期刊
RSC ADVANCES
卷 6, 期 46, 页码 40250-40257出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra03074b
关键词
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资金
- National Natural Science Foundation of China [31401505]
- Core Research Budget of the Non-profit Governmental Research Institution (ICS, CAAS) [1610092015002-03]
The aim of the present study is to investigate the antitumor activity and immunostimulatory effect of the water-soluble polysaccharides (DDP) from stem of Dendrobium devonianum in S180 tumor-bearing mice. The mice were divided into 3 groups, and then DDP or Ganoderma lucidum polysaccharides (GLP) dissolved in deionized water were given to the mice at a dose of 200 mg kg(-1) for 30 days. DDP, as well as GLP, significantly inhibited the growth of mouse transplantable tumors and promoted spleen indexes, delayed-type hypersensitivity reaction, natural killer cell activity, macrophage phagocytosis and lymphocyte proliferation. Moreover, DDP and GLP increased the colonic acetate, butyrate and total short-chain fatty acid (SCFA) concentrations. These results indicated that oral administration of DDP significantly inhibited the growth of transplanted tumors in S180 tumor-bearing mice by improving specific and non-specific immune responses, as well as increasing colonic SCFAs.
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