Article
Biotechnology & Applied Microbiology
Jiapu Wang, Xuefeng Wang, Ziwei Liang, Weiwei Lan, Yan Wei, Yinchun Hu, Longfei Wang, Qi Lei, Di Huang
Summary: By combining bionic inorganic particles and hydrogels to mimic the organic-inorganic characteristics of natural bone extracellular matrix, multifunctional hydrogels with bone tissue repair effects and excellent antibacterial activity have been developed, providing a promising minimally invasive treatment biomaterial in bone repair fields.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Environmental
Meiyue Wang, Sen Lin, Mengzhe Liu, Jing Jiao, Hongyan Mi, Jingjing Sun, Yiming Liu, Ruiying Guo, Sirui Liu, Haojie Fu, Yanyu Yang, Rui Li
Summary: By reacting carboxymethyl chitosan (CMC) with dialdehyde-functionalized polyethylene glycol (DF-PEG), an injectable and biocompatible hydrogel was developed. The hydrogel demonstrated wet tissue adhesion, self-healing, and rapid degradation within one week. It acted as a physical barrier to prevent adhesion by covering irregular wounds and fixing to targeted tissues. In a cecum-sidewall abrasion model, the hydrogel significantly reduced the severity of peritoneal adhesion by balancing the extracellular matrix, fibrinolytic system, and inhibiting inflammatory responses. The CMC/DF-PEG hydrogel holds promise as a solution for postoperative antiadhesion in surgery.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Yi Liu, Yifan Zhang, Zexiang Zheng, Wenchao Zhong, Haiyang Wang, Zhen Lin, Lihua Li, Gang Wu
Summary: A thermoresponsive, injectable NGR1-HA/nHAp composite hydrogel was fabricated in this study, which showed potential for use in bone regeneration applications with controlled inflammation and excellent osteogenic effect.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Applied
Shuo Wang, Jinhua Chi, Zhiwen Jiang, Huiwen Hu, Chaozhong Yang, Wanshun Liu, Baoqin Han
Summary: The study developed a biocompatible, self-repairing, and in-situ injectable hydrogel using CMCTS and OHA as a vitreous substitute. The hydrogel showed good cytocompatibility on mouse fibroblast L929 and histocompatibility in New Zealand Rabbits, without significant and persistent adverse effects observed.
CARBOHYDRATE POLYMERS
(2021)
Article
Biotechnology & Applied Microbiology
Jianhua Yang, Xiaoguang Jing, Zimin Wang, Xuejian Liu, Xiaofeng Zhu, Tao Lei, Xu Li, Weimin Guo, Haijun Rao, Mingxue Chen, Kai Luan, Xiang Sui, Yen Wei, Shuyun Liu, Quanyi Guo
Summary: The study comprehensively analyzed the physical properties and cytocompatibility of hydrogels as cell carriers for ADSC transplantation. Rat models of articular cartilage defect were treated with GCS/DF-PEG hydrogel, showing potential for repairing injured cartilage.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shuqin Yu, Shuo Wang, Lixin Xia, Huiwen Hu, Mingyu Zou, Zhiwen Jiang, Jinhua Chi, Yijie Zhang, Hongjian Li, Chaozhong Yang, Wanshun Liu, Baoqin Han
Summary: A study has successfully prepared a thiolated hyaluronic acid (SH-HA) hydrogel as a vitreous substitute, which demonstrated excellent biocompatibility and intraocular compatibility in experimental rabbits.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Longlong Cui, Jiankang Li, Shuaimeng Guan, Kaixiang Zhang, Kun Zhang, Jingan Li
Summary: In this study, a multi-functional injectable hydrogel was prepared and its antioxidant, gelation time, degradability, rheology, and antihemorrhagic properties were finely tuned by varying the composition ratio. The hydrogel was found to promote angiogenesis and cell proliferation, and regulate inflammation to enhance the repair of full-thickness skin injuries.
MATERIALS TODAY BIO
(2022)
Article
Infectious Diseases
Chaitany Jayprakash Raorane, Divya Shastri, Asrafali Shakila Parveen, Rajesh Haldhar, Vinit Raj, Seong-Cheol Kim
Summary: This study developed chitosan-modified materials and evaluated their ability to inhibit Candida biofilm growth. The results showed that the chitosan-modified materials had significant inhibitory effects on Candida biofilm formation.
Article
Pharmacology & Pharmacy
Minoo Ghanavi, Ali Khoshandam, Shaghayegh Aslzad, Marziyeh Fathi, Abolfazl Barzegari, Elaheh Dalir Abdolahinia, Khosro Adibkia, Jaleh Barar, Yadollah Omidi
Summary: Due to the unique structure of the human eye, ocular drug delivery faces challenges such as low bioavailability. In-situ gel-forming mucoadhesive hydrogels can improve ocular bioavailability. Chitosan has been used in the preparation of these hydrogels. Water-soluble chitosan was obtained and gel formation was accomplished using sodium beta-glycerophosphate and sodium bicarbonate. The prepared hydrogel showed sustained-release and antibacterial activity in vitro.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Petra Chocholata, Vlastimil Kulda, Jana Dvorakova, Monika Supova, Margit Zaloudkova, Vaclav Babuska
Summary: Bone tissue engineering aims to mimic the natural behavior of hard tissues. This study found that scaffolds with in situ synthesized hydroxyapatite (HAp) showed better proliferation of human osteoblast-like cells than those with physically mixed pre-prepared HAp, indicating the advantages of in situ synthesizing HAp directly in the organic matrix to improve scaffold properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chengkun Liu, Chang Liu, Zhiyuan Liu, Zhuang Shi, Shihai Liu, Xiaojuan Wang, Xiaoqiang Wang, Fang Huang
Summary: A thermogelling chitosan/glycerophosphate formulation was developed by incorporating dihydrocaffeic acid (DHCA), which significantly enhanced gel-forming capacity and tissue adherence. The thermosensitive hydrogels showed improved hemostasis and reduced blood loss in both in vitro and in vivo models. The results demonstrated the potential of enhancing thermogelling and bioadhesion of chitosan-based hydrogels through noncovalent supramolecular mechanisms.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Indu Yadav, Shiv Dutt Purohit, Hemant Singh, Neeladrisingha Das, Partha Roy, Narayan Chandra Mishra
Summary: A tri-polymer complex in situ hydrogel has been developed as a potential vitreous substitute, formed by crosslinking HA, Coll, and PEG. The hydrogels are biocompatible, transparent, elastic, injectable, and have a high water content, showing promise for vitreous replacement in ophthalmic diseases.
BIOMEDICAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Yucong Gu, Yuting Yang, Jingfeng Yuan, Yifeng Ni, Jiahui Zhou, Mengjie Si, Kaishun Xia, Wenlin Yuan, Chunbin Xu, Shengqian Xu, Yisheng Xu, Guangyan Du, Dong Zhang, Weilian Sun, Si Yu Zheng, Jintao Yang
Summary: An injectable hydrogel with programmable mechanical kinetics has been developed for oral jaw repair, which undergoes instant gelation and gradual self-strengthening. The hydrogel also possesses multiple functions including bio-adhesion, self-healing, bactericidal, hemostasis, and X-ray in situ imaging.
Article
Pharmacology & Pharmacy
Samar A. Salim, Samah A. Loutfy, Esmail M. El-Fakharany, Tarek H. Taha, Yasmen Hussien, Elbadawy A. Kamoun
Summary: The 3D scaffolds made of PVA/HA nanofiber mats, optimized with chitosan and hydroxyapatite, demonstrated improved biocompatibility and mechanical stability. The different compositions of nanofiber mats showed high cell viability and adhesion in cell evaluation and in vitro experiments.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhishu Bao, Ailing Yu, Hui Shi, Yuhan Hu, Bo Jin, Dan Lin, Mali Dai, Lei Lei, Xingyi Li, Yuqin Wang
Summary: In this study, a glycol chitosan/oxidized hyaluronic acid hydrogel film for dual ophthalmic drug delivery was fabricated successfully. The hydrogel films exhibited a stepwise release of levofloxacin and dexamethasone, demonstrating potent antibacterial and anti-inflammatory activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
