Article
Food Science & Technology
Ho-Jeong Bang, Mok-Ryeon Ahn
Summary: This study found that pinobanksin exhibits antiangiogenic effect by inducing endothelial cell apoptosis, and it can be developed as an antiangiogenic agent. The mechanism involves inactivation of the Raf/MEK/ERK pathway and activation of apoptotic signaling such as caspase cascades.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Kejia Kan, Yifei Mu, Marielle Bouschbacher, Carsten Sticht, Natalia Kuch, Martin Sigl, Nuh Rahbari, Norbert Gretz, Prama Pallavi, Michael Keese
Summary: The study revealed a novel biphasic response of human umbilical vein endothelial cells to blue light illumination. Low fluence blue light promoted cell activities, while high fluence illumination had the opposite effect by upregulating pro-apoptotic signaling pathways. These findings provide insights into photobiomodulation by blue light and potential treatment strategies for angiogenesis-dependent diseases.
Article
Environmental Sciences
Jiajing Cui, Pingwei Wang, Shuqi Yan, Yujun Liang, Dongge Liu, Shuping Ren
Summary: The study aims to explore the role of ferroptosis in endothelial cell dysfunction and its underlying mechanisms.
Article
Chemistry, Medicinal
Chin-Feng Hsuan, Thung-Lip Lee, Wei-Kung Tseng, Chau-Chung Wu, Chi-Chang Chang, Tsui-Ling Ko, Ya-Ling Chen, Jer-Yiing Houng
Summary: The study demonstrated that extracts from Glossogyne tenuifolia (GT) can significantly increase nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs), with the root methanol extract showing the most potent effect. The root methanol extract increased NO production by increasing eNOS expression and activating eNOS phosphorylation at serine(1177).
Article
Genetics & Heredity
Regina L. Binz, Rupak Pathak
Summary: This study investigated the cytogenetic integrity of primary human umbilical vein endothelial cells (HUVECs) and found that approximately 50% of the cells have a deletion of the Xq terminal region. Additionally, a similar Xq deletion was identified in the daughter cell line generated by fusing HUVECs with A549 cells.
Article
Pharmacology & Pharmacy
Wei Liu, Yanghui Ou, Yumeng Yang, Xuemei Zhang, Liqi Huang, Xiaohua Wang, Buling Wu, Mingcheng Huang
Summary: The study demonstrated that punicalagin has a protective effect on HUVECs activation through an endothelial-mediated mechanism, which may be used in the treatment of various disorders such as cancer, rheumatoid arthritis, and cardiovascular disease. This effect is achieved by reducing adhesion of monocyte cells to HUVECs, decreasing expression of ICAM-1 and VCAM-1, and inhibiting permeability, proliferation, migration, and tube formation in VEGF-induced HUVECs. Additionally, punicalagin suppresses IKK-mediated activation of NF-kappa B signaling and inhibits VEGFR2 activation and downstream p-PAK1.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Physical
Dingkun Zhang, Wen Zheng, Xin Li, Ang Li, Nan Ye, Lu Zhang, Yueqiu Liu, Xin Liu, Rui Zhang, Ming Wang, Jingqiu Cheng, Hao Yang, Meng Gong
Summary: The study demonstrated that high concentrations of MXene can significantly alter the energy metabolism of HUVECs, showing inhibition of the tricarboxylic acid (TCA) cycle and enhanced glycolysis, fatty acid biosynthesis, and lipid accumulation, which are closely related to mitochondrial functional disorder.
Article
Biochemistry & Molecular Biology
Lukasz Gwozdzinski, Joanna Bernasinska-Slomczewska, Pawel Hikisz, Anna Wiktorowska-Owczarek, Edward Kowalczyk, Anna Pieniazek
Summary: In this study, the properties of human varicose vein endothelial cells (HVVEC) and human umbilical vein endothelial cells (HUVEC) were compared. Three bioactive compounds, diosmin, escin, and bromelain, were tested on the cells. The drugs showed different effects on reactive oxygen species and nitric oxide generation in the cells. The study revealed a potential mechanism of action for VV therapy drugs on HVVEC cells.
Article
Biochemistry & Molecular Biology
Pablo C. Caracciolo, Patricia Diaz-Rodriguez, Ines Ardao, David Moreira, Florencia Montini-Ballarin, Gustavo A. Abraham, Angel Concheiro, Carmen Alvarez-Lorenzo
Summary: The study developed bioresorbable small-diameter vascular grafts functionalized with heparin to promote endothelial cell growth and inhibit smooth muscle cells over-proliferation. The tensile properties of the heparin-functionalized vascular grafts resembled those of saphenous veins, indicating potential clinical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Environmental Sciences
Zixuan Liu, Xiaomin Xia, Xuying Lv, Erqun Song, Yang Song
Summary: Iron-bearing nanoparticles (IBNPs) are abundant in particulate matter (PM) and considered hazardous to human health with unclear toxic mode-of-action. Studies show that IBNPs promote ferroptosis, affecting intracellular iron levels, disrupting cell signaling, causing mitochondrial dysregulation, and activating related genes. This highlights the importance of recognizing the ferroptotic activity of IBNPs for assessing the health risks associated with PM.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemical Research Methods
Lisha Mao, Xiaoqi Yuan, Junlei Su, Yaping Ma, Chaofan Li, Hongying Chen, Fugui Zhang
Summary: Under extreme ischemia conditions, human umbilical vein endothelial cells (HUVECs) rely on ischemic tricarboxylic acid (TCA) cycle instead of glycolysis to keep cells alive, but consideration must be given to relieve cell injury.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Plant Sciences
Yuchen Jia, Xiaoxue Chen, Yajing Chen, Hongxia Li, Xiumei Ma, Wanjin Xing, Kai Zhao
Summary: The Zhenbao pill (ZBP) has been proven to have a protective effect on vascular endothelial cells, reducing cell apoptosis rates, inhibiting ROS production induced by H2O2 exposure, and maintaining mitochondrial membrane potential. ZBP also effectively reduces the accumulation of autophagic puncta, improving cell apoptosis by inhibiting cell autophagy.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Mengqi Gu, Fengyuan Zhang, Xiaotong Jiang, Pengzheng Chen, Shuting Wan, Qingfeng Lv, Yuan Lu, Qian Zhou, Yanyun Wang, Lei Li
Summary: This study aimed to evaluate the effects of placental exosomes on endothelial cells. The results showed that H/R-exo and PE-exo inhibited the biological functions of endothelial cells and impaired vessel development, potentially leading to vascular disorders in offspring.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jae Hyuk Lee, Md. Samsuzzaman, Myoung Gyu Park, Sung Jean Park, Sun Yeou Kim
Summary: The study found that Hb-AGEs can lead to a decrease in cell viability, conformational and structural changes, increased ROS production, decreased expression of phosphorylated forms p-38 and JNK, ultimately resulting in apoptosis, decreased cell migration and proliferation in HUVECs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Hee-Seop Lee, Darshika Amarakoon, Gillian Tamia, Yeonhwa Park, Dmitriy Smolensky, Seong-Ho Lee
Summary: This study discovered previously unrecognized adverse effects of pendimethalin on vascular endothelial cells. Pendimethalin significantly repressed the viability of human endothelial cells, induced cell cycle arrest and cell death, and impaired the tube forming and migratory abilities of endothelial cells. These effects were mediated by ER stress-induced mitochondrial dysfunction.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Cell Biology
Natasha M. J. Perepelkin, Kirsten Hayward, Tumelo Mokoena, Michael J. Bentley, Lisa U. Ross-Rodriguez, Leah Marquez-Curtis, Locksley E. McGann, Jelena L. Holovati, Janet A. W. Elliott
CELL AND TISSUE BANKING
(2016)
Article
Biology
Richelle C. Prickett, Leah A. Marquez-Curtis, Janet A. W. Elliott, Locksley E. McGann
Review
Biology
Leah A. Marquez-Curtis, Anna Janowska-Wieczorek, Locksley E. McGann, Janet A. W. Elliott
Article
Biology
Leah A. Marquez-Curtis, A. Billal Sultani, Locksley E. McGann, Janet A. W. Elliott
Article
Biotechnology & Applied Microbiology
Megan Dodd, Leah Marquez-Curtis, Anna Janowska-Wieczorek, Gonzalo Hortelano
JOURNAL OF GENE MEDICINE
(2014)
Article
Oncology
Hilal Gul-Uludag, Juliana Valencia-Serna, Cezary Kucharski, Leah A. Marquez-Curtis, Xiaoyan Jiang, Loree Larratt, Anna Janowska-Wieczorek, Hasan Uludag
Article
Biotechnology & Applied Microbiology
Bahareh Sayyar, Megan Dodd, Leah Marquez-Curtis, Anna Janowska-Wieczorek, Gonzalo Hortelano
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2014)
Article
Biotechnology & Applied Microbiology
Bahareh Sayyar, Megan Dodd, Leah Marquez-Curtis, Anna Janowska-Wieczorek, Gonzalo Hortelano
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2015)
Article
Biology
Nasim Eskandari, Leah A. Marquez-Curtis, Locksley E. McGann, Janet A. W. Elliott
Article
Multidisciplinary Sciences
Leah A. Marquez-Curtis, Xiao-Qing Dai, Yan Hang, Jonathan Y. Lam, James Lyon, Jocelyn E. Manning Fox, Locksley E. McGann, Patrick E. MacDonald, Seung K. Kim, Janet A. W. Elliott
Summary: The objective of this study was to optimize the cryopreservation of dissociated islet cells and obtain functional cells for single-cell transcriptome studies on diabetes. The optimized procedure maintained the integrity, molecular, and functional phenotypes of the cells. These findings are important for investigating cellular mechanisms in diabetes and for bio-engineering applications.
Article
Biology
Lanah Mohammed, Leah A. Marquez-Curtis, Janet A. W. Elliott
Summary: The cryopreservation of hCMEC using 5% Me2SO and 6% HES resulted in over 90% cell viability. Non-toxic glycerol was tested as a cryoprotective agent and a protocol was developed to optimize its effectiveness. The viability and functionality of cryopreserved cells were confirmed through various experiments.
Article
Biology
Sergio Enrique Tapia Lishner, Leah A. Marquez-Curtis, Janet A. W. Elliott
Summary: The cornea is a transparent tissue that helps the eye focus by bending light. Cryopreservation can increase availability of corneas for transplants, but suitable donor tissue is scarce. Understanding the transport of water and cryoprotectants in the tissue is crucial for developing effective preservation protocols.
Article
Biology
Leah A. Marquez-Curtis, Locksley E. McGann, Janet A. W. Elliott
Meeting Abstract
Biotechnology & Applied Microbiology
Laura Rose, Cezary Kucharski, Dulan Jayasooriya, Leah A. Marquez-Curtis, Hilal Gul-Uludag, Anna Janowska-Wieczorek, Hasan Uludag