Review
Chemistry, Multidisciplinary
Weiqi Cai, Tianli Luo, Lanqun Mao, Ming Wang
Summary: Recent innovations in genome editing have led to precise manipulation of genetic information in mammals using stimuli-responsive nanoparticles for the delivery and release of CRISPR/Cas9 genome editing machinery. These approaches can utilize biological signals or external signals to achieve improved genome editing outcomes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Pharmacology & Pharmacy
Yijun Zhao, Xumei Ouyang, Yongjun Peng, Shaojun Peng
Summary: Gas therapy, particularly NO-based nanomedicines, holds promise in cancer treatment by enhancing therapeutic efficacy and reducing side effects. Numerous studies have focused on the design and development of NO-based nanomedicines triggered by various stimuli for synergistic cancer therapy. Challenges and future perspectives in this field are also discussed for further development.
Article
Pharmacology & Pharmacy
Hao Cai, Yufan Xiang, Yujun Zeng, Zhiqian Li, Xiuli Zheng, Qiang Luo, Hongyan Zhu, Qiyong Gong, Zhongwei Gu, Yanhui Liu, Hu Zhang, Kui Luo
Summary: Multi-modal therapeutics using polymeric carriers for simultaneous diagnosis and treatment of cancer have been developed. A theranostic nanomedicine, branched glycopolymer-PTX-DOTA-Gd, showed extended circulation time, enhanced tumor accumulation, and excellent biocompatibility with reduced gadolinium ion retention. This branched polymeric prodrug-based nanomedicine has great potential for safe and effective cancer diagnosis and treatment, achieving enhanced imaging contrast and high antitumor efficacy.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Pharmacology & Pharmacy
Dmitriy Berillo, Zharylkasyn Zharkinbekov, Yevgeniy Kim, Kamila Raziyeva, Kamila Temirkhanova, Arman Saparov
Summary: Despite the conventional use of oral and intravenous routes for drug administration, they face limitations such as reduced bioavailability and invasiveness. Therefore, alternative delivery routes and modifications to drug formulations using stimuli-responsive polymers can improve drug release and bioavailability.
Review
Chemistry, Multidisciplinary
Qi Jiang, Shufang Zhang
Summary: Osteoarthritis (OA) is a common age-related degenerative disease that poses economic and societal burdens, especially with the increasing aging population. Stimulus-responsive nanoplatforms offer improved therapeutic strategies for OA, with potential benefits such as enhanced control, longer retention time, higher loading rates, and increased sensitivity. This review summarizes the advanced application of stimulus-responsive drug delivery nanoplatforms, categorized by endogenous and exogenous stimuli, and discusses the opportunities, restrictions, and limitations of these systems.
Review
Pharmacology & Pharmacy
Marjolein I. Priester, Timo L. M. ten Hagen
Summary: Significant advancements have been made in the development of solid tumor treatment, particularly through the implementation of nanosystems for drug delivery, which have reduced side effects and improved drug delivery to tumor regions. However, challenges still exist in clinical translation, and the development of smart drug delivery systems that can be actively manipulated to control drug release shows promise as a powerful strategy to improve drug activity at the target site.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Alexander B. Cook, Paolo Decuzzi
Summary: Materials that respond to endogenous stimuli play a crucial role in enhancing spatiotemporal control in biomedical applications. These materials can be designed to undergo morphological or chemical changes in response to specific biological cues, offering promising opportunities for improving therapeutic efficacy and developing personalized healthcare systems. They can be engineered across different length scales to respond to endogenous signals such as enzymes, pH, glucose, and hold great potential for a wide range of applications.
Review
Engineering, Environmental
Jingbo Yang, Haoxiang Zhang, Tianli Hu, Chenjie Xu, Lelun Jiang, Yu Shrike Zhang, Maobin Xie
Summary: Microneedles are minimally invasive tools that have gained increasing attention for their advantages such as pain-free, self-administration, and ease of disposal. This review summarizes the latest developments in microneedle technology and its advanced applications in biomedical field.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Yilin Song, Huaqing Jing, Long Binh Vong, Jinping Wang, Nan Li
Summary: This article systematically summarizes the recent advances in stimuli-responsive nano-based drug delivery systems (NDDSs) for the treatment of atherosclerosis (AS), including internal and external stimuli-responsive NDDSs. The article also provides a detailed classification of stimuli-responsive NDDSs for AS and discusses the critical challenges and prospects in this field.
CHINESE CHEMICAL LETTERS
(2022)
Article
Polymer Science
Andres Ortega-Garcia, Bryan Giovanny Martinez-Bernal, Israel Ceja, Eduardo Mendizabal, Jorge Emilio Puig-Arevalo, Lourdes Adriana Perez-Carrillo
Summary: This paper reports the synthesis of stimulus-responsive polymer nanohydrogels with a core/shell structure using batch emulsion polymerization in the presence of chitosan micelles. The nanohydrogels were loaded with the drug doxycycline hyclate and showed a higher release amount at acidic pH. Mathematical models were used to fit the experimental drug release data.
Review
Chemistry, Multidisciplinary
Chendi Ding, Chunbo Chen, Xiaowei Zeng, Hongzhong Chen, Yanli Zhao
Summary: Prodrugs are inactive drug molecules that are converted to active drugs after administration. They play a crucial role in drug treatment, especially in cancer therapy. Current research focuses on stimuli-responsive activation mechanisms, regulation of stimuli intensity in vivo, and the design of nanoscale prodrug formulations.
Review
Biotechnology & Applied Microbiology
Leah Williams, Fiona L. Hatton, Helen Willcock, Elisa Mele
Summary: This review provides an overview of recent advancements in electrospinning of temperature- and pH-responsive polymers to create networks of nanofibres with controlled drug delivery profiles for biomedical applications.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Article
Engineering, Biomedical
Eliezer Jager, Jana Humajova, Yusuf Dolen, Jan Kucka, Alessandro Jager, Rafal Konefal, Jan Pankrac, Ewa Pavlova, Tomas Heizer, Ludek Sefc, Martin Hruby, Carl G. Figdor, Martijn Verdoes
Summary: Anticancer drug delivery strategies aim to exploit the differential chemical environment in solid tumors compared to healthy tissue, with the design and characterization of multiresponsive block amphiphilic copolymers showing promising results in enhancing drug delivery efficacy.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
F. Abedi, P. Ghandforoushan, F. Adeli, M. Yousefnezhad, A. Mohammadi, S. V. Moghaddam, S. Davaran
Summary: With the progress in nanomedicine, nano-vehicles have become crucial in innovative drug delivery systems, particularly in the field of cancer treatment. Stimuli-responsive nanogels, such as light, temperature, redox, magnetic, and pH-responsive NGs, have shown great potential in delivering anti-tumor drugs to specific sites without non-selective toxicity. This review provides a summary of the preparation, biomedical application, current progress, and challenges in stimuli-responsive NGs, emphasizing their importance in effective cancer treatment. Additionally, the exploration of 3D printing for precise nanogel production and its utilization in clinical and biomedical applications is discussed.
MATERIALS TODAY CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Moritz S. Muthwill, Phally Kong, Ionel Adrian Dinu, Danut Necula, Christoph John, Cornelia G. Palivan
Summary: This article reviews the application of polymer nanoassemblies in the design of theranostic systems. By selecting systems that are responsive to environmental changes and incorporating inorganic nanoparticles, polymer nanoassemblies with multifunctional therapeutic and/or diagnostic features can be customized. In addition, more complex structures such as multicompartments are also discussed.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Xiao-Quan Shen, Ming-Ding Li, Jun-Peng Ma, Qun-Dong Shen
Summary: This study developed a new capacitive pressure sensor with high sensitivity and low cost, capable of detecting dynamic physiological signals and being competitive in the field of wearable electronics.
Review
Pharmacology & Pharmacy
Yingyue Ding, Zhaoting Li, Ana Jaklenec, Quanyin Hu
Summary: Recent years have seen a growing interest in strategies aimed at improving the ability of vaccines to target lymph nodes. Novel vaccine delivery systems using various materials as carriers have been developed to enhance lymph node targeting and boost vaccine-triggered immune responses.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Chemistry, Multidisciplinary
Zhaoting Li, Yixin Wang, Jun Liu, Piper Rawding, Jiyoon Bu, Seungpyo Hong, Quanyin Hu
Summary: Bacteria, with their intrinsic biocompatibility and motility, have been utilized as an emerging delivery system in various biomedical applications, drawing wide interest in the diagnosis and treatment of diseases. The synergy of chemical biotechnology and bacteria has opened up many research opportunities, creating a promising frontier in biomedical applications. Research on bacteria-based delivery systems is focusing on emerging advances in diagnosis and therapy, bringing new possibilities to the field.
ADVANCED MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Yixin Wang, Zhaoting Li, Quanyin Hu
Summary: Self-regulated micro/nano drug delivery devices can sense physiological changes and adjust their performance based on internal biological signals, bringing convenience and treatment outcomes to patients. Breakthroughs have been made in developing these devices with advanced technology and a better understanding of physiology.
Article
Multidisciplinary Sciences
Hongjun Li, Zejun Wang, Edikan Archibong, Qing Wu, Guojun Chen, Quanyin Hu, Tianyuan Ci, Zhaowei Chen, Jinqiang Wang, Di Wen, Hongwei Du, Jie Jiang, Jie Sun, Xingcai Zhang, Gianpietro Dotti, Zhen Gu
Summary: A porous microneedle patch is used to load CAR T cells and escort them to solid tumors, breaking the physical barrier without losing cellular activity. This patch offers a transformative platform for scattered seeding of living cells for treating various tumors.
NATIONAL SCIENCE REVIEW
(2022)
Review
Chemistry, Multidisciplinary
Yixin Wang, Ting-Jing Chen-Mayfield, Zhaoting Li, Muhsin H. Younis, Weibo Cai, Quanyin Hu
Summary: Despite the rapid development of immunotherapy, low response rates, poor therapeutic outcomes, and severe side effects still limit its implementation. DNA has recently emerged as an important player in immune modulation. Researchers have utilized DNA or nucleic acid-based immune stimulators for the prevention and treatment of diseases. Additionally, DNA delivery vehicles and nanostructures have been used to regulate immune systems and elicit strong immune responses.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Multidisciplinary Sciences
Zhaoting Li, Yingyue Ding, Jun Liu, Jianxin Wang, Fanyi Mo, Yixin Wang, Ting-Jing Chen-Mayfield, Paul M. Sondel, Seungpyo Hong, Quanyin Hu
Summary: This study reports a method to enhance the effectiveness of anti-tumor immunotherapy by locally depleting tumor-associated macrophages (TAMs) using a hydrogel reservoir. TAMs are depleted by releasing the colony-stimulating factor 1 receptor (CSF1R) inhibitor Pexidartinib and delivering anti-PD-1 antibody-conjugated platelets locally and systemically, effectively inhibiting post-surgery tumor recurrence.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Ming-Ding Li, Xiao-Quan Shen, Xin Chen, Jia-Ming Gan, Fang Wang, Jian Li, Xiao-Liang Wang, Qun-Dong Shen
Summary: In this study, a novel electrocaloric polymer structure with a continuous three-dimensional thermal conductive network was demonstrated, which significantly improved the electrocaloric performance and thermal conductivity. This solution effectively addresses the heat dissipation issue of electroactive polymers and low thermal conductivity interfaces, while reducing the energy consumption.
NATURE COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Di Zhao, Rui Huang, Jia-Min Gan, Qun-Dong Shen
Summary: Nanomaterials at the neural interface have the potential to mimic or control neural cells or tissues, and show promise in various applications. This review focuses on the use of photoactive nanomaterials in precise control of individual neurons, vision restoration, neural tissue repair or regeneration, and deep brain stimulation. The challenges and future research directions are also discussed.
Article
Biotechnology & Applied Microbiology
Susan P. P. Foy, Kyle Jacoby, Daniela A. A. Bota, Theresa Hunter, Zheng Pan, Eric Stawiski, Yan Ma, William Lu, Songming Peng, Clifford L. L. Wang, Benjamin Yuen, Olivier Dalmas, Katharine Heeringa, Barbara Sennino, Andy Conroy, Michael T. T. Bethune, Ines Mende, William White, Monica Kukreja, Swetha Gunturu, Emily Humphrey, Adeel Hussaini, Duo An, Adam J. J. Litterman, Boi Bryant Quach, Alphonsus H. C. Ng, Yue Lu, Chad Smith, Katie M. M. Campbell, Daniel Anaya, Lindsey Skrdlant, Eva Yi-Hsuan Huang, Ventura Mendoza, Jyoti Mathur, Luke Dengler, Bhamini Purandare, Robert Moot, Michael C. C. Yi, Roel Funke, Alison Sibley, Todd Stallings-Schmitt, David Y. Y. Oh, Bartosz Chmielowski, Mehrdad Abedi, Yuan Yuan, Jeffrey A. A. Sosman, Sylvia M. M. Lee, Adam J. J. Schoenfeld, David Baltimore, James R. R. Heath, Alex Franzusoff, Antoni Ribas, Arati V. V. Rao, Stefanie J. J. Mandl
Summary: We used CRISPR-Cas9 non-viral precision genome-editing to knockout the endogenous TCR genes and insert neoantigen-specific TCRs into T cells of cancer patients. This approach demonstrated the feasibility of isolating and cloning multiple TCRs that recognize mutational neoantigens. The gene-edited T cells showed promising results in a phase I clinical trial.
NATURE REVIEWS DRUG DISCOVERY
(2023)
Article
Chemistry, Multidisciplinary
Bo Peng, Xueli Chen, Guodong Yu, Fan Xu, Ruyi Yang, Zhenghang Yu, Jia Wei, Guodong Zhu, Lang Qin, Jiayi Zhang, Qundong Shen, Yanlei Yu
Summary: Researchers have developed a neuron-readable artificial photoreceptor that converts light into strong electric signals using photodeformable liquid crystal polymers (LCPs) and polyvinylidene fluoride trifluoroethylene (P(VDF-TrFE)). This artificial photoreceptor successfully transduces photo-induced electric signals to cells and tissues, communicates with neurons, and triggers spiking activities in blind retinas.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Physics, Applied
Fang Wang, Ming-Ding Li, Jun Peng Ma, Xiao-Liang Wang, Qun-Dong Shen
Summary: Endowing bulk electrocaloric polymers with excellent thermal conductivity is an effective solution for managing the heat generated by electronic devices. By mechanically stretching or electrospinning the polymer films, the alignment of molecular chains can be improved to enhance thermal transport performance. The thermal conductivity of the stretched film increased by a factor of two, while the electrospun film had a slightly lower thermal conductivity than the unoriented one. The stretched film exhibited a significantly higher adiabatic temperature change under an applied electric field compared to the electrospun film. This study provides a perspective on designing a promising thermal management system through integrating active refrigeration and passive heat dissipation in bulk electrocaloric polymers.
APPLIED PHYSICS LETTERS
(2023)
Article
Engineering, Biomedical
Dun Liu, Lei Li, Ben-Long Shi, Bo Shi, Ming-Ding Li, Yong Qiu, Di Zhao, Qun-Dong Shen, Ze-Zhang Zhu
Summary: Researchers have designed a multifunctional nanocomposite hydrogel that promotes bacteria-infected wound healing through ultrasound-triggered piezocatalytic therapy. The hydrogel contains barium titanate nanoparticles, which rapidly generate reactive oxygen species under ultrasonic vibration, providing excellent antibacterial efficacy. Additionally, the hydrogel exhibits self-healing and bioadhesive properties that accelerate full-thickness skin wound healing.
BIOACTIVE MATERIALS
(2023)
Review
Materials Science, Biomaterials
Yu Chen, Samira Pal, Quanyin Hu
Summary: Cell-based medicines have attracted attention for biomedical applications due to their low immunogenicity, compatibility, and ability to cross biological barriers. However, challenges such as preparation, stability, manufacturing, toxicity, and affordability need to be addressed for their clinical translation. The development of biotechnology and engineering approaches in materials sciences offers a platform to overcome these issues.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Engineering, Electrical & Electronic
Xinping Hu, Yaping Che, Zijie Zhang, Qun-Dong Shen, Baojin Chu
Summary: Multifunctional materials were achieved by designing composites of P(VDF-TrFE) ferroelectric polymer and BiFeO3-BaTiO3 nanofibers, combining the properties of the polymer and nanofibers to improve dielectric, piezoelectric, and pyroelectric properties, as well as to create multiple functionalities such as ferromagnetism, magnetoelectric effect, photothermal effect, photostriction, and photo-electric response. The composite materials can detect mechanical, magnetic, and optical signals and generate actuation by electrical and optical stimuli.
ACS APPLIED ELECTRONIC MATERIALS
(2021)
