Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi

Inhibition of bacterial and fungal pathogens by the orphaned drug auranofin

(2016) Beth Burgwyn Fuchs et al.   Future Medicinal Chemistry

Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis

(2015) Michael B. Harbut et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug repositioning: auranofin as a prospective antimicrobial agent for the treatment of severe staphylococcal infections

(2014) Maria Iris Cassetta et al.   BIOMETALS

Auranofin and related heterometallic gold(I)–thiolates as potent inhibitors of methicillin-resistant Staphylococcus aureus bacterial strains

(2014) Yozane Hokai et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A Reprofiled Drug, Auranofin, Is Effective against Metronidazole-Resistant Giardia lamblia

(2013) Noa Tejman-Yarden et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High-Throughput Screening of a Collection of Known Pharmacologically Active Small Compounds for Identification of Candida albicans Biofilm Inhibitors

(2013) Samuel A. Siles et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antifungal therapy with an emphasis on biofilms

(2013) Christopher G Pierce et al.   CURRENT OPINION IN PHARMACOLOGY

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

(2012) Anjan Debnath et al.   NATURE MEDICINE

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Antifungal Drug Discovery: Something Old and Something New

(2012) Arielle Butts et al.   PLoS Pathogens

The biological activity of auranofin: implications for novel treatment of diseases

(2012) J. M. Madeira et al.   INFLAMMOPHARMACOLOGY

A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition

(2011) Andrea Ilari et al.   AMINO ACIDS

An insight into the antifungal pipeline: selected new molecules and beyond

(2010) Luis Ostrosky-Zeichner et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition ofSchistosoma mansoniThioredoxin-glutathione Reductase by Auranofin

(2009) Francesco Angelucci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro : Mechanistic and pharmacological implications

(2008) Anna Rosa Sannella et al.   FEBS LETTERS

Antifungal activity againstScedosporiumspecies and novel assays to assess antifungal pharmacodynamics against filamentous fungi

(2008) Nathan P. Wiederhold et al.   MEDICAL MYCOLOGY