Investigation of the functional role of human Interleukin-8 gene haplotypes by CRISPR/Cas9 mediated genome editing

Genetic screens and functional genomics using CRISPR/Cas9 technology

(2015) Ella Hartenian et al.   FEBS Journal

Experimental gingivitis, bacteremia and systemic biomarkers: a randomized clinical trial

(2015) D. F. Kinane et al.   JOURNAL OF PERIODONTAL RESEARCH

Quantitative Assessment of the Associations Between Interleukin-8 Polymorphisms and Periodontitis Susceptibility

(2015) Xing Chen et al.   JOURNAL OF PERIODONTOLOGY

Expanding the Biologist’s Toolkit with CRISPR-Cas9

(2015) Samuel H. Sternberg et al.   MOLECULAR CELL

Photoactivatable CRISPR-Cas9 for optogenetic genome editing

(2015) Yuta Nihongaki et al.   NATURE BIOTECHNOLOGY

Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells

(2015) Daesik Kim et al.   NATURE METHODS

A prudent path forward for genomic engineering and germline gene modification

(2015) D. Baltimore et al.   SCIENCE

Elevated Plasma P-Selectin Autoantibodies in Primary Sjögren Syndrome Patients with Thrombocytopenia

(2015) Ya-Hui Hu et al.   MEDICAL SCIENCE MONITOR

The Role of Chemokines in Hypertension

(2015) Helena Martynowicz et al.   Advances in Clinical and Experimental Medicine

Multiple roles of the coagulation protease cascade during virus infection

(2014) S. Antoniak et al.   BLOOD

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

TLR2 Promoter Hypermethylation Creates Innate Immune Dysbiosis

(2014) M. Benakanakere et al.   JOURNAL OF DENTAL RESEARCH

Neutrophil homeostasis and inflammation: novel paradigms from studying periodontitis

(2014) G. Hajishengallis et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease

(2014) Cem Kuscu et al.   NATURE BIOTECHNOLOGY

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

In vitro Coculture Assay to Assess Pathogen Induced Neutrophil Trans-epithelial Migration

(2014) Mark E. Kusek et al.   Jove-Journal of Visualized Experiments

lnterleukin-8 gene polymorphism and susceptibility to gastric cancer in a brazilian population

(2013) Aledson V Felipe et al.   BIOLOGICAL RESEARCH

Association between IL8 haplotypes and pathogen levels in chronic periodontitis

(2013) L. S. Finoti et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases

(2013) S. W. Cho et al.   GENOME RESEARCH

Clinical outcomes of periodontal therapy are not influenced by the ATC/TTC haplotype in theIL8gene

(2013) S. C. T. Corbi et al.   JOURNAL OF PERIODONTAL RESEARCH

Haplotype Analysis of Interleukin-8 Gene Polymorphisms in Chronic and Aggressive Periodontitis

(2013) Petra Borilova Linhartova et al.   MEDIATORS OF INFLAMMATION

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

(2013) Vikram Pattanayak et al.   NATURE BIOTECHNOLOGY

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

(2013) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

(2013) Thomas J. Cradick et al.   NUCLEIC ACIDS RESEARCH

Pathogen levels and clinical response to periodontal treatment in patients withInterleukin 8haplotypes

(2013) Livia S. Finoti et al.   Pathogens and Disease

Haplotypes of susceptibility to chronic periodontitis in the Interleukin 8 gene do not influence protein level in the gingival crevicular fluid

(2012) Sâmia C.T. Corbi et al.   ARCHIVES OF ORAL BIOLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Effect of scaling and root planing on interleukin-1β, interleukin-8 and MMP-8 levels in gingival crevicular fluid from chronic periodontitis patients

(2012) Ł. Konopka et al.   JOURNAL OF PERIODONTAL RESEARCH

Functional characterisation of bovine interleukin 8 promoter haplotypes in vitro

(2012) Kieran G. Meade et al.   MOLECULAR IMMUNOLOGY

IL1gene polymorphisms in relation to external apical root resorption concurrent with orthodontia

(2012) P Linhartova et al.   ORAL DISEASES

AA genotype of IL-8 −251A/T is associated with low PaO2/FiO2in critically ill patients and with increased IL-8 expression

(2012) PETCH WACHARASINT et al.   RESPIROLOGY

Haplotypes in the Interleukin 8 Gene and Their Association with Chronic Periodontitis Susceptibility

(2010) Raquel M. Scarel-Caminaga et al.   BIOCHEMICAL GENETICS

Association of haplotypes in the IL8 gene with susceptibility to chronic periodontitis in a Brazilian population

(2010) Yeon Jung Kim et al.   CLINICA CHIMICA ACTA

Interleukin-8 Gene Promoter Polymorphism (rs4073) May Contribute to Chronic Periodontitis

(2010) Denise C. Andia et al.   JOURNAL OF PERIODONTOLOGY

Modulation of TLR2 Protein Expression by miR-105 in Human Oral Keratinocytes

(2009) Manjunatha R. Benakanakere et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Interleukin-1  (IL-1 ) Single-Nucleotide Polymorphism at Position 3954 and Red Complex Periodontopathogens Independently and Additively Modulate the Levels of IL-1  in Diseased Periodontal Tissues

(2008) S. B. Ferreira et al.   INFECTION AND IMMUNITY

P. gingivalis interactions with epithelial cells

(2007) Denis et al.   Frontiers in Bioscience-Landmark