期刊
SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep19399
关键词
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资金
- Vitagora Competitive Cluster
- French FUI (Fond Unique Interministeriel) [F1010012D]
- FEDER (Fonds Europeen de Developpement Regional) [Bourgogne: 34606, Auvergne: 32025]
- Burgundy Region
- Conseil General 21
- Grand Dijon
- ANR VISCERALGY [ANR-09-MNPS-037-01]
- Conseil Regional d'Auvergne (MHIB grant)
- Merck Medication Familiale (Dijon, France)
- Biovitis (Saint Etienne de Chomeil, France)
Visceral pain and intestinal dysbiosis are associated with Irritable Bowel Syndrome (IBS), a common functional gastrointestinal disorder without available efficient therapies. In this study, a decrease of Faecalibacterium prausnitzii presence has been observed in an IBS-like rodent model induced by a neonatal maternal separation (NMS) stress. Moreover, it was investigated whether F. prausnitzii may have an impact on colonic sensitivity. The A2-165 reference strain, but not its supernatant, significantly decreased colonic hypersensitivity induced by either NMS in mice or partial restraint stress in rats. This effect was associated with a reinforcement of intestinal epithelial barrier. Thus, F. prausnitzii exhibits anti-nociceptive properties, indicating its potential to treat abdominal pain in IBS patients.
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