Article
Cell Biology
Rui Zhang, Guo-Jun Geng, Jian-Guang Guo, Yan-Jun Mi, Xiao-Lei Zhu, Ning Li, Hong-Ming Liu, Jun-Feng Lin, Jian-Weng Wang, Guang Zhao, Guan-Zhi Ye, Bo-An Li, Qi-Cong Luo, Jie Jiang
Summary: This study identified a regulatory circuit linking NF-kappa B signaling and OVOL2 in the modulation of glucose metabolism in non-small cell lung cancer.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Yingming Sun, Xiaoge Sun, Chengcheng You, Shijing Ma, Yuan Luo, Shan Peng, Fang Tang, Xiaoli Tian, Feng Wang, Zhengrong Huang, Hongnv Yu, Yu Xiao, Xiaoyong Wang, Junhong Zhang, Yan Gong, Conghua Xie
Summary: MUC3A is highly expressed in non-small cell lung cancer (NSCLC) and associated with poor prognosis, advanced staging, and low differentiation. Knockdown of MUC3A suppresses tumor growth and DNA damage repair pathways, suggesting it may be a potential oncogene.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Evan A. Mulligan, Susan J. Tudhope, Jill E. Hunter, Arabella E. G. Clift, Sarah L. Elliott, Geoffrey P. Summerfield, Jonathan Wallis, Chris J. Pepper, Barabara Durkacz, Stephany Veuger, Elaine Willmore
Summary: This study demonstrates the importance of RelB in CLL, as high basal levels of RelB DNA binding correlate with nuclear RelB protein expression and are associated with poor clinical outcomes. CD40L stimulation promotes RelB activation and CLL cell proliferation. Inhibiting non-canonical NF-kappa B signalling may be a novel therapeutic approach for CLL.
Article
Cell Biology
Tong Yu, Yanyan Liu, Junwen Xue, Xiang Sun, Di Zhu, Lu Ma, Yingying Guo, Tongzhu Jin, Huiying Cao, Yingzhun Chen, Tong Zhu, Xuelian Li, Haihai Liang, Zhimin Du, Hongli Shan
Summary: This study found that Gankyrin is upregulated in non-small cell lung cancer (NSCLC) and plays a role in promoting cancer progression through the regulation of YAP1 and glycolysis. The inhibition of Gankyrin could potentially be a therapeutic strategy for NSCLC.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Min-Kyung Yeo, Yoonjoo Kim, Da Hye Lee, Chaeuk Chung, Go Eun Bae
Summary: This study found that the expression of NF-kappa B and AICDA increased in EGFR-TKI-resistant LAC, and the suppression of NF-kappa B and AICDA had a significant therapeutic effect in overcoming EGFR-TKI resistance.
Article
Oncology
Manman Liang, Zhengui Sun, Xingwu Chen, Lijing Wang, Hanli Wang, Lilong Qin, Wenying Zhao, Biao Geng
Summary: This study identified TRIM28 as a promoter of chemokine-driven recruitment of MDSCs through RIPK1-mediated NF-kappa B activation, leading to the suppression of infiltrating activated CD8+T cells and the development of anti-PD-1 resistance. Understanding the regulation of MDSC recruitment and function by TRIM28 provides crucial insights into the association between TRIM28 signaling and the development of an immunosuppressive tumor microenvironment. There is potential for developing combination therapies to enhance the effectiveness of immune checkpoint blockade therapy in NSCLC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Cell Biology
Jinlin Zhao, Xin Wang, Zeyun Mi, Xiangli Jiang, Lin Sun, Boyu Zheng, Jing Wang, Maobin Meng, Lu Zhang, Zhongqiu Wang, Junwei Song, Zhiyong Yuan, Zhiqiang Wu
Summary: The study identified miR-135b as a tumor-promoting miRNA significantly upregulated in NSCLC and associated with poor prognosis. Overexpression of miR-135b enhanced aggressiveness of NSCLC by targeting CYLD and modulating NF-kappa B signaling, while IL-6/STAT3 could elevate miR-135b levels and form a positive feedback loop in NSCLC.
CELL DEATH & DISEASE
(2021)
Article
Plant Sciences
Zihan Lin, Lijuan Liao, Shengchao Zhao, Wei Gu, Guanzhen Wang, Ziyi Shen, Yuanhui Wang, Kun Chen, Wei Liu, Yi Cai, Chunpeng Wan, Tingdong Yan
Summary: The study found that corylin is a substance that inhibits the progression of non-small cell lung cancer cells, and it inhibits the NF-kappa B signaling pathway by blocking p65 nuclear translocation. The study provides a novel strategy for improving the prognosis and treatment of non-small cell lung cancer patients.
Review
Cell Biology
Karli Mockenhaupt, Alexandra Gonsiewski, Tomasz Kordula
Summary: Neuroinflammation involves multiple cell types in the central nervous system, which coordinate their responses by secreting and responding to inflammatory mediators. Critical activation of NF-kappa B pathways is observed during neuroinflammation, with specific mechanisms and roles of RelB activation in different cell types being less understood. This review summarizes the mechanisms of RelB activation in specific cell types within the CNS and its specialized effects during neuroinflammation.
Article
Oncology
Zimin Wang, Sika Wu, Xin Chen, Jiawei Liang, Fenglai Xue, William C. Cho, Jiaqian Bao, Baofu Chen, Minhua Ye, Dehua Ma, Chengchu Zhu, Jinrong Zhu, Jianfei Shen
Summary: Overexpression of PFKP is associated with cisplatin resistance and poor prognosis in non-small cell lung cancer (NSCLC) patients. PFKP can regulate the expression of ABCC2 through the activation of NF-kappa B, thereby promoting chemoresistance in NSCLC.
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Tobias Riedl, Suzanne Faure-Dupuy, Maude Rolland, Svenja Schuehle, Zohier Hizir, Silvia Calderazzo, Xiaodong Zhuang, Jochen Wettengel, Martin Alexander Lopez, Romain Barnault, Valbona Mirakaj, Sandra Prokosch, Danijela Heide, Corinna Leuchtenberger, Martin Schneider, Bernd Hessling, Benjamin Stottmeier, Isabel M. Wessbecher, Peter Schirmacher, Jane A. McKeating, Ulrike Protzer, David Durantel, Julie Lucifora, Emmanuel Dejardin, Mathias Heikenwalder
Summary: The stabilization of HIF1 alpha was found to inhibit the expression of APOBEC3B and its antiviral effects against HBV. Inhibiting the expression or stabilization of HIF1 alpha could serve as an anti-HBV strategy. High levels of HIF1 alpha may provide a reservoir for HBV survival in immune-active patients, and therefore should be considered as a constraining factor in the development of immune therapies.
Article
Oncology
Yanyan Zhang, Shuyi Zhu, Yuanyuan Du, Fan Xu, Wenbo Sun, Zhi Xu, Xiumei Wang, Peipei Qian, Qin Zhang, Jifeng Feng, Yong Xu
Summary: This study elucidates the molecular mechanism by which tumorous RelB contributes to immune evasion by inhibiting T cell immunity through the amplification of the PD-L1/PD-1-mediated immune checkpoint.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Stephanie Nuan-Aliman, Didier Bordereaux, Catherine Thieblemont, Veronique Baud
Summary: RelB NF-κB subunit plays a role in controlling oxidative metabolism in DLBCL, inhibiting RelB reduces DLBCL mitochondrial ATP production and increases sensitivity to antimetabolic drugs.
Article
Integrative & Complementary Medicine
Zhan-Ke Chen, Di Zhao, Su-Xiang Feng, Jiangyan Xu
Summary: In this study, a rapid and sensitive UPLC-MS/MS method was developed for the quantification of peimine and peiminine in A549 cells. The results showed good linearity, precision, and accuracy for both compounds. The uptake experiment demonstrated that the combination group had higher uptake and longer T-max. In the pharmacodynamic study, the combination group showed the most significant anti-inflammatory effects at a concentration of 100.0 mu g/mL.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Oncology
Wangyu Zhu, Yun Yu, Yuxin Ye, Xinyue Tu, Yan Zhang, Tao Wu, Lianli Ni, Xiangjie Huang, Yumin Wang, Ri Cui
Summary: The miR-196b-5p promotes NSCLC progression and metastasis by regulating NFKBIA, and other molecules such as QKI-5 and miR-224 are also involved in NSCLC development.
TRANSLATIONAL ONCOLOGY
(2023)
Review
Food Science & Technology
Jingjing Xu, Min Zhang, Yuchuan Wang, Bhesh Bhandari
Summary: Flavor is crucial for the acceptance of meat products, and conventional cooking methods often result in decreased quality and inadequate flavor release. To meet consumers' demands for good flavors and high quality, researchers are exploring emerging technologies for enhancing flavor formation and nutritional value during thermal or non-thermal processing of meat products.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Chemistry, Physical
Nadia Kashif, Boris Albijanic, Jing Jing Xu, Syahida Syahida, Teresa McGrath, Bogale Tadesse, Muhammad Kashif Nazir
Summary: The influence of bentonite on the grinding efficiencies of ores has been examined in this study. It was found that the presence of bentonite in the ore negatively affected the grinding performance of the ore, but this negative effect was mitigated by adding Ca2+ ions. The addition of Ca2+ ions reduced the repulsive forces between bentonite particles, leading to improved settling rates and grinding performance.
APPLIED CLAY SCIENCE
(2023)
Article
Engineering, Biomedical
Jingjing Xu, Xianjiao Tang, Xiaojing Yang, Mei-Xia Zhao
Summary: We developed a pH/glutathione (GSH) dual-responsive smart nano-drug delivery system for targeted release of a chemotherapeutic drug at the breast tumor site. The PEG-SS-CA-DOX micelles achieved efficient and rapid release of DOX in the tumor microenvironment due to stimulation by weak acidic pH and high GSH content. In vivo experiments demonstrated high inhibition rate of PEG-SS-CA-DOX against 4T1 breast cancer cells with good biosafety.
BIOMEDICAL MATERIALS
(2023)
Article
Cell Biology
Lin-Yan Huang, Ju-Yun Ma, Jin-Xiu Song, Jing-Jing Xu, Rui Hong, Hai-Di Fan, Heng Cai, Wan Wang, Yan-Ling Wang, Zhao-Li Hu, Jian-Gang Shen, Su-Hua Qi
Summary: This study found that succinate levels increased in serum and brain tissue after ischemia/reperfusion injury. Oxygen-glucose deprivation and reoxygenation stimulated neural stem cells to produce abundant succinate. Exogenous diethyl succinate inhibited neural stem cell proliferation and worsened cerebral ischemia/reperfusion injury. The study suggests that ischemic accumulation of succinate decreases Cdc42 GTPase activity by induction of Cdc42 succinylation, which inhibits neural stem cell proliferation and worsens cerebral ischemia/reperfusion injury.
NEURAL REGENERATION RESEARCH
(2023)
Article
Engineering, Mechanical
Zechao Di, Shaohui Li, Dongsheng Huang, Xuetao Zhang, Yuan Li, Yu Jiang, Mengjia Zhang, Jingjing Xu, Zhiyu Zhao
Summary: The anti-shudder effects of glycerol monoisostearate friction modifier (FM) in automatic transmission fluid (ATF) were investigated using a disc-on-disc tribometer. The presence of FM greatly influenced the anti-shudder durability of ATF, despite FM itself having no inherent anti-shudder properties. Chemical characterization of the tribosurface revealed that the proper presence of FM improved the reaction probability of certain components in ATF, leading to the formation of a more effective calcium hydroxyphosphate type tribofilm, thereby enhancing the anti-shudder performance.
TRIBOLOGY INTERNATIONAL
(2023)
Article
Toxicology
Chijing Zuo, Yan Liu, Jie Wang, Weidong Yu, Yujie Liu, Yanyan Zhang, Jingjing Xu, Daiyin Peng, Can Peng
Summary: Compound diclofenac sodium chlorphenamine maleate tablets (CDCT) commonly used in Asia for the cold can cause hematuria symptoms, but the underlying mechanism is unclear. This study investigated the CDCT-induced changes in kidney morphology and metabolites in order to explore the possible mechanisms of CDCT-induced nephrotoxicity. CDCT exposure in rats led to kidney injury and death, accompanied by pathological changes and disruptions in energy and glycerophospholipid metabolism pathways. Specific metabolites, such as succinate, leukotriene B-4 (LTB4), and cardiolipin (CL), were found to be significantly altered. Functionally, succinate accumulation caused mitochondrial damage, LTB4 activated NF-kappa B signaling, and reduced CL triggered apoptosis, inflammation, and mitochondrial reactive oxygen species (mito SOX). This study provides comprehensive information on the mechanism of CDCT-induced nephrotoxicity.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Neurosciences
Jie Xu, Yan-Tian Lv, Xiao-Yun Zhao, Jing-Jing Wang, Zhong-Shan Shen, Jian Li, Fei-Fei Zhang, Jing Liu, Xiao-Hui Wang, Yun Xu, Qi Geng, Yi-Tong Ding, Jing-Jing Xu, Meng-Jiao Tan, Zhi-Xiao Li, Ran Wang, Jian Chen, Wen Sun, Meng Cui, Diomedes E. Logothetis, Jun-li Cao, Qiong-Yao Tang, Zhe Zhang
Summary: In this study, two potential sodium-sensitive sites were identified in the C-terminal domain of the rat Slack channel, and R379 was determined to be a chloride interaction site. These findings contribute to a better understanding of the sodium gating mechanism and the regulation of Slack channel function.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Polymer Science
Xueyan Hou, Jingjing Xu, Sisi He, Jintao Bai, Yalin Guan, Xiaofei Pan, Jiake Yang, Nan Zhang, Shang Yang, Jie Hu, Xue Yang
Summary: A novel poloxamer(188)-based drug delivery system, P188TT NPs, was developed for the treatment of glioma. The P188TT NPs showed low critical micelle concentration, appropriate size, good stability, and increased anti-tumor activity of encapsulated drugs.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Medicine, General & Internal
Jingjing Xu, Zhengye Cao, Chunqin Miao, Minming Zhang, Xiaojun Xu
Summary: This study used machine learning algorithms based on computed tomography (CT) imaging to predict disease severity and outcome in Omicron pneumonia, and compared its performance with clinical and biological features. The results showed that CT and clinical assessment had similar accuracy in predicting severity and outcome of Omicron pneumonia. Oxygen saturation, IL-6, and chest CT infiltration were found to be important biomarkers.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jinhua Ren, QiaoXian Lin, Qi Chen, Jingjing Xu, Dabin Chen, Renli Chen, Kangni Lin, Haojie Zhu, Chenjing Ye, Xiaofeng Luo, Shaozhen Chen, Hui Kong, Qiong Lin, Nan Li, Xu Lin, Zhizhe Chen, Jianda Hu, Ting Yang
Summary: Adoptive transfer of HBV immunity was investigated in 112 patients without HBsAb at the time of their first allo-HSCT. After allo-HSCT, HBV-DNA and HBsAg cleared in HBsAg+ patients, while all HBsAg- patients acquired HBsAb immediately. However, HBsAb subsequently declined, with 58.2% of patients losing HBsAb during follow-up. Multivariate analysis suggested that lack of CMV clearance, aGVHD, and no HBsAb loss were independent risk factors for overall survival. Overall, adoptive immune transfer provides anti-HBV protection, and HBsAb loss after allo-HSCT predicts better survival.
Article
Cell Biology
Chen Zhang, Yue Sun, Yingying Guo, Jingjing Xu, Haiyan Zhao
Summary: The study reveals that JMJD1C is highly expressed in a PAH mouse model, and its inhibition can ameliorate pathological features of PAH. JMJD1C knockdown reduces PASMC proliferation and impairs their adaptation to hypoxia, while suppressing the STAT3 signaling pathway. The findings suggest that JMJD1C induces glycolytic processes and promotes PASMC proliferation and pulmonary vascular remodeling in PAH.
CELL DEATH DISCOVERY
(2023)
Article
Computer Science, Artificial Intelligence
Jingjing Xu
Summary: This article builds a sentiment analysis model based on natural language processing technology and proposes an improved TF-IDF algorithm. The emotional value of each emotional word is determined using a weighted average method. Inspirational words are used to obtain the emotional tendency and emotional value of the English corpus. The results show that the model has high classification accuracy and operation efficiency when selecting feature words. The improved TF-IDF algorithm significantly improves the efficiency of college English learning by adding necessary information weight processing and word density weight processing.
PEERJ COMPUTER SCIENCE
(2023)
Article
Chemistry, Physical
Maja Hanic, Lewis M. Antill, Angela S. Gehrckens, Jessica Schmidt, Katharina Gortemaker, Rabea Bartolke, Tarick J. El-Baba, Jingjing Xu, Karl-Wilhelm Koch, Henrik Mouritsen, Justin L. P. Benesch, P. J. Hore, Ilia A. Solov'yov
Summary: Experimental and computational investigations were conducted to explore the dimerization of robin Cry4a protein. It was found that disulfide-linked dimers are routinely formed, especially under blue light exposure. Computational modeling and molecular dynamics simulations were used to assess possible dimer structures. The relevance of these findings to avian magnetoreception was discussed.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Food Science & Technology
Jingjing Xu, Ruyue Wang, Weibao Liu, Zhongwei Yin, Jianrong Wu, Xun Yu, Wen Wang, Hongtao Zhang, Zhitao Li, Minjie Gao, Li Zhu, Xiaobei Zhan
Summary: This study found that ten non-digestible carbohydrates have different effects on gut microbial metabolism, and xanthan gum oligosaccharides and gellan gum oligosaccharides have significant impact on butyrate-producing bacteria and butyrate production.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Biology
Joe Wynn, Bo Leberecht, Miriam Liedvogel, Lars Burnus, Raisa Chetverikova, Sara Doege, Thiemo Karwinkel, Dmitry Kobylkov, Jingjing Xu, Henrik Mouritsen
Summary: The role of inherited orientation programmes in determining migratory routes of birds is well understood, but not much is known about the influence of inherited information on return migration. This study shows that juvenile Eurasian blackcaps, which have never left northwest Europe, exhibit significant spring orientation in a direction similar to that expected based on ringing recoveries. It suggests that birds may inherit an orientation programme for both spring and autumn migration, and that inherited spring migratory trajectories could be accurate enough for targeting breeding sites.
Article
Oncology
Masashi Nishimura, Yoshifumi Kimizuka, Takunori Ogawa, Motohiro Tsuchiya, Yoshiki Kato, Akira Matsukida, Shunya Igarashi, Koki Ito, Yusuke Serizawa, Tomomi Tanigaki, Yuji Fujikura, Yuka Katsurada, Sho Ogata, Akihiko Kawana
Summary: This study reports a case of IgG4-related retroperitoneal fibrosis occurring after chemotherapy. The patient showed improvement after discontinuing immunotherapy and receiving steroid treatment.
Article
Oncology
Yuta Ohishi, Yoko Nakanishi, Yukari Hirotani, Atsuko Suzuki, Tomoyuki Tanino, Haruna Nishimaki-Watanabe, Hiroko Kobayashi, Fumi Nozaki, Sumie Ohni, Xiaoyan Tang, Kentaro Hayashi, Yoshiko Nakagawa, Tetsuo Shimizu, Ichiro Tsujino, Noriaki Takahashi, Yasuhiro Gon, Shinobu Masuda
Summary: This study aimed to investigate the clinicopathological differences and therapeutic response of NSCLC patients with SDC4::ROS1 fusion to crizotinib. The study found that different ROS1 fusion partners may affect the efficacy of crizotinib and patient prognosis. In addition, higher expression levels of ROS1 and pERK1/2 in tumor cells of case 2 may be related to the therapeutic response and prognosis.
Review
Oncology
Zitong Zheng, Juanjuan Liu, Junling Ma, Runting Kang, Zhen Liu, Jiangyong Yu
Summary: Small cell lung cancer (SCLC) is a highly aggressive malignancy with limited treatment options. Over the past decade, immunotherapy has made progress in the treatment of SCLC, but current immune checkpoint inhibitors have limited benefits for patient survival. Therefore, it is important to explore new targets and develop drugs with novel mechanisms for immunotherapy in SCLC.
Article
Oncology
Kazuto Sugai, Kojiro Nakaoka, Rika Tobita, Shinji Kikuchi, Kei Inoue, Midori Enokido, Moriyuki Kiyoshima
Summary: This article presents a case of multilocular mediastinal cyst leading to the development of thymic cancer. Resection of multilocular anterior mediastinal cysts should be considered due to the challenges in preoperative diagnosis, the potential for coexisting tumors with cysts, and the risk of malignant tumor development.
