期刊
STEM CELL RESEARCH & THERAPY
卷 7, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13287-016-0330-3
关键词
Mesenchymal stem cells; Cell therapy; Hepatic differentiation; Liver-derived mesenchymal stem cells
资金
- Chinese High Tech Research & Development (863) Program [SS2013AA020102]
- National Science and Technology Major Project [2012ZX10002004]
Mesenchymal stem cells (MSCs) represent an attractive cell type for research and therapy due to their ability to proliferate, differentiate, modulate immune reactions, and secrete trophic factors. MSCs exist in a multitude of tissues, including bone marrow, umbilical cord, and adipose tissues. Moreover, MSCs have recently been isolated from the liver. Compared with other MSC types, liver-derived human MSCs (LHMSCs) possess general morphologies, immune functions, and differentiation capacities. Interestingly, LHMCSs produce higher levels of pro-angiogenic, antiinflammatory, and anti-apoptotic cytokines than those of bone marrow-derived MSCs. Thus, these cells may be a promising therapeutic source for liver diseases. This paper summarizes the biological characteristics of LHMSCs and their potential benefits and risks for the treatment of liver diseases.
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