Article
Multidisciplinary Sciences
Nichole Owen, Irina G. Minko, Samantha A. Moellmer, Sydney K. Cammann, R. Stephen Lloyd, Amanda K. McCullough
Summary: Human clinical trials suggest that inhibition of enzymes in the DNA base excision repair (BER) pathway, such as PARP1 and APE1, can be useful in anticancer strategies when combined with certain DNA-damaging agents. Specifically, in acute myeloid leukemia (AML), AML cell lines deficient in OGG1 have enhanced sensitivity to cytarabine (Ara-C) treatment. This enhanced cytotoxicity is likely due to the insertion of Ara-C opposite unrepaired 8-oxo-dG in OGG1-deficient AML cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Applied
Yuanyuan Li, Bingxue Liu, Xiaoxue Zhang, Yanjie Liu, Siying Wang, Shujun Li, Xiuhua Zhao
Summary: A new amphiphilic oligosaccharide derivative was synthesized by lutein modification onto the OH position of stachyose through esterification. It showed better digestibility, scavenging ability, and inhibition of lutein degradation in the gastrointestinal tract compared to free lutein. In rats, it exhibited significantly higher oral bioavailability than free lutein, making stachyose modification a promising strategy for improving the oral bioavailability of fat-soluble lutein.
Review
Pharmacology & Pharmacy
Qing Pei, Bowen Jiang, Dengyuan Hao, Zhigang Xie
Summary: Chemotherapy plays a critical role in cancer treatment, especially for advanced and metastatic tumors. However, the therapeutic effect of Paclitaxel-based formulations is limited by off-target toxicity and drug resistance. Self-assembled PTX nanoparticles have shown promise in enhancing therapeutic index. This study summarizes the self-assembly strategy of PTX nanodrugs and outlines the advancements in tumor therapy, including mono chemotherapy, combination therapy, and theranostics.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Instruments & Instrumentation
Min-Jong Choi, Mi Ran Woo, Kyungho Baek, Jung Suk Kim, Jong Oh Kim, Yong Seok Choi, Han-Gon Choi, Sung Giu Jin
Summary: This study compares polymeric microsphere systems with different surface microstructures and finds that solvent-evaporated microspheres show the most improvement in enhancing the oral bioavailability of rivaroxaban.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Yuanyuan Li, Min Yang, Yanli Zhao, Lingbing Li, Wei Xu
Summary: A series of novel amphiphilic paclitaxel prodrugs were designed, synthesized, and evaluated, showing improved aqueous solubility and potential for enhanced oral bioavailability mediated by the PEPT1 transporter. These prodrugs could self-assemble into nanoparticles, effectively improving paclitaxel solubility, stability, and anticancer activity. PTX-SS-Val demonstrated particularly promising results in enhancing oral bioavailability and anticancer effects.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Xiaoyu Lu, Hangyi Wu, Yiping Liang, Zhenhai Zhang, HuiXia Lv
Summary: This study successfully enhanced the oral bioavailability of BCS class IV drug PTX using a polymeric prodrug strategy, improving drug release and permeability in vivo, and ultimately enhancing the antitumor efficacy against breast cancer.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Veterinary Sciences
Danielle M. Zwueste, Karen M. Vernau, William Vernau, Bruno H. Pypendop, Heather K. Knych, Carlos A. Rodrigues, Amir Kol, Maria Questa, Peter J. Dickinson
Summary: This study demonstrates that oral CO can produce prolonged serum half-lives of Ara-C at concentrations sufficient to induce functional changes in peripheral leukocytes, and is associated with prolonged retention of DNA-incorporated Ara-CTP.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Yaru Zou, Dong Mei, Jinjie Yuan, Jiaqi Han, Jiamin Xu, Ning Sun, Huan He, Changqing Yang, Libo Zhao
Summary: The study focused on constructing 6-mercaptopurine (6-MP)-loaded nanomedicines to enhance its anticancer efficacy for acute lymphoblastic leukemia (ALL) treatment. The results showed that the nanomedicines significantly improved the cytotoxicity in Jurkat cells and prolonged the survival time of ALL model mice, demonstrating their potential as a promising delivery strategy for 6-MP with reduced systemic toxicity.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Pharmacology & Pharmacy
Shital Trivedi, Shreeraj Shah, Riya Patel
Summary: This study discusses the issues with conventional and sustained-release iron products and focuses on the delivery of iron using innovative oral iron formulations designed to enhance bioavailability with reduced side effects. The authors propose gastroretentive iron tablets, capsules, and pellets as a better approach compared to liposomal nanoproducts, providing valuable insights for researchers working on the development of iron formulations.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Dong Xu, Yuxin Wan, Zhenze Xie, Chang Du, Yingjun Wang
Summary: Efficient delivery of cargo into target cells is a formidable challenge in modern medicine. In this study, biomimetic multifunctional composite microparticles (Bm-cMPs) are developed by integrating an amphiphilic prodrug of curcumin with hierarchically structured HA microspheres. The hierarchical structure of the vehicles strongly influences the self-assembly behavior of the prodrug and enhances the stability of the cargo. Bm-cMPs show potential for targeted therapy and suggest a feasible strategy for developing effective treatments for osteosarcoma.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Wookyung Kim, Jung Suk Kim, Han-Gon Choi, Sung Giu Jin, Cheong-Weon Cho
Summary: This study developed a novel electrospray-based fibrous microparticle loaded with ezetimibe, which significantly improved its water solubility and dissolution. The optimized microparticles exhibited higher solubility and dissolution rates compared to ezetimibe powder, and showed enhanced bioavailability in vivo, providing a new approach for enhancing the poorly water-soluble drug ezetimibe.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Zhaopei Guo, Yingying Hu, Mengyao Zhao, Kai Hao, Pan He, Huayu Tian, Xuesi Chen, Meiwan Chen
Summary: The combination of chemo-immunotherapy is challenging due to poor tumor penetration of therapeutic agents. A new strategy using a helix self-assembly camptothecin prodrug combined with plasmids to down-regulate tumor surface PD-L1 expression and degrade ECM showed significant inhibition of tumor growth and prevention of recurrence.
Article
Chemistry, Applied
Ping Hu, Gan Xu, De-Chao Yang, Jian-Yong Liu, Zhuo Chen, Mingdong Huang
Summary: In this study, a multifunctional prodrug B-BDP-CL-CPT was designed and synthesized, which showed high targeted and combined anticancer activities. The prodrug could generate light-induced ROS and release CPT to achieve dual therapeutic effects. It exhibited preferential accumulation and specific activation in tumor tissues, reducing damage to adjacent healthy tissues. Additionally, the prodrug could be used for imaging-guided PDT and real-time tracking of therapeutic agent release.
Article
Chemistry, Multidisciplinary
Abd Al-Wali Mohammed M. Japir, Wendong Ke, Junjie Li, Jean Felix Mukerabigwi, Alhadi Ibrahim, Yuheng Wang, Xiang Li, Qinghao Zhou, Fathelrahman Mohammed, Zhishen Ge
Summary: Combination chemo-immunotherapy of cancers has shown significant synergistic antitumor effects by enhancing immune response rates and therapeutic efficacy. However, it is often limited by immune-related adverse events and systemic toxicity. This study demonstrates an efficient nanofactory-directed enzyme prodrug chemo-immunotherapy based on enzyme-loaded tumor-dilatable polymersomes, offering a promising paradigm for enhanced treatment.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Chemistry, Multidisciplinary
Tingrui Zhang, Lu Li, Suticha Chunta, Wei Wu, Zhongjian Chen, Yi Lu
Summary: The oral route is considered the most ideal method for drug administration. Food protein nanoparticles show potential for oral drug delivery, offering improved safety and cost-effectiveness compared to polymeric nanoparticles. These nanoparticles have the ability to enhance oral bioavailability of a wide range of drugs, from small molecules to biomacromolecules, due to the variety of food proteins available and their easy surface modification capabilities. Despite being in its early stages, food protein nanoparticles hold promise for the development of oral drug delivery systems.
JOURNAL OF CONTROLLED RELEASE
(2023)