Article
Biochemistry & Molecular Biology
Hugues Fausther-Bovendo, Marie-Eve Hamelin, Julie Carbonneau, Marie-Christine Venable, Liva Checkmahomed, Pierre-Olivier Lavoie, Marie-Eve Ouellet, Guy Boivin, Marc-Andre D'aoust, Gary P. Kobinger
Summary: This study identifies several human monoclonal antibodies (mAbs) with virus-specific therapeutic potential through flow cytometry-based cell sorting, and discovers a unique mAb with inhibitory activities against both HRSV and HMPV.
Review
Cell Biology
Jose Luis Rodriguez-Fernandez, Olga Criado-Garcia
Summary: Dendritic cells are powerful antigen-presenting cells that control T cell activation through the immunological synapse. While most studies focus on the T cell side, dendritic cell side also plays a significant role in T cell activation, especially through actin polarization at the IS.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Bonah Kim, Hee Young Kim, Won-Woo Lee
Summary: Zinc, an essential microelement, plays immunoregulatory roles by influencing signaling pathways to enhance immune function. Zinc deficiency impairs immunity and increases susceptibility to infection. The interaction between Zip6-mediated zinc influx and TCR activation regulates T-cell responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Huiping Shi, Bojing Shao
Summary: This review briefly summarizes the activation and roles of LFA-1 with varied ligand-binding affinities in the regulation of T-cell migration and immunological synapse formation.
Article
Virology
Ricardo de Souza Cardoso, Rosa Maria Mendes Viana, Brenda Cristina Vitti, Ana Carolina Lunardello Coelho, Bruna Lais Santos de Jesus, Juliano de Paula Souza, Marjorie Cornejo Pontelli, Tomoyuki Murakami, Armando Morais Ventura, Akira Ono, Eurico Arruda
Summary: HRSV infection of A3.01 CD4(+) T cells is virtually unproductive compared to HEp-2 cells, as a result of defects at several steps of the viral cycle: Fusion, genome replication, formation of inclusion bodies, recruitment of cellular proteins, virus assembly, and budding.
Article
Virology
Olga G. Kurskaya, Elena A. Prokopyeva, Ivan A. Sobolev, Mariya V. Solomatina, Tereza A. Saroyan, Nikita A. Dubovitskiy, Anastasiya A. Derko, Alina R. Nokhova, Angelika V. Anoshina, Natalya V. Leonova, Olga A. Simkina, Tatyana V. Komissarova, Alexander M. Shestopalov, Kirill A. Sharshov
Summary: This study analyzed the changes in the epidemic patterns of common respiratory viruses among children and adolescents hospitalized with acute respiratory infections in Novosibirsk, Russia from 2019 to 2022. The findings showed that the SARS-CoV-2 virus had a significant impact on the etiology of acute respiratory infections, and different respiratory viruses dominated in different epidemic seasons.
Article
Cell Biology
Juan Jose Saez, Stephanie Dogniaux, Massiullah Shafaq-Zadah, Ludger Johannes, Claire Hivroz, Andres Ernesto Zucchetti
Summary: The paragraph discusses the important role of LAT in the signaling cascade induced by TCR activation, and its distribution and trafficking pathways in T cells upon activation. It shows that different proteins play specific roles in regulating the retrograde and anterograde transport of LAT during T cell activation.
Article
Multidisciplinary Sciences
En Cai, Casey Beppler, John Eichorst, Kyle Marchuk, Scott W. Eastman, Matthew F. Krummel
Summary: This study demonstrates the randomness of receptor patch localization within the membrane and on microvillar projections prior to antigen detection, which may play a role in the generation of multiple individually composed receptor patch compositions at a single synapse.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Wei Lin, Shuping Zhou, Meng Feng, Yong Yu, Qinghong Su, Xiaofan Li
Summary: The study demonstrated that sCD83 inhibits T cell activation by disrupting DC-T contact and immunological synapse formation, mainly through disrupting F-actin rearrangements in dendritic cells. This novel signaling pathway may be a potential target for developing new immunosuppressive therapies for autoimmune diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Virology
K. Groen, S. van Nieuwkoop, M. M. Lamers, R. A. M. Fouchier, B. G. van den Hoogen
Summary: Understanding the interaction between viruses and the innate immune response is crucial for the design of antiviral therapies. This study investigates the role of G, SH, and M2-2 proteins of HMPV as type I IFN antagonists. The results show that the M2-2 mutant virus induces the production of type I interferon and contains defective interfering RNAs and hypermutated genomes. These findings suggest that the role of the M2-2 protein as an IFN antagonist in HMPV is still unclear.
JOURNAL OF VIROLOGY
(2022)
Article
Immunology
Juncal Fernandez-Orth, Leoni Rolfes, Lukas Gola, Stefan Bittner, Joseph Andronic, Vladimir L. Sukhorukov, Dmitri Sisario, Peter Landgraf, Daniela C. Dieterich, Manuela Cerina, Karl-Heinz Smalla, Thilo Kaehne, Thomas Budde, Stjepana Kovac, Tobias Ruck, Markus Sauer, Sven G. Meuth
Summary: The immunological synapse is a junction between a T cell and an antigen-presenting cell, involving CRAC, K(v)1.3, and KCa3.1 channels. TASK2 channels are newly identified players recruited to the immunological synapse, potentially contributing to T cell activation and treatment of autoimmune diseases.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Lukas Velas, Mario Brameshuber, Johannes B. Huppa, Elke Kurz, Michael L. Dustin, Philipp Zelger, Alexander Jesacher, Gerhard J. Schuetz
Summary: This study utilized 3D-SMLM technique to accurately measure the three-dimensional topography of the immunological synapse, revealing the interface characteristics and cleft size between T-cells and antigen-presenting cells.
Review
Microbiology
Gaspar A. Pacheco, Nicolas M. S. Galvez, Jorge A. Soto, Catalina A. Andrade, Alexis M. Kalergis
Summary: hRSV is a major cause of acute lower respiratory tract infections in children under five years old, leading to pneumonia and other respiratory complications. Despite the significant social and economic burden, there are currently no approved vaccines to prevent diseases caused by hRSV.
Review
Immunology
Jaishree Sharma, Srinivasu Mudalagiriyappa, Som Gowda Nanjappa
Summary: In recent years, significant findings have been made in the field of antifungal T-cell immunity research, particularly in understanding the development and role of antifungal memory T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maider Garnica, Anna Aiello, Mattia Emanuela Ligotti, Giulia Accardi, Hugo Arasanz, Ana Bocanegra, Ester Blanco, Anna Calabro, Luisa Chocarro, Miriam Echaide, Grazyna Kochan, Leticia Fernandez-Rubio, Pablo Ramos, Fanny Pojero, Nahid Zareian, Sergio Pineiro-Hermida, Farzin Farzaneh, Giuseppina Candore, Calogero Caruso, David Escors
Summary: The number of people aged 65 or older is increasing, but their quality of life is not improving. Older people have a weaker immune system due to immunosenescence, making them more vulnerable to infections. This article reviews the impact of aging on T and B cells and discusses approaches to modulate and reverse the decline of the aging adaptive immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Claudia A. Rivera, Violaine Randrian, Wilfrid Richer, Yohan Gerber-Ferder, Maria-Graciela Delgado, Aleksandra S. Chikina, Annika Frede, Chiara Sorini, Mathieu Maurin, Hana Kammoun-Chaari, Sara M. Parigi, Christel Goudot, Mar Cabeza-Cabrerizo, Sylvain Baulande, Sonia Lameiras, Pierre Guermonprez, Caetano Reis e Sousa, Marc Lecuit, Helene D. Moreau, Julie Helft, Danijela Matic Vignjevic, Eduardo J. Villablanca, Ana-Maria Lennon-Dumenil
Summary: There are two pools of cDC2s in the small intestine, originating from common pre-DC precursors, and their phenotypes are influenced by food-derived retinoic acid.
Review
Microbiology
Catalina A. Andrade, Alexis M. Kalergis, Karen Bohmwald
Summary: Respiratory infections, especially caused by human respiratory syncytial virus (hRSV), are a major public health burden, particularly during winter. Recent evidence suggests that hRSV infection during pregnancy can affect both the mother and fetus, leading to developmental issues and neuroinflammation.
Review
Biochemistry & Molecular Biology
Karen Bohmwald, Catalina A. Andrade, Valentina P. Mora, Jose T. Munoz, Robinson Ramirez, Maria F. Rojas, Alexis M. Kalergis
Summary: Neurotrophins play important roles in the central nervous system and disruption of their signaling pathways can lead to neurological disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Enrique Gonzalez-Madrid, Ma. Andreina Rangel-Ramirez, Maria Jose Mendoza-Leon, Oscar Alvarez-Mardones, Pablo A. Gonzalez, Alexis M. Kalergis, Ma. Cecilia Opazo, Claudia A. Riedel
Summary: This review discusses the relevance of the gestational period for the development of multiple sclerosis (MS) in adulthood, pointing out that thyroid hormone deficiency during pregnancy may increase susceptibility to MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Monica A. Farias, Benjamin Diethelm-Varela, Areli J. Navarro, Alexis M. Kalergis, Pablo A. Gonzalez
Summary: This article reviews and discusses the interplay between neutral lipid metabolism and lipid droplets (LDs) in the replication cycle of different DNA viruses. It highlights the role of LDs in modulating viral infection and identifies potentially new molecular targets for the treatment of viral infections.
Article
Immunology
Katia Abarca, Carolina Iturriaga, Marcela Urzua, Nicole Le Corre, Augusto Pineda, Carolina Fernandez, Angelica Dominguez, Pablo A. Gonzalez, Susan M. Bueno, Paulina Donato, Pilar Espinoza, Daniela Fuentes, Marcela Gonzalez, Paula Guzman, Paula Munoz-Venturelli, Carlos M. Perez, Marcela Potin, Alvaro Rojas, Jose Gonzalez-Aramundiz, Nicolas M. S. Galvez, Francisca Aguirre-Boza, Sofia Aljaro, Luis Federico Batiz, Yessica Campisto, Mariela Cepeda, Aaron Cortes, Sofia Lopez, Maria Loreto Perez, Andrea Schilling, Alexis M. Kalergis
Summary: This study investigated the safety and effectiveness of two different immunization schedules of CoronaVac(R) in healthy adults. The results showed that CoronaVac(R) vaccine is safe and effective in preventing severe cases of COVID-19. There were no significant differences in adverse events between the two schedules, and both schedules provided protection against COVID-19 hospitalization.
Review
Biochemistry & Molecular Biology
Jorge A. Soto, Felipe Melo-Gonzalez, Claudia A. Riedel, Susan M. Bueno, Alexis M. Kalergis
Summary: CLE is an autoimmune disorder characterized by autoantibody secretion and immune cell recruitment, similar to SLE. It can be divided into different types with varying severity of skin lesions. Type I IFN plays a significant role in the development of CLE. Research aims to develop effective treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Luisa F. Duarte, Sebastian Gatica, Almendra Castillo, Alexis M. Kalergis, Susan M. Bueno, Claudia A. Riedel, Pablo A. Gonzalez
Summary: Numerous studies have linked the onset and severity of multiple sclerosis (MS) with viral infections. Herpes simplex virus type 1 (HSV-1), which is neurotropic and commonly found in the brains of healthy individuals, has been suggested to be associated with MS. This review discusses the reported connections between HSV-1 and MS.
MICROBES AND INFECTION
(2023)
Review
Virology
Linmar Rodriguez-Guilarte, Mario A. Ramirez, Catalina A. Andrade, Alexis M. Kalergis
Summary: LAG-3 is an inhibitory receptor expressed on immune cells, which regulates T cell activation and effector functions in the immune response. Immunotherapies targeting immune checkpoints, including LAG-3, have shown promise in controlling malignant tumors and chronic viral diseases.
Article
Biochemistry & Molecular Biology
Eduardo I. Tognarelli, Luisa F. Duarte, Monica A. Farias, Felipe A. Cancino, Nicolas Corrales, Francisco J. Ibanez, Claudia A. Riedel, Susan M. Bueno, Alexis M. Kalergis, Pablo A. Gonzalez
Summary: Stimulating HO-1 expression in HSV-infected dendritic cells can promote cell viability and inhibit viral egress. It also promotes the expression of anti-inflammatory molecules and activation of virus-specific CD4(+) T cells. Transferring HSV-infected dendritic cells with induced HO-1 expression can enhance virus-specific T cell activation and improve the outcome of HSV-1 skin infection.
Article
Immunology
Luisa F. Duarte, Yaneisi Vazquez, Benjamin Diethelm-Varela, Valentina Pavez, Roslye Berrios-Rojas, Claudia A. Riedel, Constanza Mendez, Jessica A. White, Alexis M. Kalergis, Susan M. Bueno, Pablo A. Gonzalez
Summary: This study aimed to identify potential antigens for distinguishing humoral responses after vaccination with CoronaVac, natural infection, or breakthrough infection. The results showed that CoronaVac vaccination induced higher levels of antibodies against the viral membrane protein, while the levels of IgG antibodies against the nucleocapsid protein were similar between the booster dose group and convalescent subjects. Breakthrough case patients had the highest antibody levels against the N and M proteins.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Sebastian Mondaca, Benjamin Walbaum, Nicole Le Corre, Marcela Ferres, Alejandro Valdes, Constanza Martinez-Valdebenito, Cinthya Ruiz-Tagle, Patricia Macanas-Pirard, Patricio Ross, Betzabe Cisternas, Patricia Perez, Olivia Cabrera, Valentina Cerda, Ivana Ormazabal, Aldo Barrera, Maria E. Prado, Maria I. Venegas, Silvia Palma, Richard Broekhuizen, Alexis M. Kalergis, Susan M. Bueno, Manuel A. Espinoza, M. Elvira Balcells, Bruno Nervi
Summary: Cancer patients receiving chemotherapy treatment have a lower immune response to SARS-CoV-2 vaccines. Our study demonstrated that booster vaccines elicit strong humoral and cellular responses among cancer patients receiving chemotherapy, regardless of the type of vaccine used as a priming dose. The homologous vaccine regimen was associated with higher neutralizing antibody positivity and total antibody levels.
Review
Microbiology
Xanthippi Topalidou, Alexis M. Kalergis, Georgios Papazisis
Summary: RSV is a significant cause of morbidity and mortality in young children and older adults. The development of RSV vaccines is guided by epidemiologic and pathophysiological evidence, using various vaccine technologies. Currently, there are 24 vaccines in clinical development, including two licensed vaccines.