The Regulation of Cellular Functions by the p53 Protein: Cellular Senescence

TP53 Silencing Bypasses Growth Arrest of BRAFV600E-Induced Lung Tumor Cells in a Two-Switch Model of Lung Tumorigenesis

(2015) A. Shai et al.   CANCER RESEARCH

CXCL5 Promotes Prostate Cancer Progression

(2015) Lesa A Begley et al.   NEOPLASIA

Identification of Distinct Basal and Luminal Subtypes of Muscle-Invasive Bladder Cancer with Different Sensitivities to Frontline Chemotherapy

(2014) Woonyoung Choi et al.   CANCER CELL

TP53 Mutation Spectrum in Breast Cancer Is Subtype Specific and Has Distinct Prognostic Relevance

(2014) L. Silwal-Pandit et al.   CLINICAL CANCER RESEARCH

Poor survival with wild-type TP53 ovarian cancer?

(2013) Kwong-Kwok Wong et al.   GYNECOLOGIC ONCOLOGY

p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer

(2012) James G. Jackson et al.   CANCER CELL

Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models

(2012) Cynthia X. Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Value of TP53 Status for Predicting Response to Neoadjuvant Chemotherapy in Breast Cancer: A Meta-Analysis

(2012) Min-Bin Chen et al.   PLoS One

Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells

(2012) J Cahu et al.   Cell Death & Disease

Chemotherapy response and recurrence-free survival in neoadjuvant breast cancer depends on biomarker profiles: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657)

(2011) Laura J. Esserman et al.   BREAST CANCER RESEARCH AND TREATMENT

Chronic lymphocytic leukemia and treatment resistance in cancer: The role of the p53 pathway

(2011) Thorsten Zenz et al.   CELL CYCLE

Drug-induced Senescence Generates Chemoresistant Stemlike Cells with Low Reactive Oxygen Species

(2011) Santhi Achuthan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells

(2011) C Canino et al.   ONCOGENE

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

(2011) M V Astle et al.   ONCOGENE

Senescence induction in human fibroblasts and hematopoietic progenitors by leukemogenic fusion proteins

(2010) N. Wajapeyee et al.   BLOOD

Oncogene-induced senescence: the bright and dark side of the response

(2010) Vassilis G Gorgoulis et al.   CURRENT OPINION IN CELL BIOLOGY

Induction of senescence markers after neo-adjuvant chemotherapy of malignant pleural mesothelioma and association with clinical outcome: An exploratory analysis

(2010) Roy Sidi et al.   EUROPEAN JOURNAL OF CANCER

Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo

(2010) James G Jackson et al.   JOURNAL OF PATHOLOGY

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice

(2009) Nathalie Dhomen et al.   CANCER CELL

The role of senescence and prosurvival signaling in controlling the oncogenic activity of FGFR2 mutants associated with cancer and birth defects

(2009) Sara Ota et al.   HUMAN MOLECULAR GENETICS

Role of Anthracyclines in the Treatment of Early Breast Cancer

(2009) Luca Gianni et al.   JOURNAL OF CLINICAL ONCOLOGY

Cytokine expression and signaling in drug-induced cellular senescence

(2009) Z Novakova et al.   ONCOGENE

p53-dependent senescence delays Eμ-myc-induced B-cell lymphomagenesis

(2009) S M Post et al.   ONCOGENE

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

(2009) J. P. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug-induced senescence bystander proliferation in prostate cancer cells in vitro and in vivo

(2008) J A Ewald et al.   BRITISH JOURNAL OF CANCER

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7

(2008) Narendra Wajapeyee et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

p53 dependent cell-cycle arrest triggered by chemotherapy in xenografted breast tumors

(2008) Mariana Varna et al.   INTERNATIONAL JOURNAL OF CANCER

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY