Metformin sensitizes the response of oral squamous cell carcinoma to cisplatin treatment through inhibition of NF-κB/HIF-1α signal axis

Mechanisms of cisplatin resistance and targeting of cancer stem cells: Adding glycosylation to the equation

(2016) José Alexandre Ferreira et al.   DRUG RESISTANCE UPDATES

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

(2016) Caroline Wigerup et al.   PHARMACOLOGY & THERAPEUTICS

Prognostic Factors of Primary Intraosseous Squamous Cell Carcinoma (PIOSCC): A Retrospective Review

(2016) Xu Wenguang et al.   PLoS One

Crosstalk between the HIF-1 and Toll-like receptor/nuclear factor-κB pathways in the oral squamous cell carcinoma microenvironment

(2016) Shengwei Han et al.   Oncotarget

Repurposing metformin for cancer treatment: current clinical studies

(2016) Young Kwang Chae et al.   Oncotarget

Metformin Synergistically Enhances Cisplatin-Induced Cytotoxicity in Esophageal Squamous Cancer Cells under Glucose-Deprivation Conditions

(2016) Hongliang Yu et al.   Biomed Research International

The BH3-mimetic obatoclax reduces HIF-1α levels and HIF-1 transcriptional activity and sensitizes hypoxic colon adenocarcinoma cells to 5-fluorouracil

(2015) Marzia B. Gariboldi et al.   CANCER LETTERS

Synergistic effects of metformin in combination with EGFR-TKI in the treatment of patients with advanced non-small cell lung cancer and type 2 diabetes

(2015) Hengyi Chen et al.   CANCER LETTERS

Panobinostat reduces hypoxia-induced cisplatin resistance of non-small cell lung carcinoma cells via HIF-1α destabilization

(2015) Carina Fischer et al.   Molecular Cancer

Metformin: A Novel but Controversial Drug in Cancer Prevention and Treatment

(2015) Xinbing Sui et al.   MOLECULAR PHARMACEUTICS

Inflammation and cancer: Till death tears them apart

(2015) T.P. Raposo et al.   VETERINARY JOURNAL

Metformin induces an intracellular reductive state that protects oesophageal squamous cell carcinoma cells against cisplatin but not copper-bis(thiosemicarbazones)

(2014) Leonard Howard Damelin et al.   BMC CANCER

Metformin Sensitizes EGFR-TKI-Resistant Human Lung Cancer Cells In Vitro and In Vivo through Inhibition of IL-6 Signaling and EMT Reversal

(2014) L. Li et al.   CLINICAL CANCER RESEARCH

Use of Metformin Alone Is Not Associated with Survival Outcomes of Colorectal Cancer Cell but AMPK Activator AICAR Sensitizes Anticancer Effect of 5-Fluorouracil through AMPK Activation

(2014) Xinbing Sui et al.   PLoS One

Oral squamous cell carcinoma in relation to field precancerisation: pathobiology

(2013) Liviu L Feller et al.   Cancer Cell International

Overexpression of HIF-1α indicates a poor prognosis in tongue carcinoma and may be associated with tumour metastasis

(2013) YANG ZHENG et al.   Oncology Letters

Metformin use and improved response to therapy in rectal cancer

(2013) Heath D. Skinner et al.   Cancer Medicine

Metformin use and improved response to therapy in esophageal adenocarcinoma

(2012) Heath D. Skinner et al.   ACTA ONCOLOGICA

Expression of glucose transporters in cancers

(2012) Leszek Szablewski   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway

(2012) Rabbie K. Hanna et al.   GYNECOLOGIC ONCOLOGY

Global estimates of cancer prevalence for 27 sites in the adult population in 2008

(2012) Freddie Bray et al.   INTERNATIONAL JOURNAL OF CANCER

Metformin in cancer: translational challenges

(2012) Ryan J O Dowling et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Cancer Risk in Diabetic Patients Treated with Metformin: A Systematic Review and Meta-analysis

(2012) Hiroshi Noto et al.   PLoS One

Noscapine sensitizes chemoresistant ovarian cancer cells to cisplatin through inhibition of HIF-1α

(2011) Wenjing Su et al.   CANCER LETTERS

Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types

(2011) D. Iliopoulos et al.   CANCER RESEARCH

Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways

(2011) Nadine Rohwer et al.   DRUG RESISTANCE UPDATES

Epidemiology of cancer from the oral cavity and oropharynx

(2011) René Lambert et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Activation of PI3 kinase/Akt/HIF-1α pathway contributes to hypoxia-induced epithelial-mesenchymal transition and chemoresistance in hepatocellular carcinoma

(2011) Ke-Jun Nan   INTERNATIONAL JOURNAL OF ONCOLOGY

Metformin and cancer: new applications for an old drug

(2011) Taxiarchis V. Kourelis et al.   MEDICAL ONCOLOGY

Evolutionary Conserved Regulation of HIF-1β by NF-κB

(2011) Patrick van Uden et al.   PLoS Genetics

Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE transcriptional activity through AMPK activation

(2010) Hyung Gyun Kim et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

(2010) I. Ben Sahra et al.   MOLECULAR CANCER THERAPEUTICS

MicroRNAs contribute to the chemoresistance of cisplatin in tongue squamous cell carcinoma lines

(2010) Zhi-wei Yu et al.   ORAL ONCOLOGY

Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis

(2009) Lavinia Nardinocchi et al.   Molecular Cancer

Regulation of hypoxia-inducible factor-1α by NF-κB

(2008) Patrick van Uden et al.   BIOCHEMICAL JOURNAL