Article
Clinical Neurology
Elisa Dal Bo, Ludovica Natali, Claudio Gentili, Cinzia Cecchetto
Summary: This study found that odor awareness may be a key factor in the relationship between emotional symptoms and olfactory abilities. The association between depressive symptoms and olfactory abilities was moderated by odor awareness, while the relationship between anxiety symptoms and olfactory abilities was not affected by odor awareness. Therefore, odor awareness may be a useful target for treating olfactory dysfunction in clinical settings.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Behavioral Sciences
Karen Rihani, Silke Sachse
Summary: Inter-individual differences in behavioral responses, anatomy or functional properties of neuronal populations of animals having the same genotype were for a long time disregarded. Recent studies have shown that individuals with the same genotype can have significant differences in their behavioral biases and preferences to olfactory stimuli. This review focuses on olfaction in the vinegar fly Drosophila melanogaster and discusses the factors that might influence individuality with regard to olfactory perception.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Albert Lin, Shanshan Qin, Helena Casademunt, Min Wu, Wesley Hung, Gregory Cain, Nicolas Z. Tan, Raymond Valenzuela, Leila Lesanpezeshki, Vivek Venkatachalam, Cengiz Pehlevan, Mei Zhen, Aravinthan D. T. Samuel
Summary: Animals perceive odorant molecules by collecting information from olfactory neurons, which use receptors to recognize specific odorant molecules. The olfactory system can detect and discriminate diverse odorants using coding strategies. Using microfluidics and multineuronal imaging, we studied the olfactory representations in the nematode C. elegans and found high-dimensional representations of olfactory information. The collective activity of chemosensory neurons encodes the intensity and identity of diverse chemical stimuli.
Article
Multidisciplinary Sciences
Carl E. Schoonover, Sarah N. Ohashi, Richard Axel, Andrew J. P. Fink
Summary: The study found that although activity in the primary olfactory cortex could discriminate between odorants at any time, the odor-evoked responses drifted over days to weeks. Daily exposure to the same odorant slowed the rate of drift, but when exposure was halted the rate increased again. This instability may be related to the unstructured connectivity of the piriform cortex.
Article
Biology
Brian Kim, Seth Haney, Ana P. Milan, Shruti Joshi, Zane Aldworth, Nikolai Rulkov, Alexander T. Kim, Maxim Bazhenov, Mark A. Stopfer
Summary: Odorants binding to olfactory receptor neurons trigger distinct response motifs, which can switch and adapt when activated repeatedly. These motifs provide benefits for classifying and processing odors, and contribute to the encoding of odor plume composition and structure. Multiple motifs and motif switching further improve odor classification and can be useful for olfactory navigation.
Article
Nutrition & Dietetics
Agnieszka Sorokowska, Dominika Chabin, Thomas Hummel, Maciej Karwowski
Summary: This study examines the relationship between food neophobia and olfaction in adolescents, and significant correlations were found between the two. Self-assessed sensitivity and odor awareness were identified as the most influential predictors of food neophobia related to olfaction.
Article
Multidisciplinary Sciences
Mei Peng, Hazel Potterton, Joanna Ting Wai Chu, Paul Glue
Summary: Postpartum Depression (PPD) is associated with olfactory abilities, where patients perceive unpleasant odors as more unpleasant and some odors as less intense compared to control group, with no significant interaction with perinatal stage.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Ying Wang, Quan Zhou, Weiwen Zhang, Chaoshi Niu
Summary: The study found that the connectivity between the left olfactory gyrus and the left superior temporal pole, as well as the regional homogeneity in the left middle temporal gyrus, were negatively correlated with the Pittsburgh sleep quality index. These results suggest that these sensory-related brain regions are related to sleep quality and may predict diseases together.
Article
Computer Science, Artificial Intelligence
Xiuxin Xia, Yan Shi, Pengwei Li, Xiaosong Liu, Jingjing Liu, Hong Men
Summary: Currently, the evaluation of food sensory largely relies on artificial sensory evaluation and machine perception. However, the former is influenced by subjective factors and the latter fails to capture human feelings. This article proposes a Frequency Band Attention Network (FBANet) for distinguishing differences in food odor using olfactory electroencephalogram (EEG). The FBANet effectively mines the olfactory EEG data information and accurately distinguishes between eight food odors, presenting a new approach for food sensory evaluation.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Biology
Sudeshna Das Chakraborty, Hetan Chang, Bill S. Hansson, Silke Sachse, Sonia Sen
Summary: This study investigated the transformation and representation of odor information in higher-order neurons of the lateral horn in Drosophila melanogaster. The researchers found that these neurons exhibited reproducible, stereotypic, and odor-specific response patterns. Importantly, the response amplitude of these neurons was positively correlated with innate odor preferences, suggesting that their activity is valence-specific. The study also revealed that the excitatory input to glutamatergic lateral horn neurons primarily came from uniglomerular projection neurons, while odor-specific inhibition was mediated by inhibitory multiglomerular neurons.
Article
Cell Biology
Zhen Chen, Krishnan Padmanabhan
Summary: This study explores multiple models proposed to explain odor representation in the olfactory cortex. It finds that top-down feedback control plays a critical role in determining the coding strategies and information transmission from the main olfactory bulb to the piriform cortex. By influencing the excitation-inhibition balance in neural cells, the feedback control improves the performance of odor discrimination tasks.
Article
Computer Science, Artificial Intelligence
Yu Wang, Qilong Zhao, Mingyuan Ma, Jin Xu
Summary: This paper proposes a neural network-based perception prediction model that accurately predicts the relationship between the chemical structure and physicochemical properties of odor molecules. By imitating the lateral inhibition mechanism and attention mechanism of animal olfaction, the model achieves state-of-the-art results in olfactory perception prediction, which is of great significance for product design and quality assessment in the food, beverage, and fragrance industries.
APPLIED INTELLIGENCE
(2023)
Article
Clinical Neurology
Rachel R. Pacyna, S. Duke Han, Kristen E. Wroblewski, Martha K. McClintock, Jayant M. Pinto
Summary: Rapid olfactory decline during normal cognition predicts subsequent cognitive impairment, dementia, and smaller gray matter volumes in the brain. This measurement has the potential to be a simple biomarker for early detection of AD.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biology
Shivathmihai Nagappan, Kevin M. Franks
Summary: The study found that semilunar (SL) and superficial pyramidal (PYR) neurons play different roles in odor processing in the olfactory cortex, with SLs receiving and integrating olfactory bulb input, and PYRs transforming and transmitting this input.
Article
Biochemistry & Molecular Biology
Laura K. Shanahan, Surabhi Bhutani, Thorsten Kahnt
Summary: Evidence suggests that internal factors such as hunger and satiety can influence olfactory perceptual decision-making in a food-specific manner. Participants were less likely to perceive meal-matched odors as dominant in the sated state, with fMRI data showing neural changes that reflected these behavioral effects. These findings demonstrate a potential brain mechanism underlying the bias in olfactory perceptual decision-making based on motivational states.
Article
Biochemistry & Molecular Biology
Hiroyuki Chaya, Mitsuru Naito, Masaru Cho, Kazuko Toh, Kotaro Hayashi, Shigeto Fukushima, Yuichi Yamasaki, Kazunori Kataoka, Kanjiro Miyata
Summary: The study investigated how the polymerization degree of lysine affected the stability of uPICs in the bloodstream. A smaller polymerization degree resulted in a decreased association constant and prolonged blood retention of free bPEG-PLys. Therefore, the lysine polymerization degree can influence the dynamic stability of uPICs.
Article
Engineering, Biomedical
Naoto Yoshinaga, Satoshi Uchida, Anjaneyulu Dirisala, Mitsuru Naito, Kyoko Koji, Kensuke Osada, Horacio Cabral, Kazunori Kataoka
Summary: The study successfully stabilized Polyplex micelles (PMs) by developing RNA oligonucleotide (OligoRNA) derivatives to bridge mRNA and polycation, improving their stability against polyion exchange reaction and ribonuclease attack. This bridging strategy provides a new approach for mRNA delivery by enhancing the efficiency of mRNA introduction in cultured cells and mouse lungs after intratracheal administration.
ADVANCED HEALTHCARE MATERIALS
(2022)
Editorial Material
Chemistry, Multidisciplinary
Nicholas A. Kotov, Deji Akinwande, C. Jeffrey Brinker, Jillian M. Buriak, Warren C. W. Chan, Xiaodong Chen, Manish Chhowalla, William Chueh, Sharon C. Glotzer, Yury Gogotsi, Mark C. Hersam, Dean Ho, Tony Hu, Ali Javey, Cherie R. Kagan, Kazunori Kataoka, Il-Doo Kim, Shuit-Tong Lee, Young Hee Lee, Luis M. Liz-Marzan, Jill E. Millstone, Paul Mulvaney, Andre E. Nel, Peter Nordlander, Wolfgang J. Parak, Reginald M. Penner, Andrey L. Rogach, Mathieu Salanne, Raymond E. Schaak, Ajay K. Sood, Molly Stevens, Vladimir Tsukruk, Andrew T. S. Wee, Ilja Voets, Tanja Weil, Paul S. Weiss
Article
Otorhinolaryngology
Aina Suto, Rumi Ueha, Takafumi Ogura, Eriko Maeda, Masaki Tatebayashi, Daiki Shimada, Misaki Koyama, Taku Sato, Takao Goto, Akihito Yamauchi, Tatsuya Yamasoba
Summary: Swallowing CT/VR technology has been used to diagnose two cases of cervical discomfort as clicking larynx. The imaging revealed that the thyroid cartilage collided with the hyoid bone during swallowing, leading to the diagnosis. Patient management included weight loss observation and hormonal therapy adjustment. The technique is beneficial for evaluating swallowing function and identifying the underlying causes of globus sensation and pain upon swallowing.
AURIS NASUS LARYNX
(2023)
Article
Otorhinolaryngology
Sachiko Koyama, Eri Mori, Rumi Ueha
Summary: One of the unique symptoms of COVID-19 is chemosensory dysfunction. Numerous studies have been conducted on the symptoms, progress, and possible causes of COVID-19, as well as treatments for recovery. Recovery of chemosensory functions varies among individuals, with some recovering within weeks, while others may take months or never fully recover. This paper provides a summary of symptoms and progress, reviews studies on causation and treatments, and discusses the need for personalized strategies based on severity and pathological venues.
AURIS NASUS LARYNX
(2023)
Article
Otorhinolaryngology
Misaki Koyama, Rumi Ueha, Taku Sato, Takao Goto, Akihito Yamauchi, Asako Kaneoka, Sayaka Suzuki, Takaharu Nito, Tatsuya Yamasoba
Summary: In recent years, the use of aspiration prevention surgery (APS) for the treatment of severe dysphagia has been increasing. This study investigates the clinical features of patients undergoing APS and the impact on their oral-intake status and suction frequency before and after surgery.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Polymer Science
Yasuhiro Nakagawa, Kotaro Ushidome, Keita Masuda, Kazunori Igarashi, Yu Matsumoto, Tatsuya Yamasoba, Yasutaka Anraku, Madoka Takai, Horacio Cabral
Summary: Multi-arm star-shaped block copolymers consisting of poly(furfuryl glycidol) (PFG) and poly(ethylene glycol) (PEG) were developed for drug delivery. The block copolymers showed controlled sizes and effectively loaded and released model drugs. When injected intravenously, they exhibited prolonged blood circulation, indicating their potential as long-circulating nanocarriers.
Article
Medicine, General & Internal
Mariko Hara, Rumi Ueha, Taku Sato, Takao Goto, Ayumi Yoshizaki, Hayakazu Sumida, Shinichi Sato, Tatsuya Yamasoba
Summary: Systemic sclerosis is often associated with dysphagia and esophageal dysmotility. This study evaluated the association between dysphagia and esophageal dysmotility in patients with systemic sclerosis and identified risk factors. The results showed that dysphagia was associated with autoantibody positivity and older age, while there were no identified risk factors for esophageal dysmotility. No correlation was found between dysphagia and esophageal dysmotility.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Otorhinolaryngology
Yoko Inamoto, Rumi Ueha, Marlis Gonzalez-Fernandez
Summary: This review article summarizes the application of area-detector CT in swallowing evaluation, highlighting its benefits in research, clinical practice, and education. Recent findings have expanded our understanding of the physiology of swallowing, and virtual reality and spatial display techniques have enhanced educational applications.
CURRENT OTORHINOLARYNGOLOGY REPORTS
(2023)
Editorial Material
Chemistry, Multidisciplinary
Warren C. W. Chan, Natalie Artzi, Chunying Chen, Xiaodong Chen, Dean Ho, Tony Hu, Kazunori Kataoka, Luis M. Liz-Marzan, Rahmi Oklu, Wolfgang J. Parak
Article
Otorhinolaryngology
Takahiro Katsuno, Rumi Ueha, Aiko Fujisaki, Takeshi Unno, Carmel Cotaoco, Asako Kaneoka, Misaki Koyama, Taku Sato, Takao Goto, Kenji Kondo
Summary: This study highlights the persistence of residual material on cuffed tracheostomy tubes and emphasizes the need for improved tube design to reduce accumulation of residue.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hsi-Kai Tsou, Cheng-Hsin Wu, Long Yi Chan, Kazunori Kataoka, Nanae Itokazu, Minoru Tsuzuki, Hsuan Hu, Guan-Yu Zhuo, Keiji Itaka, Chin-Yu Lin
Summary: Large-area craniofacial defects pose a challenge for orthopaedists. In order to develop a safe and effective tissue engineering strategy, cytokines and chemokines can be utilized to attract endogenous stem cells for bone regeneration. The combination of BMP2 and TGF-beta3 mRNA nanomedicine promotes bone formation and provides an alternative cell-free tissue engineering method for craniofacial defect healing.
Review
Respiratory System
Rumi Ueha, Redentor B. Magdayao, Misaki Koyama, Taku Sato, Takao Goto, Tatsuya Yamasoba
Summary: Severe dysphagia can lead to life-threatening conditions such as intractable pneumonia. Surgical intervention is necessary to prevent intractable aspiration and its complications. This review aims to increase awareness among medical professionals about aspiration prevention surgeries and guide the selection of appropriate surgical options.
RESPIRATORY RESEARCH
(2023)
Article
Materials Science, Biomaterials
Yukiya Kitayama, Takuya Yamada, Kentaro Kiguchi, Aoi Yoshida, Shuhei Hayashi, Hiroaki Akasaka, Kazunori Igarashi, Yuya Nishimura, Yu Matsumoto, Ryohei Sasaki, Eri Takano, Hirobumi Sunayama, Toshifumi Takeuchi
Summary: A novel stealth radiation sensitizer based on Au-embedded molecularly imprinted polymer nanogels (Au MIP-NGs) was developed for low-dose X-ray radiation therapy. It showed good affinity and selectivity towards human serum albumin, and improved the efficiency of pancreatic cancer treatment in mouse models.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Meeting Abstract
Oncology
Hiroaki Kinoh, Sabina Quader, Horacio Cabral, Kazunori Kataoka
