Targeting human respiratory syncytial virus transcription anti-termination factor M2-1 to inhibit in vivo viral replication

A dual drug regimen synergistically blocks human parainfluenza virus infection

(2016) Benjamin Bailly et al.   Scientific Reports

Characterization of novel respiratory syncytial virus inhibitors identified by high throughput screen

(2015) Valerie A. Laganas et al.   ANTIVIRAL RESEARCH

In silico structure-based design and synthesis of novel anti-RSV compounds

(2015) Michela Cancellieri et al.   ANTIVIRAL RESEARCH

Discovery of an Oral Respiratory Syncytial Virus (RSV) Fusion Inhibitor (GS-5806) and Clinical Proof of Concept in a Human RSV Challenge Study

(2015) Richard L. Mackman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di-O-isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

(2015) Guangyi Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification and Characterization of the Binding Site of the Respiratory Syncytial Virus Phosphoprotein to RNA-Free Nucleoprotein

(2015) Marie Galloux et al.   JOURNAL OF VIROLOGY

Characterization of a Respiratory Syncytial Virus L Protein Inhibitor

(2014) Choi-Lai Tiong-Yip et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanism of Action for Respiratory Syncytial Virus Inhibitor RSV604

(2014) SreeRupa Challa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Vismodegib for the treatment of basal cell carcinoma: results and implications of the ERIVANCE BCC trial

(2014) Clio Dessinioti et al.   Future Oncology

Oral GS-5806 Activity in a Respiratory Syncytial Virus Challenge Study

(2014) John P. DeVincenzo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation

(2014) S. J. Tanner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a potent respiratory syncytial virus RNA polymerase inhibitor

(2013) Hui Xiong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors

(2013) A. Jimeno et al.   CLINICAL CANCER RESEARCH

Structure of the human smoothened receptor bound to an antitumour agent

(2013) Chong Wang et al.   NATURE

Abstract 2819: Identification and characterization of a novel smoothened antagonist for the treatment of cancer with deregulated hedgehog signaling

(2012) Mark H. Bender et al.   CANCER RESEARCH

An Analog of the Natural Steroidal Alkaloid Cortistatin A Potently Suppresses Tat-Dependent HIV Transcription

(2012) Guillaume Mousseau et al.   Cell Host & Microbe

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Hedgehog pathway as a drug target: Smoothened inhibitors in development

(2012) Tara Lin et al.   OncoTargets and Therapy

A review of cost–effectiveness of palivizumab for respiratory syncytial virus

(2012) Julia M Hussman et al.   Expert Review of Pharmacoeconomics & Outcomes Research

Structure and Functional Analysis of the RNA- and Viral Phosphoprotein-Binding Domain of Respiratory Syncytial Virus M2-1 Protein

(2012) Marie-Lise Blondot et al.   PLoS Pathogens

Up-regulation of Hedgehog pathway is associated with cellular permissiveness for hepatitis C virus replication

(2011) Steve S. Choi et al.   HEPATOLOGY

Cyclopamine and Hedgehog Signaling: Chemistry, Biology, Medical Perspectives

(2010) Philipp Heretsch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antiviral and lung protective activity of a novel respiratory syncytial virus fusion inhibitor in a mouse model

(2010) W. Olszewska et al.   EUROPEAN RESPIRATORY JOURNAL

Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis

(2010) Harish Nair et al.   LANCET

Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication

(2010) Christopher M Owens et al.   Molecular Systems Biology

Inactivation of respiratory syncytial virus by zinc finger reactive compounds

(2010) Marina S Boukhvalova et al.   Virology Journal

Protein Expression Redirects Vesicular Stomatitis Virus RNA Synthesis to Cytoplasmic Inclusions

(2010) Bianca S. Heinrich et al.   PLoS Pathogens

GDC-0449—A potent inhibitor of the hedgehog pathway

(2009) Kirk D. Robarge et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)

(2009) Martin R. Tremblay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evidence for Allosteric Interactions of Antagonist Binding to the Smoothened Receptor

(2009) C. M. Rominger et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Respiratory Syncytial Virus M2-1 Protein Forms Tetramers and Interacts with RNA and P in a Competitive Manner

(2009) T.-L. Tran et al.   JOURNAL OF VIROLOGY

Functional Characterization of Negri Bodies (NBs) in Rabies Virus-Infected Cells: Evidence that NBs Are Sites of Viral Transcription and Replication

(2009) X. Lahaye et al.   JOURNAL OF VIROLOGY

A small molecule that binds Hedgehog and blocks its signaling in human cells

(2009) Benjamin Z Stanton et al.   Nature Chemical Biology

Crystal Structure of a Nucleocapsid-Like Nucleoprotein-RNA Complex of Respiratory Syncytial Virus

(2009) R. G. Tawar et al.   SCIENCE

Viral Infection in Adults Hospitalized With Community-Acquired Pneumonia

(2008) Jennie Johnstone et al.   CHEST