Article
Infectious Diseases
Delveen R. Ibrahim, Christine E. R. Dodd, Dov J. Stekel, Remilekun T. Meshioye, Mathew Diggle, Michelle Lister, Jon L. Hobman
Summary: Cephalosporin therapy failure is a serious problem worldwide for infection control. Cephalosporin-resistant infections are often caused by multidrug-resistant E. coli producing ESBLs and/or pAmpC beta-lactamases. Analysis of MDR E. coli isolates from a UK hospital revealed a high prevalence of ESBL/pAmpC genetic determinants and significant correlations between resistance genes and specific antibiotics. The findings emphasize the importance of improved antibiotic therapy guidelines, including reduced usage and enhanced surveillance.
Article
Environmental Sciences
Xiangpeng Zeng, Yu Cao, Lanning Wang, Min Wang, Qiang Wang, Qingxiang Yang
Summary: This study reveals that multidrug resistant (MDR) bacterial strains have a higher viability and different gene expression patterns compared to susceptible strains under hexavalent chromium (Cr(VI) stress. The MDR strain showed higher bacteriostatic rates and lower levels of reactive oxygen species compared to the susceptible strain. Moreover, the MDR strain also exhibited higher expression levels of antibiotic resistance genes and other related genes.
ENVIRONMENTAL POLLUTION
(2023)
Article
Microbiology
Yuhang Wang, Junfeng Su, Ziyan Zhou, Jie Yang, Wenjuan Liu, Yafen Zhang, Pengyu Zhang, Tingting Guo, Guocai Li
Summary: As multidrug-resistant pathogens emerge and spread rapidly, novel antibiotics are urgently needed. Traditional Chinese medicine, such as baicalein, can be used as an adjuvant to enhance the efficacy of antibiotics. Baicalein was found to potentiate doxycycline against multidrug-resistant Gram-negative pathogens by disrupting the bacterial membrane and enhancing antibiotic entry. It can also increase the production of reactive oxygen species and inhibit multidrug efflux pumps and biofilm formation to potentiate antibiotic efficacy.
MICROBIOLOGY SPECTRUM
(2023)
Review
Gastroenterology & Hepatology
Irene Wuethrich, Benedikt W. Pelzer, Yascha Khodamoradi, Maria J. G. T. Vehreschild
Summary: The introduction of the first antibiotic drug about 100 years ago has had a significant impact on human medicine, but has also led to the rise of resistant pathogen strains and a reduction in microbiota diversity. In addition to traditional antibiotics, microbiota-based treatments and other promising interventions show potential in combating antibiotic resistance.
Article
Biotechnology & Applied Microbiology
Naveen Chaudhary, Balvinder Mohan, Ravimohan S. Mavuduru, Yashwant Kumar, Neelam Taneja
Summary: The study investigated a novel lytic phage vB_EcoA_RDN8.1 active against drug-resistant uropathogenic E. coli isolates, showing good killing efficacy, stability, and biofilm inhibition capability. This phage has the potential for treating highly drug-resistant UTIs caused by UPEC.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Environmental Sciences
Samar Ragab, Shrouk Mohamed Gouda, Mohamed Abdelmoteleb, Ayman El-Shibiny
Summary: This study aims to explore the possibility of using phages against pathogenic and MDR Escherichia coli strains isolated from wastewater treatment plants. Phage ZCEC13 was selected based on its promising activity and host range to undergo identification and characterization. The results reported the stability of ZCEC13 under various conditions and its high efficiency in killing MDR bacteria.
ENVIRONMENTAL TECHNOLOGY
(2023)
Article
Microbiology
Daniel Gulyas, Katalin Kamotsay, Dora Szabo, Bela Kocsis
Summary: In this study, the antibacterial efficacy of delafloxacin was analyzed in 47 Escherichia coli strains, revealing resistance rates of 47% for delafloxacin and 51% for ciprofloxacin. Whole-genome sequencing of two multidrug-resistant strains identified multiple chromosomal mutations mediating delafloxacin resistance. The study highlights the high rate of delafloxacin resistance in multidrug-resistant E. coli and the presence of the E. coli ST43 international high-risk clone in Hungary.
Article
Veterinary Sciences
Iqra Nazir, Masood Rabbani, Ali Ahmad Sheikh, Sehrish Firyal, Sohail Raza, Muhammad Ilyas Riaz
Summary: The study demonstrated the significant antibacterial activity of seven different flower ethanolic extracts against MDR E. coli, with Rosa damascena Miller and Bombax ceiba having the lowest MIC values.
PAKISTAN VETERINARY JOURNAL
(2021)
Article
Microbiology
Belkys C. Sanchez, Emmaline R. Heckmann, Sabrina I. Green, Justin R. Clark, Heidi B. Kaplan, Robert F. Ramig, Casey Hines-Munson, Felicia Skelton, Barbara W. Trautner, Anthony W. Maresso
Summary: The development of phage cocktails that can lyse contemporary E. coli strains isolated from patients with spinal cord injury (SCI) and display strong biofilm-forming properties is reported in this study. The phage cocktails showed high efficacy against biofilms in two in vitro CAUTI models, and the use of antibiotics together with the phage cocktail prevented or reduced the emergence of E. coli resistant to phage in human urine. These findings suggest that the phage cocktails have therapeutic potential against CAUTI.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Microbiology
Johann D. D. Pitout, Gisele Peirano, Liang Chen, Rebekah DeVinney, Yasufumi Matsumura
Summary: Escherichia coli ST1193 is an emerging global high-risk clone and an important cause of community-onset urinary and bloodstream infections. It imitates the success of the MDR clone E. coli ST131 and is the only other MDR clone that is dominant among unselected E. coli populations.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Immunology
Chankiat Songsantiphap, Jakapat Vanichanan, Tanittha Chatsuwan, Pravit Asawanonda, Einapak Boontaveeyuwat
Summary: The study demonstrated that methylene blue-mediated antimicrobial photodynamic therapy effectively decreased the quantity of various drug-resistant gram-negative bacteria, especially when using high light fluence. This treatment option shows promise for addressing the current crisis of highly drug-resistant bacteria.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Naveen Chaudhary, Ravi Kumar Maurya, Dharminder Singh, Balvinder Mohan, Neelam Taneja
Summary: Urinary tract infections (UTIs) are common bacterial infections in humans. A lytic phage 590B has been discovered to effectively disrupt bacterial biofilms and can be used as an alternative to antibiotics in the treatment of multidrug-resistant UTIs.
Article
Engineering, Environmental
Eri van Heijnsbergen, Gunnar Niebaum, Volker Laemmchen, Alicia Borneman, Lucia Hernandez Leal, Joerg Klasmeier, Heike Schmitt
Summary: This study investigated the occurrence of Escherichia coli and antibiotic-resistant E. coli in the Dutch-German transboundary catchment of the Vecht River. The study found a higher proportion of ESBL-EC in German wastewater treatment plants compared to Dutch plants. The modeling approach predicted E. coli concentrations to be below the threshold for good bathing water quality.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Microbiology
Miklos Fuzi, Evgeni Sokurenko
Summary: Favorable fitness in commensal colonization is a prime facilitator of clonal dissemination in bacteria. The pandemic-like global expansion of uropathogenic strains of E. coli-ST131-H30 and ST1193 in the last few decades can be attributed to the presence of colonization-associated genes, low-cost plasmids, integrons with weak promoters, and fluoroquinolone-resistance conferring mutations. These genetic factors contribute to the long-term colonization of healthy individuals and circulation in the community, even in low or no fluoroquinolone use environments, and warrant further studies to monitor and reduce antibiotic resistance spread.
Review
Infectious Diseases
Mikaela M. Walker, Jason A. Roberts, Benjamin A. Rogers, Patrick N. A. Harris, Fekade B. Sime
Summary: Escherichia coli is a common commensal and pathogenic bacterium in the human microbiota, but multi drug resistance poses challenges in its treatment. This paper reviewed the literature on the development of multi drug resistance in uropathogenic E. coli (UPEC) and explored current and emerging treatment strategies. Overreliance on carbapenems has led to the dissemination of carbapenem resistance, calling for alternative treatment options. The emergence of new antimicrobials brings hope to the treatment of multi drug resistant E. coli urosepsis.
