Article
Biochemistry & Molecular Biology
Yuria Jang, Hong Moon Sohn, Young Jong Ko, Hoon Hyun, Wonbong Lim
Summary: The mutant RANKL demonstrated the ability to inhibit osteoclastogenesis by competitively inhibiting RANKL, serving as a potential therapeutic agent for osteoporosis with fewer toxic side effects compared to traditional treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Honglei Kang, Qian Guo, Yimin Dong, Renpeng Peng, Kehan Song, Jia Wang, Haiyang Liu, Meipeng Zhu, Hongjian Zhao, Hanfeng Guan, Feng Li
Summary: MAT2A is crucial for osteoclastogenesis and may be a potential therapeutic target for the treatment of osteoporosis.
Article
Pharmacology & Pharmacy
Yin Cheng, Haixia Liu, Jing Li, Yujie Ma, Changheng Song, Yuhan Wang, Pei Li, Yanjing Chen, Zhiguo Zhang
Summary: Monascin was found to inhibit osteoclastogenesis in RANKL-induced RAW264.7 cells by suppressing MAPKs signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Zechao Qu, Bo Zhang, Lingbo Kong, Yining Gong, Mingzhe Feng, Xiangcheng Gao, Dong Wang, Liang Yan
Summary: This paper provides an overview of the molecular mechanisms of osteoclasts in osteolysis-related diseases and the potential of natural plant derivatives and compounds for treating these diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Hematology
Paolo Giannoni, Cecilia Marini, Giovanna Cutrona, Serena Matis, Maria Cristina Capra, Francesca Puglisi, Paola Luzzi, Simona Pigozzi, Gabriele Gaggero, Antonino Neri, Katia Todoerti, Fortunato Morabito, Adalberto Ibatici, Maurizio Miglino, Micaela Bergamaschi, Silvia Bruno, Gian Mario Sambuceti, Jean Louis Ravetti, Manlio Ferrarini, Franco Fais, Daniela de Totero
Summary: Bone skeletal alterations in CLL are no longer rare, with CLL cells affecting osteoblast differentiation and enhancing monocyte differentiation into mature osteoclasts. Inhibition of certain cytokines or drugs can reverse these effects, indicating a potential therapeutic approach.
Article
Dentistry, Oral Surgery & Medicine
Rui Wang, Huikun Luo, Di Yang, Bo Yu, Jiajie Guo, Lina Shao, Hirohiko Okamura, Lihong Qiu
Summary: The histone demethylase Jumonji domain-containing 3 (Jmjd3) plays a crucial role in regulating the communication between osteoblasts and osteoclasts. Jmjd3 inhibition in osteoblasts promotes osteoclastogenesis and upregulates RANKL expression, while decreasing EphB4 expression. Conversely, overexpression of EphB4 in osteoblasts inhibits osteoclastogenesis and RANKL expression.
Article
Pharmacology & Pharmacy
Chang-hong Li, Zi-rui Lu, Zhen-da Zhao, Xin-yu Wang, Hui-jie Leng, Yan Niu, Mo-pei Wang
Summary: Nitazoxanide (NTZ) has shown potential in inhibiting osteoclastogenesis and bone loss by modulating the STAT3-NFATc1 signaling pathway. The study found that NTZ suppressed osteoclast formation and activity through inhibition of STAT3 phosphorylation and reduction of NFATc1 expression. NTZ could be a potential alternative treatment for bone destruction-related diseases like osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tao Jiang, Tianshuang Xia, Fangliang Qiao, Nani Wang, Yiping Jiang, Hailiang Xin
Summary: Bones serve mechanical and defensive functions, as well as regulating calcium ions and housing bone marrow. The qualities of bones fluctuate throughout life, with functions increasing in some situations while deteriorating in others. Excessive osteoclast differentiation can lead to various bone pathologies, and the transcription factors and developmental/environmental signals play crucial roles in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Jinjin Cao, Shaoming Wang, Congmin Wei, Hongru Lin, Chen Zhang, Yehui Gao, Zixian Xu, Zhou Cheng, Wan-chun Sun, Hong-bing Wang
Summary: In this study, Agrimophol (AGR) was found to inhibit RANKL-induced osteoclastogenesis through various mechanisms, suggesting its potential as a therapeutic agent against bone lysis diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wenqiang Zhang, Ruonan Ning, Ting Ran, Qi Peng, Yong Liu, Tao Lu, Yadong Chen, Min Jiang, Yu Jiao
Summary: In this study, a novel 3-acetylindole compound was identified as a bone antiresorptive agent with selective inhibitory activity against BRPF1B. It showed outstanding inhibitory activity against osteoclastogenesis and differentiation, and demonstrated a strong bone antiresorptive effect by modulating the RANKL/RANK/NFATc1 pathway.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Huimin Hu, Xiaodong Wang, Yansheng Huang, Baorong He, Jinwen Zhu, Kai Sun, Chaoyang Deng, Yunshan Guo, Dingjun Hao, Bin Jian
Summary: The natural compound obacunone found in citrus fruits can inhibit osteoclast differentiation through modulating the Integrin-FAK-Src pathway, suggesting its potential as a therapeutic candidate for the treatment and prevention of bone diseases such as osteoporosis.
Article
Biochemistry & Molecular Biology
Nawab Azizi, Jelena Toma, Mickenzie Martin, Muhammad Faran Khalid, Fatemeh Mousavi, Phyo Wei Win, Maria Teresa Borrello, Nina Steele, Jiaqi Shi, Marina Pasca di Magliano, Christopher L. Pin
Summary: The study suggests a critical role of ATF3 in pancreatic cancer development through promoting ADM and PanIN formation. Loss of ATF3 can reduce response to pancreatic injury and decrease the incidence of PDAC.
Article
Chemistry, Medicinal
Hai-Wei Chen, Chi-Fen Chen, Pei-Rong Lee, Shuenn-Jium Yiin, Jia-Yun Liang, Jue-Liang Hsu, Chi- Chang, Chi-Liang Chern
Summary: 2,5-dihydroxyacetophenone (DHAP), a phenolic compound in Ganoderma bambusicola, inhibits osteoclastogenesis by inhibiting the NFATc1 signaling pathway.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Dermatology
Anne M. Brauweiler, Donald Y. M. Leung, Elena Goleva
Summary: Atopic Dermatitis is linked to defects in skin barrier function caused by increased levels of type-2 cytokines, repressing keratinocyte differentiation. Gene repression induced by type-2 cytokines requires the master regulator p63, affecting multiple genes involved in KC differentiation through pathways converging on transcription factors p63 and Notch.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jin-Yong Lee, Maki Tokumoto, Masahiko Satoh
Summary: Cadmium exerts its cytotoxicity through the inhibition of MEF2A activity and suppression of GLUT4 expression, leading to reduced cellular glucose concentration and ATP levels. This study provides a crucial breakthrough in understanding the mechanism of Cd toxicity in renal cells.
Article
Neurosciences
Kwang Il Nam, Gwangho Yoon, Young-Kook Kim, Juhyun Song
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2020)
Article
Genetics & Heredity
Dana Lau-Corona, Woo Kyun Bae, Lothar Hennighausen, David J. Waxman
Article
Cell Biology
Lothar Hennighausen, Hye Kyung Lee
Article
Medicine, Research & Experimental
Nakwon Choe, Duk-Hwa Kwon, Juhee Ryu, Sera Shin, Hye Jung Cho, Hosouk Joung, Gwang Hyeon Eom, Youngkeun Ahn, Woo Jin Park, Kwang-Il Nam, Young-Kook Kim, Hyun Kook
MOLECULAR THERAPY-NUCLEIC ACIDS
(2020)
Article
Cardiac & Cardiovascular Systems
Somy Yoon, Mira Kim, Hangyeol Lee, Gaeun Kang, Kenneth Bedi, Kenneth B. Margulies, Rajan Jain, Kwang-Il Nam, Hyun Kook, Gwang Hyeon Eom
Summary: The study reveals that neuronal nitric oxide synthase induces diastolic dysfunction by S-nitrosylation of HDAC2, suggesting a new therapeutic platform for refractory heart failure with preserved ejection fraction.
Article
Multidisciplinary Sciences
Hye Kyung Lee, Michaela Willi, Tyler Kuhns, Chengyu Liu, Lothar Hennighausen
Summary: Enhancers that activate gene expression in the lactating mouse mammary gland were investigated, revealing the importance of a lactation-specific distal enhancer and a super-enhancer in coordinating with the promoter for gene activation. The study provides insights into the regulatory mechanisms of enhancers and super-enhancers during lactation.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Hye Kyung Lee, Olive Jung, Lothar Hennighausen
Summary: The study reveals that interferon-induced expression of dACE2 and ACE2 genes can be suppressed by JAK inhibitors, providing insights into SARS-CoV-2 infection of airway cells and potential therapeutic strategies.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Duk-Hwa Kwon, Nakwon Choe, Sera Shin, Juhee Ryu, Nacksung Kim, Gwang Hyeon Eom, Kwang-Il Nam, Hyung Seok Kim, Youngkeun Ahn, Young-Kook Kim, Woo Jin Park, Susan M. Mendrysa, Hyun Kook
Summary: The study revealed the driver and activation pathway of vascular calcification, causing severe complications in patients with cardiovascular and renal diseases, potentially providing valuable information for novel therapeutic strategies targeting related conditions.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Surgery
Dong Hoon Lee, Young-Suk Cho, Wook Hyun Jung, Sang Chul Lim, Kwang Il Nam
Summary: The study conducted an anatomical analysis of the anterior jugular vein in Koreans, finding that a safety zone at the main landmark of the neck could be used to prevent damage to the AJV.
JOURNAL OF CRANIOFACIAL SURGERY
(2022)
Article
Multidisciplinary Sciences
Hye Kyung Lee, Ludwig Knabl, Mary Walter, Priscilla A. Furth, Lothar Hennighausen
Summary: The study suggests that prior infection status significantly impacts the immune response following BA.2 infection, with significantly increased neutralizing antibody levels in patients with a previous history of COVID-19.
Article
Anatomy & Morphology
Hyeng-Kyu Park, Jae-Young Han, Young-Suk Cho, Kwang-Il Nam
Summary: The tensor of the vastus intermedius (TVI) originated from the anteroinferior greater trochanter and inserts into the upper patella. It has been overlooked but warrants more research due to the development of micro-surgery and detailed rehabilitation treatments.
Article
Immunology
Alejandro V. Villarino, Arian D. J. Laurence, Fred P. Davisi, Luis Nivelo, Stephen R. Brooks, Hong-Wei Sun, Kan Jiang, Behdad Afzali, Daniela Frasca, Lothar Hennighausen, Yuka Kanno, John J. O'Shea
Summary: This study reveals that STAT5 is a crucial regulator of energy and amino acid metabolism in CD4+ T helper cells, and it plays a role in transcriptional regulation of key enzymes and transporters. Additionally, STAT5 interacts with the mTOR signaling pathway and MYC transcription factor to regulate T-cell metabolism.
SCIENCE IMMUNOLOGY
(2022)
Article
Respiratory System
Chung Man Sung, Hong Chan Kim, Jisun Kim, Jae Gu Kim, Sang Chul Lim, Min-Ho Shin, Kwangil Nam, Jongho Lee, Daniel Vena, David P. White, Hyung Chae Yang, Andrew Wellman
Summary: This study analyzed adherence to autotitrating positive airway pressure (APAP) treatment in patients with epiglottic collapse. It found that patients with epiglottic collapse had a higher APAP adherence failure rate and lower usage time compared to patients without epiglottic collapse. These patients also had a lower body mass index, which is an unfavorable predictor of APAP adherence.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Allergy
Hyung Chae Yang, Eun Jeong Won, Moon-Ju Kim, Chung Man Sung, Joon Haeng Rhee, Kwang Il Nam
Summary: The intralymphatic injection of Metagonimus yokogawai extract protein (My-TP) was shown to reduce allergic symptoms and eosinophil infiltration in the nasal mucosa of OVA-sensitized allergic rhinitis mice. Additionally, My-TP treatment group exhibited significantly decreased levels of OVA-specific IgE and white blood cell counts in nasal lavage. This study suggests a potential therapeutic effect of My-TP in allergic rhinitis by modulating the Treg/Th2 balance.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Hyunjong Kim, Chung Man Sung, Hunpyo Ju, Hyeongoh Park, Jinmo Jeong, Kwang Il Nam, Hyung Chae Yang, Jongho Lee
ADVANCED MATERIALS TECHNOLOGIES
(2020)