Synthesis of 1,2,4-triazine derivatives via [4+2] domino annulation reactions in one pot

Simple and efficient [4 + 2] domino annulation reactions have been developed for the synthesis of 1,2,4-triazine derivatives. The strategies exhibit high performance with moderate to high yields, using easily available materials including ketones, aldehydes, alkynes, secondary alcohols and alkenes, representing a powerful tool for the formation of potentially biologically active derivatives.