Article
Clinical Neurology
Anna Pink, Janina Krell-Roesch, Jeremy A. Syrjanen, Maria Vassilaki, Val J. Lowe, Prashanthi Vemuri, Gorazd B. Stokin, Teresa J. Christianson, Walter K. Kremers, Clifford R. Jack, David S. Knopman, Ronald C. Petersen, Yonas E. Geda
Summary: This study found that cortical amyloid deposition, anxiety, and depression independently increased the risk of incident mild cognitive impairment. Additionally, anxiety modified the association between cortical amyloid deposition and incident mild cognitive impairment.
ALZHEIMERS & DEMENTIA
(2022)
Article
Chemistry, Organic
Min Ho Jeon, Young-Do Kwon, Min Pyeong Kim, Gianluca Bartolini Torres, Jeong Kon Seo, Jeongmin Son, Young Hoon Ryu, Sung You Hong, Joong-Hyun Chun
Summary: The study presents a successful synthesis of various sulfamoyl [F-18]fluorides using an F-18/F-19 isotopic exchange approach, improving synthetic efficiency with radiochemical yields up to 97%. This late-stage labeling protocol offers an efficient route to diversify the chemical library possessing sulfamoyl functionalities by incorporating nucleophilic F-18 within nitrogen-containing sulfur(VI) frameworks.
Article
Medicine, General & Internal
Min Young Chun, Jongmin Lee, Jee Hyang Jeong, Jee Hoon Roh, Seung Jun Oh, Minyoung Oh, Jungsu S. Oh, Jae Seung Kim, Seung Hwan Moon, Sook-young Woo, Young Ju Kim, Yeong Sim Choe, Hee Jin Kim, Duk L. Na, Hyemin Jang, Sang Won Seo
Summary: This study suggests that increased 18F-THK5351 uptake may be a useful predictor of cognitive decline among AB- aMCI patients. The patients in the 18F-THK5351-positive group were older and had a faster rate of deterioration in clinical dementia rating-sum of boxes (CDR-SOB) scores.
YONSEI MEDICAL JOURNAL
(2022)
Article
Endocrinology & Metabolism
Jessie Fanglu Fu, Cristina Lois, Justin Sanchez, J. Alex Becker, Zoe B. Rubinstein, Emma Thibault, Andrew N. Salvatore, Hasan Sari, Michelle E. Farrell, Nicolas J. Guehl, Marc D. Normandin, Georges El Fakhri, Keith A. Johnson, Julie C. Price
Summary: This study investigated the kinetics and longitudinal changes of [F-18]MK-6240 PET in cognitively-normal and cognitively-impaired subjects. The results suggest that eroded cerebral white matter or pons may be preferred for longitudinal studies, while eroded cerebellar gray matter showed larger cross-sectional effect sizes for group differentiation. The study also found high variability in extracerebral signal, which exhibited irreversible kinetics and nonsignificant longitudinal changes with high individual variability.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Clinical Neurology
Tharick A. Pascoal, Andrea L. Benedet, Dana L. Tudorascu, Joseph Therriault, Sulantha Mathotaarachchi, Melissa Savard, Firoza Z. Lussier, Cecile Tissot, Mira Chamoun, Min Su Kang, Jenna Stevenson, Gassan Massarweh, Marie-Christine Guiot, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Neto
Summary: It is crucial to track longitudinal tau tangles accumulation across the Alzheimer's disease spectrum to understand the natural history of tau pathology. The novel subnanomolar affinity tau tracer F-18-MK-6240 demonstrated the ability to detect tau accumulation in asymptomatic and symptomatic individuals. The study found different patterns of tau accumulation in early vs. late Braak stages, with implications for diagnosis and treatment of Alzheimer's disease.
Article
Chemistry, Multidisciplinary
Raul M. Perez-Garcia, Patrick J. Riss
Summary: A tris(pentafluorophenyl)borane catalysed method for the synthesis of boronic acid esters from aromatic amines with high yields was developed. The method features mild conditions, benign reagents, short reaction times, low temperatures, and a wide substrate scope, making it suitable for the synthesis of boronic acid ester derivatives of complex drug molecules.
FRONTIERS IN CHEMISTRY
(2022)
Review
Immunology
Jie Huang
Summary: This review discusses the current status and applications of molecule-based positron emission tomography (PET) imaging in neuroinflammation. Despite certain limitations, neuroinflammation PET imaging is considered a promising approach to understanding the pathophysiological process of Alzheimer's disease (AD) and mild cognitive impairment (MCI).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Geriatrics & Gerontology
Ping Zhou, Rong Zeng, Lun Yu, Yabo Feng, Chuxin Chen, Fang Li, Yang Liu, Yanhui Huang, Zhongxiong Huang
Summary: The deep-learning radiomics (DLR) model based on F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG PET) images combined with clinical parameters (DLR+C) showed superior classification performance in predicting conversion from MCI to AD. This novel approach provides a valuable quantitative biomarker for the computer-assisted diagnosis of AD conversion in MCI patients.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yuuki Sasaki, Noriyuki Kimura, Yasuhiro Aso, Kenichi Yabuuchi, Miki Aikawa, Etsuro Matsubara
Summary: The study found that CSF levels of MMP-2 were negatively correlated with brain amyloid deposition, especially in the parietotemporal lobe and posterior cingulate gyrus, and that CSF levels of MMP-7 were positively correlated with the severity of WMLs. These findings provide insights into the role of MMPs in amyloid beta catabolism and blood-brain barrier integration at the MCI stage.
Article
Biochemistry & Molecular Biology
Shanshan Chen, Yu Song, Huimin Wu, Honglin Ge, Wenzhang Qi, Yue Xi, Jiayi Wu, Yuxiang Ji, Kexin Chen, Xingjian Lin, Jiu Chen
Summary: In patients with amnestic mild cognitive impairment (aMCI), anosognosia is associated with increased tau accumulation in specific brain regions, disrupted functional connectivity, and accelerates progression to Alzheimer's disease dementia.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Ksenia Lisova, Jia Wang, Tibor Jacob Hajagos, Yingqing Lu, Alexander Hsiao, Arkadij Elizarov, R. Michael van Dam
Summary: This study presents a simple and efficient method for synthesizing clinically-relevant batches of [F-18]FET and [F-18]FBB using a microfluidic radiosynthesizer, with the potential for batch-on-demand synthesis of F-18-labeled radiopharmaceuticals for human use. The method demonstrated high production efficiency and suitability for human use, with quality control testing passed for all batches.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Antoinette O'Connor, David M. Cash, Teresa Poole, Pawel J. Markiewicz, Maggie R. Fraser, Ian B. Malone, Jieqing Jiao, Philip S. J. Weston, Shaney Flores, Russ Hornbeck, Eric McDade, Michael Schoell, Brian A. Gordon, Randall J. Bateman, Tammie L. S. Benzinger, Nick C. Fox
Summary: Cortical tau accumulation is a crucial pathological event in Alzheimer's disease, and understanding the timing and pattern of tau deposition can help track the disease progression. This study used data from participants in AD cohort studies to investigate if tau PET can detect early changes in presymptomatic carriers and found that there were regional differences in tau accumulation prior to symptom onset, particularly in posterior regions.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Ophthalmology
Kallene Summer Moreira Vidal, Diego Decleva, Mirella Telles Salgueiro Barboni, Balazs Vince Nagy, Paulo Augusto Hidalgo de Menezes, Avinash Aher, Artur Martins Coutinho, Paula Squarzoni, Daniele de Paula Faria, Fabio Luis de Souza Duran, Carlos Alberto Buchpiguel, Jan Kremers, Geraldo Busatto Filho, Dora Fix Ventura
Summary: This study evaluated color vision changes and retinal processing in patients with AD and MCI, finding that both groups showed acquired color vision deficiency, which may be related to impaired brain metabolism.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Geriatrics & Gerontology
Hyun Jeong Lee, Eun-Chong Lee, Seongho Seo, Kwang-Pil Ko, Jae Myeong Kang, Woo-Ram Kim, Ha-Eun Seo, Sang-Yoon Lee, Yeong-Bae Lee, Kee Hyung Park, Byeong Kil Yeon, Nobuyuki Okamura, Duk L. Na, Joon-Kyung Seong, Young Noh
Summary: Using cluster analyses with [F-18]THK5351 retention patterns, it is possible to identify clinically-distinct subgroups of MCI patients and those at greater risk of progression to dementia. These subgroups show significant differences in cognitive function and risk of dementia progression.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Ayla Mansur, Eugenii A. Rabiner, Hideo Tsukada, Robert A. Comley, Yvonne Lewis, Mickael Huiban, Jan Passchier, Roger N. Gunn
Summary: The study evaluates the test-retest reproducibility of F-18-BCPP-EF in humans, showing its suitability for quantifying MC-I in clinical studies. Results indicate that both DVR-1 and SUVR-1 have improved test-retest variability, with SUVR-1 highly correlated with DVR-1.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Zachary Winder, Tiffany L. Sudduth, Sonya Anderson, Ela Patel, Janna Neltner, Barbara J. Martin, Katherine E. Snyder, Erin L. Abner, Gregory A. Jicha, Peter T. Nelson, Donna M. Wilcock
Summary: The study evaluated the relationship between plasma biomarkers and neuropathology associated with Alzheimer's disease (AD) and vascular contributions to cognitive impairment and dementia (VCID). The results showed certain plasma biomarkers were associated with AD and VCID pathology, providing support for further research in using plasma biomarkers as a clinical screening tool.
ALZHEIMERS & DEMENTIA
(2023)
Review
Biochemistry & Molecular Biology
Brian J. Lopresti, Sarah K. Royse, Chester A. Mathis, Savannah A. Tollefson, Rajesh Narendran
Summary: With the emergence of PET, psychiatry gained access to a non-invasive tool for assessing human brain function. Early applications focused on measuring blood flow and metabolism, but specific probes for dopamine and serotonin receptors were later developed. However, the development of monoamine-enhancing drugs was not very successful, leading to a shift in drug development towards other targets. In recent years, PET imaging techniques have also been developed for studying non-monoamine targets.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Sarah K. Royse, Brian J. Lopresti, Chester A. Mathis, Savannah Tollefson, Rajesh Narendran
Summary: Early PET applications in psychiatry aimed to identify cerebral blood flow and metabolism abnormalities, but the need for more specific neurochemical imaging probes became evident. The development of monoaminergic PET radiopharmaceuticals was driven by the belief in the centrality of monoamine dysfunction in psychiatric disorders. However, as drug development shifted away from monoamines, new PET imaging agents for non-monoamine targets were developed. Part two of the review focuses on clinical research studies using these novel targets and radiotracers across different psychiatric disorders.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Constantinos Constantinides, Laura K. M. Han, Clara Alloza, Linda Antonella Antonucci, Celso Arango, Rosa Ayesa-Arriola, Nerisa Banaj, Alessandro Bertolino, Stefan Borgwardt, Jason Bruggemann, Juan Bustillo, Oleg Bykhovski, Vince Calhoun, Vaughan Carr, Stanley Catts, Young-Chul Chung, Benedicto Crespo-Facorro, Covadonga M. Diaz-Caneja, Gary Donohoe, Stefan Du Plessis, Jesse Edmond, Stefan Ehrlich, Robin Emsley, Lisa T. Eyler, Paola Fuentes-Claramonte, Foivos Georgiadis, Melissa Green, Amalia Guerrero-Pedraza, Minji Ha, Tim Hahn, Frans A. Henskens, Laurena Holleran, Stephanie Homan, Philipp Homan, Neda Jahanshad, Joost Janssen, Ellen Ji, Stefan Kaiser, Vasily Kaleda, Minah Kim, Woo-Sung Kim, Matthias Kirschner, Peter Kochunov, Yoo Bin Kwak, Jun Soo Kwon, Irina Lebedeva, Jingyu Liu, Patricia Mitchie, Stijn Michielse, David Mothersill, Bryan Mowry, Victor Ortiz-Garcia de la Foz, Christos Pantelis, Giulio Pergola, Fabrizio Piras, Edith Pomarol-Clotet, Adrian Preda, Yann Quide, Paul E. Rasser, Kelly Rootes-Murdy, Raymond Salvador, Marina Sangiuliano, Salvador Sarro, Ulrich Schall, Andre Schmidt, Rodney J. Scott, Pierluigi Selvaggi, Kang Sim, Antonin Skoch, Gianfranco Spalletta, Filip Spaniel, Sophia Thomopoulos, David Tomecek, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Therese van Amelsvoort, Javier Vazquez-Bourgon, Daniela Vecchio, Aristotle Voineskos, Cynthia S. Weickert, Thomas Weickert, Paul M. Thompson, Lianne Schmaal, Theo G. M. van Erp, Jessica Turner, James H. Cole, Danai Dima, Esther Walton
Summary: Schizophrenia patients show evidence of advanced brain ageing, which is not associated with clinical characteristics.
MOLECULAR PSYCHIATRY
(2023)
Article
Biology
Nirmal Verma, Gopal Viswanathan Velmurugan, Edric Winford, Han Coburn, Deepak Kotiya, Noah Leibold, Laura Radulescu, Sanda Despa, Kuey C. Chen, Linda J. Van Eldik, Peter T. Nelson, Donna M. Wilcock, Gregory A. Jicha, Ann M. Stowe, Larry B. Goldstein, David K. Powel, Jeffrey H. Walton, Manuel F. Navedo, Matthew A. Nystoriak, Andrew J. Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, Florin Despa
Summary: Impairment of vascular pathways contributes to Alzheimer's disease. Blood amylin secreted from the pancreas perturbs cerebral A beta clearance, leading to amylin and A beta co-deposits in the brain microvasculature. Altering bloodborne amylin could potentially reduce cerebrovascular amylin deposits and A beta pathology.
COMMUNICATIONS BIOLOGY
(2023)
Article
Neurosciences
Marlena Duda, Armin Iraji, Judith M. Ford, Kelvin O. Lim, Daniel H. Mathalon, Bryon A. Mueller, Steven G. Potkin, Adrian Preda, Theo G. M. Van Erp, Vince D. Calhoun
Summary: By using spatially constrained independent component analysis (scICA), this study found that rsfMRI scans of just 2-5 minutes can provide good clinical utility without significant loss of individual functional network connectivity (FNC) information from longer scan lengths.
HUMAN BRAIN MAPPING
(2023)
Article
Pharmacology & Pharmacy
Bryan Shapiro, Eric Kramer, Dina Khoury, Adrian Preda
Summary: This study investigated the prevalence and severity of common withdrawal symptoms after chronic antidepressant treatment. The symptoms of dizziness, brain zaps, irritability/agitation, and anxiety/nervousness showed the largest increase in severity during withdrawal. Almost all participants reported worsening of at least one of these four symptoms. Incorporating these four core symptoms into a screening test may be useful in ruling out antidepressant withdrawal.
PHARMACOPSYCHIATRY
(2023)
Article
Clinical Neurology
Eun-jin Cheon, Alie G. Male, Bingchen Gao, Bhim M. Adhikari, Jesse T. Edmond, Stephanie M. Hare, Aysenil Belger, Steven G. Potkin, Juan R. Bustillo, Daniel H. Mathalon, Judith M. Ford, Kelvin O. Lim, Bryon A. Mueller, Adrian Preda, Daniel O'Leary, Gregory P. Strauss, Anthony O. Ahmed, Paul M. Thompson, Neda Jahanshad, Peter Kochunov, Vince D. Calhoun, Jessica A. Turner, Theo G. M. van Erpa
Summary: This study examined the association between resting-state amplitude of low frequency fluctuations (ALFF) and negative symptoms in schizophrenia. It found positive associations between total negative symptom scores and ALFF in temporal and frontal brain regions. Additionally, it found that negative symptom domain scores had stronger associations with regional ALFF compared to total scores, suggesting that domain scores may be better indicators of neural signatures.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2023)
Article
Neurosciences
Deniz Alacam, Robyn Miller, Oktay Agcaoglu, Adrian Preda, Judith Ford, Vince Calhoun
Summary: In this study, a framework was proposed to analyze time-resolved spectral coupling among different brain circuits using independent component analysis. The results showed significant differences in visual network connectivity and spectral power profiles between people with schizophrenia and healthy controls. This approach can be useful in understanding the underlying causes of impaired visual processing in schizophrenia.
FRONTIERS IN NEUROSCIENCE
(2023)
Editorial Material
Pharmacology & Pharmacy
Adrian Preda
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Justin R. Deters, Alexandra C. Fietsam, Phillip E. Gander, Laura L. Boles L. Ponto, Thorsten Rudroff
Summary: Combining MRI and PET imaging with FDG can provide a comprehensive overview of the effects of PCS on brain volumes and metabolism. This study found differences in MRI/PET outcomes between individuals <6 months and >6 months post-COVID-19, as well as associations between these outcomes and fatigue symptoms.
Article
Neurosciences
A. Iraji, Z. Fu, A. Faghiri, M. Duda, J. Chen, S. Rachakonda, T. DeRamus, P. Kochunov, B. M. Adhikari, A. Belger, J. M. Ford, D. H. Mathalon, G. D. Pearlson, S. G. Potkin, A. Preda, J. A. Turner, T. G. M. van Erp, J. R. Bustillo, K. Yang, K. Ishizuka, A. Faria, A. Sawa, K. Hutchison, E. A. Osuch, J. Theberge, C. Abbott, B. A. Mueller, D. Zhi, C. Zhuo, S. Liu, Y. Xu, M. Salman, J. Liu, Y. Du, J. Sui, T. Adali, V. D. Calhoun
Summary: This study identifies replicable multi-spatial-scale canonical intrinsic connectivity network (ICN) templates using rsfMRI data from over 100k individuals through multi-model-order independent component analysis (ICA). The feasibility of estimating subject-specific ICNs via spatially constrained ICA is also studied. The results show that subject-level ICN estimations vary as a function of the ICN itself, the data length, and the spatial resolution. Longer scans may not always be desirable and spatial smoothness should be considered in optimizing data length.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Maxwell J. Roeske, Maureen Mchugo, Baxter Rogers, Kristan Armstrong, Suzanne Avery, Manus Donahue, Stephan Heckers
Summary: This study found that patients with schizophrenia have hippocampal hyperactivity and the drug levetiracetam may be able to regulate hippocampal activity. Neuroimaging methods can be used to study the regulation of hippocampal hyperactivity, but not all methods are suitable. Further research is needed to establish levetiracetam as a treatment for schizophrenia.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Soichiro Nakahara, Alie G. Male, Jessica A. Turner, Vince D. Calhoun, Kelvin O. Lim, Bryon A. Mueller, Juan R. Bustillo, Daniel S. O'Leary, James Voyvodic, Aysenil Belger, Adrian Preda, Daniel H. Mathalon, Judith M. Ford, Guia Guffanti, Fabio Macciardi, Steven G. Potkin, Theo G. M. Van Erp
Summary: Individuals with schizophrenia show abnormal brain activation during auditory oddball tasks, which is associated with cognitive performance and genetic contributions. This study compares individuals with schizophrenia to healthy volunteers and identifies novel relationships between regional brain activity, cognitive performance, and genetic loci. The findings highlight the importance of continued data sharing and collaborative efforts in schizophrenia research.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2023)
Article
Psychiatry
Akiko Mizuno, Helmet Talib Karim, Maria J. Ly, Brian J. Lopresti, Ann D. Cohen, Areej A. Ali, Chester A. Mathis, William E. Klunk, Howard J. Aizenstein, Beth E. Snitz
Summary: The study aimed to explore the symptoms of subjective cognitive decline (SCD) using fMRI brain activity and investigate the association with amyloid-beta (Ass) load. The results showed that SCD severity was associated with lower dorsomedial thalamus activation.
FRONTIERS IN PSYCHIATRY
(2023)
