Article
Neurosciences
Julia Leschik, Antonietta Gentile, Cigdem Cicek, Sophie Peron, Margaryta Tevosian, Annika Beer, Konstantin Radyushkin, Anna Bludau, Karl Ebner, Inga Neumann, Nicolas Singewald, Benedikt Berninger, Volkmar Lessmann, Beat Lutz
Summary: The neurotrophin brain-derived neurotrophic factor (BDNF) affects adult neurogenesis, structural plasticity and function of serotonergic neurons. Both BDNF/TrkB signaling and serotonergic system regulate behavioral responses to stress. Overexpression of BDNF in serotonergic neurons enhances hippocampus-dependent contextual learning and reduces the impact of chronic social defeat stress (CSDS). Increased neurogenesis is correlated with improved stress resilience.
PROGRESS IN NEUROBIOLOGY
(2022)
Review
Medicine, Research & Experimental
Vahideh Zalouli, Hosnieh Rajavand, Mahdi Bayat, Jalil Khaleghnia, Fariborz Sharifianjazi, Farzad Jafarinazhad, Nima Beheshtizadeh
Summary: Physical exercise has positive effects on adult hippocampal neurogenesis (AHN) and cognitive processes. The effects of anaerobic resistance training and high-intensity interval training on AHN are not clear. Individual genetic diversity may play a role in the response to exercise on AHN. Exercise can improve health on average, but the benefits may vary due to genetic differences. This review discusses the capability of AHN for peripheral nervous system regeneration and central nervous system control through physical exercise, as well as the genes and factors involved.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Desiree R. Seib, Delane F. Espinueva, Oren Princz-Lebel, Erin Chahley, Jordann Stevenson, Timothy P. O'Leary, Stan B. Floresco, Jason S. Snyder
Summary: Adult hippocampal neurogenesis plays a crucial role in decision making regarding future rewards, with inhibition of neurogenesis leading to aversion towards delayed rewards and preference for immediately available rewards. This suggests a specific role for newborn neurons in regulating choices involving future-oriented cognition.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Marta Gronksa-Peski, J. Tiago Goncalves, Jean M. Hebert
Summary: Research shows that an enriched environment promotes adult neurogenesis by increasing the function of fibroblast growth factor receptor (FGFR) within neurogenic cells. Activation of FGFR by an enriched environment signals through FGFR substrate (FRS) to induce stem cell proliferation and via FRS and phospholipase C gamma to increase the number of adult-born neurons.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Wenqiang Fan, Jeronimo Jurado-Arjona, Gregorio Alanis-Lobato, Sophie Peron, Christian Berger, Miguel A. Andrade-Navarro, Sven Falk, Benedikt Berninger
Summary: Most adult hippocampal neural stem cells (NSCs) remain quiescent, but the activity of the transcriptional co-activator Yap1 is enriched in active NSCs. Genetic deletion of Yap1 reduces the proportion of active NSCs, indicating its role in regulating the transition from quiescence to activation. Overexpression of a gain-of-function Yap1 mutant leads to cell cycle entry in NSCs and astrocytes, and dysregulated Yap1 activity represses neurogenesis and induces glioblastoma stem cell-like characteristics.
Article
Cell Biology
Dae Young Yoo, Hyo Young Jung, Woosuk Kim, Kyu Ri Hahn, Hyun Jung Kwon, Sung Min Nam, Jin Young Chung, Yeo Sung Yoon, Dae Won Kim, In Koo Hwang
Summary: Entacapone treatment promoted hippocampal neurogenesis and improved memory function through activating the BDNF-TrkB-pCREB pathway, while also antagonizing the effects of TrkB receptor antagonist.
NEURAL REGENERATION RESEARCH
(2021)
Article
Immunology
Kanza M. Khan, Gabrielle Bierlein-De La Rosa, Natalie Biggerstaff, Govindhasamy Pushpavathi Selvakumar, Ruixiang Wang, Suzanne Mason, Michael E. Dailey, Catherine A. Marcinkiewcz
Summary: Adolescent alcohol use can permanently alter brain function and lead to poor health outcomes in adulthood. Emerging evidence suggests that alcohol use can predispose individuals to pain disorders or exacerbate existing pain conditions, but the underlying neural mechanisms are currently unknown.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Psychiatry
David P. Herzog, Diego Pascual Cuadrado, Giulia Treccani, Tanja Jene, Verena Opitz, Annika Hasch, Beat Lutz, Klaus Lieb, Inge Sillaber, Michael A. Van der Kooij, Vijay K. Tiwari, Marianne B. Mueller
Summary: The study revealed differentially expressed genes associated with paroxetine treatment and candidate mechanisms related to good treatment response, such as neuropeptide signaling and synaptic transmission. The results suggest that general paroxetine effects can be distinguished from treatment response-associated molecular signatures, offering potential new targets for future antidepressant treatments.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Immunology
Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Chen
Summary: This review explores the roles of adult hippocampal neurogenesis and microglia in the etiology of depression, and discusses the mechanisms by which microglia regulate adult hippocampal neurogenesis in depression and potential drugs for improving neurogenesis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Sebastian B. Arredondo, Daniel T. Reyes, Andrea Herrera-Soto, Muriel D. Mardones, Nibaldo C. Inestrosa, Lorena Varela-Nallar
Summary: The study found that Andrographolide (ANDRO) can promote neurogenesis in the hippocampus of Alzheimer's disease mice, increase the number of newborn neurons, and improve spatial memory performance.
SCIENTIFIC REPORTS
(2021)
Article
Agriculture, Multidisciplinary
Shu-Hua Ouyang, Yu-Jia Zhai, Yan-Ping Wu, Guo Xie, Guo-En Wang, Zhong-Fu Mao, Hui-Hua Hu, Xue-Hua Luo, Wan-Yang Sun, Lei Liang, Wen-Jun Duan, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong He
Summary: The study revealed that a special variety of tea in China, Camellia assamica var. kucha, possesses antidepressant effects with less adverse effects compared to traditional tea Camellia sinensis, primarily due to its high theacrine content. Through experiments on mouse models, it was found that theacrine could counteract depression induced by chronic stress by promoting adult hippocampal neurogenesis, possibly through modulation of the PDE4/cAMP/CREB/BDNF/TrkB pathway. This suggests that theacrine has the potential to be developed as a novel antidepressant medicine.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Cell Biology
Barbara Planchez, Natalia Lagunas, Anne-Marie Le Guisquet, Marc Legrand, Alexandre Surget, Rene Hen, Catherine Belzung
Summary: Studies have shown that increasing adult hippocampal neurogenesis can promote stress resilience and prevent the development of stress-induced depressive-like symptoms.
Article
Neurosciences
Siqi Sun, Jinlong Zhou, Zhongqi Li, Yuzi Wu, Hao Wang, Qi Zheng, Frank Adu-Nti, Juan Fan, Yingfang Tian
Summary: The study found that PGRN significantly alleviated anxiety and cognitive impairment caused by cerebral ischemia in mice, possibly through promoting hippocampal neurogenesis and activating the MAPK/ERK and PI3K/Akt pathways.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Cell & Tissue Engineering
Dan Song, Yaohua Chen, Cheng Chen, Lili Chen, Oumei Cheng
Summary: Inhibition of GABA(B) receptor can effectively promote hippocampal neurogenesis and improve spatial learning and memory in adult mice following cerebral ischemia.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Clinical Neurology
Eric M. Schoenfeld, Nishant K. Gupta, Shariful A. Syed, Anna Rozenboym, Sasha L. Fulton, Andrea P. Jackowski, Tarique D. Perera, Jeremy D. Coplan
Summary: The study suggests that bonnet macaques reared under stress, carrying the ?s?-allele and having smaller adolescent hippocampal volume, exhibit reduced neurogenesis in adulthood. The positive impact of ipsilateral hippocampal volume on neurogenesis levels was observed.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Sophia Frangou, Amirhossein Modabbernia, Steven C. R. Williams, Efstathios Papachristou, Gaelle E. Doucet, Ingrid Agartz, Moji Aghajani, Theophilus N. Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Micael Andersson, Nancy C. Andreasen, Ole A. Andreassen, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt, Josiane Bourque, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Geraldo F. Busatto, Randy L. Buckner, Vincent Calhoun, Erick J. Canales-Rodriguez, Dara M. Cannon, Xavier Caseras, Francisco X. Castellanos, Simon Cervenka, Tiffany M. Chaim-Avancini, Christopher R. K. Ching, Victoria Chubar, Vincent P. Clark, Patricia Conrod, Annette Conzelmann, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline A. Crone, Anders M. Dale, Christopher Davey, Eco J. C. de Geus, Lieuwe de Haan, Greig de Zubicaray, Anouk den Braber, Erin W. Dickie, Annabella Di Giorgio, Nhat Trung Doan, Erlend S. Dorum, Stefan Ehrlich, Susanne Erk, Thomas Espeseth, Helena Fatouros-Bergman, Simon E. Fisher, Jean-Paul Fouche, Barbara Franke, Thomas Frodl, Paola Fuentes-Claramonte, David C. Glahn, Ian H. Gotlib, Hans-Joergen Grabe, Oliver Grimm, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Rachel E. Gur, Ruben C. Gur, Ben J. Harrison, Catharine A. Hartman, Sean N. Hatton, Andreas Heinz, Dirk J. Heslenfeld, Derrek P. Hibar, Ian B. Hickie, Beng-Choon Ho, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony James, Terry L. Jernigan, Jiyang Jiang, Erik G. Jonsson, John A. Joska, Rene Kahn, Andrew Kalnin, Ryota Kanai, Marieke Klein, Tatyana P. Klyushnik, Laura Koenders, Sanne Koops, Bernd Kraemer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina Lebedeva, Won Hee Lee, Klaus-Peter Lesch, Christine Lochner, Marise W. J. Machielsen, Sophie Maingault, Nicholas G. Martin, Ignacio Martinez-Zalacain, David Mataix-Cols, Bernard Mazoyer, Colm McDonald, Brenna C. McDonald, Andrew M. McIntosh, Katie L. McMahon, Genevieve McPhilemy, Jose M. Menchon, Sarah E. Medland, Andreas Meyer-Lindenberg, Jilly Naaijen, Pablo Najt, Tomohiro Nakao, Jan E. Nordvik, Lars Nyberg, Jaap Oosterlaan, Victor Ortiz-Garcia de la Foz, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J. Portella, Steven G. Potkin, Joaquim Radua, Andreas Reif, Daniel A. Rinker, Joshua L. Roffman, Pedro G. P. Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Pascual Sanchez-Juan, Salvador Sarro, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Lianne Schmaal, Knut Schnell, Gunter Schumann, Kang Sim, Jordan W. Smoller, Iris Sommer, Carles Soriano-Mas, Dan J. Stein, Lachlan T. Strike, Suzanne C. Swagerman, Christian K. Tamnes, Henk S. Temmingh, Sophia Thomopoulos, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Julian N. Trollor, Jessica A. Turner, Anne Uhlmann, Odile A. van den Heuvel, Dennis van den Meer, Nic J. A. van der Wee, Neeltje E. M. van Haren, Dennis van't Ent, Theo G. M. van Erp, Ilya M. Veer, Dick J. Veltman, Aristotle Voineskos, Henry Voelzke, Henrik Walter, Esther Walton, Lei Wang, Yang Wang, Thomas H. Wassink, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather Whalley, Lara M. Wierenga, Katharina Wittfeld, Daniel H. Wolf, Amanda Worker, Margaret J. Wright, Kun Yang, Yulyia Yoncheva, Marcus Zanetti, Georg C. Ziegler, Paul M. Thompson, Danai Dima
Summary: The study used data from the ENIGMA Consortium to explore the relationship between age and cortical thickness, finding that most regions peak in cortical thickness during childhood, with a negative association between age and cortical thickness where the slope is steeper before the age of 30 and more gradual afterwards.
HUMAN BRAIN MAPPING
(2022)
Article
Biochemistry & Molecular Biology
Britt Mossink, Jon-Ruben Van Rhijn, Shan Wang, Katrin Linda, Maria R. Vitale, Johanna E. M. Zoller, Eline J. H. van Hugte, Jitske Bak, Anouk H. A. Verboven, Martijn Selten, Moritz Negwer, Brooke L. Latour, Ilse van der Werf, Jason M. Keller, Teun M. Klein Gunnewiek, Chantal Schoenmaker, Astrid Oudakker, Alessia Anania, Sophie Jansen, Klaus-Peter Lesch, Monica Frega, Hans van Bokhoven, Dirk Schubert, Nael Nadif Kasri
Summary: This study revealed the regulatory role of CDH13 in inhibitory synapse function by establishing a human neuronal model. By culturing iGABAs in vitro, we found that CDH13 deficiency increases inhibition, thereby reducing the excitatory/inhibitory balance. Through these findings, we identified a potential mechanism by which CDH13 may contribute to the pathophysiology of brain disorders.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Chun-Hui He, Lei Zhang, Ning-Ning Song, Wan-Ying Mei, Jia-Yin Chen, Ling Hu, Qiong Zhang, Yu-Bing Wang, Yu-Qiang Ding
Summary: Soma spacing and dendritic arborization are crucial for the establishment of proper neural circuitry and function during brain development. This study reveals the involvement of transcription factor Satb2 in regulating these processes. Satb2 is shown to be necessary for the regionalization of retrosplenial cortex, the determination of callosal neuron fate, and the regulation of soma spacing and dendritic self-avoidance of cortical pyramidal neurons. The study also identifies EphA7 as a downstream effector of Satb2, with Satb2 directly suppressing the expression of EphA7. These findings provide new insights into the transcriptional regulation of cerebral cortex morphogenesis.
Article
Biochemistry & Molecular Biology
Tatyana Strekalova, Dmitrii Pavlov, Alexander Trofimov, Daniel C. Anthony, Andrei Svistunov, Andrey Proshin, Aleksei Umriukhin, Alexei Lyundup, Klaus-Peter Lesch, Raymond Cespuglio
Summary: The role of hippocampal cyclooxygenase-2 (COX-2) in stress-induced anhedonia has been investigated. Inhibition of COX-2 in the hippocampus has antidepressant effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Tatyana Strekalova, Yanzhi Liu, Daniel Kiselev, Sharafuddin Khairuddin, Jennifer Lok Yu Chiu, Justin Lam, Ying-Shing Chan, Dmitrii Pavlov, Andrey Proshin, Klaus-Peter Lesch, Daniel C. Anthony, Lee Wei Lim
Summary: The Chronic Mild Stress (CMS) paradigm is a widely used model for finding antidepressant drugs for Major Depressive Disorder (MDD). While literature analysis supports the validity of this model, further improvements could be achieved by stratifying animals, using refined experimental protocols, and systematically evaluating non-specific effects.
PSYCHOPHARMACOLOGY
(2022)
Article
Genetics & Heredity
Noelia Fernandez-Castillo, Judit Cabana-Dominguez, Djenifer B. Kappel, Barbara Torrico, Heike Weber, Klaus-Peter Lesch, Oscar Lao, Andreas Reif, Bru Cormand
Summary: By studying genes related to Mendelian disorders presenting with ADHD symptoms, we identified new candidate risk genes for ADHD that are mainly associated with neurodevelopment and brain function. We also found rare variants associated with the severity of inattention symptoms and identified common variants associated with ADHD and its comorbidities.
Article
Environmental Sciences
Yun-Qing Hu, Ting-Ting Niu, Jian-Ming Xu, Li Peng, Qing-Hua Sun, Ying Huang, Ji Zhou, Yu-Qiang Ding
Summary: The exposure to negative air ions (NAI) has been found to alleviate depressive-like behaviors induced by chronic mild stress (CMS) in mice, possibly by modulating corticosterone levels and rebalancing the function of Th1 and Th2 cells.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Genetics & Heredity
Andrew D. Grotzinger, Travis T. Mallard, Wonuola A. Akingbuwa, Hill F. Ip, Mark J. Adams, Cathryn M. Lewis, Andrew M. McIntosh, Jakob Grove, Soren Dalsgaard, Klaus-Peter Lesch, Nora Strom, Sandra M. Meier, Manuel Mattheisen, Anders D. Borglum, Ole Mors, Gerome Breen, Phil H. Lee, Kenneth S. Kendler, Jordan W. Smoller, Elliot M. Tucker-Drob, Michel G. Nivard
Summary: A joint analysis of 11 major psychiatric disorders identified four broad factors underlying the genetic correlations among the disorders, along with multiple loci acting on these factors. These findings suggest the presence of genetic overlap among different psychiatric disorders, but also highlight the heterogeneity within each factor. However, a single dimension of genetic risk does not appear to be useful in explaining the biobehavioral correlates or individual variants of psychiatric disorders.
Article
Clinical Neurology
Ya-Bo Zhao, Xue-Fei Hou, Xin Li, Li-Su Zhu, Jing Zhu, Guo-Rui Ma, Yu-Xuan Liu, Yu-Can Miao, Qian-Yu Zhou, Lin Xu, Qi-Xin Zhou
Summary: This study explores the neurobiological mechanisms of early AD damage and finds that memory impairment occurs as early as 4 months in APP/PS1 mice and worsens with age. The findings have important implications for understanding the mechanism of early AD.
CURRENT ALZHEIMER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shangyao Qin, Yimin Yuan, Xiao Huang, Zijian Tan, Xin Hu, Hong Liu, Yingyan Pu, Yu-qiang Ding, Zhida Su, Cheng He
Summary: This study reveals the preferential expression of TOP2a in neurogenic niches and its crucial role in the self-renewal and proliferation of adult neural stem cells. The researchers identified Usp37 as a direct target gene of TOP2a through RNA sequencing and chromatin immunoprecipitation sequencing, and found that overexpression of Usp37 can rescue the impaired self-renewal ability of adult neural stem cells caused by Top2a knockout.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Pengcheng Ma, Li Pear Wan, Yuwei Li, Chun-Hui He, Ning-Ning Song, Shiping Zhao, Huishan Wang, Yu-Qiang Ding, Bingyu Mao, Nengyin Sheng
Summary: RNF220 acts as an E3 ubiquitin ligase for AMPARs, playing a significant role in excitatory synaptic transmission and brain function. Lack of RNF220 increases AMPAR protein levels, enhancing basal synaptic activity and impairing synaptic plasticity.
Article
Neurosciences
Xue-Fei Hou, Ya-Bo Zhao, Yue-Xiong Yang, Chen Ma, Meng Li, Xin Li, Guo-Rui Ma, Li-Su Zhu, Lin Xu, Qi-Xin Zhou
Summary: This study found that learning ability in mice is negatively correlated with susceptibility to morphine use disorder (MUD), suggesting that impaired learning ability can predict SUD susceptibility. FVB mice, which showed impaired learning ability, exhibited higher sensitivity to MUDs compared to C57 mice. These findings highlight the importance of considering learning ability in identifying high-risk SUD groups.
Article
Cell Biology
Chun-Hui He, Ning-Ning Song, Pin-Xi Xie, Yu-Bing Wang, Jia-Yin Chen, Ying Huang, Ling Hu, Zhao Li, Jun-Hui Su, Xiao-Qing Zhang, Lei Zhang, Yu-Qiang Ding
Summary: Overexpression of EphB6 or EphrinB2 leads to clustering of cortical neurons, but co-overexpression of both proteins prevents this phenomenon, indicating a synergistic role of EphrinB2/EphB6 in controlling soma spacing in cortical development.
CELL DEATH & DISEASE
(2023)
Article
Behavioral Sciences
Xue-Fei Hou, Ya-Bo Zhao, Yue-Xiong Yang, Jing Zhu, Li-Su Zhu, Lin Xu, Qi-Xin Zhou
Summary: In this study, a simple and effective experimental model was designed to investigate the generalization memory of morphine reward. By replacing the conditioning CPP box, it was found that mice still showed a clear preference for generalized information. The establishment of this study provides a new tool for studying generalization memory in substance use disorders.
BRAIN AND BEHAVIOR
(2023)
