Article
Biochemistry & Molecular Biology
Irina Kozhukharova, Natalia Minkevich, Larisa Alekseenko, Alisa Domnina, Olga Lyublinskaya
Summary: The study aimed to evaluate the role of secreted VEGF in stimulating angiogenesis and maintaining eMSC viability and migration. The results showed that spheroid eMSCs produced higher amounts of VEGF and had a stronger paracrine effect on HUVEC, while knockdown of VEGF caused a decrease in eMSC viability and migration. Moreover, VEGF-VEGFR1 and VEGFR2 were found to be important in the response of eMSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Talia Guardia, Yuqi Zhang, Keyata N. Thompson, Se Jong Lee, Stuart S. Martin, Konstantinos Konstantopoulos, Aikaterini Kontrogianni-Konstantopoulos
Summary: Mounting evidence suggests that obscurin, a giant cytoskeletal protein, is involved in the predisposition and development of breast cancer. Low levels of obscurin correlate with reduced overall and relapse-free survival in breast cancer patients. The antisense lncRNA OBSCN-AS1 regulates obscurin expression and functions as a metastasis suppressor, potentially serving as prognostic biomarkers and therapeutic targets for metastatic breast cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Medicinal
Nehal Gupta, Sanjay K. Srivastava
Summary: Atovaquone shows anti-metastatic effects on triple-negative breast cancer by inducing apoptosis and reducing the expression of genes related to metastatic potential. In vivo experiments demonstrate that atovaquone significantly suppresses the growth of metastatic tumors in the lungs, liver, and brain, suggesting its potential as a treatment for breast cancer metastasis.
Article
Pharmacology & Pharmacy
Xiyu Mei, Hao Ouyang, Hong Zhang, Wangya Jia, Bin Lu, Jingnan Zhang, Lili Ji
Summary: This study found that the natural flavonoid scutellarin (SC) suppressed the metastasis of TNBC by regulating tumor vasculature. SC reduced the production of G-CSF, thereby inhibiting the migration and invasion of TNBC cells. SC also hindered the interaction between TNF alpha and TNFR2, leading to reduced TNBC metastasis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Chemistry, Physical
Yanlin Feng, Jianlin Wang, Xin Ning, Aiyun Li, Qing You, Wanzhen Su, Deping Wang, Jianyun Shi, Lan Zhou, Fangfang Cao, Xiaoyuan Chen, Jimin Cao
Summary: A new nanostructure has been developed to selectively and persistently block energy generation of triple-negative breast cancer cells, inducing apoptosis. The therapeutic effects have been demonstrated in vitro and in vivo, providing a new approach for metabolic interventions.
Article
Chemistry, Physical
Yanlin Feng, Jianlin Wang, Xin Ning, Aiyun Li, Qing You, Wanzhen Su, Deping Wang, Jianyun Shi, Lan Zhou, Fangfang Cao, Xiaoyuan Chen, Jimin Cao
Summary: We developed a stable pyroelectric BaTiO3@Au core-shell nanostructure that can selectively block energy generation of tumor cells, providing a promising therapeutic approach for triple-negative breast cancer.
Article
Mathematics, Applied
Li Xie, Shigui Ruan
Summary: In this paper, a homogeneous Neumann initial-boundary value problem for a chemotaxis model with two species and two stimuli, including paracrine and autocrine loops, is considered. The existence of global bounded classical solutions is proved under certain conditions, and an inequality is derived that guarantees the existence of solutions.
COMMUNICATIONS ON PURE AND APPLIED ANALYSIS
(2022)
Article
Biotechnology & Applied Microbiology
Xiangming Xu, Jiao Nie, Lin Lu, Chao Du, Fansheng Meng, Duannuo Song
Summary: This study demonstrates that LINC00337 facilitates tumorigenesis and angiogenesis in colorectal cancer by recruiting DNMT1 to inhibit the expression of CNN1.
CANCER GENE THERAPY
(2021)
Article
Medicine, Research & Experimental
Ping Jin, Jingwen Jiang, Li Zhou, Zhao Huang, Siyuan Qin, Hai-Ning Chen, Liyuan Peng, Zhe Zhang, Bowen Li, Maochao Luo, Tingting Zhang, Hui Ming, Ning Ding, Lei Li, Na Xie, Wei Gao, Wei Zhang, Edouard C. Nice, Yuquan Wei, Canhua Huang
Summary: This study demonstrates that long-term exposure to metformin leads to metabolic adaptation in hepatocellular carcinoma cells, characterized by epithelial-mesenchymal transition and increased oxidative phosphorylation. TOMM34, a protein involved in mitochondrial transport, was found to promote tumor metastasis in response to metformin-induced metabolic stress. The study also shows that inhibiting the interaction between TOMM34 and ATP5B using a specific oxidative phosphorylation inhibitor increases sensitivity to metformin and suppresses tumor progression.
EMBO MOLECULAR MEDICINE
(2022)
Article
Oncology
Olivia K. Provance, Eric S. Geanes, Asona J. Lui, Anuradha Roy, Sean M. Holloran, Sumedha Gunewardena, Christy R. Hagan, Scott Weir, Joan Lewis-Wambi
Summary: Overexpression of IFITM1 in TNBC promotes tumor progression, but targeting IFITM1 can inhibit cell proliferation and invasion through the NF-kappa B signaling pathway. Parthenolide, identified as an NF kappa B inhibitor, shows potential as a cytotoxic agent for TNBC treatment.
Article
Oncology
Huicheng Liu, Lili Bai, Liu Huang, Na Ning, Lin Li, Yijia Li, Xuejiao Dong, Qiuyang Du, Minghui Xia, Yufei Chen, Likun Zhao, Yanhu Li, Qingwu Meng, Jing Wang, Yaqi Duan, Jie Ming, Andy Qingan Yuan, Xiang-Ping Yang
Summary: The study developed a bispecific antibody F7AK3 targeting TROP2 and CD3 antigens for TNBC, showing potential antitumor activity in vitro and in vivo by activating T cells against TNBC cells. Further preclinical and clinical evaluation of F7AK3 is warranted for advanced or metastatic TNBC patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Yunxiang Zhang, Xiaotong Dong, Xiangyu Guo, Chunsen Li, Yanping Fan, Pengju Liu, Dawei Yuan, Xialin Ma, Jingru Wang, Jie Zheng, Hongli Li, Peng Gao
Summary: It was found that lncRNA BC069792 is down-regulated in breast cancer tissues and decreases significantly in breast cancer with high pathological grade, lymph node metastasis, and high Ki-67 index. BC069792 acts as a molecular sponge to adsorb hsa-miR-658 and hsa-miR-4739, up-regulates the protein expression of Potassium Voltage-Gated Channel Q4 (KCNQ4), inhibits JAK2 and p-AKT activities, and thus suppresses breast cancer growth in vitro and in vivo.
Article
Chemistry, Multidisciplinary
Shan-mei Chen, Chuan-ke Zhao, Li-cheng Yao, Li-xin Wang, Yu-nan Ma, Lin Meng, Shao-qing Cai, Cai-yun Liu, Li-ke Qu, Yan-xing Jia, Cheng-chao Shou
Summary: The high incidence of lymphatic metastasis is closely related to poor prognosis and mortality in cancers. In this study, the researchers evaluated the antilymphangiogenic and antimetastatic potency of a natural compound called aiphanol. They found that aiphanol could inhibit lymphangiogenesis and lymphatic spread by targeting VEGFR3 and the COX2-PGE2-VEGF-C signaling axis.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Endocrinology & Metabolism
Yangyou Liao, Ruiling Li, Jingyuan Pei, Juan Zhang, Bo Chen, Haojie Dong, Xiaoyu Feng, Hongshuo Zhang, Yuhong Shang, Linlin Sui, Ying Kong
Summary: It is found that melatonin and GATA2 play significant roles in the development of endometrial cancer by regulating the expression of GATA2 and the AKT pathway, leading to the inhibition of cancer cell proliferation and metastasis.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Oncology
Asif Amin, Aabid Mustafa Koul, Umer Majeed Wani, Faizah Farooq, Basit Amin, Zubair Wani, Asif Lone, Ayub Qadri, Raies A. Qadri
Summary: This study demonstrates that the interaction between lung cancer cells and monocytes can regulate the secretion of various proteins, thereby promoting tumor growth and metastasis. Some of these proteins are associated with inflammation and pro-metastatic environment, and are also linked to the prognosis of lung adenocarcinoma.
Review
Biochemistry & Molecular Biology
Hsing-Ju Wu, Pei-Yi Chu
Summary: Breast cancer is the most commonly diagnosed cancer type in women worldwide and has six molecular subtypes. Early detection and screening are crucial for improving therapeutic outcomes, requiring reliable noninvasive diagnostic and prognostic biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Tsai-Wen Wan, Yu-Jung Liu, Yu-Ting Wang, Yu-Tzu Lin, Jia-Chuan Hsu, Jui-Chang Tsai, Hao-Chieh Chiu, Po -Ren Hsueh, Wei-Chun Hung, Lee-Jene Teng
Summary: This study provides detailed genetic characterization of Tn6636, a multidrug-resistant mobile element, in clinical isolates of Staphylococcus aureus. The prevalence of Tn6636 in methicillin-susceptible S. aureus (MSSA) is higher than that in methicillin-resistant S. aureus (MRSA). The presence of this mobile element with various sequence types suggests its broad dissemination and the potential for continued spread of resistant plasmids.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Review
Health Care Sciences & Services
Ya-Ling Yang, Yen-Hsiang Chang, Chia-Jung Li, Ying-Hsien Huang, Ming-Chao Tsai, Pei-Yi Chu, Hung-Yu Lin
Summary: Hepatocellular carcinoma (HCC) remains one of the most lethal cancers globally, with no established curative plan for advanced cases and a poor prognosis. Studies show that miR-29a plays an important role in regulating tumorigenesis and tumor microenvironment development, with potential therapeutic implications in hepatoprotection and HCC progression.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yu-Hsuan Hung, Shih-Han Hsu, Ya-Chin Hou, Pei-Yi Chu, Yung-Yeh Su, Yan-Shen Shan, Wen-Chun Hung, Li-Tzong Chen
Summary: This study discovered that SEMA6C is downregulated in pancreatic cancer and its reduction is associated with worse survival rates. The research revealed the mechanism by which SEMA6C acts as a tumor suppressor in pancreatic cancer and identified a novel regulatory role of miR-124-3p in suppressing SEMA6C. These findings provide new insights into the potential treatment of SEMA6C-downregulated cancer using CDK4/6 inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Hsing-Ju Wu, Pei-Yi Chu
Summary: This article summarizes the recent discoveries on liquid biopsy and detection techniques. Breast cancer is the most common cancer and leading cause of death worldwide, highlighting the importance of early diagnosis. Liquid biopsy, as a less invasive diagnostic tool, is gaining more attention.
Article
Biology
Chun-Chi Chen, Pei-Yi Chu, Hung-Yu Lin
Summary: Using multi-omics analysis, this study reveals the clinical value and possible mechanisms of ATAD1 in prostate adenocarcinoma (PRAD). The downregulation of ATAD1 serves as a clinical biomarker for pathologic diagnosis and prognosis in PRAD patients. It is involved in enhanced activity of mitochondria and cell cycle as well as shaping an immunosuppressive tumor microenvironment.
Article
Microbiology
Hui-Hui Yeo, Chung-Wei Shiau, Yu-Hsuan Jao, Tsai-Wen Wan, Hao-Chieh Chiu
Summary: This study found that oleic acid enhances the activity of the antibacterial agent SC5005 against Staphylococcus aureus and MRSA strains. Specifically, cis-form unsaturated fatty acids, such as docosahexaenoic acid (DHA), synergistically increase the potency of SC5005. The combination of SC5005 and DHA can effectively eradicate MRSA planktonic and persister cells, as well as biofilms.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Po-Ming Chen, Chui-Nguk Wong, Chui-Na Wong, Pei-Yi Chu
Summary: Ovarian cancer has a high mortality rate and lacks effective targeted therapy. This study aimed to explore genetic markers and their clinical value in ovarian cancer development. 11 genetic markers, including ACTL6A, were found to be significantly elevated in invasive and chemoresistant ovarian cancer. ACTL6A expression was correlated with survival prognosis, and HER2 inhibitor CP724714 showed potential therapeutic benefits in high ACTL6A expression cases. High ACTL6A expression can serve as a biomarker for predicting treatment-refractory, metastasis, and prognosis of ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Tsai-Wen Wan, Hui-Hui Yeo, Tai-Fen Lee, Yu-Tsung Huang, Po-Ren Hsueh, Hao-Chieh Chiu
Summary: This study investigated the molecular epidemiology of VREfm bacteremic isolates in northern Taiwan from 2019-2020 and evaluated their susceptibility to last-line antibiotics and a new antimicrobial agent, SC5005. The results showed that all VREfm isolates harbored the vanA gene, with the most prevalent sequence types being ST17 and ST78. Four new STs were identified, and the arrival of multidrug-resistant ST1885 was observed in Taiwan. SC5005 was effective against all VREfm isolates, including those non-susceptible to last-line antibiotics, without detectable resistance.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Immunology
Shih-Hsiu Chou, Tsai-Wen Wan, Chung-Wai Shiau, Ling -Han Chen, Hsueh-Chun Lin, Hao-Chieh Chiu
Summary: In this study, it was found that the tyrosine kinase inhibitor nilotinib has antibacterial activity against intracellular Salmonella enterica. The aim was to exploit the antibacterial activity of nilotinib and understand its mechanism of action.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Biochemistry & Molecular Biology
Chun-Chi Chen, Pei-Yi Chu, Hung-Yu Lin
Summary: This study investigated the clinical significance of Inner membrane mitochondrial protein (IMMT) in Kidney renal clear cell carcinoma (KIRC) using supervised learning and multi-omics integration. The results showed that low expressions of IMMT in tumors were associated with poor prognosis, tumor progression, mitochondrial inhibition, angiogenetic activation, reduced immunogenicity, and an immunosuppressive tumor immune microenvironment (TIME). Inter-database verification further confirmed these findings. Pharmacogenetic prediction identified potential drug efficacy in the context of low IMMT expressions. IMMT has the potential to be a novel biomarker, prognostic predictor, and pharmacogenetic predictor for personalized cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pei-Yi Chu, Dev-Aur Chou, Po-Ming Chen, En-Pei Isabel Chiang
Summary: This study found that the translocation of MAT2A is associated with the prognosis of female patients with liver cancer and has important clinical significance in liver cancer. The study also found that estrogen may be used as a therapeutic modality against female liver cancer by regulating the localization of SP1 and MAT2A. Rating: 8/10
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kuo-Chu Lai, Prabha Regmi, Chung-Ji Liu, Jeng-Fan Lo, Te-Chang Lee
Summary: The study demonstrates that IFIT2 depletion promotes the CSC-like phenotypes in oral cancer cells. Clinically, there is a positive correlation between IFIT2 and CD24 in oral cancer patients, and the expression pattern of IFIT2(high)/CD24(high)/CD44(low) predicts a better prognosis. Furthermore, TNF-alpha blockade can abolish the sphere formation induced by IFIT2 depletion, suggesting its involvement in CSC-like phenotypes in oral cancer.
Article
Engineering, Multidisciplinary
Ming-Hsien Hu, Pei-Yi Chu, Ssu-Meng Huang, Bo-Sin Shih, Chia-Ling Ko, Jin-Jia Hu, Wen-Cheng Chen
Summary: The composite bone cement of calcium phosphate cement (CPC) and mesoporous bioactive glass (MBG) shows potential advantages in clinical applications, with good injectability and disintegration resistance. However, increasing the MBG content decreases the working/setting time and compressive strength.
Article
Biochemistry & Molecular Biology
Hsueh-Chun Lin, Yi-Lun Wu, Cheng-Yun Hsu, Man-Yi Lin, Ling-Han Chen, Chung-Wai Shiau, Hao-Chieh Chiu
Summary: The study identified a newly synthesized compound, SW14, with potent inhibitory activity against multidrug-resistant and fluoroquinolone-resistant bacteria. It also showed broad-spectrum antibacterial activity against intracellular bacteria.
RSC MEDICINAL CHEMISTRY
(2022)