Article
Biochemistry & Molecular Biology
Amna Ramzan, Azra Mehmood, Ramla Ashfaq, Anisa Andleeb, Hira Butt, Saima Zulfiqar, Muhammad Nasir, Anwarul Hasan, Kamran Khalid, Muhammad Yar, Kausar Malik, Sheikh Riazuddin
Summary: Hydrogels are used in regenerative medicine for their biocompatibility. This study aimed to develop a porous hydrogel composite scaffold for chronic skin wound repair. The addition of zinc oxide nanoparticles to the chitosan-based hydrogel showed good antibacterial activity and demonstrated compatibility with human adipose stem cells. The findings suggest potential clinical applications for tissue engineering and chronic wound treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Yuying Wu, Cen-Feng Fu, Qiang Huang, Pengpeng Zhang, Peng Cui, Jin Ran, Jinlong Yang, Tongwen Xu
Summary: Adding g-C3N4 sheets into GO membranes to establish stable and sub-nanometer wide channels can significantly improve salt rejection and water permeance. Experimental and theoretical studies have shown that size exclusion is the main mechanism for high rejections, while the ultra-low friction water flow along g-C3N4 sheets enhances permeation. Additionally, the GO/g-C3N4 membrane exhibits promising long-term, antioxidation, and antipressure stability.
Article
Nanoscience & Nanotechnology
Zhangsong Peng, Qiang Chang, Malcolm Xing, Feng Lu
Summary: Researchers developed a stem cell-based anticancer system using modified graphene oxide nanocomposites for breast cancer therapy. The nanocomposites were released through near-infrared radiation and directly targeted cancer cells for ablation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Engineering, Chemical
Rui Wang, Hong You, Yingjie Zhang, Zhipeng Li, Yi Ding, Qiqing Qin, Han Wang, Jinxu Sun, Yuhong Jia, Feng Liu, Jun Ma, Xiquan Cheng
Summary: By incorporating graphene oxide (GO)/reduced graphene oxide (rGO), researchers have developed a highly conductive polypyrrole (PPy) coated ceramic membrane (CM) with excellent anti-fouling performance and high flux.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Daowen Wu, Mengyao Sun, Wenbin Zhang, Weiming Zhang
Summary: The surface properties and microstructure of graphene oxide (GO) membranes can be regulated to enhance nanofiltration performance. The surface hydrophilicity and zeta potential of GO membranes can be adjusted by alkaline treatment time, and the presence of tiny defects in GO sheets can increase the number of pores and decrease the length of water nanochannels. These adjustments enable GO membranes to exhibit fast and selective water permeation, demonstrating excellent nanofiltration performance.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Chemical
Abedalkader Alkhouzaam, Hazim Qiblawey
Summary: Novel PSF composite UF membranes incorporating low loadings of polydopamine-functionalized graphene oxide particles were fabricated and investigated, showing improved pure water flux without affecting rejection properties. The membranes exhibited enhanced fouling resistance and are expected to have great potential in ultrafiltration and other membrane processes.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Multidisciplinary Sciences
Kisuk Yang, Eoin D. O'Cearbhaill, Sophie S. Liu, Angela Zhou, Girish D. Chitnis, Allison E. Hamilos, Jun Xu, Mohan K. S. Verma, Jaime A. Giraldo, Yoshimasa Kudo, Eunjee A. Lee, Yuhan Lee, Ramona Pop, Robert Langer, Douglas A. Melton, Dale L. Greiner, Jeffrey M. Karp
Summary: Traditional islet transplantation for type 1 diabetes treatment has been hindered by lifelong immunosuppression, however, new convective nutrient transport technology shows potential to increase loading capacity, promote cell viability, and improve insulin secretion and fibrosis reduction for diabetic patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Chemical
Yuhui Jia, Guorong Xu, Xiaochan An, Yunxia Hu
Summary: Inspired by the special antiwetting properties of graphene-based membrane, a simple and scalable approach has been developed to fabricate anti-wetting composite membranes with a reduced graphene oxide (rGO) skin layer and a microporous polytetrafluomethylene (PTFE) substrate. The prepared rGO-PTFE composite membrane exhibited outstanding membrane distillation performance with high water flux, excellent salt rejection and robust anti-wetting properties.
Article
Chemistry, Applied
MeeiChyn Goh, Giyoong Tae
Summary: Cell microencapsulation is a process to trap cells within a matrix for a favorable microenvironment. This study demonstrated the use of cellulose nanofiber (CNF) microbeads for the 3D culture of human adipose-derived stem cells (hADSCs). Hyaluronic acid (HA) was incorporated into the microbeads to enhance cellular bioactivities. The results showed that HA incorporation significantly improved cell proliferation and VEGF secretion while maintaining stemness.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Physical
Aaron Morelos-Gomez, Souya Terashima, Ayaka Yamanaka, Rodolfo Cruz-Silva, Josue Ortiz-Medina, Roque Sanchez-Salas, Juan L. Fajardo-Diaz, Emilio Munoz-Sandoval, Florentino Lopez-Urias, Kenji Takeuchi, Syogo Tejima, Mauricio Terrones, Morinobu Endo
Summary: This study demonstrates that graphene oxide membranes have higher lactose permeation flux and water flux recovery compared to commercial nanofiltration and ultrafiltration membranes, showing better filtration performance and anti-fouling ability.
Article
Engineering, Chemical
Fan-xin Kong, Qian Liu, Lian You, Peng Lu, Tao Liu, Guang-dong Sun, Yi Wang, Jin-fu Chen
Summary: In this study, the effects of dopamine addition on the performance and stability of dopamine-mediated graphene oxide membranes were systematically investigated. The results showed that dopamine addition could improve the hydrophilicity and interlayer spacing of the membranes, thus enhancing water flux. Moreover, the stability of the membranes was also improved with increasing dopamine addition.
Article
Materials Science, Multidisciplinary
Rutuja Bhoje, Asim K. Ghosh, Parag R. Nemade
Summary: The desalination performance of thin-film composite seawater reverse osmosis membranes was improved by incorporating graphene oxide nanoparticles. These nanostructured membranes showed increased water flux and improved compaction resistance.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Engineering, Environmental
Saeed Seraj, Toraj Mohammadi, Maryam Ahmadzadeh Tofighy
Summary: Membrane distillation (MD) is a promising membrane technology with the ability to treat high-salinity water bodies, attracting widespread attention worldwide. The use of graphene-based nanomaterials has provided new opportunities for the development of MD membranes due to their unique properties and simple synthesis procedures.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Polymer Science
Mariia Dmitrenko, Anastasia Chepeleva, Vladislav Liamin, Anton Mazur, Konstantin Semenov, Nikolay Solovyev, Anastasia Penkova
Summary: In this study, graphene oxide (GO) nanoparticles were introduced into a poly(2,6-dimethyl-1,4-phenylene oxide) (PPO) membrane to improve its pervaporation performance in the dehydration of ethylene glycol (EG). Through a series of experiments and tests, researchers successfully developed a PPO/GO composite membrane and found that the supported PPO/GO/MFFC membrane exhibited the best permeation properties in the dehydration of ethylene glycol.
Article
Biochemistry & Molecular Biology
Jiangyi Yan, Lihong Nie, Guiliang Li, Yuanlu Zhu, Ming Gao, Ruili Wu, Beifu Wang
Summary: A novel asymmetric polyamide 66 composite ultrafiltration (UF) membrane was fabricated by incorporating graphene oxide (GO) into the polyamide 66 microporous substrate, improving the contamination resistance and performance of the membrane. The modified membrane showed enhanced hydrophilicity and anti-pollution performance, making it an ideal solution for long-life ultrafiltration membranes.
Article
Biochemical Research Methods
H. Busra Cagirici, Hikmet Budak, Taner Z. Sen
Summary: G4Boost is a decision tree-based prediction tool that accurately predicts the folding state and thermodynamic stability of G-quadruplexes (G4s). It outperforms other machine-learning prediction tools in terms of accuracy and F1-score, and has important applications in gene regulation in both plants and humans.
BMC BIOINFORMATICS
(2022)
Review
Plant Sciences
Babar Hussain, Bala A. Akpinar, Michael Alaux, Ahmed M. Algharib, Deepmala Sehgal, Zulfiqar Ali, Gudbjorg I. Aradottir, Jacqueline Batley, Arnaud Bellec, Alison R. Bentley, Halise B. Cagirici, Luigi Cattivelli, Fred Choulet, James Cockram, Francesca Desiderio, Pierre Devaux, Munevver Dogramaci, Gabriel Dorado, Susanne Dreisigacker, David Edwards, Khaoula El-Hassouni, Kellye Eversole, Tzion Fahima, Melania Figueroa, Sergio Galvez, Kulvinder S. Gill, Liubov Govta, Alvina Gul, Goetz Hensel, Pilar Hernandez, Leonardo Abdiel Crespo-Herrera, Amir Ibrahim, Benjamin Kilian, Viktor Korzun, Tamar Krugman, Yinghui Li, Shuyu Liu, Amer F. Mahmoud, Alexey Morgounov, Tugdem Muslu, Faiza Naseer, Frank Ordon, Etienne Paux, Dragan Perovic, Gadi V. P. Reddy, Jochen Christoph Reif, Matthew Reynolds, Rajib Roychowdhury, Jackie Rudd, Taner Z. Sen, Sivakumar Sukumaran, Bahar Sogutmaz Ozdemir, Vijay Kumar Tiwari, Naimat Ullah, Turgay Unver, Selami Yazar, Rudi Appels, Hikmet Budak
Summary: Recent technological advances in next-generation sequencing have made DNA sequencing more accessible for species with large and complex genomes, including bread wheat. Despite its importance as a food crop, breeding in bread wheat has been limited by its large polyploid genome. However, after years of effort, draft and reference genome sequences of bread wheat have been released, providing valuable resources for breeding. These advances have also facilitated the use of genotyping arrays in wheat breeding, allowing for fast and reliable characterization of wheat lines. Additionally, gene-editing and genomic selection methods have shown promise in improving important traits in wheat breeding.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biophysics
Omur Acet, Emrah Dikici, Burcu Onal Acet, Mehmet Odabasi, Ivan Mijakovic, Santosh Pandit
Summary: Microbial adhesion and formation of biofilms pose serious problems in various areas. Preventing microbial adhesion and biofilm formation is a promising strategy to address these issues. In this study, attaching EGCG to membranes effectively prevented bacterial colonization.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Bala Ani Akpinar, Tugdem Muslu, Gadi V. P. Reddy, Munevver Dogramaci, Hikmet Budak
Summary: This article examines long noncoding RNAs (lncRNAs), a type of noncoding RNA that is typically over 200 nucleotides in length but lacks coding potential. Through analyzing two different wheat varieties, potential lncRNAs were identified, and potential functional networks with microRNAs were observed. Additionally, lncRNAs with perfect or near-perfect matches to organellar genomes were discovered.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Shadi Rahimi, Daniel van Leeuwen, Fariba Roshanzamir, Santosh Pandit, Lei Shi, Nima Sasanian, Jens Nielsen, Elin K. Esbjoerner, Ivan Mijakovic
Summary: To enhance the delivery of doxorubicin (DOX) and minimize its side effects, researchers developed a pH-responsive delivery system based on graphene oxide (GO) that can release drugs specifically in acidic tumor environments.
Review
Microbiology
Pragati Rajendra More, Santosh Pandit, Anna De Filippis, Gianluigi Franci, Ivan Mijakovic, Massimiliano Galdiero
Summary: This review focuses on the synthesis of silver nanoparticles (AgNPs) and their mechanism of action against antibiotic-resistant and biofilm-forming bacteria. AgNPs exert their antibacterial effects through oxidative stress, protein dysfunction, membrane disruption, and DNA damage in bacteria. They also prevent biofilm formation by altering bacterial cell adhesion. However, the medical use of AgNPs is limited by their harmful effects on humans and the environment. The review compiles recent studies on the antibacterial activity of AgNPs and discusses their potential applications in medicine.
Article
Engineering, Biomedical
Efsun Senturk, Cigdem Bilici, Ferdows Afghah, Zaeema Khan, Suleyman Celik, Chengtie Wu, Bahattin Koc
Summary: This study developed a new 3D bioprinting approach using a combination of different materials and in situ crosslinking to fabricate tissue interfaces between cartilage and bone. The biofabricated constructs were cultured with specific media and evaluated for cell viability, morphology, and differentiation into chondrogenic and osteogenic tissues. The results showed that mechanical and chemical cues successfully induced the differentiation of human bone marrow mesenchymal stem cells into the desired tissues.
Article
Immunology
Santosh Pandit, Lucas Jacquemin, Jian Zhang, Zhengfeng Gao, Yuta Nishina, Rikke Louise Meyer, Ivan Mijakovic, Alberto Bianco, Chengfang Pang
Summary: The absorption of antimicrobial peptide polymyxin B onto the surface of graphene oxide significantly enhances its antibacterial activity and can effectively combat bacterial biofilms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Shadi Rahimi, Teo Lovmar, Alexandra Aulova, Santosh Pandit, Martin Lovmar, Sven Forsberg, Magnus Svensson, Roland Kadar, Ivan Mijakovic
Summary: To combat bacterial infections in the post-antibiotic era, efforts are being made to engineer new materials with antibacterial properties. A new automated pipeline based on scanning electron microscopy images has been developed to predict the antibacterial potential of these materials. The density of sharp exposed edges of graphite-oriented nanoplatelets (GNPs) is a key factor in killing bacteria on contact.
Article
Chemistry, Multidisciplinary
Xin Chen, Santosh Pandit, Lei Shi, Vaishnavi Ravikumar, Julie Bonne Kohler, Ema Svetlicic, Zhejian Cao, Abhroop Garg, Dina Petranovic, Ivan Mijakovic
Summary: Alzheimer's disease is a common neurodegenerative disease characterized by the aggregation of misfolded amyloid-beta peptides in the brain. Graphene oxide nanoflakes have been found to effectively inhibit A beta aggregation in vitro. In this study using yeast as a model, it is shown that graphene oxide can penetrate yeast cells and reduce A beta 42 toxicity. The findings provide insights for designing graphene oxide-based therapies for attenuating cytotoxicity of A beta 42 and other misfolded proteins involved in neurodegenerative pathology.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Jian Zhang, Priyanka Singh, Zhejian Cao, Shadi Rahimi, Santosh Pandit, Ivan Mijakovic
Summary: The development of antibacterial coatings is important for preventing biofilm formation on medical devices. This study presents a simple method to fabricate antibacterial coatings by combining the properties of polydopamine and graphene oxide. The coatings successfully loaded with tetracycline and green-synthesized silver nanoparticles exhibited strong inhibitory effects on Staphylococcus aureus and Escherichia coli biofilms, with over 1000-fold reduction in biofilm formation. The results suggest that these coatings have potential as an approach to prevent infection associated with implantable biomedical devices.
APPLIED SURFACE SCIENCE
(2023)
Article
Energy & Fuels
Muthusankar Eswaran, Shadi Rahimi, Santosh Pandit, Bavatharani Chokkiah, Ivan Mijakovic
Summary: In this work, a flexible, multifunctional polyimide (PI)/Au-polyaniline (PAN)/Pd nanocomposite electrode with excellent electrochemical properties was fabricated. The electrode showed high conductivity, rapid response, and high electron transfer rate due to the strong metal-polymer interaction between PAN and Pd. It demonstrated successful biomedical sensing of glucose and electrooxidation of alcohols such as methanol and ethanol, making it promising for healthcare diagnostics and alternative energy conversion devices.
Article
Chemistry, Multidisciplinary
Zhejian Cao, Xiaozhi Fu, Hao Li, Santosh Pandit, Francoise M. Amombo Noa, Lars Ohrstrom, Aleksej Zelezniak, Ivan Mijakovic
Summary: This study successfully synthesized MOFs using enzymatically recycled PET, demonstrating the feasibility of this approach. Compared to conventional methods, this approach avoids the use of strong acids or bases and high temperatures, leading to reduced environmental and energy penalties.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Jian Zhang, Nisha Neupane, Puspa Raj Dahal, Shadi Rahimi, Zhejian Cao, Santosh Pandit, Ivan Mijakovic
Summary: Developed antibiotic-loaded boron nitride nanoconjugates with strong antimicrobial properties for combating bacterial biofilms.
ACS APPLIED BIO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Hengzhi Ruan, Marko Bek, Santosh Pandit, Alexandra Aulova, Jian Zhang, Philip Bjellheim, Martin Lovmar, Ivan Mijakovic, Roland Kadar
Summary: This study presents a facile approach of incorporating dopamine and [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide via in situ synthesis into gelatin hydrogels. The resulting hydrogels show exceptional antibacterial efficiency and multifunctional performance, making them highly promising for various biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
