Article
Biochemistry & Molecular Biology
Morteza Eskandani, Hossein Derakhshankhah, Rana Jahanban-Esfahlan, Mehdi Jaymand
Summary: Novel electrically conductive nanofibrous scaffolds were fabricated through electrospinning with poly(vinyl alcohol) (PVA) after grafting aniline monomer onto a phenylamine-functionalized alginate (Alg-NH2). The scaffolds showed excellent hydrophilicities and 3D, inter-connected and uniform porous structures. They exhibited acceptable cytocompatibilities, enhanced cell adhesion and proliferation, and had low hemolysis rates and good protein adsorption capacities. Overall, the developed scaffolds have great potential for bone tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Yusuf Ozcan, Dicle Erden Gonenmis, Esranur Kizilhan, Cem Gok
Summary: This study aimed to produce high porous and non-toxic hydrogel scaffolds using chitosan, alginate, and diatom. The scaffolds were examined for density, porosity, swelling tests, as well as morphologic, chemical, and cytotoxic analysis. The results showed that the scaffolds have potential in the field of tissue engineering.
Article
Biochemistry & Molecular Biology
Yakui Liu, Qingxi Hu, Wenpei Dong, Suihong Liu, Haiguang Zhang, Yan Gu
Summary: In recent years, 3D bioprinting has gained extensive research interest for biomedical engineering and clinical applications. This study developed a gelatin/sodium alginate-based hydrogel with protein-rich ink for 3D printing tissue engineering scaffold. The ink exhibited excellent shear-thinning behavior and good crosslinking ability. The printed scaffold showed favorable physicochemical properties and enhanced cell attachment, spreading, migration, and proliferation. Furthermore, the scaffold promoted the growth of neo-vessels, indicating its potential for angiogenesis.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Gianluca Viscusi, Giuliana Gorrasi
Summary: This paper explores the facile preparation of alginate beads encapsulating layered double hydroxide (LDH) intercalated with diclofenac sodium for drug delivery systems. The study evaluates the effect of LDH carrier, release kinetics of diclofenac at different pH and temperatures, and the fabrication of a sustainable composite characterized by a triggered drug release rate. Empirical relationships correlating the drug diffusion as a function of temperature and pH were also extrapolated.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Nohra E. Beltran-Vargas, Eduardo Pena-Mercado, Concepcion Sanchez-Gomez, Mario Garcia-Lorenzana, Juan-Carlos Ruiz, Izlia Arroyo-Maya, Sara Huerta-Yepez, Jose Campos-Teran
Summary: This study investigates the effects of different scaffolds containing sodium alginate and chitosan, with the addition of metal nanoparticles, on cardiomyocyte growth. The results demonstrate that the incorporation of metal nanoparticles can enhance cardiac protein expression and cell proliferation, indicating their potential use in cardiac tissue engineering.
Article
Biochemistry & Molecular Biology
R. Olmos-Juste, G. Larranaga-Jaurrieta, I. Larraza, S. Ramos-Diez, S. Camarero-Espinosa, N. Gabilondo, A. Eceiza
Summary: In this study, functional alginate and waterborne polyurethane scaffolds were developed for articular cartilage regeneration using 3D bioprinting technology. It was found that scaffolds with a higher alginate content showed better 3D printing performance, structural integrity, and cell viability. After 28 days of experiments, these scaffolds were capable of maintaining cell numbers and synthesizing glycosaminoglycans, indicating their potential application for in vitro regeneration of articular cartilage tissue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Yue Wu, Yingkun Fu, Hongfu Pan, Cong Chang, Ningjian Ao, Hui Xu, Zhengnan Zhang, Ping Hu, Riwang Li, Shuxia Duan, Yan Yan Li
Summary: In this study, a new type of bioactive material was designed and prepared using stingray skin collagen and oyster shell powder as raw materials. The stingray skin collagen/oyster osteoinductive composite scaffold (Col-OSP) was prepared for the first time and characterized through various tests. The Col-OSP scaffold exhibited a three-dimensional porous structure, enhanced mechanical properties, and promoted cell proliferation, adhesion, and differentiation, as well as osteogenesis-related gene expressions.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Engineering, Biomedical
Qifan Wang, Zhiyong Ma, Ying Wang, Linna Zhong, Wenjia Xie
Summary: The study embedded nano-zirconium dioxide (ZrO2) powder in PCL material through a melt-mixing process and constructed a regular grid scaffold by 3D printing. The composite scaffold showed improved hydrophilicity and water absorption, facilitating cell adhesion, proliferation, and growth, as well as nutrient exchange. Furthermore, the addition of ZrO2 significantly enhanced the mechanical properties of the scaffold, leading to better biological activity and osteogenic differentiation compared to pure PCL materials.
BIO-DESIGN AND MANUFACTURING
(2021)
Article
Chemistry, Applied
Amitava Bhattacharyya, Hyeong-wook Ham, JiAe Sonh, Marla Gunbayar, R. Jeffy, R. Nagarajan, Mst Rita Khatun, Insup Noh
Summary: Controlled in situ 3D bioprinting of hydrogel without toxic crosslinker is achieved using an advanced pen-type extruder, allowing for tissue regeneration by distributing reinforcing agent during fabrication of large area and complex tissue engineering scaffolds. The addition of kaolin to the alginate-chitosan bioink improves mechanical properties and printability, while also promoting uniform cell growth and proliferation throughout the bioprinted gel matrix. The advanced pen-type extruder ensures better mixing effectiveness and suitability for in vitro tissue regeneration.
CARBOHYDRATE POLYMERS
(2023)
Article
Polymer Science
Dengbang Jiang, Haoying Zou, Heng Zhang, Wan Zhao, Yaozhong Lan, Mingwei Yuan
Summary: By varying the mass ratio of PLLA to PTMC, the diameter, elastic modulus, and elongation at breaking point of electrospun fibers can be modified. The PLLA/PTMC electrospun fiber membrane exhibits improved mechanical properties while maintaining good histocompatibility compared to PLLA electrospun fiber membrane.
Article
Engineering, Biomedical
Abudureheman Maihemuti, Han Zhang, Xiang Lin, Yangyufan Wang, Zhihong Xu, Dagan Zhang, Qing Jiang
Summary: In this study, a three-dimensional printed porous multilayer scaffold made of cold-water fish skin gelatin was developed for osteoarticular cartilage regeneration. The scaffold mimics the structure of native cartilage, allowing chondrocytes to adhere, proliferate, and communicate, as well as transport nutrients and prevent further joint damage. Moreover, the gelatin scaffolds were found to be nonimmunogenic, nontoxic, and biodegradable. Implanting the scaffold into rat cartilage defects resulted in satisfactory repair outcomes in an animal model. Therefore, cold-water fish skin gelatin scaffolds have promising applications in regenerative medicine.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Chunyang Ma, Hetong Wang, Yongjie Chi, Yanling Wang, Le Jiang, Nan Xu, Qiong Wu, Qingling Feng, Xiaodan Sun
Summary: Collagen fibers in the body have a complex arrangement, which plays an important role in cell adhesion, migration, proliferation, and secretion. Oriented collagen fiber scaffolds have shown exciting results in tissue repair. Bone is crucial for bearing loads in the human body, and the arrangement of collagen fibers in bone significantly affects its mechanical properties and physiological functions. Oriented collagen fiber scaffolds can promote new bone growth and induce cells to secrete oriented extracellular matrix. However, the complex arrangement of collagen fibers in bone poses challenges for bone tissue repair and bionics.
APPLIED MATERIALS TODAY
(2021)
Review
Chemistry, Medicinal
Hengtong Zhang, Junqiu Cheng, Qiang Ao
Summary: Alginates are natural polysaccharides extracted from brown marine algae and bacteria, known for their biocompatibility, biodegradability, non-toxicity, and gel formation properties. They can be processed into various forms like hydrogels, microspheres, fibers, and sponges, and have found wide applications in wound healing, tissue repair, and drug delivery in recent years.
Article
Materials Science, Multidisciplinary
Ammara Sathain, Pathavuth Monvisade, Punnama Siriphannon
Summary: The porous bioactive alginate/carrageenan/calcium silicate scaffolds prepared through a specific process demonstrated high stability, strong bioactivity, and good mechanical properties, suitable for bone tissue engineering and bone replacement materials.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Nanoscience & Nanotechnology
Ramin Jafari, Maryam Tohidi, Banafsheh Rastegari, Sedigheh Zeinali
Summary: This study explores the potential application of BioMIL-4, a biological metal-organic framework, and its composite with chitosan and alginate as natural polymers, for bone tissue engineering. The biomimetic mineralization of BioMIL-4 on chitosan nanofibers enhances the scaffold's degradation rate and mechanical strength, while the incorporation of chitosan particles and alginate solutions further improves the scaffold's performance.
ACS APPLIED NANO MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Fei Huang, Taiying Chen, Jun Chang, Chi Zhang, Faxue Liao, Linwei Wu, Wenbin Wang, Zongsheng Yin
Summary: The study introduced a novel hydrogel for sustainable release of BDNF in SCI repair, mimicking the properties of natural spinal cords with the ability to promote neural stem cell differentiation into neurons and inhibit astrocyte differentiation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Biomedical
Taiying Chen, Ngalei Tam, Yu Mao, Chengjun Sun, Zekang Wang, Yuchen Hou, Wuzheng Xia, Jia Yu, Linwei Wu
Summary: This study introduces a convenient all-in-one therapeutic nanoplatform for hepatocellular carcinoma treatment. The nanoplatform possesses multiple functional elements, and its specially designed pH-responsive charge-reversal nanocarrier prolongs drug release and improves cellular uptake efficiency. It also generates oxygen by catalyzing tumor over-expressed H2O2, improving the hypoxic tumor microenvironment. The nanoplatform shows promising potential for dual-modal imaging-guided synergistic therapy of hepatocellular carcinoma.
MATERIALS TODAY BIO
(2022)
