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Medicine, Research & Experimental
Minji Choi, Nagyeong Byun, Jae Ryoung Hwang, Yun-Sun Choi, Ji-Hee Sung, Suk-Joo Choi, Jung-Sun Kim, Soo-Young Oh, Cheong-Rae Roh
Summary: This study evaluated the effect of chloroquine compounds on syncytial differentiation and autophagy in primary human trophoblasts. The results showed that chloroquine compounds could mitigate biochemical and morphological syncytial trophoblast differentiation through the JAK signaling pathway rather than the inhibition of autophagic activity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Ghizlane Choukrani, Nienke Visser, Natasha Ustyanovska Avtenyuk, Mirjam Olthuis, Glenn Marsman, Emanuele Ammatuna, Harm Jan Lourens, Toshiro Niki, Gerwin Huls, Edwin Bremer, Valerie R. Wiersma
Summary: AML is a malignancy associated with poor survival rates, especially due to therapy-resistant relapse. The glycan-binding protein Gal-9 has shown tumor-selective cytotoxicity, dependent on autophagy inhibition, making it a potential therapeutic option for AML. In this study, Gal-9 was found to be cytotoxic for AML cells, including stem cells, and showed efficacy in AraC-resistant AML cases. It also enhanced the cytotoxic effect of Azacytidine, providing a possible treatment approach for AML patients not eligible for intensive AraC treatment.
CELL DEATH DISCOVERY
(2023)
Editorial Material
Dermatology
Wendy B. Bollag
Summary: The calcium-sensing receptor (CaSR) plays a crucial role in skin functions such as differentiation, barrier repair, and wound healing. Reduced levels of CaSR in aged individuals may lead to impaired functions, but CaSR agonists could potentially be used to correct these defects and improve aging-related skin wound healing.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Respiratory System
Ruijuan Guan, Liang Yuan, Jingpei Li, Jian Wang, Ziying Li, Zhou Cai, Hua Guo, Yaowei Fang, Ran Lin, Wei Liu, Lan Wang, Qiuyu Zheng, Jingyi Xu, You Zhou, Jing Qian, Mingjing Ding, Jieping Luo, Yuanyuan Li, Kai Yang, Dejun Sun, Hongwei Yao, Jianxing He, Wenju Lu
Summary: Bone morphogenetic protein 4 (BMP4) plays a crucial role in modulating lung fibrosis by reducing cellular senescence and promoting mitophagy, which inhibits the differentiation of fibroblasts into myofibroblasts and decreases extracellular matrix production.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Cell Biology
Qian Xu, Yonghui Song, Lili Lu
Summary: In this study, we found increased expression of let-7d and decreased expression of KDM3A and ENO2 in pre-eclampsia (PE) patients. Experimental evidence demonstrated that let-7d suppressed trophoblast cell progression and induced apoptosis by inhibiting KDM3A and promoting ENO2 methylation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Mai Sato, Asako Inohaya, Eriko Yasuda, Haruta Mogami, Yoshitsugu Chigusa, Kaoru Kawasaki, Yosuke Kawamura, Yusuke Ueda, Hiroshi Takai, Masaki Mandai, Eiji Kondoh
Summary: A three-dimensional placental organ bud was successfully generated from human iPSCs and transplanted into the murine uterus, showing a 22% engraftment success rate. These iPSC-derived placental organ buds could serve as a new model for studying placental function and pathology in research.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Jian Li, Cheng Quan, Yun-Ling He, Yan Cao, Ying Chen, Yu-Fei Wang, Li-Ying Wu
Summary: This study reveals that hypoxia accelerates erythroid differentiation by enhancing autophagy through suppressing mTORC1 signaling. The upregulation of the HIF-1 target gene REDD1 is responsible for the suppression of mTORC1 signaling and enhancement of autophagy, promoting erythroid differentiation under hypoxic conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Fisheries
W. A. D. L. R. Warnakula, H. M. V. Udayantha, D. S. Liyanage, W. K. M. Omeka, Chaehyeon Lim, Gaeun Kim, D. M. K. P. Sirisena, B. P. M. Vileka Jayamali, Qiang Wan, Jehee Lee
Summary: This study demonstrates for the first time that PhGal9 promotes M2 macrophage polarization and prevents VHSV attachment and replication by neutralizing virion and autophagy in teleost fish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Cell Biology
Xiaoheng Li, Yinghui Fang, Lanlan Chen, Hehua Quan, Yiyan Wang, Ren-Shan Ge
Summary: BMP4 regulates the development of Leydig cells and blocks the differentiation of stem/progenitor Leydig cells into adult Leydig cells through both SMAD-dependent and SMAD-independent signaling pathways.
CELL DEATH & DISEASE
(2022)
Article
Environmental Sciences
Khursheed Iqbal, Stephen H. Pierce, Keisuke Kozai, Pramod Dhakal, Regan L. Scott, Katherine F. Roby, Carrie A. Vyhlidal, Michael J. Soares
Summary: TCDD exposure affects placental adaptations, with higher doses leading to pregnancy termination. These adaptations depend on maternal AHR signaling, rather than placental or fetal AHR signaling or the presence of CYP1A1 as a prominent AHR target.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Multidisciplinary Sciences
Weizhen Jia, Lingyu Kong, Hiroyasu Kidoya, Hisamichi Naito, Fumitaka Muramatsu, Yumiko Hayashi, Han-Yun Hsieh, Daishi Yamakawa, Daniel K. Hsu, Fu-Tong Liu, Nobuyuki Takakura
Summary: This study demonstrates that Gal-3 expression in long-term repopulating HSCs is induced in response to Tie2 and Mpl, and plays a crucial role in maintaining HSC quiescence through regulation of p21.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Lingxin Zhu, Yi Tang, Xiao-Yan Li, Samuel A. Kerk, Costas A. Lyssiotis, Xiaoyue Sun, Zijun Wang, Jung-Sun Cho, Jun Ma, Stephen J. Weiss
Summary: The interaction between metalloproteins Mmp9 and Mmp14 and carbohydrate-binding protein galectin-3 plays a critical role in osteoclast-mediated bone resorption. The ability of Mmp9 and Mmp14 to degrade galectin-3 on the cell surface depends on its binding protein Lrp-1. These findings reveal a previously unrecognized galectin-3/Lrp1 axis that regulates both the transcriptional programs and intracellular signaling cascades essential for osteoclast function.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Cell & Tissue Engineering
Jie Zhou, Junying Yang, Yuan Dong, Yaru Shi, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: Our study has for the first time established the direct role of OSMR in regulating osteogenic differentiation of marrow stromal progenitor cells through ERK-mediated autophagy signaling. OSMR thus contributes to bone homeostasis through dual regulation of osteoblasts and osteoclasts. It also suggests that OSMR may be a potential target for the treatment of metabolic disorders such as osteoporosis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Obstetrics & Gynecology
John D. Aplin, Carolyn J. P. Jones
Summary: This study investigates the regulation of cytotrophoblast proliferation and differentiation in the human placental villus. A new hypothesis on vCTB dynamics has been proposed, suggesting a reversible transition from a reserve population to a mitotically active state, followed by irreversible differentiation to intermediate cells. The study also highlights the need for further research on trophoblast lifecycle and dynamics in normal pregnancy and diseases such as pre-eclampsia and fetal growth restriction.
HUMAN REPRODUCTION UPDATE
(2021)
Article
Immunology
Ji Li, Ziquan Sun, Yu Lin, Yan Yan, Haichao Yan, Bao Jing, Zhiyang Han
Summary: The study found that SDC4 is highly expressed in periodontitis and promotes osteoclast differentiation by activating autophagy, shedding light on its important role in bone resorption during periodontitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)