Isidoro Caraballo
Summary: In this study, we successfully synthesized stimuli-responsive polymersomes that can respond to the tumor cell environment, and demonstrated their efficient encapsulation and release of the highly cytotoxic anticancer drug doxorubicin hydrochloride (Dox center dot HCl). The polymersomes were formed under physiological conditions using a solvent-exchange method, and showed stable morphology and size. In vitro release studies revealed a delayed release of the drug from the polymersomes, and enhanced drug release through cleavage of the disulfide bonds in the reductive environment.
Article
Pharmacology & Pharmacy
Fatemeh Shojaie, Carmen Ferrero, Isidoro Caraballo
Summary: Dual-nozzle fused deposition modeling (FDM) is a 3D printing technique that allows for the simultaneous printing of two polymeric filaments and the design of complex geometries. In this study, a novel bicompartmental device for colon-specific drug delivery was developed using dual-nozzle FDM. The device demonstrated a pH-responsive biphasic release pattern, with a slow and sustained release period controlled by drug diffusion and a faster release phase governed by polymer relaxation/erosion.
Review
Respiratory System
Martin Thoenes, Anurag Agarwal, David Gnmdmann, Carmen Ferrero, Andrew McDonald, Peter Bramlages, Richard P. Steeds
Summary: Valvular heart disease is a chronic progressive condition that is becoming more prevalent in the Western world due to aging populations. The use of artificial intelligence, particularly machine learning, shows promise in early diagnosis, timely treatment, and optimizing outcomes for VHD. Computer-aided auscultation improves the detection and classification of heart murmurs, while AI algorithms can assist in transcatheter valve replacement by automated measurements of anatomical dimensions.
JOURNAL OF THORACIC DISEASE
(2021)
Letter
Peripheral Vascular Disease
Peter Bramlage, Stephan Lueders, Ulrich Tholl
BLOOD PRESSURE MONITORING
(2017)
Article
Cardiac & Cardiovascular Systems
Christian Ott, Agnes Jumar, Kristina Striepe, Stefanie Friedrich, Marina V. Karg, Peter Bramlage, Roland E. Schmieder
CARDIOVASCULAR DIABETOLOGY
(2017)