期刊
SCIENTIFIC REPORTS
卷 6, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep21816
关键词
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资金
- Guangdong Innovative and Entrepreneurial Research Team Program [2013S046]
- Shenzhen Peacock Plan
- Hundred Talents program
- Qing Lan Project of Nanjing Normal University
- Jiangsu Provincial Natural Science Foundation [BK20140917, BK20150983]
- Open Fund of Guangxi Key Laboratory of Manufacturing System & Advanced Manufacturing Technology [15-140-30-008K]
- Natural Science Foundation of China [81501164]
- Funds of Leading Talents of Guangdong
- Programme of Introducing Talents of Discipline to Universities [B14036]
Microglia are the mononuclear phagocytes with various functions in the central nervous system, and the morphologies of microglia imply the different stages and functions. In optical nerve transection model of the retina, the retrograde degeneration of retinal ganglion cells induces microglial activations to a unique morphology termed rod microglia. A few studies described the rod microglia in the cortex and retina; however, the spatial characteristic of rod microglia is not fully understood. In this study, we built a mathematical model to characterize the spatial trait of rod microglia. In addition, we developed a Matlab-based image processing pipeline that consists of log enhancement, image segmentation, mathematical morphology based cell detection, area calculation and angle analysis. This computer program provides researchers a powerful tool to quickly analyze the spatial trait of rod microglia.
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