期刊
ACS MACRO LETTERS
卷 5, 期 3, 页码 301-305出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.5b00870
关键词
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资金
- NSFC [21425311, 51273064, 51403061]
- Shanghai Sci. Tech. Comm. [14YF1404700]
- Postdoctoral Fund in China [2015T80405]
- Fundamental Research Funds for Central University
In situ forming redox responsive nanoparticles have been developed based on amphiphilic copolymers-phototriggered disulfide-cross-link macromolecules (PDCM). Upon 405 nm light irradiation, the macrocyclic thiol caged coumarin phototrigger in PDCM can release free thiols, and these free thiols subsequently realize in situ disulfide cross-link via reacting with a pyridyl disulfide group inside the PDCM assembled nanoparticles. The photo triggered disulfide -cross-link strategy can be conducted rapidly, conveniently, and cleanly without adding any cross-linkers or catalysts. Via changing irradiation condition, nanoparticles with different cross-link densities can be formed. These nanoparticles can encapsulate hydrophobic guest molecules with good stability and achieve redox-triggered release under GSH reduction. Intracellular experiments show that these nanoparticles can be used as promising drug carriers.
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