Article
Biochemistry & Molecular Biology
Sven Kuspiel, Dominik Wiemuth, Stefan Gruender
Summary: Research shows that the neuropeptide nocistatin does not directly activate ASIC1a channels, but rather indirectly activates them by acidifying the bath solution. This indicates the complexity of the regulatory mechanism of acid-sensing ion channels.
Article
Neurosciences
Miguel Salinas, Pascal Kessler, Dominique Douguet, Daad Sarraf, Nicolo Tonali, Robert Thai, Denis Servent, Eric Lingueglia
Summary: This study elucidated the inhibition mechanism of the snake venom toxin Mamb-1 on the acid-sensing ion channel ASIC1a through structure-activity relationship, molecular dynamics simulation, and experimental research. It provides important insights for further improvement and optimization of ASIC blockers.
Article
Endocrinology & Metabolism
Wei Wang, Mengyun Xu, Jiayin Yue, Qilun Zhang, Xiaomin Nie, Yan Jin, Zhi Zhang
Summary: ASIC1a in the PVN may serve as a potential new target for the therapeutic intervention of metabolic disorders.
Review
Immunology
Yayun Xu, Feihu Chen
Summary: ASIC1a is implicated in the pathogenesis of rheumatoid arthritis by promoting inflammation and joint damage. Blocking ASIC1a may offer a potential therapeutic approach to improve RA symptoms by regulating the biological processes of articular cartilage.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Yan Yang, Shi Jin, Jian Zhang, Weize Chen, Yufei Lu, Jun Chen, Zhixin Yan, Bo Shen, Yichun Ning, Yiqin Shi, Jing Chen, Jialin Wang, Sujuan Xu, Ping Jia, Jie Teng, Yi Fang, Nana Song, Xiaoqiang Ding
Summary: Ischemia-reperfusion injury (IRI) caused by acidification in ischemic tissues is the main driver of acute kidney injury (AKI). In this study, the researchers found that inhibiting acid-sensing ion channel 1a (ASIC1a) can alleviate renal IRI and reduce the expression of inflammatory factors. They also discovered that ASIC1a activation promotes the NF-kappa B/NLRP3 inflammasome pathway, which is involved in AKI. These findings suggest that ASIC1a may be a potential therapeutic target for treating AKI.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Cardiac & Cardiovascular Systems
Meredith A. Redd, Sarah E. Scheuer, Natalie J. Saez, Yusuke Yoshikawa, Han Sheng Chiu, Ling Gao, Mark Hicks, Jeanette E. Villanueva, Yashutosh Joshi, Chun Yuen Chow, Gabriel Cuellar-Partida, Jason N. Peart, Louise E. See Hoe, Xiaoli Chen, Yuliangzi Sun, Jacky Y. Suen, Robert J. Hatch, Ben Rollo, Di Xia, Mubarak A. H. Alzubaidi, Snezana Maljevic, Gregory A. Quaife-Ryan, James E. Hudson, Enzo R. Porrello, Melanie Y. White, Stuart J. Cordwell, John F. Fraser, Steven Petrou, Melissa E. Reichelt, Walter G. Thomas, Glenn F. King, Peter S. Macdonald, Nathan J. Palpant
Summary: Ischemia-reperfusion injury (IRI) is a major risk factor in cardiovascular disease, and acid-sensing ion channel 1a (ASIC1a) is significantly associated with cardiac IRI. Genetic ablation of ASIC1a improves cardiomyocyte viability after acute IRI, and therapeutic blockade of ASIC1a shows cardioprotective effects equivalent to benchmark drugs.
Article
Multidisciplinary Sciences
Ben Cristofori-Armstrong, Elena Budusan, Lachlan D. Rash
Summary: The study compared the potency and mechanism of action of mambalgins on rat and human ASIC1 variants, revealing that mambalgin-3 weakly inhibits human ASIC1b under severe acidosis, but potentiates currents under mild/moderate acidosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Aleksandr P. Kalinovskii, Dmitry I. Osmakov, Sergey G. Koshelev, Kseniya I. Lubova, Yuliya V. Korolkova, Sergey A. Kozlov, Yaroslav A. Andreev
Summary: In this study, neuroblastoma cells were differentiated into a neuronal-like phenotype and the expression and functionality of acid-sensing ion channels were investigated. It was found that retinoic acid-treated neuroblastoma expressed predominantly the acid-sensing ion channel 1a, which plays important roles in synaptic plasticity, neurodegeneration, and pain perception. This model system can be used for studying the effects of different ligands on native acid-sensing ion channels.
Article
Neurosciences
Vasilii Shteinikov, Konstantin Evlanenkov, Konstantin Bolshakov, Denis Tikhonov
Summary: Glutamate potentiates the activity of ASIC1a, allowing it to function in glutamatergic synapses. This potentiation occurs through a shift in the pH-dependent activation threshold.
Correction
Biochemistry & Molecular Biology
Kanchan Vats, Deepaneeta Sarmah, Aishika Datta, Jackson Saraf, Harpreet Kaur, Kanta Pravalika, Madhuri Wanve, Kiran Kalia, Anupom Borah, Kunjan R. Dave, Dileep R. Yavagal, Pallab Bhattacharya
Summary: The inadvertent misupload of loading control images for ASIC1a and NLRP1 blots was corrected without affecting the study conclusions. Despite the debate over using GAPDH as a loading control, the results obtained with beta-actin as the loading control were consistent with previous findings.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Review
Neurosciences
Victoria S. Foster, Lachlan D. Rash, Glenn F. King, Michelle M. Rank
Summary: This review discusses the expression of ASICs in peripheral and CNS-resident immune cells, and how their activation during pathological tissue acidosis can affect immune cell function, modulating inflammatory pathology in the CNS. It also highlights the importance of understanding the contribution of ASICs to immune cell function in neuropathology for potential therapeutic benefits.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Physiology
Selina M. Garcia, Jay S. Naik, Thomas C. Resta, Nikki L. Jernigan
Summary: This study demonstrates that ASIC1a activates IKCa/SKCa channels in mesenteric resistance arteries, which are crucial mediators of endothelium-dependent hyperpolarization and vasodilation. This novel evidence suggests that ASIC1a is an important contributor to endothelium-dependent vasodilation.
JOURNAL OF GENERAL PHYSIOLOGY
(2022)
Article
Biology
Yi Liu, Jichun Ma, Renee L. DesJarlais, Rebecca Hagan, Jason Rech, David Lin, Changlu Liu, Robyn Miller, Jeffrey Schoellerman, Jinquan Luo, Michael Letavic, Bruce Grasberger, Michael Maher
Summary: Liu et al's study reveals that small molecules can allosterically inhibit ASIC1 channel activation and desensitization by binding at the acidic pocket and stabilizing the closed state of the channel.
COMMUNICATIONS BIOLOGY
(2021)
Article
Neurosciences
Shaopeng Chi, Yaxiong Cui, Haiping Wang, Jinghui Jiang, Tingxin Zhang, Suhua Sun, Zhuan Zhou, Yi Zhong, Bailong Xiao
Summary: This study reveals the importance of mechanotransduction mediated by Piezo1 in astrocytes for adult neurogenesis and cognitive functions. Piezo1 in astrocytes mediates mechanically evoked calcium responses and ATP release, and its deficiency leads to severe impairment in brain structure and function.
Article
Cell Biology
Kangcheng Zhao, Ran An, Qian Xiang, Gaocai Li, Kun Wang, Yu Song, Zhiwei Liao, Shuai Li, Wenbin Hua, Xiaobo Feng, Xinghuo Wu, Yukun Zhang, Abhirup Das, Cao Yang
Summary: Extracellular lactate regulates intercellular reactive oxygen species (ROS) levels through ASIC1 and ASIC3, activating the NF-kappa B signaling pathway to promote NLRP3 inflammasome activation and IL-1 beta release, ultimately contributing to NP degeneration.
CELL PROLIFERATION
(2021)
Article
Neurosciences
Chang-geng Song, Xin Kang, Fang Yang, Wan-qing Du, Jia-jia Zhang, Long Liu, Jun-jun Kang, Ning Jia, Hui Yue, Lu-yu Fan, Sheng-xi Wu, Wen Jiang, Fang Gao
Summary: This review delves into the important role of the endocannabinoid system (ECS) in neurodevelopment, particularly its impact on GABAergic interneurons. It also discusses the regulatory effects of the ECS on processes such as the expansion of neural stem/progenitor cells, migration, specification, and maturation of neurons, as well as its potential implications in various neurological and psychiatric disorders such as epilepsy, schizophrenia, major depressive disorder, and autism spectrum disorder.
REVIEWS IN THE NEUROSCIENCES
(2021)
Article
Clinical Neurology
Jingjing Zhao, Fang Yang, Changgeng Song, Li Li, Xiai Yang, Xiaofeng Wang, Liping Yu, Jun Guo, Kangjun Wang, Feng Fu, Wen Jiang
Summary: The GATE-ICH trial aims to investigate the effects of small doses of oral glibenclamide on perihematomal edema and prognosis of patients with ICH. This multicenter randomized controlled trial in China will assess the primary outcome of poor functional outcomes at 90 days post-enrollment.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Yingying Su, Huijin Huang, Mengdi Jiang, Suyue Pan, Li Ding, Le Zhang, Wen Jiang, Xiaorong Zhuang
Summary: The multicenter study compared the efficacy and safety of phenobarbital and valproate for generalized convulsive status epilepticus, with phenobarbital showing a higher rate of SE termination compared to valproate. There were no significant differences in EEG epileptic discharge nontermination rates between the two groups.
Review
Clinical Neurology
Tom J. Moullaali, Xia Wang, Else Charlotte Sandset, Lisa J. Woodhouse, Zhe Kang Law, Hisatomi Arima, Kenneth S. Butcher, John Chalmers, Candice Delcourt, Leon Edwards, Salil Gupta, Wen Jiang, Sebastian Koch, John Potter, Adnan Qureshi, Thompson G. Robinson, Rustam Al-Shahi Salman, Jeffrey L. Saver, Nikola Sprigg, Joanna M. Wardlaw, Craig S. Anderson, Philip M. Bath
Summary: Interventions to lower blood pressure within 7 days of intracerebral hemorrhage onset were effective in reducing bleeding, but did not show overall benefit on functional recovery. The treatment effect varied according to strategy and agent.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Yong-Li Jiang, Chang-Geng Song, Hui-Min Zhou, Ban Feng, Jing-Jing Zhao, Yu Liu, Yu-Lin Man, Jing Han, Shui-Bing Liu, Wen Jiang
Summary: Sleep-related hypermotor epilepsy (SHE) is a focal epilepsy syndrome that may be caused by disruption of GABAergic neurotransmission. Rare variants in the GABRG2 gene may contribute to the pathogenesis of SHE. Our study found three rare GABRG2 variants in three unrelated SHE patients and showed that these variants affect GABA-evoked current amplitudes and synaptic clustering and distribution of GABA(A)R.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Jingjing Zhao, Fang Yuan, Changgeng Song, Rong Yin, Mingze Chang, Wei Zhang, Bei Zhang, Liping Yu, Yi Jia, Wiling Ma, Yongbin Song, Chengkai Wang, Chaohui Song, Xinfai Wang, Lei Shang, Fang Yang, Wen Jiang
Summary: In patients with severe stroke, modified full enteral nutrition or hypocaloric enteral nutrition did not significantly reduce the risk of poor outcomes compared with full enteral nutrition over a 90-day period. Hypocaloric enteral nutrition might be associated with increased mortality compared with modified full enteral nutrition. Further studies are needed to investigate the optimal strategy.
Article
Neurosciences
Xin Kang, Zheng-Ping Zhang, Chang-Geng Song, Long Liu, Yan Zhao, Jin-Le Du, Yu-Bo Lai, Xiu-Li Cao, Wen-Min Ye, Yu-Fei Zhang, Min-Hua Zheng, Yu-Hong Zeng, Xiao-Long Sun, Sheng-Xi Wu, Fang Gao
Summary: During neurodevelopment, the differentiation of neural stem/progenitor cells into neurons is regulated by the Notch signaling pathway. In this study, the effect of a Notch signaling blocker, gamma-secretase inhibitor (GSI), on the morphological development of differentiating neurons was investigated. The results showed that GSI application impeded neurite outgrowth and increased the expression of miR-342-5p, a downstream effector of Notch signaling. Furthermore, the shorter neurites induced by GSI could be partially rescued by miR-342-5p inhibitors, indicating the involvement of STAT3 as a possible target of miR-342-5p in this process. These findings provide important insights for future therapeutic research.
NEUROSCIENCE LETTERS
(2022)
Article
Endocrinology & Metabolism
Xin-shang Wang, Yong-li Jiang, Liang Lu, Ban Feng, Xue Ma, Kun Zhang, Shao-yu Guan, Le Yang, Qing-yu Fan, Xiao-chen Zhu, Fan Yang, Jing-yu Qi, Liu-kun Yang, Xu-bo Li, Ming-gao Zhao, Wen Jiang, Zhen Tian, Shui-bing Liu
Summary: Chronic pain, often accompanied by anxiety disorders, is difficult to treat due to the exacerbating relationship between the two conditions. GIP, previously studied in neurodegenerative diseases, was found to have analgesic and anxiolytic effects in the treatment of chronic inflammatory pain and pain-related anxiety, possibly through attenuation of neuroinflammation and inhibition of excitatory transmission in the ACC. GIPR activation may be a promising target for future therapies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Xin Kang, Bing Zhang, Wanqing Du, Rui Zhao, Xuedong Liu, Ya Bai, Xiaobing Jiang, Jie Pang, Chenguang Zhao, Xiang Mou, Fang Gao, Hua Yuan, Xiaolong Sun
Summary: In this study, the therapeutic effectiveness of high-frequency (HF) and low-frequency (LF) rTMS in a rat model of Parkinson's disease (PD) was compared. The results showed that HF rTMS had stronger anti-inflammatory and neuroprotective effects compared to LF rTMS. Furthermore, the expression of endocannabinoid receptor 2 (CB2R), as well as the levels of anandamide (AEA) and 2-arachidonoylglycerol (2-AG), were significantly suppressed by HF rTMS. This study suggests that the modulation of the endocannabinoid/CB2R system may be a potential mechanism for the greater effectiveness of HF rTMS in inhibiting astrogliosis.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Xiaojing Shi, Yuanyuan Wang, Xuan Wang, Xiaogang Kang, Fang Yang, Fang Yuan, Wen Jiang
Summary: This study investigated the long-term outcomes of adult cryptogenic febrile infection-related epilepsy syndrome (FIRES). The results revealed that over one-third of patients died in the hospital, but 55% of survivors regained functional independence. However, most patients developed drug-resistant epilepsy and required long-term use of anti-seizure medications.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Yan Liu, Xiao-Gang Kang, Qiong Gao, Yu Liu, Chang-Geng Song, Xiao-Jing Shi, Jia-Ning Wu, Wen Jiang
Summary: This retrospective study evaluated the long-term survival and functional outcomes of patients with prolonged disorders of consciousness (pDoC) 1-8 years after brain injuries. The presence of sleep spindles was found to be significantly associated with both long-term survival and functional outcomes in pDoC patients.
Article
Medicine, General & Internal
Jingjing Zhao, Changgeng Song, Deshuai Li, Xiai Yang, Liping Yu, Kangjun Wang, Jun Wu, Xiaofeng Wang, Dongsong Li, Bo Zhang, Binyong Li, Jun Guo, Weikui Feng, Feng Fu, Xinrong Gu, Jian Qian, Jialong Li, Xiangjun Yuan, Qiuwu Liu, Jiang Chen, Xiaocheng Wang, Yi Liu, Dong Wei, Ling Wang, Lei Shang, Fang Yang, Wen Jiang
Summary: This study found no evidence that glibenclamide (1.25 mg, 3/day) significantly reduces the proportion of poor outcome at day 90 after intracerebral hemorrhage. Additionally, glibenclamide may result in a higher incidence of hypoglycemia.
Article
Neurosciences
Xuan Wang, Yuan-Yuan Wang, Qiong Gao, Yao-Yao Zhang, Jian Wan, Chang-Geng Song, Jing-Ya Wei, Xiao-Gang Kang, Fang Yang, Wen Jiang
Summary: Age, etiology of CSE, non-convulsive SE, mechanical ventilation, and abnormal albumin level at CSE onset are the predictors used to construct and validate a nomogram for predicting individualized risks of poor functional outcomes in CSE patients. This nomogram is an important modification of the END-IT score.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cell Biology
Changgeng Song, Jingjing Zhao, Jianmin Hao, Dan Mi, Jiajia Zhang, Yingying Liu, Shengxi Wu, Fang Gao, Wen Jiang
Summary: This study found that the neuropeptide fragment NPCT is widely distributed in the brain and is involved in neuronal death by regulating energy status. NPCT can promote ATP production, enhance mitochondrial respiratory chain activity, increase neuronal respiration capacity, and have multiple effects on promoting neuronal growth and inhibiting cell apoptosis. In the RSE model, NPCT's protective effect on hippocampal neurons was confirmed through immunoneutralization experiments.
CELL DEATH DISCOVERY
(2023)
Article
Medicine, General & Internal
Chang-geng Song, Li-jie Bi, Jing-jing Zhao, Xuan Wang, Wen Li, Fang Yang, Wen Jiang
Summary: The study results indicate that in the secondary prevention of cardioembolic stroke due to NVAF, hirudin plus aspirin therapy has higher safety and comparable efficacy compared to warfarin.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)