Article
Oncology
Yu Tung Lo, Vivian Yujing Lim, Melissa Ng, Ya Hwee Tan, Jianbang Chiang, Esther Wei Yin Chang, Jason Yongsheng Chan, Eileen Yi Ling Poon, Nagavalli Somasundaram, Mohamad Farid Bin Harunal Rashid, Miriam Tao, Soon Thye Lim, Valerie Shiwen Yang
Summary: The study explores the prognostic value of hematological indices in primary central nervous system lymphomas (PCNSLs) and the impact of corticosteroids on these indices. It suggests that post-steroid NLR, when considered together with baseline NLR, can be a useful prognostic tool for accurate stratification of patients into different risk profiles related to survival outcomes.
Article
Oncology
Chen Wang, Shengyan Liu, Xin Li, Kang Cui, Weijie Zhang, Yabing Du
Summary: This study aimed to investigate the value of baseline neutrophil-to-lymphocyte ratio (BLNLR) and relative change of NLR (Delta NLR%) before the third cycle of treatment on the prognosis of patients with metastatic malignant melanoma treated with PD-1 inhibitors. The results showed that BLNLR and Delta NLR% were associated with progression-free survival (PFS) and overall survival (OS) in patients. Patients can be stratified based on BLNLR and Delta NLR% to predict their prognosis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Infectious Diseases
Haotian Wu, Chunxia Li, Song Liu, Shuangquan Yao, Zhaohui Song, Dong Ren, Pengcheng Wang
Summary: This study aimed to investigate the independent association of neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and red blood cell distribution width (RDW) with mortality in necrotizing fasciitis (NF). The results showed that NLR > 11.1 and PLR > 196.0 were independently associated with an increased risk of mortality in NF patients.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Oncology
Honggang Cao, Hongtai Shi, Miaomiao Zhao, Zhenhua Liu, Jun Qian
Summary: The combination of preoperative fibrinogen and systemic inflammatory indexes may have greater predictive value in esophageal squamous cell carcinoma (ESCC). The F-NLR score was found to be more valuable than other systemic inflammatory indexes in predicting prognosis. It is closely related to TNM stage and can be used as an important independent prognostic index for ESCC patients. The nomogram model constructed by F-NLR and TNM stage shows higher prognostic ability than that of AJCC stage for ESCC patients. Preoperative F-NLR is a new independent prognostic index and a potential marker for treatment response monitoring in patients with ESCC.
Article
Immunology
Qiu-Yue Han, Xia Zhang, Jian-Gang Zhang, Wen-Jun Zhou, Qiong-Yuan Chen, Yuan-Yuan Chen, Wei-Hua Yan, Aifen Lin
Summary: Pre-operative NLR is an independent prognostic factor for patients with gastric cancer and has stratified prognostic value for patients with AJCC stage III.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Yuxin Li, Yaxian Kong, Ke Shi, Yunyi Huang, Qun Zhang, Bingbing Zhu, Hui Zeng, Xianbo Wang
Summary: This study established a predictive model for the prognosis of HBV-ACLF patients based on CD200R(+)CD4(+)T cells and NLR levels, showing potential predictive value for mortality within 90 days.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Sher Ting Chim, Paul Sanfilippo, Terence J. O'Brien, Kate J. Drummond, Mastura Monif
Summary: The study findings suggest that pre-treatment NLR and MLR are associated with survival and functional outcomes in glioma patients. Higher NLR and MLR values are correlated with poorer prognosis.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Article
Neurosciences
Yiyun Weng, Jingyu Hu, Junli Ren, Honghao Huang, Chenguang Yang, Jiamin Shen, Wenjing Pan, Fangyue Sun, Haojie Qiu, Yufan Gao, Shengqi Li, Xuerong Huang, Guangyong Chen
Summary: The study revealed that the neutrophils-lymphocytes ratios (NLRs) measured at admission and 7 days after thrombolysis treatment in patients with acute ischemic stroke (AIS) were associated with prognosis outcomes after 3 months. Dynamic increase in NLR within 24 hours was significantly related to good and excellent outcomes.
NEUROTOXICITY RESEARCH
(2021)
Review
Oncology
Yanqing Li, Tianxiang Xu, Xin Wang, Xiangdong Jia, Meng Ren, Xiaoxia Wang
Summary: This meta-analysis investigated the impact of preoperative neutrophil-to-lymphocyte ratio (NLR) on the prognosis of colorectal liver metastasis (CRLM) patients. The pooled analysis of 18 studies showed that high NLR was associated with poor overall survival (OS), disease-free survival (DFS), and relapse-free survival (RFS) in CRLM patients. Therefore, NLR can be considered as an independent risk factor for adverse prognosis in CRLM patients.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Qifan Li, Yiwei Pu, Zetian Gong, Yue Yu, Wei Sun, Zhike Cheng, Wei Wang, Jun Zhao
Summary: This study investigated the clinical significance of preoperative systemic immune-inflammation index (SII) in patients with thymoma who underwent radical resection. The results showed that preoperative SII can predict the prognosis of thymoma patients who have undergone radical resection, but further multicenter prospective studies are needed to investigate the role of SII in thymoma.
Article
Medicine, General & Internal
Kamil Konopka, Agnieszka Micek, Sebastian Ochenduszko, Joanna Streb, Pawel Potocki, Lukasz Kwinta, Piotr J. Wysocki
Summary: Chemotherapy is essential in treating advanced gastric cancer, but reliable predictive markers are lacking. Elevated NLR and decreased PVPR are associated with detrimental outcomes in advanced GC patients. A novel inflammatory marker combining NLR and PVPR helps classify patients into prognostic groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Yao Feng, Xuesong Bai, Wei Li, Wenbo Cao, Xin Xu, Fan Yu, Zhaolin Fu, Qiuyue Tian, Xiaofan Guo, Tao Wang, Arman Sha, Yanfei Chen, Peng Gao, Yabing Wang, Jian Chen, Yan Ma, Fei Chen, Adam A. Dmytriw, Robert W. Regenhardt, Jie Lu, Qingfeng Ma, Bin Yang, Liqun Jiao
Summary: This study found that advanced age, increased stroke severity, poor collaterals, general anesthesia, and NLR are independent predictors for an unfavorable clinical outcome following complete reperfusion after EVT. Neuroinflammation may merit particular attention in future studies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Cong Shi, Shengping Gong, Tingting Niu, Tongyu Li, An Wu, Xiaojiao Zheng, Shujun Yang, Guifang Ouyang, Qitian Mu
Summary: Inflammation plays a critical role in carcinogenesis tumor growth, and the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and plasma C-reactive protein (CRP) are considered indicators of systemic inflammatory response and clinical prognosis. The prognostic value of these inflammatory indices in myelodysplastic syndrome (MDS) patients is still unclear. This study found that elevated PLR and CRP levels are associated with poor prognosis in MDS patients, independently of the Revised International Prognostic Scoring System (IPSS-R).
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Simon Garinet, Pascal Wang, Audrey Mansuet-Lupo, Ludovic Fournel, Marie Wislez, Helene Blons
Summary: This review discusses the need for improved risk assessment and patient selection for adjuvant and neoadjuvant chemotherapy following resected lung cancer. The current evaluation of recurrence risk is primarily based on TNM classification, but more than 25% of early-stage patients still experience relapse. Validated prognostic and theranostic markers are needed to better stratify patients and guide adjuvant therapies in resected lung cancer.
Article
Oncology
Bingqing Shang, Liping Guo, Rongfang Shen, Chuanzhen Cao, Ruiyang Xie, Weixing Jiang, Li Wen, Xingang Bi, Hongzhe Shi, Shan Zheng, Changling Li, Jianhui Ma, Kaitai Zhang, Lin Feng, Jianzhong Shou
Summary: The study revealed that NLR is an independent risk factor for the prognosis of patients with localized RCC with tumor thrombus, and neutrophils-associated NETosis and systemic lymphocyte abnormalities are considered as markers of tumor progression in these patients.
FRONTIERS IN ONCOLOGY
(2021)