Article
Medicine, General & Internal
Antonio Maria Fea, Martina Menchini, Alessandro Rossi, Chiara Posarelli, Lorenza Malinverni, Michele Figus
Summary: The study investigated the efficacy and safety of the XEN63 implant in open-angle glaucoma patients, showing significant reduction in intraocular pressure and the need for hypotensive medications, with good short-term safety profile.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Skanda Rajasundaram, Nazlee Zebardast, Puja Mehta, Anthony P. Khawaja, Alasdair Warwick, Katherine Duchinski, Stephen Burgess, Dipender Gill, Ayellet V. Segre, Janey Wiggs
Summary: This study provides novel human genetic support for a causal role of both TIE1 and TEK signalling in regulating IOP. Combined evidence from cis-MR and colocalization analyses provide stronger support for TIE1 than TEK as a potential IOP-lowering therapeutic target.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Medicine, General & Internal
Liting Zhao, Jinfei Li, Lemeng Feng, Cheng Zhang, Wulong Zhang, Chao Wang, Ye He, Dan Wen, Weitao Song
Summary: This study assessed the current status and global trend of primary open angle glaucoma, the most common type of glaucoma. The research found an increase in interest, research, and publications on this topic. The study identified key researchers, institutions, partnerships, and scientific works, and described the study hotspots that transitioned from epidemiology to pathogenesis, diagnosis, and treatment. Interest and research in primary open angle glaucoma extend beyond ophthalmology to various other disciplines.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Aditya Belamkar, Alon Harris, Francesco Oddone, Alice Verticchio Vercellin, Anna Fabczak-Kubicka, Brent Siesky
Summary: Primary open-angle glaucoma (POAG) is prevalent in aging Asian populations, with distinctive characteristics and genetic differences compared to other ethnicities. Further research is needed to improve treatment plans for this high prevalence of glaucoma in Asian populations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Henry N. Marshall, Sean Mullany, Xikun Han, Ayub Qassim, Weixiong He, Mark M. Hassall, Joshua Schmidt, Daniel Thomson, Thi Thi Nguyen, Ella C. Berry, Lachlan S. W. Knight, Georgina L. Hollitt, Bronwyn Ridge, Angela Schulz, Richard A. Mills, Paul R. Healey, Ashish Agar, Anna Galanopoulos, John Landers, Stuart L. Graham, Alex W. Hewitt, Robert J. Casson, Stuart MacGregor, Owen M. Siggs, Jamie E. Craig
Summary: This study found an association between glaucoma polygenic risk score and the risk of commencement or escalation of intraocular pressure (IOP)-lowering therapy, highlighting the potential clinical usefulness of genetic risk stratification in glaucoma.
Article
Medicine, General & Internal
Pei-Yao Chang, Jiun-Yi Wang, Jia-Kang Wang, Tzu-Lun Huang, Yung-Ray Hsu
Summary: SLT treatment showed equivalent efficacy in controlling intraocular pressure in POAG and pseudophakic PACG patients after one year, but was more effective in eyes with PACG, especially in those with a lower baseline IOP.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Weijia Zhang, Yiwei Wang, Chen Xin, Yang Sun, Kai Cao, Huaizhou Wang, Ningli Wang
Summary: This study compared the outcomes of ab interno and ab externo circumferential trabeculotomy in patients with primary open-angle glaucoma, finding no significant difference in intraocular pressure reduction and surgical success rate between the two approaches. Both methods were found to be effective options for patients with a history of incisional glaucoma surgery.
FRONTIERS IN MEDICINE
(2021)
Article
Ophthalmology
Qing Sang, Chen Xin, Diya Yang, Dapeng Mu, Ningli Wang
Summary: This study investigated the pattern of intraocular pressure (IOP) changes in different postures among patients with open-angle glaucoma (OAG). The results showed that IOP significantly decreased with an increase in position height. The head tilted downwards, supine, left lateral decubitus, and right lateral decubitus positions resulted in higher IOP than in the seated position. Standing and walking significantly decreased IOP.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Ophthalmology
Rachel S. Chong, Hengtong Li, Alex J. Y. Cheong, Qiao Fan, Victor Koh, Lavanya Raghavan, Monisha E. Nongpiur, Ching-Yu Cheng
Summary: Observational studies suggest a link between myopia and primary open-angle glaucoma (POAG), but the evidence is inconsistent. This study used Mendelian randomization (MR) analysis to investigate the genetic causal associations among myopia, glaucoma, and glaucoma-related traits, overcoming confounding factors.
Review
Biochemistry & Molecular Biology
Saray Tabak, Sofia Schreiber-Avissar, Elie Beit-Yannai
Summary: Reactive oxygen species (ROS) play a key role in the pathogenesis of primary open-angle glaucoma (POAG), damaging trabecular meshwork cells and inducing apoptosis of retinal ganglion cells. Certain microRNAs (miRNAs) have been identified as potential therapeutic targets for regulating inflammatory and degenerative processes in POAG patients, offering promise for lowering or preventing oxidative stress injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Carmelo Macri, Christopher X. Wong, Samuel J. Tu, Robert Casson, Kuldev Singh, Sophia Y. Wang, Michelle T. Sun
Summary: This study aimed to investigate the association between systemic blood pressure and incident primary open-angle glaucoma (POAG). The results showed that higher systolic blood pressure (SBP) and pulse pressure (PP) were associated with an increased risk of incident POAG, while diastolic blood pressure (DBP) and mean arterial pressure (MAP) were not significantly associated with incident glaucoma.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Nutrition & Dietetics
Joelle E. Vergroesen, Tosca O. E. de Crom, Lauren C. Blekkenhorst, Caroline C. W. Klaver, Trudy Voortman, Wishal D. Ramdas
Summary: This study found that dietary nitrate intake was associated with a reduced risk of iOAG, particularly nitrate intake from vegetables and non-vegetable food sources. However, dietary nitrate intake was not associated with intraocular pressure.
Article
Medicine, General & Internal
Hiromitsu Onoe, Kazuyuki Hirooka, Koji Namiguchi, Shiro Mizoue, Hiroko Hosokawa, Hideki Mochizuki, Naoki Okada, Kana Tokumo, Hideaki Okumichi, Yoshiaki Kiuchi
Summary: This study compared the surgical outcomes of mu LOT-Phaco and iStent-Phaco procedures in primary open-angle glaucoma patients and found that both methods had comparable results.
FRONTIERS IN MEDICINE
(2023)
Article
Health Care Sciences & Services
Gabriel Zeno Munteanu, Zeno Virgiliu Ioan Munteanu, George Roiu, Cristian Marius Daina, Raluca Moraru, Liviu Moraru, Cristian Trambitas, Dana Badau, Lucia Georgeta Daina
Summary: The study is an epidemiological, retrospective, observational investigation aimed at assessing the health impact of tertiary prevention activities dedicated to preventing blindness caused by POAG and NTG. Results showed that specialized care led to a significant reduction in intraocular pressure in glaucoma patients, preventing disease progression.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biology
Tommaso Verdina, Matteo Gironi, Bruno Battaglia, Michele Gentile, Johanna Chester, Shaniko Kaleci, Gianluca Scatigna, Rodolfo Mastropasqua, Gian Maria Cavallini
Summary: The study aimed to investigate the efficacy and safety of micropulse laser trabeculoplasty (MLT) in patients with primary open-angle glaucoma (POAG). The results showed that MLT using a 577 nm yellow wavelength laser significantly reduced intraocular pressure (IOP) and the number of topical medications required for POAG patients, with no significant difference in terms of effectiveness and safety between 1500mW and 1000mW.