Apremilast reversed carfilzomib-induced cardiotoxicity through inhibition of oxidative stress, NF-κB and MAPK signaling in rats

An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response

(2016) Max Brown et al.   JOURNAL OF CELL SCIENCE

Carfilzomib-induced cardiotoxicity mitigated by dexrazoxane through inhibition of hypertrophic gene expression and oxidative stress in rats

(2016) Naif O. Al-Harbi   TOXICOLOGY MECHANISMS AND METHODS

Carfilzomib-induced cardiotoxicity mitigated by dexrazoxane through inhibition of hypertrophic gene expression and oxidative stress in rats

(2016) Naif O. Al-Harbi   TOXICOLOGY MECHANISMS AND METHODS

Rutin Attenuates Carfilzomib-Induced Cardiotoxicity Through Inhibition of NF-κB, Hypertrophic Gene Expression and Oxidative Stress

(2015) Faisal Imam et al.   Cardiovascular Toxicology

Histamine 4 receptor promotes expression of costimulatory B7.1/B7.2 molecules, CD28 signaling and cytokine production in stress-induced immune responses

(2015) Sheikh Fayaz Ahmad et al.   JOURNAL OF NEUROIMMUNOLOGY

Diosmin downregulates the expression of T cell receptors, pro-inflammatory cytokines and NF-κB activation against LPS-induced acute lung injury in mice

(2015) Faisal Imam et al.   PHARMACOLOGICAL RESEARCH

Riboflavin attenuates lipopolysaccharide-induced lung injury in rats

(2015) Naif O. Al-Harbi et al.   TOXICOLOGY MECHANISMS AND METHODS

Riboflavin attenuates lipopolysaccharide-induced lung injury in rats

(2015) Naif O. Al-Harbi et al.   TOXICOLOGY MECHANISMS AND METHODS

Case series discussion of cardiac and vascular events following carfilzomib treatment: possible mechanism, screening, and monitoring

(2014) Ajai Chari et al.   BMC CANCER

Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma

(2013) M. Wang et al.   BLOOD

U.S. Food and Drug Administration Approval: Carfilzomib for the Treatment of Multiple Myeloma

(2013) T. M. Herndon et al.   CLINICAL CANCER RESEARCH

Integrated safety profile of single-agent carfilzomib: experience from 526 patients enrolled in 4 phase II clinical studies

(2013) D. Siegel et al.   HAEMATOLOGICA

Proteotoxicity and Cardiac Dysfunction — Alzheimer's Disease of the Heart?

(2013) Monte S. Willis et al.   NEW ENGLAND JOURNAL OF MEDICINE

The role of aryl hydrocarbon receptor signaling pathway in cardiotoxicity of acute lead intoxication in vivo and in vitro rat model

(2013) Mushtaq A. Ansari et al.   TOXICOLOGY

An open-label, single-arm, phase 2 (PX-171-004) study of single-agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma

(2012) R. Vij et al.   BLOOD

A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma

(2012) D. S. Siegel et al.   BLOOD

Design and rationale of FOCUS (PX-171-011): A randomized, open-label, phase 3 study of carfilzomib versus best supportive care regimen in patients with relapsed and refractory multiple myeloma (R/R MM)

(2012) Roman Hájek et al.   BMC CANCER

Role of carfilzomib in the treatment of multiple myeloma

(2012) Rashid Z Khan et al.   Expert Review of Hematology

Key roles of endothelin-1 and p38 MAPK in the regulation of atrial stretch response

(2010) Risto Kerkelä et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation

(2010) Daniela Impellizzeri et al.   BIOCHEMICAL PHARMACOLOGY

Role of nuclear factor κB in cardiovascular health and disease

(2010) Kim van der Heiden et al.   CLINICAL SCIENCE

MAPK signalling in cellular metabolism: stress or wellness?

(2010) Helmuth Gehart et al.   EMBO REPORTS

Protective effects of aliskiren in doxorubicin-induced acute cardiomyopathy in rats

(2010) Azhar Rashikh et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Targeting Cyclic Nucleotide Phosphodiesterase in the Heart: Therapeutic Implications

(2010) Clint L. Miller et al.   Journal of Cardiovascular Translational Research

Cardioprotective Effect of Ficus hispida Linn. on Cyclophosphamide Provoked Oxidative Myocardial Injury in a Rat Model

(2009) T.S. Shanmugarajan et al.   International Journal of Pharmacology

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

Advances in Targeting IKK and IKK-Related Kinases for Cancer Therapy

(2008) D.-F. Lee et al.   CLINICAL CANCER RESEARCH

Mechanisms of Myocyte Cytotoxicity Induced by the Multiple Receptor Tyrosine Kinase Inhibitor Sunitinib

(2008) B. B. Hasinoff et al.   MOLECULAR PHARMACOLOGY

Phosphodiesterase inhibitors

(2006) Victoria Boswell-Smith et al.   BRITISH JOURNAL OF PHARMACOLOGY